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Cardiac glycoside inhibits IL‐8‐induced biological responses by downregulating IL‐8 receptors through altering membrane fluidity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Matrix metalloproteinase 12–dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis
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Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis)
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RECEPTOR-MEDIATED ENDOCYTOSIS OF IL-8: A FLUORESCENT MICROSCOPIC EVIDENCE AND IMPLICATION OF THE PROCESS IN LIGAND-INDUCED BIOLOGICAL RESPONSE IN HUMAN NEUTROPHILS
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Antimutagenesis and Anticarcinogenesis Mechanisms
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Tissue injury in neutrophilic inflammation
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Expression of neurotrophins and their receptors in peripheral lung cells of mice
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Human cell mutants affected in the interaction of the 12β-OH group of cardiac glycosides with the digitalis receptor
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
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Oleandrin suppresses activation of nuclear transcription factor-κB and activator protein-1 and potentiates apoptosis induced by ceramide
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Fully Humanized Neutralizing Antibodies to Interleukin-8 (ABX-IL8) Inhibit Angiogenesis, Tumor Growth, and Metastasis of Human Melanoma
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Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by anvirzel and its cardiac glycoside component, oleandrin11Abbreviations: PARP, poly(ADP-ribose) polymerase; NF-κB, nuclear factor-κB; FGF-2, fibroblast growth factor-2; ER, endoplasmic…
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The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells
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α‐Melanocyte‐stimulating hormone inhibits lipopolysaccharide‐induced biological responses by downregulating CD14 from macrophages
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Characterization of two high affinity human interleukin-8 receptors.
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Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453.
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Interleukin 8 (monocyte-derived neutrophil chemotactic factor) dynamically regulates its own receptor expression on human neutrophils.
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lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines
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NF-κB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules**This article was accepted for publication on 27 September 1996.
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Chemokines in health and disease
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Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung
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THE NEUTROPHIL IN RHEUMATOID ARTHRITIS
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Apoptosis: Activate NF-κB or die?
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Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells
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Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma
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Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2.
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Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV
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Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1
inferredcites →https://doi.org/10.1074/jbc.273.50.33333openalex-snapshot
Interleukin-4 Down-regulates Both Forms of Tumor Necrosis Factor Receptor and Receptor-mediated Apoptosis, NF-κB, AP-1, and c-Jun N-Terminal Kinase
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Commitment of Neutrophilic Differentiation and Proliferation of HL-60 Cells Coincides with Expression of Transferrin Receptor
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Nerve Growth Factor Stimulates Proliferation and Survival of Human Breast Cancer Cells through Two Distinct Signaling Pathways
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β-d-Glucoside Suppresses Tumor Necrosis Factor-induced Activation of Nuclear Transcription Factor κB but Potentiates Apoptosis
inferredcites →https://doi.org/10.1074/jbc.m410994200openalex-snapshot
Interleukin-8 Induces Nuclear Transcription Factor-κB through a TRAF6-dependent Pathway
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Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP
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Structure and Functional Expression of a Human Interleukin-8 Receptor
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Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor
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Human Chemokines: An Update
inferredcites →https://doi.org/10.1165/rcmb.2002-0110ocopenalex-snapshot
Neurotrophin and Neurotrophin Receptor Protein Expression in the Human Lung
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Nuclear Factor Kappa B: Important Transcription Factor and Therapeutic Target
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Host defense function of the airway epithelium in health and disease: clinical background
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Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37)
inferredcites →https://doi.org/10.14670/hh-15.843openalex-snapshot
IL-8 expression in malignant melanoma: implications in growth and metastasis.
inferredcites →https://doi.org/10.4049/jimmunol.136.12.4496openalex-snapshot
Properties of a specific interleukin 1 (IL 1) receptor on human Epstein Barr virus-transformed B lymphocytes: identity of the receptor for IL 1-alpha and IL 1-beta.
inferredcites →https://doi.org/10.4049/jimmunol.159.10.5042openalex-snapshot
Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils
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Distinct signal transduction pathways mediate nuclear factor-kappaB induction by IL-1beta in epithelial and lymphoid cells
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4667960openalex-extracted
Anti-inflammatory activity of the new cardiotonic steroid γ-Benzylidene Digoxin 8 (BD-8) on macrophages
inferred← citeshttps://doi.org/10.1007/s00232-021-00203-zopenalex-snapshot
Evaluation of Cardiotonic Steroid Modulation of Cellular Cholesterol and Phospholipid
inferred← citeshttps://doi.org/10.1007/s10495-006-0626-3openalex-snapshot
RETRACTED ARTICLE: Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases
inferred← citeshttps://doi.org/10.1007/s10495-013-0853-3openalex-snapshot
Retraction Note to: Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases
inferred← citeshttps://doi.org/10.1007/s10875-006-9028-0openalex-snapshot
RETRACTED ARTICLE: Oleandrin-Mediated Expression of Fas Potentiates Apoptosis in Tumor Cells
inferred← citeshttps://doi.org/10.1007/s10875-013-9884-3openalex-snapshot
Retraction Note: Oleandrin-Mediated Expression of Fas Potentiates Apoptosis in Tumor Cells
inferred← citeshttps://doi.org/10.1007/s12013-026-02108-xopenalex-snapshot
Digoxin Derivative BD-8 Attenuates Oxidative Stress and Neuroinflammation in an LPS-Induced Experimental Model
inferred← citeshttps://doi.org/10.1016/b978-0-12-803951-9.00005-7openalex-snapshot
Cardiac Glycosides and Oxidative Stress in Liver Cancer
inferred← citeshttps://doi.org/10.1016/bs.mie.2022.08.003openalex-snapshot
Quantification of plant cardenolides by HPLC, measurement of Na+/K+-ATPase inhibition activity, and characterization of target enzymes
inferred← citeshttps://doi.org/10.1016/j.bcp.2009.06.027openalex-snapshot
Odoroside A and ouabain inhibit Na+/K+-ATPase and prevent NF-κB-inducible protein expression by blocking Na+-dependent amino acid transport
inferred← citeshttps://doi.org/10.1016/j.bcp.2018.06.008openalex-snapshot
Effects of digitoxin on cell migration in ovarian cancer inflammatory microenvironment
inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115453openalex-snapshot
Cardiac glycoside neriifolin exerts anti-cancer activity in prostate cancer cells by attenuating DNA damage repair through endoplasmic reticulum stress
inferred← citeshttps://doi.org/10.1016/j.biochi.2023.04.010openalex-snapshot
Activity of Na+/K+- and Ca2+-ATPases in human erythrocyte membranes: Protocol improvement, relation to cholesterol content, and effects of polyphenols
inferred← citeshttps://doi.org/10.1016/j.fct.2020.111570openalex-snapshot
Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways
inferred← citeshttps://doi.org/10.1016/j.fitote.2016.04.023openalex-snapshot
Cardenolides from the Apocynaceae family and their anticancer activity
inferred← citeshttps://doi.org/10.1016/j.isci.2022.104925openalex-snapshot
Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization
inferred← citeshttps://doi.org/10.1016/j.mito.2012.06.003openalex-snapshot
Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides
inferred← citeshttps://doi.org/10.1016/j.molimm.2006.11.009openalex-snapshot
Oleandrin induces apoptosis in human, but not in murine cells: Dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity
inferred← citeshttps://doi.org/10.1016/j.molimm.2008.11.014openalex-snapshot
Decrease in RelA phosphorylation by inhibiting protein kinase A induces cell death in NF-κB-expressing and drug-resistant tumor cells
inferred← citeshttps://doi.org/10.1016/j.neo.2024.101008openalex-snapshot
PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2011.01.009openalex-snapshot
Common cardiovascular medications in cancer therapeutics
inferred← citeshttps://doi.org/10.1016/j.toxicon.2023.107047openalex-snapshot
A toxic shrub turned therapeutic: The dichotomy of Nerium oleander bioactivities
inferred← citeshttps://doi.org/10.1016/j.yexcr.2017.07.017openalex-snapshot
Differences of lipid membrane modulation and oxidative stress by digoxin and 21-benzylidene digoxin
inferred← citeshttps://doi.org/10.1038/ja.2009.98openalex-snapshot
Chemical biology of inflammatory cytokine signaling
inferred← citeshttps://doi.org/10.1038/nrd2682openalex-snapshot
Novel therapeutic applications of cardiac glycosides
inferred← citeshttps://doi.org/10.1038/s41598-022-26087-0openalex-snapshot
Qualitative and quantitative phytochemical screening of Nerium oleander L. extracts associated with toxicity profile
inferred← citeshttps://doi.org/10.1074/jbc.m110.191916openalex-snapshot
Ras Puts the Brake on Doxorubicin-mediated Cell Death in p53-expressing Cells
inferred← citeshttps://doi.org/10.1080/10408440701524519openalex-snapshot
Lipid Vesicles as Membrane Models for Toxicological Assessment of Xenobiotics
inferred← citeshttps://doi.org/10.1089/jpm.2013.0126openalex-snapshot
Herbal Administration and Interaction of Cancer Treatment
inferred← citeshttps://doi.org/10.1093/pcp/pcac144openalex-snapshot
Cardenolide Increase in Foxglove after 2,1,3-Benzothiadiazole Treatment Reveals a Potential Link between Cardenolide and Phytosterol Biosynthesis
inferred← citeshttps://doi.org/10.1111/bph.12493openalex-snapshot
Short‐term exposure to oleandrin enhances responses to IL ‐8 by increasing cell surface IL ‐8 receptors
inferred← citeshttps://doi.org/10.1111/febs.12355openalex-snapshot
Cardiac glycosides correct aberrant splicing of IKBKAP ‐encoded m RNA in familial dysautonomia derived cells by suppressing expression of SRSF 3
inferred← citeshttps://doi.org/10.1124/mi.8.1.8openalex-snapshot
Cardiac Glycosides as Novel Cancer Therapeutic Agents
inferred← citeshttps://doi.org/10.1152/ajpcell.00098.2007openalex-snapshot
Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth
inferred← citeshttps://doi.org/10.1155/2014/312684openalex-snapshot
Toad Glandular Secretions and Skin Extractions as Anti‐Inflammatory and Anticancer Agents
inferred← citeshttps://doi.org/10.1155/2015/265798openalex-snapshot
Ouabain Modulates Zymosan‐Induced Peritonitis in Mice
inferred← citeshttps://doi.org/10.1155/2019/1094520openalex-snapshot
Marinobufagenin Inhibits Neutrophil Migration and Proinflammatory Cytokines
inferred← citeshttps://doi.org/10.1158/1535-7163.c.6535384openalex-snapshot
Data from Digitoxin-Induced Cytotoxicity in Cancer Cells Is Mediated through Distinct Kinase and Interferon Signaling Networks
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-11-0421openalex-snapshot
Digitoxin-Induced Cytotoxicity in Cancer Cells Is Mediated through Distinct Kinase and Interferon Signaling Networks
inferred← citeshttps://doi.org/10.11606/d.42.2023.tde-14122023-101330openalex-snapshot
Avaliação dos efeitos >i /i< e>i< in vitro>/i< da 21-p-hexoxi-m-metoxibenzilideno digoxina (BD-15) nas respostas induzidas por LPS.
inferred← citeshttps://doi.org/10.1248/bpb.b14-00532openalex-snapshot
Cardenolide Aglycones Inhibit Tumor Necrosis Factor α-Induced Expression of Intercellular Adhesion Molecule-1 at the Translation Step by Blocking Na+/K+-ATPase
inferred← citeshttps://doi.org/10.2139/ssrn.4038525openalex-snapshot
Identification of Druggable Host Targets Needed for SARS-CoV-2 Infection by Combined Pharmacological Evaluation and Cellular Network Directed Prioritization Both in vitro and in vivo
inferred← citeshttps://doi.org/10.2174/9789815049633123010008openalex-snapshot
Glycosides in the Treatment of Gastrointestinal Tract Cancer
inferred← citeshttps://doi.org/10.2310/7200.2006.035openalex-snapshot
Acupuncture for Chemotherapy-Induced Leukopenia: Exploratory Meta-Analysis of Randomized Controlled Trials
inferred← citeshttps://doi.org/10.25904/1912/3403openalex-snapshot
Cane Toad Skin Extracts as Anti-Inflammatory and Anti-Cancer Agents
inferred← citeshttps://doi.org/10.3389/fendo.2016.00010openalex-snapshot
Cardiotonic Steroids as Modulators of Neuroinflammation
inferred← citeshttps://doi.org/10.3389/fphar.2020.552428openalex-snapshot
The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties
inferred← citeshttps://doi.org/10.3389/fphar.2022.822726openalex-snapshot
Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology
inferred← citeshttps://doi.org/10.3389/fphar.2025.1520927openalex-snapshot
Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells
inferred← citeshttps://doi.org/10.3390/biom11050659openalex-snapshot
Cardiac Glycosides as Immune System Modulators
inferred← citeshttps://doi.org/10.3390/cells13181568openalex-snapshot
Evaluation of Anti-Inflammatory Activity of the New Cardiotonic Steroid γ-Benzylidene Digoxin 8 (BD-8) in Mice
inferred← citeshttps://doi.org/10.3390/ijms19113350openalex-snapshot
Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway
inferred← citeshttps://doi.org/10.3390/microorganisms13020269openalex-snapshot
Evaluation of the Anti-Mycobacterial and Anti-Inflammatory Activities of the New Cardiotonic Steroid γ-Benzylidene Digoxin-15 in Macrophage Models of Infection
inferred← citeshttps://doi.org/10.3390/molecules26185627openalex-snapshot
Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting Viruses
inferred← citeshttps://doi.org/10.3390/toxins13050344openalex-snapshot
Quo vadis Cardiac Glycoside Research?
inferred← citeshttps://doi.org/10.35248/1948-5964.19.11.184openalex-snapshot
The Botanical Glycoside Oleandrin Inhibits Human T-cell Leukemia Virus Type-1 Infectivity and Env-Dependent Virological Synapse Formation
inferred← citeshttps://doi.org/10.4103/0973-7847.120512openalex-snapshot
Oleandrin: A cardiac glycosides with potent cytotoxicity
inferred← citeshttps://doi.org/10.4103/ijp.ijp_934_24openalex-snapshot
Cardiac glycosides: Looking beyond heart failure and atrial fibrillation
inferred← citeshttps://doi.org/10.58837/chula.the.2016.1323openalex-snapshot
In vitro study of efficacy of pramlintide in osteosarcoma
inferred← citeshttps://doi.org/10.70675/29f5f50bzc1cdz477az8310z184df96e3636openalex-snapshot
Hétérogénéité des glioblastomes et mise en évidence de nouvelles approches thérapeutiques
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