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Inhibition of HIF‐1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3‐M cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/bies.20002openalex-snapshot
Hypoxia‐inducible factor‐1 and oncogenic signalling
inferredcites →https://doi.org/10.1002/mc.10016openalex-snapshot
A p21waf1‐independent pathway for inhibitory phosphorylation of cyclin‐dependent kinase p34cdc2 and concomitant G2/M arrest by the chemopreventive flavonoid apigenin
inferredcites →https://doi.org/10.1002/mc.10168openalex-snapshot
Molecular mechanisms for apigenin‐induced cell‐cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells
inferredcites →https://doi.org/10.1002/mc.20123openalex-snapshot
Inhibition of TPA‐induced cyclooxygenase‐2 (COX‐2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes
inferredcites →https://doi.org/10.1006/abbi.1996.0469openalex-snapshot
Absolute Requirement of Aryl Hydrocarbon Receptor Nuclear Translocator Protein for Gene Activation by Hypoxia
inferredcites →https://doi.org/10.1006/bbrc.2001.4981openalex-snapshot
Hypoxia-Inducible Factor 1α and 1β Proteins Share Common Signaling Pathways in Human Prostate Cancer Cells
inferredcites →https://doi.org/10.1006/bbrc.2001.5532openalex-snapshot
MAPK and Akt Act Cooperatively but Independently on Hypoxia Inducible Factor-1α in rasV12 Upregulation of VEGF
inferredcites →https://doi.org/10.1007/s00018-007-7045-7openalex-snapshot
Glycogen synthase kinase 3: A key regulator of cellular fate
inferredcites →https://doi.org/10.1007/s10637-006-9019-2openalex-snapshot
A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
inferredcites →https://doi.org/10.1016/j.canlet.2004.04.028openalex-snapshot
Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers
inferredcites →https://doi.org/10.1016/j.cell.2007.06.009openalex-snapshot
AKT/PKB Signaling: Navigating Downstream
inferredcites →https://doi.org/10.1016/j.febslet.2004.08.036openalex-snapshot
Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF‐1α protein
inferredcites →https://doi.org/10.1016/j.febslet.2004.12.023openalex-snapshot
Inhibition of GSK3β by indirubins restores HIF‐1α accumulation under prolonged periods of hypoxia/anoxia
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2004.12.004openalex-snapshot
Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells
inferredcites →https://doi.org/10.1016/j.yexcr.2005.01.017openalex-snapshot
Activation of hypoxia-induced transcription in normoxia
inferredcites →https://doi.org/10.1016/s0006-2952(97)82453-7openalex-snapshot
Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition
inferredcites →https://doi.org/10.1016/s0014-5793(01)02737-5openalex-snapshot
Apigenin decreases expression of the myofibroblast phenotype
inferredcites →https://doi.org/10.1016/s0014-5793(01)03252-5openalex-snapshot
Apigenin and LY294002 prolong EGF‐stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation
inferredcites →https://doi.org/10.1016/s0022-5347(01)64775-xopenalex-snapshot
Vascular Endothelial Growth Factor (VEGF) Expression in Human Prostate Cancer: In Situ and in Vitro Expression of VEGF by Human Prostate Cancer Cells
inferredcites →https://doi.org/10.1021/bi051618uopenalex-snapshot
Evidence for the Presence of a Guanine Quadruplex Forming Region within a Polypurine Tract of the Hypoxia Inducible Factor 1α Promoter
inferredcites →https://doi.org/10.1038/386403a0openalex-snapshot
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
inferredcites →https://doi.org/10.1038/bjc.1996.456openalex-snapshot
Vascular endothelial growth factor (VEGF) expression in prostatic tumours and its relationship to neuroendocrine cells
inferredcites →https://doi.org/10.1038/nrc704openalex-snapshot
Hypoxia — a key regulatory factor in tumour growth
inferredcites →https://doi.org/10.1038/nrc839openalex-snapshot
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
inferredcites →https://doi.org/10.1038/nrc909openalex-snapshot
VEGF and the quest for tumour angiogenesis factors
inferredcites →https://doi.org/10.1038/sj.bjc.6601186openalex-snapshot
Overexpression of hypoxia-inducible-factor 1α(HIF-1α) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage
inferredcites →https://doi.org/10.1038/sj.embor.7400598openalex-snapshot
The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling
inferredcites →https://doi.org/10.1038/sj.onc.1202221openalex-snapshot
Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53
inferredcites →https://doi.org/10.1038/sj.onc.1209643openalex-snapshot
Hypoxia-inducible factor-1α expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas
inferredcites →https://doi.org/10.1038/sj.pcan.4500506openalex-snapshot
Prostate cancer chemoprevention agents exhibit selective activity against early stage prostate cancer cells
inferredcites →https://doi.org/10.1038/sj.pcan.4500776openalex-snapshot
The emerging role of the PI3-K-Akt pathway in prostate cancer progression
inferredcites →https://doi.org/10.1073/pnas.94.11.5667openalex-snapshot
Activation of hypoxia-inducible factor 1α: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor
inferredcites →https://doi.org/10.1074/jbc.270.22.13333openalex-snapshot
Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia
inferredcites →https://doi.org/10.1074/jbc.271.25.15117openalex-snapshot
The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression
inferredcites →https://doi.org/10.1074/jbc.271.48.30392openalex-snapshot
The Interaction of an Epidermal Growth Factor/Transforming Growth Factor α Tail Chimera with the Human Epidermal Growth Factor Receptor Reveals Unexpected Complexities
inferredcites →https://doi.org/10.1074/jbc.m200017200openalex-snapshot
Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension
inferredcites →https://doi.org/10.1074/jbc.m206405200openalex-snapshot
Enhanced Glycogen Synthase Kinase-3β Activity Mediates Hypoxia-induced Apoptosis of Vascular Smooth Muscle Cells and Is Prevented by Glucose Transport and Metabolism
inferredcites →https://doi.org/10.1074/jbc.m300763200openalex-snapshot
Regulation of Hypoxia-inducible Factor-1α Protein Level during Hypoxic Conditions by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Pathway in HepG2 Cells
inferredcites →https://doi.org/10.1074/jbc.m305529200openalex-snapshot
Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway
inferredcites →https://doi.org/10.1074/jbc.m312241200openalex-snapshot
c-Myc Sensitization to Oxygen Deprivation-induced Cell Death Is Dependent on Bax/Bak, but Is Independent of p53 and Hypoxia-inducible Factor-1
inferredcites →https://doi.org/10.1093/carcin/21.4.633openalex-snapshot
Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes
inferredcites →https://doi.org/10.1093/carcin/bgl205openalex-snapshot
Apigenin inhibits tumor angiogenesis through decreasing HIF-1 and VEGF expression
inferredcites →https://doi.org/10.1093/jn/136.3.664openalex-snapshot
Functional Diversity of Flavonoids in the Inhibition of the Proinflammatory NF-κB, IRF, and Akt Signaling Pathways in Murine Intestinal Epithelial Cells
inferredcites →https://doi.org/10.1096/fj.04-2175comopenalex-snapshot
Apigenin inhibits VEGF and HIF‐1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
inferredcites →https://doi.org/10.1096/fj.05-3740fjeopenalex-snapshot
Up‐regulation of insulin‐like growth factor binding protein‐3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice
inferredcites →https://doi.org/10.1097/01.ju.0000141580.30910.57openalex-snapshot
CELL LINES USED IN PROSTATE CANCER RESEARCH: A COMPENDIUM OF OLD AND NEW LINES—PART 1
inferredcites →https://doi.org/10.1101/gad.14.4.391openalex-snapshot
Loss of PTEN facilitates HIF-1-mediated gene expression
inferredcites →https://doi.org/10.1111/j.1582-4934.2004.tb00467.xopenalex-snapshot
HIF‐1 and p53: communication of transcription factors under hypoxia
inferredcites →https://doi.org/10.1113/expphysiol.2006.033498openalex-snapshot
Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia‐inducible factor 1
inferredcites →https://doi.org/10.1124/mol.105.011254openalex-snapshot
Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer
inferredcites →https://doi.org/10.1126/science.1059796openalex-snapshot
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
inferredcites →https://doi.org/10.1128/mcb.00015-07openalex-snapshot
Glycogen Synthase Kinase 3 Phosphorylates Hypoxia-Inducible Factor 1α and Mediates Its Destabilization in a VHL-Independent Manner
inferredcites →https://doi.org/10.1128/mcb.21.12.3995-4004.2001openalex-snapshot
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
inferredcites →https://doi.org/10.1158/0008-5472.can-03-2707openalex-snapshot
Bortezomib as a Potential Treatment for Prostate Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-04-1284openalex-snapshot
A Hypoxia-Independent Hypoxia-Inducible Factor-1 Activation Pathway Induced by Phosphatidylinositol-3 Kinase/Akt in HER2 Overexpressing Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-04-2807openalex-snapshot
Genistein Inhibits p38 Map Kinase Activation, Matrix Metalloproteinase Type 2, and Cell Invasion in Human Prostate Epithelial Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-06-2201openalex-snapshot
Activation of Akt Predicts Poor Outcome in Neuroblastoma
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-1602openalex-snapshot
Protein Kinase CK2α as an Unfavorable Prognostic Marker and Novel Therapeutic Target in Acute Myeloid Leukemia
inferredcites →https://doi.org/10.1200/jco.2004.02.141openalex-snapshot
The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
inferredcites →https://doi.org/10.1200/jco.2005.03.108openalex-snapshot
Phase II Study of Proteasome Inhibitor Bortezomib in Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma
inferredcites →https://doi.org/10.1677/erc.1.01126openalex-snapshot
Mechanisms of action of novel agents for prostate cancer chemoprevention
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4460655openalex-extracted
Antioxidant and Cytotoxic Effects of the Bioactive Compounds of Fodder Beet (Beta Vulgaris VAR. Crassa) Against Mcf-7 and Hela Cell Cultures
inferred← citeshttps://doi.org/10.1002/biof.2113openalex-snapshot
The influence of apigenin on cellular responses to radiation: From protection to sensitization
inferred← citeshttps://doi.org/10.1002/cam4.198openalex-snapshot
Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia
inferred← citeshttps://doi.org/10.1002/ddr.22035openalex-snapshot
Design, synthesis, and antitumor evaluation of trimethoxyflavonoid with arylurea structure against hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1002/ijc.26141openalex-snapshot
Methylseleninic acid downregulates hypoxia‐inducible factor‐1α in invasive prostate cancer
inferred← citeshttps://doi.org/10.1002/mc.20866openalex-snapshot
Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study
inferred← citeshttps://doi.org/10.1002/mc.22005openalex-snapshot
Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism
inferred← citeshttps://doi.org/10.1002/ptr.3696openalex-snapshot
Liquiritigenin Inhibits Serum‐induced HIF‐1α and VEGF Expression via the AKT/mTOR‐p70S6K Signalling Pathway in HeLa Cells
inferred← citeshttps://doi.org/10.1002/ptr.70029openalex-snapshot
Potential Therapeutic Actions of Flavonoids Present in Propolis That Modulate Vascular Endothelial Growth Factor Signaling to Regulate Angiogenesis
inferred← citeshttps://doi.org/10.1002/ptr.7255openalex-snapshot
Anticancer effects of root and beet leaf extracts ( Beta vulgaris L.) in cervical cancer cells ( HeLa )
inferred← citeshttps://doi.org/10.1002/rmb2.12323openalex-snapshot
Resveratrol protects mitochondrial quantity by activating SIRT1/PGC‐1α expression during ovarian hypoxia
inferred← citeshttps://doi.org/10.1007/978-3-319-28140-7_53openalex-snapshot
Transforming Growth Factor α and β (TGF-α and TGF-β)
inferred← citeshttps://doi.org/10.1007/978-94-007-2923-0_2openalex-snapshot
Micronutrients and Cancer: Add Spice to Your Life
inferred← citeshttps://doi.org/10.1007/s10495-014-0971-6openalex-snapshot
Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70–Bax interaction in prostate cancer
inferred← citeshttps://doi.org/10.1007/s11095-010-0089-7openalex-snapshot
Apigenin: A Promising Molecule for Cancer Prevention
inferred← citeshttps://doi.org/10.1016/b978-0-12-374628-3.00041-4openalex-snapshot
Apigenin and Cancer Chemoprevention
inferred← citeshttps://doi.org/10.1016/b978-0-443-21842-2.00002-4openalex-snapshot
Molecular signaling of prostate cancer chemoprevention by natural products: current perspectives and future directions
inferred← citeshttps://doi.org/10.1016/b978-0-443-21842-2.00008-5openalex-snapshot
Flavones and prostate cancer
inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.07.086openalex-snapshot
Hypoxia-induced autophagy promotes human prostate stromal cells survival and ER-stress
inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.03.010openalex-snapshot
Overcoming the hypoxia-induced drug resistance in liver tumor by the concurrent use of apigenin and paclitaxel
inferred← citeshttps://doi.org/10.1016/j.bcp.2010.02.004openalex-snapshot
Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism
inferred← citeshttps://doi.org/10.1016/j.biochi.2009.08.005openalex-snapshot
Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.11.001openalex-snapshot
FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis
inferred← citeshttps://doi.org/10.1016/j.canlet.2011.03.005openalex-snapshot
Anti-cancer effects of a novel compound HS-113 on cell growth, apoptosis, and angiogenesis in human hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1016/j.canlet.2014.10.026openalex-snapshot
Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells
inferred← citeshttps://doi.org/10.1016/j.cbi.2020.108942openalex-snapshot
Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α–KV1.5 channel pathway
inferred← citeshttps://doi.org/10.1016/j.cbi.2020.109186openalex-snapshot
FB-15 inhibits MGC-803 cells growth by regulating energy metabolism
inferred← citeshttps://doi.org/10.1016/j.cellsig.2016.02.008openalex-snapshot
Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention
inferred← citeshttps://doi.org/10.1016/j.ejps.2012.08.013openalex-snapshot
Anticancer activity, toxicity and pharmacokinetic profile of an indanone derivative
inferred← citeshttps://doi.org/10.1016/j.foodchem.2009.01.085openalex-snapshot
Phenolic glucosides in the course of ligulate flower development in diploid and tetraploid Matricaria chamomilla
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2019.04.006openalex-snapshot
A critical review on anti-angiogenic property of phytochemicals
inferred← citeshttps://doi.org/10.1016/j.jss.2010.10.041openalex-snapshot
Apigenin Down-Regulates the Hypoxia Response Genes: HIF-1α, GLUT-1, and VEGF in Human Pancreatic Cancer Cells
inferred← citeshttps://doi.org/10.1016/j.mehy.2020.109723openalex-snapshot
Flavones and flavonols may have clinical potential as CK2 inhibitors in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.neo.2018.07.005openalex-snapshot
Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2010.08.003openalex-snapshot
Targeting tissue oxidative damage by means of cell signaling modulators: The antioxidant concept revisited
inferred← citeshttps://doi.org/10.1016/j.taap.2013.07.009openalex-snapshot
Quantitative proteomic analysis of the inhibitory effects of CIL-102 on viability and invasiveness in human glioma cells
inferred← citeshttps://doi.org/10.1017/s1462399409001173openalex-snapshot
Targeting the hypoxia-inducible factor (HIF) pathway in cancer
inferred← citeshttps://doi.org/10.1038/s41598-025-20757-5openalex-snapshot
Pharmacokinetic, docking, and DFT analyses reveal Moringa oleifera phytochemicals as inhibitors of HIF-1α/VEGF/GLUT1 signaling pathway in breast cancer
inferred← citeshttps://doi.org/10.1039/c8nj04533jopenalex-snapshot
Design, synthesis, and preliminary biological evaluation of 3′,4′,5′-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents
inferred← citeshttps://doi.org/10.1039/d3md00128hopenalex-snapshot
Synthesis and anti-hepatocellular carcinoma evaluation of salicylic acid-modified indole trimethoxy flavonoid derivatives
inferred← citeshttps://doi.org/10.1080/01635581.2020.1802494openalex-snapshot
Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells
inferred← citeshttps://doi.org/10.1080/10406638.2021.2021251openalex-snapshot
Discovery of a Potential Multi-Target Anti-Tumor Agent via Structural Modification on Flavonoid
inferred← citeshttps://doi.org/10.1080/10408390903584094openalex-snapshot
Effects of Flavonoids and other Polyphenols on Inflammation
inferred← citeshttps://doi.org/10.1080/10942912.2016.1207188openalex-snapshot
Health functionality of apigenin: A review
inferred← citeshttps://doi.org/10.1080/25785826.2020.1843267openalex-snapshot
Protein kinase 2 (CK2): a potential regulator of immune cell development and function in cancer
inferred← citeshttps://doi.org/10.1089/ars.2020.8051openalex-snapshot
Reductive Stress, Bioactive Compounds, Redox-Active Metals, and Dormant Tumor Cell Biology to Develop Redox-Based Tools for the Treatment of Cancer
inferred← citeshttps://doi.org/10.1089/jop.2021.0046openalex-snapshot
Antiproliferative and Mitochondrial Protective Effects of Apigenin in an Oxygen-Induced Retinopathy In Vivo Mouse Model
inferred← citeshttps://doi.org/10.1093/carcin/bgn201openalex-snapshot
Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study
inferred← citeshttps://doi.org/10.1093/carcin/bgp009openalex-snapshot
Grape seed extract inhibits VEGF expression via reducing HIF-1 protein expression
inferred← citeshttps://doi.org/10.1097/mcg.0000000000001663openalex-snapshot
A Randomized Double-blind Clinical Trial of Weierkang Pills for the Treatment of Chronic Atrophic Gastritis
inferred← citeshttps://doi.org/10.1111/cas.12458openalex-snapshot
Gambogic acid suppresses hypoxia‐induced hypoxia‐inducible factor‐1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3‐kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells
inferred← citeshttps://doi.org/10.1155/2012/850429openalex-snapshot
Complementary and Alternative Medicine and Cancer Survivorship
inferred← citeshttps://doi.org/10.1155/2012/873175openalex-snapshot
Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
inferred← citeshttps://doi.org/10.1155/2013/817674openalex-snapshot
Subtoxic Levels of Apigenin Inhibit Expression and Secretion of VEGF by Uveal Melanoma Cells via Suppression of ERK1/2 and PI3K/Akt Pathways
inferred← citeshttps://doi.org/10.1155/2019/2651037openalex-snapshot
Weiqi Decoction Attenuated Chronic Atrophic Gastritis with Precancerous Lesion through Regulating Microcirculation Disturbance and HIF-1 α Signaling Pathway
inferred← citeshttps://doi.org/10.1155/2019/3868354openalex-snapshot
The Role of Herbal Bioactive Components in Mitochondria Function and Cancer Therapy
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-12-0093openalex-snapshot
Sorafenib-Induced Hepatocellular Carcinoma Cell Death Depends on Reactive Oxygen Species Production In Vitro and In Vivo
inferred← citeshttps://doi.org/10.1158/1940-6207.capr-09-0066openalex-snapshot
The Chemopreventive Bioflavonoid Apigenin Inhibits Prostate Cancer Cell Motility through the Focal Adhesion Kinase/Src Signaling Mechanism
inferred← citeshttps://doi.org/10.1186/s12894-024-01585-7openalex-snapshot
Autophagy in benign prostatic hyperplasia: insights and therapeutic potential
inferred← citeshttps://doi.org/10.1201/b11196-8openalex-snapshot
Natural Products as Inhibitors of Hypoxia-Inducible Factor-1
inferred← citeshttps://doi.org/10.1248/bpb.33.1835openalex-snapshot
1,2,3,4,6-Penta-O-galloly-beta-D-glucose Suppresses Hypoxia-Induced Accumulation of Hypoxia-Inducible Factor-1.ALPHA. and Signaling in LNCaP Prostate Cancer Cells
inferred← citeshttps://doi.org/10.1248/bpb.34.850openalex-snapshot
Rhapontigenin Inhibited Hypoxia Inducible Factor 1 Alpha Accumulation and Angiogenesis in Hypoxic PC-3 Prostate Cancer Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0059045openalex-snapshot
Identification of Small Molecule Activators of BMP Signaling
inferred← citeshttps://doi.org/10.1371/journal.pone.0121113openalex-snapshot
The Tyrosine Phosphatase SHP-1 Regulates Hypoxia Inducible Factor-1α (HIF-1α) Protein Levels in Endothelial Cells under Hypoxia
inferred← citeshttps://doi.org/10.1515/jcim-2023-0182openalex-snapshot
Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer
inferred← citeshttps://doi.org/10.1637/11641-032817-regropenalex-snapshot
In VitroEffect of Apigenin and Danshen in Tibial Dyschondroplasia Through Inhibition of Heat-Shock Protein 90 and Vascular Endothelial Growth Factor Expressions in Avian Growth Plate Cells
inferred← citeshttps://doi.org/10.18632/oncotarget.2551openalex-snapshot
Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1
inferred← citeshttps://doi.org/10.18632/oncotarget.5377openalex-snapshot
ERβ regulation of NF-κB activation in prostate cancer is mediated by HIF-1
inferred← citeshttps://doi.org/10.2174/0115733947302449240522063702openalex-snapshot
Plant-derived Molecules as Potent Anti-skin Cancer Agents
inferred← citeshttps://doi.org/10.2174/1385272823666191203122030openalex-snapshot
Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway
inferred← citeshttps://doi.org/10.2174/1389557515666150414152933openalex-snapshot
Regulation of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids
inferred← citeshttps://doi.org/10.2174/18715206113139990119openalex-snapshot
Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention
inferred← citeshttps://doi.org/10.3177/jnsv.60.276openalex-snapshot
Resveratrol Inhibits Hypoxia-Inducible Factor-1^|^alpha;-Mediated Androgen Receptor Signaling and Represses Tumor Progression in Castration-Resistant Prostate Cancer
inferred← citeshttps://doi.org/10.3181/0902-mr-78openalex-snapshot
Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis
inferred← citeshttps://doi.org/10.32469/10355/64004openalex-snapshot
Targeting estrogen- and hedgehog-signaling pathways in prostate cancer
inferred← citeshttps://doi.org/10.3390/biomedicines12081636openalex-snapshot
The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens
inferred← citeshttps://doi.org/10.3390/cancers14030675openalex-snapshot
Systemic Effects Reflected in Specific Biomarker Patterns Are Instrumental for the Paradigm Change in Prostate Cancer Management: A Strategic Paper
inferred← citeshttps://doi.org/10.3390/cells9020460openalex-snapshot
Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets
inferred← citeshttps://doi.org/10.3390/ijms20133143openalex-snapshot
Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6 Expression
inferred← citeshttps://doi.org/10.3390/ijms222413455openalex-snapshot
Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
inferred← citeshttps://doi.org/10.3390/ijms25105349openalex-snapshot
Electro-Metabolic Coupling of Cumulus–Oocyte Complex
inferred← citeshttps://doi.org/10.3390/molecules26072029openalex-snapshot
The Hallmarks of Flavonoids in Cancer
inferred← citeshttps://doi.org/10.3390/molecules26082200openalex-snapshot
Bioassay-Guided Identification of the Antiproliferative Compounds of Cissus trifoliata and the Transcriptomic Effect of Resveratrol in Prostate Cancer Pc3 Cells
inferred← citeshttps://doi.org/10.34172/jhp.2023.21openalex-snapshot
Apigenin role against thioacetamide-triggered liver fibrosis: Deciphering the PPARγ/TGF-β1/NF-κB and the HIF/FAK/AKT pathways
inferred← citeshttps://doi.org/10.3748/wjg.v17.i44.4875openalex-snapshot
Inhibition of tumor angiogenesis by TTF1 from extract of herbal medicine
inferred← citeshttps://doi.org/10.3892/etm.2021.9746openalex-snapshot
Chronic atrophic gastritis and intestinal metaplasia induced by high‑salt and N‑methyl‑N'‑nitro‑N‑nitrosoguanidine intake in rats
inferred← citeshttps://doi.org/10.3892/ijmm.2014.1804openalex-snapshot
Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferation
inferred← citeshttps://doi.org/10.3892/ijo.2013.2116openalex-snapshot
A novel resveratrol analogue, HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells
inferred← citeshttps://doi.org/10.3892/ijo.2014.2339openalex-snapshot
Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells
inferred← citeshttps://doi.org/10.3892/ijo.2014.2808openalex-snapshot
Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells
inferred← citeshttps://doi.org/10.3892/ijo.2015.3200openalex-snapshot
Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells
inferred← citeshttps://doi.org/10.3892/or_00000624openalex-snapshot
Anti-tumor effects of AMT in the renal cell carcinoma model
inferred← citeshttps://doi.org/10.58830/ozgur.pub1437.c5767openalex-snapshot
Apigeninin Kanser Metabolizmasındaki Biyokimyasal Modülasyonu
inferred← citeshttps://doi.org/10.5937/savteh1501054zopenalex-snapshot
The optimization of the extraction process of flavonoids from fermented chamomile ligulate flowers
inferred← citeshttps://doi.org/10.70675/9cadea77z03ccz4a54zb381zf34a432615a5openalex-snapshot
EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancer
inferred← citeshttps://doi.org/10.7314/apjcp.2015.16.10.4303openalex-snapshot
Significance of Rumex Vesicarius as Anticancer Remedy Against Hepatocellular Carcinoma: a Proposal-Based on Experimental Animal Studies
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