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Identification of Druggable Host Targets Needed for SARS-CoV-2 Infection by Combined Pharmacological Evaluation and Cellular Network Directed Prioritization Both in vitro and in vivo

https://doi.org/10.2139/ssrn.4038525
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics
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Human small intestinal organotypic culture model for drug permeation, inflammation, and toxicity assays
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Proscillaridin A induces apoptosis and inhibits the metastasis of osteosarcoma in vitro and in vivo
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
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A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
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Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
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Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
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Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells
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SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium
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Middle East respiratory syndrome
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Middle East respiratory syndrome
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An interactive web-based dashboard to track COVID-19 in real time
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Get Your Atoms in Order—An Open-Source Implementation of a Novel and Robust Molecular Canonicalization Algorithm
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Early Returns on Small Molecule Therapeutics for SARS-CoV-2
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Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV‑2 and Potential Mechanisms
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SARS-CoV-2 viral load is associated with increased disease severity and mortality
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The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
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A new coronavirus associated with human respiratory disease in China
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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
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SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function
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Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling
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Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide
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ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization
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Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges
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Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
inferredcites →https://doi.org/10.1073/pnas.2025581118openalex-snapshot
Network medicine framework for identifying drug-repurposing opportunities for COVID-19
inferredcites →https://doi.org/10.1093/nar/gkw784openalex-snapshot
smiFISH and FISH-quant – a flexible single RNA detection approach with super-resolution capability
inferredcites →https://doi.org/10.1099/jgv.0.001453openalex-snapshot
SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
inferredcites →https://doi.org/10.1101/2020.03.22.002386openalex-snapshot
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
inferredcites →https://doi.org/10.1126/science.abc1669openalex-snapshot
SARS-CoV-2 productively infects human gut enterocytes
inferredcites →https://doi.org/10.1126/science.abi4708openalex-snapshot
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
inferredcites →https://doi.org/10.1128/aac.00143-20openalex-snapshot
Filovirus Antiviral Activity of Cationic Amphiphilic Drugs Is Associated with Lipophilicity and Ability To Induce Phospholipidosis
inferredcites →https://doi.org/10.1128/aac.02227-16openalex-snapshot
Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments
inferredcites →https://doi.org/10.1128/jvi.00051-17openalex-snapshot
Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells
inferredcites →https://doi.org/10.1128/jvi.01360-15openalex-snapshot
Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes
inferredcites →https://doi.org/10.1128/jvi.02149-19openalex-snapshot
Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses
inferredcites →https://doi.org/10.1128/jvi.78.23.12964-12974.2004openalex-snapshot
Cyclooxygenase-1 and -2 Are Required for Production of Infectious Pseudorabies Virus
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Digitalis
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Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
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Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim
inferredcites →https://doi.org/10.1371/journal.pbio.2005970openalex-snapshot
CellProfiler 3.0: Next-generation image processing for biology
inferredcites →https://doi.org/10.1371/journal.pone.0008292openalex-snapshot
Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis
inferredcites →https://doi.org/10.1371/journal.pone.0146021openalex-snapshot
Dose-Response Analysis Using R
inferredcites →https://doi.org/10.15585/mmwr.mm7008e1openalex-snapshot
First Identified Cases of SARS-CoV-2 Variant B.1.1.7 in Minnesota — December 2020–January 2021
inferredcites →https://doi.org/10.15585/mmwr.mm7008e2openalex-snapshot
Detection of B.1.351 SARS-CoV-2 Variant Strain — Zambia, December 2020
inferredcites →https://doi.org/10.21105/joss.00861openalex-snapshot
UMAP: Uniform Manifold Approximation and Projection
inferredcites →https://doi.org/10.2139/ssrn.3678908openalex-snapshot
Drug Repurposing Screens Reveal FDA Approved Drugs Active Against SARS-CoV-2
inferredcites →https://doi.org/10.3390/v11100964openalex-snapshot
Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine
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Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
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UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Repurposing Polyether Ionophores as a New-Class of Anti-SARS-Cov-2 Agents as Adjunct Therapy
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Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo
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Genomics-based tools for drug discovery and development: From network maps to efficacy prediction
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Online numerical association rule miner
inferred← citeshttps://doi.org/10.1038/s41598-021-01410-3openalex-snapshot
Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis
inferred← citeshttps://doi.org/10.1073/pnas.2025581118openalex-snapshot
Network medicine framework for identifying drug-repurposing opportunities for COVID-19
inferred← citeshttps://doi.org/10.1080/08927022.2022.2111421openalex-snapshot
Epitopes mapped onto SARS-CoV-2 receptor-binding motif by five distinct human neutralising antibodies
inferred← citeshttps://doi.org/10.1109/tetci.2022.3182354openalex-snapshot
A Deep Integrated Framework for Predicting SARS-CoV2–Human Protein-Protein Interaction
inferred← citeshttps://doi.org/10.1111/cts.13384openalex-snapshot
A review of clinical efficacy data supporting emergency use authorization for COVID ‐19 therapeutics and lessons for future pandemics
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