On the public citation graph
Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding
0 signed · 338 inferred · view as graph
Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
Is this your work? Sign in with ORCID and put your name on the
claims that are yours.
Reference health. See whether every reference in this work resolves to a
known work and none has been retracted — and get a dated CiteStamped
badge you can embed.
What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/1520-6017(200008)89:8<1008::aid-jps5>3.0.co;2-bopenalex-snapshot
Determination of the Free Fraction and Relative Free Fraction of Drugs Strongly Bound to Plasma Proteins
inferredcites →https://doi.org/10.1002/1520-6017(200105)90:5<580::aid-jps1014>3.0.co;2-4openalex-snapshot
Development of a High Throughput Equilibrium Dialysis Method
inferredcites →https://doi.org/10.1002/j.1552-4604.1982.tb02671.xopenalex-snapshot
Importance of Protein Binding for the Interpretation of Serum or Plasma Drug Concentrations
inferredcites →https://doi.org/10.1002/jps.2600721133openalex-snapshot
Quantitative Analysis of Ethchlorvynol in a Capsule Dosage Form by NMR Spectroscopy
inferredcites →https://doi.org/10.1002/jps.2600721137openalex-snapshot
Errors in Estimating the Unbound Fraction of Drugs Due to the Volume Shift in Equilibrium Dialysis
inferredcites →https://doi.org/10.1002/jps.2600730617openalex-snapshot
Fluid Shifts and Other Factors Affecting Plasma Protein Binding of Prednisolone by Equilibrium Dialysis
inferredcites →https://doi.org/10.1002/jps.2600740115openalex-snapshot
Factors Affecting the Measurement of Lidocaine Protein Binding by Equilibrium Dialysis in Human Serum
inferredcites →https://doi.org/10.1007/bf00607095openalex-snapshot
The binding of ketamine to plasma proteins: Emphasis on human plasma
inferredcites →https://doi.org/10.1007/bf01062207openalex-snapshot
Influence of volume shifts on drug binding during equilibrium dialysis: Correction and attenuation
inferredcites →https://doi.org/10.1016/0009-8981(85)90082-8openalex-snapshot
Free drug measurements: methodology and clinical significance
inferredcites →https://doi.org/10.1016/0378-5173(85)90227-3openalex-snapshot
Simultaneous correction for volume shifts and protein leakage in equilibrium dialysis protein binding experiments
inferredcites →https://doi.org/10.1016/b978-0-407-02275-1.50016-8openalex-snapshot
Pharmacokinetics of natural and synthetic glucocorticoids
inferredcites →https://doi.org/10.1016/s0065-7743(08)61095-7openalex-snapshot
Current and Future Trends in High Throughput Screening for Drug Discovery
inferredcites →https://doi.org/10.1016/s1367-5931(98)80017-3openalex-snapshot
High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds
inferredcites →https://doi.org/10.1016/s1367-5931(99)80056-8openalex-snapshot
Pharmacokinetics and metabolism in early drug discovery
inferredcites →https://doi.org/10.1038/clpt.1980.40openalex-snapshot
Diazepam disposition determinants
inferredcites →https://doi.org/10.1038/clpt.1980.46openalex-snapshot
Lidocaine plasma protein binding
inferredcites →https://doi.org/10.1038/clpt.1991.47openalex-snapshot
Disposition of drugs in cystic fibrosis. I. Sulfamethoxazole and trimethoprim
inferredcites →https://doi.org/10.1038/clpt.1992.52openalex-snapshot
Age and propranolol stereoselective disposition in humans
inferredcites →https://doi.org/10.1097/00000542-198202000-00007openalex-snapshot
Ketamine—Its Pharmacology and Therapeutic Uses
inferredcites →https://doi.org/10.1097/00004630-198703000-00015openalex-snapshot
Ketamine Pharmacology and Therapeutics
inferredcites →https://doi.org/10.1111/j.1365-2125.1985.tb05040.xopenalex-snapshot
Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations.
inferredcites →https://doi.org/10.1111/j.1365-2125.1994.tb04305.xopenalex-snapshot
Disposition of warfarin enantiomers and metabolites in patients during multiple dosing with rac‐warfarin [see comments]
inferredcites →https://doi.org/10.1111/j.1472-8206.1990.tb00073.xopenalex-snapshot
Methods of drug protein binding determinations
inferredcites →https://doi.org/10.1111/j.1600-0773.1982.tb00954.xopenalex-snapshot
Equilibrium Dialysis for Determination of Protein Binding of Imipramine – Evaluation of a Method
inferredcites →https://doi.org/10.2165/00003088-198106030-00003openalex-snapshot
Clinical Pharmacokinetics of Sulphonylurea Hypoglycaemic Drugs
inferredcites →https://doi.org/10.2165/00003088-198510030-00005openalex-snapshot
Discrepancies Between Pharmacokinetic Studies of Amitriptyline
inferredcites →https://doi.org/10.2165/00003088-198611060-00003openalex-snapshot
Free Drug Concentration Monitoring in Clinical Practice
inferredcites →https://doi.org/10.2165/00003088-198712010-00004openalex-snapshot
Plasma Protein Binding of Drugs in the Elderly
inferredcites →https://doi.org/10.2165/00003088-198713050-00002openalex-snapshot
The Pharmacokinetics of Lignocaine and β-Adrenoceptor Antagonists in Patients with Acute Myocardial Infarction
inferredcites →https://doi.org/10.2165/00003088-199018050-00002openalex-snapshot
Clinical Pharmacokinetics of Imipramine and Desipramine
inferredcites →https://doi.org/10.2165/00003088-199019020-00004openalex-snapshot
Disease-Induced Variations in Plasma Protein Levels
inferredcites →https://doi.org/10.2165/00003088-199019030-00005openalex-snapshot
Disease-Induced Variations in Plasma Protein Levels
inferredcites →https://doi.org/10.2165/00003088-199223060-00005openalex-snapshot
Methods of Determining Plasma and Tissue Binding of Drugs
inferredcites →https://doi.org/10.2165/00003088-199426010-00004openalex-snapshot
Drug Binding in Plasma
inferredcites →https://doi.org/10.3109/03602537608995839openalex-snapshot
Plasma and Tissue Protein Binding of Drugs in Pharmacokinetics
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/0471141755.ph0705s34openalex-snapshot
Determination of Compound Binding to Plasma Proteins
inferred← citeshttps://doi.org/10.1002/9780470431818.ch1openalex-snapshot
Focus on the Fundamentals: Toward Better Therapeutic Index Prediction
inferred← citeshttps://doi.org/10.1002/9780470613191.ch2openalex-snapshot
ADME Strategies in Lead Optimization
inferred← citeshttps://doi.org/10.1002/9780470921920.edm032openalex-snapshot
The Significance and Determination of Plasma Protein Binding
inferred← citeshttps://doi.org/10.1002/9780470921920.edm062openalex-snapshot
In VitroLiver Systems to Study Induction/Inhibition: Prediction ofIn VivoMetabolism and Drug–Drug Interactions
inferred← citeshttps://doi.org/10.1002/9780470921920.edm090openalex-snapshot
Bioanalytical Support for BothIn VitroandIn VivoAssays Across Drug Discovery and Drug Development
inferred← citeshttps://doi.org/10.1002/9780470921920.edm114openalex-snapshot
Plasma Protein Binding Methods in Drug Discovery and Development: Bioanalysis
inferred← citeshttps://doi.org/10.1002/9781118180730.ch6openalex-snapshot
LC‐MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective
inferred← citeshttps://doi.org/10.1002/9781118180778.ch12openalex-snapshot
Techniques for Determining Protein Binding in Drug Discovery and Development
inferred← citeshttps://doi.org/10.1002/9781118354483.ch4openalex-snapshot
Drug Metabolism and Pharmacokinetics in Drug Discovery
inferred← citeshttps://doi.org/10.1002/9781118819586.ch7openalex-snapshot
Experimental Screening Strategies to Reduce Attrition Risk
inferred← citeshttps://doi.org/10.1002/9781118838440.ch2openalex-snapshot
Distribution: Principle, Methods, and Applications
inferred← citeshttps://doi.org/10.1002/9781119678496.ch2openalex-snapshot
The LeadSampler (LS‐1) Sample Delivery System
inferred← citeshttps://doi.org/10.1002/9783527627448.ch9openalex-snapshot
Plasma Protein Binding and Volume of Distribution: Determination, Prediction and Use in Early Drug Discovery
inferred← citeshttps://doi.org/10.1002/biof.102openalex-snapshot
Insilico studies of organosulfur‐functional active compounds in garlic
inferred← citeshttps://doi.org/10.1002/cbic.202400506openalex-snapshot
( S )‐ML‐SA1 Activates Autophagy via TRPML1‐TFEB Pathway
inferred← citeshttps://doi.org/10.1002/cmdc.200900226openalex-snapshot
2,3‐Dihydro‐1‐Benzofuran Derivatives as a Series of Potent Selective Cannabinoid Receptor 2 Agonists: Design, Synthesis, and Binding Mode Prediction through Ligand‐Steered Modeling
inferred← citeshttps://doi.org/10.1002/cmdc.201700170openalex-snapshot
Preparation and Evaluation of Potent Pentafluorosulfanyl‐Substituted Anti‐Tuberculosis Compounds
inferred← citeshttps://doi.org/10.1002/dta.2387openalex-snapshot
Experimental versus theoretical log D7.4, pKa and plasma protein binding values for benzodiazepines appearing as new psychoactive substances
inferred← citeshttps://doi.org/10.1002/dta.3621openalex-snapshot
Log D7.4 and plasma protein binding of synthetic cannabinoid receptor agonists and a comparison of experimental and predicted lipophilicity
inferred← citeshttps://doi.org/10.1002/elps.201400513openalex-snapshot
A comparative study of capillary electrophoresis and isothermal titration calorimetry for the determination of binding constant of human serum albumin to monoclonal antibody
inferred← citeshttps://doi.org/10.1002/jps.20558openalex-snapshot
Determination of drug plasma protein binding by solid phase microextraction
inferred← citeshttps://doi.org/10.1002/jps.21317openalex-snapshot
Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding
inferred← citeshttps://doi.org/10.1002/jps.22124openalex-snapshot
Lack of Appreciable Species Differences in Nonspecific Microsomal Binding
inferred← citeshttps://doi.org/10.1002/jps.22188openalex-snapshot
Semi-Automated Protein Binding Methodology Using Equilibrium Dialysis and A Novel Mixed-Matrix Cassette Approach
inferred← citeshttps://doi.org/10.1002/jps.22323openalex-snapshot
Estimating Unbound Volume of Distribution and Tissue Binding by In Vitro HPLC-Based Human Serum Albumin and Immobilised Artificial Membrane-Binding Measurements
inferred← citeshttps://doi.org/10.1002/jps.22452openalex-snapshot
Validation of 96-well Equilibrium Dialysis with Non-radiolabeled Drug for Definitive Measurement of Protein Binding and Application to Clinical Development of Highly-Bound Drugs
inferred← citeshttps://doi.org/10.1002/jps.23013openalex-snapshot
Impact of Recovery on Fraction Unbound Using Equilibrium Dialysis
inferred← citeshttps://doi.org/10.1002/jps.23081openalex-snapshot
How Well Do Lipophilicity Parameters, MEEKC Microemulsion Capacity Factor, and Plasma Protein Binding Predict CNS Tissue Binding?
inferred← citeshttps://doi.org/10.1002/jps.24064openalex-snapshot
Protein-Binding Characteristics of Voriconazole Determined by High-Throughput Equilibrium Dialysis
inferred← citeshttps://doi.org/10.1002/jps.24119openalex-snapshot
Understanding and Reducing the Experimental Variability of In Vitro Plasma Protein Binding Measurements
inferred← citeshttps://doi.org/10.1002/prp2.993openalex-snapshot
Characterization of TR ‐107, a novel chemical activator of the human mitochondrial protease ClpP
inferred← citeshttps://doi.org/10.1002/rcm.1958openalex-snapshot
Single run measurements of drug‐protein binding by high‐performance frontal analysis capillary electrophoresis and mass spectrometry
inferred← citeshttps://doi.org/10.1002/rcm.2265openalex-snapshot
Rapid and direct measurement of free concentrations of highly protein‐bound fluoxetine and its metabolite norfluoxetine in plasma
inferred← citeshttps://doi.org/10.1007/978-1-4614-9105-7_10openalex-snapshot
Drug Discovery Methods for Studying Brain Drug Delivery and Distribution
inferred← citeshttps://doi.org/10.1007/978-1-62703-562-0_5openalex-snapshot
Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP): From Hits to Leads
inferred← citeshttps://doi.org/10.1007/978-3-030-73317-9_101-1openalex-snapshot
Distribution - In Vitro Test: Protein Binding
inferred← citeshttps://doi.org/10.1007/978-3-030-88773-5_13openalex-snapshot
Drug Discovery Methods for Studying Brain Drug Delivery and Distribution
inferred← citeshttps://doi.org/10.1007/978-3-031-35529-5_101openalex-snapshot
Distribution—In Vitro Test: Protein Binding
inferred← citeshttps://doi.org/10.1007/978-981-99-7858-8_3openalex-snapshot
Pharmacokinetic, Pharmacodynamic, Preclinical and Clinical Models for Evaluation of Nanoparticles
inferred← citeshttps://doi.org/10.1007/bf02854892openalex-snapshot
Microdialysis as a tool in local pharmacodynamics
inferred← citeshttps://doi.org/10.1007/s00210-011-0686-yopenalex-snapshot
Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity
inferred← citeshttps://doi.org/10.1007/s00216-010-3737-1openalex-snapshot
Drug–protein binding: a critical review of analytical tools
inferred← citeshttps://doi.org/10.1007/s00280-012-1892-0openalex-snapshot
Comparison of a homologous series of benzonaphthyridine anti-cancer agents in mice: divergence between tumour and plasma pharmacokinetics
inferred← citeshttps://doi.org/10.1007/s00414-016-1365-9openalex-snapshot
Determination of the unbound fraction of R- and S-methadone in human brain
inferred← citeshttps://doi.org/10.1007/s10157-018-1611-1openalex-snapshot
Differences in peritoneal solute transport rates in peritoneal dialysis
inferred← citeshttps://doi.org/10.1007/s10822-015-9850-7openalex-snapshot
Interpreting physicochemical experimental data sets
inferred← citeshttps://doi.org/10.1007/s10928-015-9415-3openalex-snapshot
Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis
inferred← citeshttps://doi.org/10.1007/s10928-020-09680-6openalex-snapshot
A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor
inferred← citeshttps://doi.org/10.1007/s11095-006-9663-4openalex-snapshot
Predictions of the In Vivo Clearance of Drugs from Rate of Loss Using Human Liver Microsomes for Phase I and Phase II Biotransformations
inferred← citeshttps://doi.org/10.1007/s11671-007-9063-7openalex-snapshot
Pharmacokinetic evaluation of a 1,3-dicyclohexylurea nanosuspension formulation to support early efficacy assessment
inferred← citeshttps://doi.org/10.1007/s12010-012-0042-9openalex-snapshot
Physicochemical and Biochemical Profiling of Diphenyl Diselenide
inferred← citeshttps://doi.org/10.1007/s12272-013-0258-4openalex-snapshot
Effect of para halogen modification of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides on metabolism and clearance
inferred← citeshttps://doi.org/10.1007/s13318-024-00931-2openalex-snapshot
Determination of Intrinsic Clearance and Fraction Unbound in Human Liver Microsomes and In Vitro-In Vivo Extrapolation of Human Hepatic Clearance for Marketed Central Nervous System Drugs
inferred← citeshttps://doi.org/10.1007/s40199-020-00366-5openalex-snapshot
Electromembrane extraction as a new approach for determination of free concentration of phenytoin in plasma using capillary electrophoresis
inferred← citeshttps://doi.org/10.1007/s42452-019-0778-8openalex-snapshot
Analysis of drug–protein interaction in bio-inspired microwells
inferred← citeshttps://doi.org/10.1016/b0-08-045044-x/00129-2openalex-snapshot
In Vitro Models for Plasma Binding and Tissue Storage
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12312-1openalex-snapshot
Drug Discovery Technologies: Current and Future Trends
inferred← citeshttps://doi.org/10.1016/b978-0-12-416017-0.00011-5openalex-snapshot
Ligand—Receptor Binding and Determination of Free Concentrations
inferred← citeshttps://doi.org/10.1016/b978-0-12-801076-1.00033-2openalex-snapshot
Plasma and Tissue Binding Methods
inferred← citeshttps://doi.org/10.1016/b978-012369520-8.50034-6openalex-snapshot
Plasma Protein Binding Methods
inferred← citeshttps://doi.org/10.1016/b978-081551567-8.50011-5openalex-snapshot
In Vitro Toxicology for Cosmetics
inferred← citeshttps://doi.org/10.1016/j.ab.2007.10.040openalex-snapshot
Protein–ligand binding detected using ultrafiltration Raman difference spectroscopy
inferred← citeshttps://doi.org/10.1016/j.addr.2009.03.009openalex-snapshot
Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy
inferred← citeshttps://doi.org/10.1016/j.addr.2015.03.011openalex-snapshot
In vitro, in silico and integrated strategies for the estimation of plasma protein binding. A review
inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115797openalex-snapshot
Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis
inferred← citeshttps://doi.org/10.1016/j.biochi.2017.05.010openalex-snapshot
Exploring binding characteristics and the related competition of different protein-bound uremic toxins
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107137openalex-snapshot
In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6
inferred← citeshttps://doi.org/10.1016/j.bmc.2017.09.037openalex-snapshot
The antitubercular activity of various nitro(triazole/imidazole)-based compounds
inferred← citeshttps://doi.org/10.1016/j.ceca.2018.08.005openalex-snapshot
Comprehensive analysis of the roles of ‘black’ and ‘gray’ clusters in structure and function of rat β-parvalbumin
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.108982openalex-snapshot
A selective p53 activator and anticancer agent to improve colorectal cancer therapy
inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.02.013openalex-snapshot
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
inferred← citeshttps://doi.org/10.1016/j.chroma.2005.10.030openalex-snapshot
High-throughput screening of protein binding by equilibrium dialysis combined with liquid chromatography and mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.04.010openalex-snapshot
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice
inferred← citeshttps://doi.org/10.1016/j.dmd.2025.100066openalex-snapshot
Applications of contemporary tools to measure plasma protein binding of targeted protein degraders
inferred← citeshttps://doi.org/10.1016/j.dmd.2026.100419openalex-snapshot
Evaluation of a Long-Term Human Hepatocyte Culture Maintained in PowerHEP Maintenance Medium for Drug Clearance Prediction
inferred← citeshttps://doi.org/10.1016/j.drudis.2020.03.012openalex-snapshot
Fundamental aspects of DMPK optimization of targeted protein degraders
inferred← citeshttps://doi.org/10.1016/j.ejmech.2009.06.004openalex-snapshot
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.12.007openalex-snapshot
Antagonists of the adenosine A 2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.12.008openalex-snapshot
Benzo[d]thiazol-2(3H)-ones as new potent selective CB2 agonists with anti-inflammatory properties
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111736openalex-snapshot
Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114218openalex-snapshot
Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.118771openalex-snapshot
N-aryl-N-acyl diamine derivatives as novel selective serotonin/norepinephrine transporter inhibitors for the treatment of premature ejaculation
inferred← citeshttps://doi.org/10.1016/j.ejphar.2011.04.017openalex-snapshot
Identification of short-acting κ-opioid receptor antagonists with anxiolytic-like activity
inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.175054openalex-snapshot
Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.175187openalex-snapshot
Novel benzoxazinone derivative as potent human neutrophil elastase inhibitor: Potential implications in lung injury
inferred← citeshttps://doi.org/10.1016/j.ejps.2014.08.012openalex-snapshot
Pregnancy influences the plasma pharmacokinetics but not the cerebrospinal fluid pharmacokinetics of raltegravir: A preclinical investigation
inferred← citeshttps://doi.org/10.1016/j.ejps.2018.06.018openalex-snapshot
Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier
inferred← citeshttps://doi.org/10.1016/j.euroneuro.2009.01.008openalex-snapshot
Tic hydantoin sigma-1 agonist: Pharmacological characterization on cocaine-induced stimulant and appetitive effects
inferred← citeshttps://doi.org/10.1016/j.gene.2020.144668openalex-snapshot
KMN-159, a novel EP4 receptor selective agonist, stimulates osteoblastic differentiation in cultured whole rat bone marrow
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2023.123257openalex-snapshot
Protein corona investigations of polyplexes with varying hydrophobicity – From method development to in vitro studies
inferred← citeshttps://doi.org/10.1016/j.jala.2005.03.004openalex-snapshot
Automatable Formats of Higher Throughput ADMET Profiling for Drug Discovery Support
inferred← citeshttps://doi.org/10.1016/j.jala.2010.06.002openalex-snapshot
Development and Validation of a Higher-Throughput Equilibrium Dialysis Assay for Plasma Protein Binding
inferred← citeshttps://doi.org/10.1016/j.jchromb.2005.04.014openalex-snapshot
Stability, pKa and plasma protein binding of roscovitine
inferred← citeshttps://doi.org/10.1016/j.jconrel.2011.02.021openalex-snapshot
Kinetics of reciprocating drug delivery to the inner ear
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2020.111305openalex-snapshot
Spectrofluorimetric analysis of the binding of a target molecule to serum albumin: tricky aspects and tips
inferred← citeshttps://doi.org/10.1016/j.jpba.2005.01.015openalex-snapshot
Studies of drug binding to plasma proteins using a variant of equilibrium dialysis
inferred← citeshttps://doi.org/10.1016/j.jpba.2005.10.031openalex-snapshot
Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids
inferred← citeshttps://doi.org/10.1016/j.jpba.2008.08.023openalex-snapshot
Automated study of ligand–receptor binding using solid-phase microextraction
inferred← citeshttps://doi.org/10.1016/j.jpba.2011.02.006openalex-snapshot
A kinetic method for the determination of plasma protein binding of compounds unstable in plasma: Specific application to enalapril
inferred← citeshttps://doi.org/10.1016/j.jpba.2015.02.024openalex-snapshot
Induced circular dichroism as a tool to investigate the binding of drugs to carrier proteins: Classic approaches and new trends
inferred← citeshttps://doi.org/10.1016/j.jpba.2016.01.051openalex-snapshot
Surface plasmon resonance and circular dichroism characterization of cucurbitacins binding to serum albumins for early pharmacokinetic profiling
inferred← citeshttps://doi.org/10.1016/j.jpba.2016.04.009openalex-snapshot
Lipophilicity and biomimetic properties measured by HPLC to support drug discovery
inferred← citeshttps://doi.org/10.1016/j.jpba.2017.03.019openalex-snapshot
Automation of plasma protein binding assay using rapid equilibrium dialysis device and Tecan workstation
inferred← citeshttps://doi.org/10.1016/j.jpba.2017.03.054openalex-snapshot
Monitoring drug–serum protein interactions for early ADME prediction through Surface Plasmon Resonance technology
inferred← citeshttps://doi.org/10.1016/j.jpba.2019.112952openalex-snapshot
Determination of total and free voriconazole in human plasma: Application to pharmacokinetic study and therapeutic monitoring
inferred← citeshttps://doi.org/10.1016/j.jpet.2026.103816openalex-snapshot
Preclinical characterization of pharmacokinetics, enzyme occupancy, and pharmacodynamics of soticlestat (TAK-935), a novel cholesterol 24-hydroxylase inhibitor
inferred← citeshttps://doi.org/10.1016/j.pep.2009.07.017openalex-snapshot
Automated system for high-throughput protein production using the dialysis cell-free method
inferred← citeshttps://doi.org/10.1016/j.pep.2012.01.014openalex-snapshot
Single pH buffer refolding screen for protein from inclusion bodies
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.108021openalex-snapshot
Kinetic multiplex assay to assess biased signaling of clinical GPCR agonists
inferred← citeshttps://doi.org/10.1016/j.talanta.2020.121220openalex-snapshot
Sample preparation techniques for protein binding measurement in radiopharmaceutical approaches: A short review
inferred← citeshttps://doi.org/10.1016/j.trac.2006.11.003openalex-snapshot
Bioanalytical applications of solid-phase microextraction
inferred← citeshttps://doi.org/10.1016/j.trac.2013.01.004openalex-snapshot
High-throughput solid-phase microextraction in multi-well-plate format
inferred← citeshttps://doi.org/10.1016/j.vascn.2014.06.002openalex-snapshot
Measurement of plasma protein and lipoprotein binding of pyrethroids
inferred← citeshttps://doi.org/10.1016/j.vascn.2016.01.002openalex-snapshot
PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data
inferred← citeshttps://doi.org/10.1016/j.vascn.2020.106899openalex-snapshot
Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints
inferred← citeshttps://doi.org/10.1016/j.vascn.2022.107167openalex-snapshot
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species
inferred← citeshttps://doi.org/10.1016/j.xphs.2017.09.005openalex-snapshot
Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs
inferred← citeshttps://doi.org/10.1016/j.xphs.2018.10.004openalex-snapshot
Plasma Protein Binding of Highly Bound Drugs Determined With Equilibrium Gel Filtration of Nonradiolabeled Compounds and LC-MS/MS Detection
inferred← citeshttps://doi.org/10.1016/j.xphs.2018.10.011openalex-snapshot
Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis
inferred← citeshttps://doi.org/10.1016/j.xphs.2020.09.012openalex-snapshot
Evaluation of a Competitive Equilibrium Dialysis Approach for Assessing the Impact of Protein Binding on Clearance Predictions
inferred← citeshttps://doi.org/10.1016/j.xphs.2020.11.018openalex-snapshot
A Novel Method for Preventing Non-specific Binding in Equilibrium Dialysis Assays Using Solutol® as an Additive
inferred← citeshttps://doi.org/10.1016/j.xphs.2026.104367openalex-snapshot
A framework for plasma protein binding: Comparing methods for diverse small molecules and adapting for novel modalities
inferred← citeshttps://doi.org/10.1016/s1570-0232(03)00564-6openalex-snapshot
Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography–tandem mass spectrometry
inferred← citeshttps://doi.org/10.1021/ac048685zopenalex-snapshot
High-Throughput Solution-Based Medicinal Library Screening against Human Serum Albumin
inferred← citeshttps://doi.org/10.1021/ac070296sopenalex-snapshot
Biocompatible Solid-Phase Microextraction Coatings Based on Polyacrylonitrile and Solid-Phase Extraction Phases
inferred← citeshttps://doi.org/10.1021/ac102055aopenalex-snapshot
Measurement of Protein−Ligand Binding Constants from Reaction-Diffusion Concentration Profiles
inferred← citeshttps://doi.org/10.1021/ac902854gopenalex-snapshot
Development, Characterization, and Application of Paper Spray Ionization
inferred← citeshttps://doi.org/10.1021/acs.analchem.5b04278openalex-snapshot
Direct Biofluid Analysis Using Hydrophobic Paper Spray Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b00899openalex-snapshot
Femtomole-Scale High-Throughput Screening of Protein Ligands with Droplet-Based Thermal Shift Assay
inferred← citeshttps://doi.org/10.1021/acs.jcim.9b00460openalex-snapshot
Prediction of Oral Bioavailability in Rats: Transferring Insights from in Vitro Correlations to (Deep) Machine Learning Models Using in Silico Model Outputs and Chemical Structure Parameters
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00369openalex-snapshot
Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00627openalex-snapshot
Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00640openalex-snapshot
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00814openalex-snapshot
Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01394openalex-snapshot
Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01395openalex-snapshot
Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00762openalex-snapshot
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01000openalex-snapshot
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01499openalex-snapshot
Structural Alterations of the “Address” Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01804openalex-snapshot
Discovery of Orally Available and Brain Penetrant AEP Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c02469openalex-snapshot
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01092openalex-snapshot
Hit-to-Lead Optimization of Heterocyclic Carbonyloxycarboximidamides as Selective Antagonists at Human Adenosine A3 Receptor
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01187openalex-snapshot
Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01578openalex-snapshot
Preferential Synaptic Type of GABA-A Receptor Ligands Enhancing Neuronal Survival and Facilitating Functional Recovery After Ischemic Stroke
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01645openalex-snapshot
Pyrazolo-Pyrimidinones with Improved Solubility and Selective Inhibition of Adenylyl Cyclase Type 1 Activity for Treatment of Inflammatory Pain
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01769openalex-snapshot
Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c02024openalex-snapshot
Deciphering the Therapeutic Potential of Novel Pentyloxyamide-Based Class I, IIb HDAC Inhibitors against Therapy-Resistant Leukemia
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00963openalex-snapshot
Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01752openalex-snapshot
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c00214openalex-snapshot
Challenging the “Undruggable”─Targeting STAT3 but Identifying Potent TrkA-Targeted Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c00358openalex-snapshot
In Vitro ADME Profiling of PROTACs: Successes, Challenges, and Lessons Learned from Analysis of Clinical PROTACs from a Diverse Physicochemical Space
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c00484openalex-snapshot
Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT1AR Agonist with Superior Antidepressant and Antiparkinsonian Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c00649openalex-snapshot
Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c01584openalex-snapshot
Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02093openalex-snapshot
Novel 3-Methoxypropanamide Derivatives as Potential Antiseizure and Antinociceptive Agents: Experimental Evidence from In Vitro and In Vivo Studies
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00866openalex-snapshot
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H -indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6c00012openalex-snapshot
Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anhydrase Inhibitors with In Vivo Efficacy against Drug-Resistant Neisseria gonorrhoeae
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6c01737openalex-snapshot
Structure-Guided Design of a Brain-Penetrant Covalent Inhibitor of Human Butyrylcholinesterase with In Vivo Procognitive Efficacy
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00345openalex-snapshot
Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00497openalex-snapshot
Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00947openalex-snapshot
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01086openalex-snapshot
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00190openalex-snapshot
Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00062openalex-snapshot
Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.7b00746openalex-snapshot
From Structure–Activity Relationships on Thiazole Derivatives to the In Vivo Evaluation of a New Radiotracer for Cannabinoid Subtype 2 PET Imaging
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.9b00769openalex-snapshot
Establishment of an In Vitro–In Vivo Correlation for Melanin Binding and the Extension of the Ocular Half-Life of Small-Molecule Drugs
inferred← citeshttps://doi.org/10.1021/acschemneuro.2c00526openalex-snapshot
Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure–Activity Relationship Study on Nalfurafine Analogues
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.6b00438openalex-snapshot
Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.7b00316openalex-snapshot
An Inexpensive, In-House-Made, Microdialysis Device for Measuring Drug–Protein Binding
inferred← citeshttps://doi.org/10.1021/acsptsci.2c00178openalex-snapshot
Preclinical Characterization and Development on NAQ as a Mu Opioid Receptor Partial Agonist for Opioid Use Disorder Treatment
inferred← citeshttps://doi.org/10.1021/acsptsci.4c00593openalex-snapshot
Discovery of 6α-Thiazolylcarboxamidonaltrexamine Derivative (NTZ) as a Potent and Central Nervous System Penetrant Opioid Receptor Modulator with Drug-like Properties for Potential Treatment of Opioid Use Disorder
inferred← citeshttps://doi.org/10.1021/cc100057eopenalex-snapshot
Analysis of Protein−Small Molecule Interactions by Microscale Equilibrium Dialysis and Its Application As a Secondary Confirmation Method for on-Bead Screening
inferred← citeshttps://doi.org/10.1021/cc800127ropenalex-snapshot
Simple and Economical High-Throughput Equilibrium Dialysis System
inferred← citeshttps://doi.org/10.1021/jm030408hopenalex-snapshot
Prediction of Human Volume of Distribution Values for Neutral and Basic Drugs. 2. Extended Data Set and Leave-Class-Out Statistics
inferred← citeshttps://doi.org/10.1021/jm070375wopenalex-snapshot
High-Throughput Screening of Drug−Brain Tissue Binding and in Silico Prediction for Assessment of Central Nervous System Drug Delivery
inferred← citeshttps://doi.org/10.1021/jm100732topenalex-snapshot
A Novel Pyrazolo[1,5- a ]pyrimidine Is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2, and 9, Which Demonstrates Antitumor Effects in Human Tumor Xenografts Following Oral Administration
inferred← citeshttps://doi.org/10.1021/jm101011yopenalex-snapshot
FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation
inferred← citeshttps://doi.org/10.1021/jm200377ropenalex-snapshot
Synthesis and Structure–Activity Relationships of Varied Ether Linker Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
inferred← citeshttps://doi.org/10.1021/jm2012276openalex-snapshot
Structure–Activity Relationships for Amide-, Carbamate-, And Urea-Linked Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
inferred← citeshttps://doi.org/10.1021/jm300192xopenalex-snapshot
Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success
inferred← citeshttps://doi.org/10.1021/jm4006324openalex-snapshot
Ligand–Protein Interactions of Selective Casein Kinase 1δ Inhibitors
inferred← citeshttps://doi.org/10.1021/jm5007935openalex-snapshot
Rational Use of Plasma Protein and Tissue Binding Data in Drug Design
inferred← citeshttps://doi.org/10.1021/jm501524qopenalex-snapshot
FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile
inferred← citeshttps://doi.org/10.1021/jm501608qopenalex-snapshot
Synthesis and Structure–Activity Relationships for Extended Side Chain Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
inferred← citeshttps://doi.org/10.1021/jm501748hopenalex-snapshot
Simple Method Provides Resolution of Albumin, Lipoprotein, Free Fraction, and Chylomicron To Enhance the Utility of Protein Binding Assays
inferred← citeshttps://doi.org/10.1021/jm7012826openalex-snapshot
New Approach To Measure Protein Binding Based on a Parallel Artificial Membrane Assay and Human Serum Albumin
inferred← citeshttps://doi.org/10.1021/np3007167openalex-snapshot
Design, Synthesis, and Structure–Activity Relationship Studies of Tryptanthrins As Antitubercular Agents
inferred← citeshttps://doi.org/10.1038/ncomms13958openalex-snapshot
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
inferred← citeshttps://doi.org/10.1038/nprot.2009.180openalex-snapshot
Automated solid-phase microextraction and thin-film microextraction for high-throughput analysis of biological fluids and ligand–receptor binding studies
inferred← citeshttps://doi.org/10.1038/s41429-019-0140-9openalex-snapshot
Benzaldehyde thiosemicarbazone derivatives against replicating and nonreplicating Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1038/s41467-017-02794-5openalex-snapshot
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
inferred← citeshttps://doi.org/10.1038/s41467-021-22012-7openalex-snapshot
trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo
inferred← citeshttps://doi.org/10.1038/s41598-018-27974-1openalex-snapshot
2-[2-(4-(trifluoromethyl)phenylamino)thiazol-4-yl]acetic acid (Activator-3) is a potent activator of AMPK
inferred← citeshttps://doi.org/10.1038/sj.bjp.0707373openalex-snapshot
Origin and evolution of high throughput screening
inferred← citeshttps://doi.org/10.1038/srep17391openalex-snapshot
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)
inferred← citeshttps://doi.org/10.1039/bk9781849733274-00631openalex-snapshot
Glycoconjugates: Biosynthesis and Properties
inferred← citeshttps://doi.org/10.1039/c1sm05570dopenalex-snapshot
Adsorption of antibody onto Pluronic F68-covered nanoparticles: link with surface properties
showing the first 200 of 302 · page through all 302
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.