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Glycogen Synthase Kinase 3 Phosphorylates Hypoxia-Inducible Factor 1α and Mediates Its Destabilization in a VHL-Independent Manner

https://doi.org/10.1128/mcb.00015-07
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1097-4547(20000701)61:1<21::aid-jnr3>3.0.co;2-7openalex-snapshot
Wnt-1 dependent activation of the survival factor NF-?B in PC12 cells
inferredcites →https://doi.org/10.1006/bbrc.2000.3789openalex-snapshot
Induction of Hypoxia-Inducible-Factor 1 by Nitric Oxide Is Mediated via the PI 3K Pathway
inferredcites →https://doi.org/10.1006/bbrc.2001.5532openalex-snapshot
MAPK and Akt Act Cooperatively but Independently on Hypoxia Inducible Factor-1α in rasV12 Upregulation of VEGF
inferredcites →https://doi.org/10.1006/scdb.2001.0287openalex-snapshot
Oxygen sensors and angiogenesis
inferredcites →https://doi.org/10.1007/978-3-642-18930-2_18openalex-snapshot
mTOR as a Positive Regulator of Tumor Cell Responses to Hypoxia
inferredcites →https://doi.org/10.1007/pl00005073openalex-snapshot
Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells
inferredcites →https://doi.org/10.1016/0092-8674(91)90241-popenalex-snapshot
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
inferredcites →https://doi.org/10.1016/s0006-2952(02)01168-1openalex-snapshot
Signal transduction to hypoxia-inducible factor 1
inferredcites →https://doi.org/10.1016/s0014-5793(02)02247-0openalex-snapshot
Normoxic induction of the hypoxia‐inducible factor 1α by insulin and interleukin‐1β involves the phosphatidylinositol 3‐kinase pathway
inferredcites →https://doi.org/10.1016/s0014-5793(99)01434-9openalex-snapshot
Role of protein kinase B and the MAP kinase cascade in mediating the EGF‐dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells1
inferredcites →https://doi.org/10.1016/s0301-0082(01)00011-9openalex-snapshot
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
inferredcites →https://doi.org/10.1016/s0925-4773(97)00674-6openalex-snapshot
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels
inferredcites →https://doi.org/10.1016/s0955-0674(98)80150-6openalex-snapshot
The mRNA 5′ cap-binding protein eIF4E and control of cell growth
inferredcites →https://doi.org/10.1016/s1471-4914(01)02090-1openalex-snapshot
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
inferredcites →https://doi.org/10.1038/19328openalex-snapshot
Direct control of the Forkhead transcription factor AFX by protein kinase B
inferredcites →https://doi.org/10.1038/35017574openalex-snapshot
Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation
inferredcites →https://doi.org/10.1038/sj.onc.1203245openalex-snapshot
Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
inferredcites →https://doi.org/10.1042/0264-6021:3540531openalex-snapshot
Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver
inferredcites →https://doi.org/10.1042/0264-6021:3590001openalex-snapshot
GSK3 takes centre stage more than 20 years after its discovery
inferredcites →https://doi.org/10.1042/bj3030701openalex-snapshot
Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation
inferredcites →https://doi.org/10.1042/bj3340141openalex-snapshot
Transcriptional activation of the haem oxygenase-1 gene by cGMP via a cAMP response element/activator protein-1 element in primary cultures of rat hepatocytes
inferredcites →https://doi.org/10.1042/bj3550609openalex-snapshot
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase
inferredcites →https://doi.org/10.1073/pnas.0400265101openalex-snapshot
A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression
inferredcites →https://doi.org/10.1073/pnas.94.9.4273openalex-snapshot
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
inferredcites →https://doi.org/10.1074/jbc.272.13.8581openalex-snapshot
Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway
inferredcites →https://doi.org/10.1074/jbc.273.49.32377openalex-snapshot
CREB Is a Regulatory Target for the Protein Kinase Akt/PKB
inferredcites →https://doi.org/10.1074/jbc.274.29.20611openalex-snapshot
Requirement for Akt (Protein Kinase B) in Insulin-induced Activation of Glycogen Synthase and Phosphorylation of 4E-BP1 (PHAS-1)
inferredcites →https://doi.org/10.1074/jbc.m100677200openalex-snapshot
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
inferredcites →https://doi.org/10.1074/jbc.m203781200openalex-snapshot
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
inferredcites →https://doi.org/10.1074/jbc.m204152200openalex-snapshot
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
inferredcites →https://doi.org/10.1074/jbc.m300763200openalex-snapshot
Regulation of Hypoxia-inducible Factor-1α Protein Level during Hypoxic Conditions by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Pathway in HepG2 Cells
inferredcites →https://doi.org/10.1074/jbc.m404097200openalex-snapshot
Vascular Endothelial Growth Factor Transcriptional Activation Is Mediated by Hypoxia-inducible Factor 1α, HDM2, and p70S6K1 in Response to Phosphatidylinositol 3-Kinase/AKT Signaling
inferredcites →https://doi.org/10.1091/mbc.e03-05-0308openalex-snapshot
Integration of Cell Attachment, Cytoskeletal Localization, and Signaling by Integrin-linked Kinase (ILK), CH-ILKBP, and the Tumor Suppressor PTEN
inferredcites →https://doi.org/10.1093/emboj/17.17.5085openalex-snapshot
Insulin induces transcription of target genes through the hypoxia‐inducible factor HIF‐1α/ARNT
inferredcites →https://doi.org/10.1093/emboj/17.22.6573openalex-snapshot
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of theCBP/p300 coactivator by the hypoxia‐induciblefactor‐1α
inferredcites →https://doi.org/10.1093/emboj/19.16.4298openalex-snapshot
Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein
inferredcites →https://doi.org/10.1093/nar/17.18.7539openalex-snapshot
A vector for expressing GAL4(1–147) fusions tn mammalian cells
inferredcites →https://doi.org/10.1096/fj.01-0944revopenalex-snapshot
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
inferredcites →https://doi.org/10.1101/gad.14.4.391openalex-snapshot
Loss of PTEN facilitates HIF-1-mediated gene expression
inferredcites →https://doi.org/10.1101/gad.836800openalex-snapshot
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
inferredcites →https://doi.org/10.1101/gad.924501openalex-snapshot
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
inferredcites →https://doi.org/10.1111/j.1432-1033.1980.tb06059.xopenalex-snapshot
Glycogen Synthase Kinase‐3 from Rabbit Skeletal Muscle
inferredcites →https://doi.org/10.1126/science.1059796openalex-snapshot
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
inferredcites →https://doi.org/10.1126/science.1059817openalex-snapshot
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
inferredcites →https://doi.org/10.1126/science.1068592openalex-snapshot
Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch
inferredcites →https://doi.org/10.1126/science.1069825openalex-snapshot
Oxygen Sensing Gets a Second Wind
inferredcites →https://doi.org/10.1126/science.272.5264.1023openalex-snapshot
Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly
inferredcites →https://doi.org/10.1126/stke.3062005re12openalex-snapshot
Integration of Oxygen Signaling at the Consensus HRE
inferredcites →https://doi.org/10.1128/mcb.20.1.402-415.2000openalex-snapshot
Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α
inferredcites →https://doi.org/10.1128/mcb.21.12.3995-4004.2001openalex-snapshot
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
inferredcites →https://doi.org/10.1128/mcb.24.7.2905-2914.2004openalex-snapshot
Growth Factor-Mediated Induction of HDM2 Positively Regulates Hypoxia-Inducible Factor 1α Expression
inferredcites →https://doi.org/10.1146/annurev.nu.16.070196.001143openalex-snapshot
Zonation of Parenchymal and Nonparenchymal Metabolism in Liver
inferredcites →https://doi.org/10.1152/jappl.2000.88.4.1474openalex-snapshot
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
inferredcites →https://doi.org/10.1152/physrev.1996.76.3.839openalex-snapshot
Oxygen sensing and molecular adaptation to hypoxia
inferredcites →https://doi.org/10.1160/th03-12-0784openalex-snapshot
Plasminogen activator inhibitor-1 and tumour growth, invasion, and metastasis
inferredcites →https://doi.org/10.1161/01.res.0000018952.70505.f1openalex-snapshot
Glycogen Synthase Kinase-3β
inferredcites →https://doi.org/10.1161/hh1301.092678openalex-snapshot
Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells
inferredcites →https://doi.org/10.1182/blood-2002-06-1693openalex-snapshot
Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes
inferredcites →https://doi.org/10.1182/blood.v90.9.3322openalex-snapshot
Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element
inferredcites →https://doi.org/10.1182/blood.v94.12.4177openalex-snapshot
Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes
inferredcites →https://doi.org/10.1182/blood.v97.9.2657openalex-snapshot
The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site
inferredcites →https://doi.org/10.1203/00006450-200105000-00002openalex-snapshot
Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and Disease
inferredcites →https://doi.org/10.1267/thro03040666openalex-snapshot
Regulation of the hypoxia-dependent plasminogen activator inhibitor 1 expression by MAP kinases.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-11
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Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
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Carbon Monoxide Transport and Actions in Blood and Tissues
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Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase‐3 inhibition
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Hemin, an iron‐binding porphyrin, inhibits HIF‐1α induction through its binding with heat shock protein 90
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FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma
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Carbon Monoxide Transport and Actions in Blood and Tissues
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Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia
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Protein Kinase C Isoforms Differentially Regulate Hypoxia-Inducible Factor-1α Accumulation in Cancer Cells
inferred← citeshttps://doi.org/10.1002/jcp.24409openalex-snapshot
Differential effect of hypoxia on etoposide‐induced DNA damage response and p53 regulation in different cell types
inferred← citeshttps://doi.org/10.1002/mc.20421openalex-snapshot
Inhibition of HIF‐1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3‐M cells
inferred← citeshttps://doi.org/10.1002/med.21867openalex-snapshot
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases
inferred← citeshttps://doi.org/10.1002/ptr.7925openalex-snapshot
Salvianolic acid A diminishes LDHA ‐driven aerobic glycolysis to restrain myofibroblasts activation and cardiac fibrosis via blocking Akt/ GSK ‐3β/ HIF ‐1α axis
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The Complexity of the HIF-1-Dependent Hypoxic Response in Breast Cancer Presents Multiple Avenues for Therapeutic Intervention
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MicroRNAs in Epithelial Mesenchymal Transition and Breast Cancer Progression
inferred← citeshttps://doi.org/10.1007/978-1-60761-738-9_13openalex-snapshot
Hypoxia-Inducible Factors: Post-translational Crosstalk of Signaling Pathways
inferred← citeshttps://doi.org/10.1007/978-2-8178-0466-8_9openalex-snapshot
Sphingosine-1-Phosphate in Hypoxic Signaling
inferred← citeshttps://doi.org/10.1007/978-3-030-71612-7_13openalex-snapshot
RNA m6A Modification: The Mediator Between Cellular Stresses and Biological Effects
inferred← citeshttps://doi.org/10.1007/978-3-642-00150-5_27openalex-snapshot
Hypoxia-Inducible Factor-1 Signaling System
inferred← citeshttps://doi.org/10.1007/978-981-16-1247-3_105-1openalex-snapshot
Delineating the Role of PI3K Signaling Pathway in the Stem Cell Therapeutics of ROS-Induced Carcinomas
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Delineating the Role of PI3K Signaling Pathway in the Stem Cell Therapeutics of ROS-Induced Carcinomas
inferred← citeshttps://doi.org/10.1007/978-981-99-0313-9_10openalex-snapshot
Hypoxia and Extracellular Matrix-Major Drivers of Tumor Metastasis
inferred← citeshttps://doi.org/10.1007/s00018-009-0039-xopenalex-snapshot
15-Deoxy-Δ12,14-prostaglandin-J2 reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation
inferred← citeshttps://doi.org/10.1007/s00018-010-0459-7openalex-snapshot
Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression
inferred← citeshttps://doi.org/10.1007/s00018-012-1052-zopenalex-snapshot
The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies
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Combinatorial regulation by ERK1/2 and CK1δ protein kinases leads to HIF-1α association with microtubules and facilitates its symmetrical distribution during mitosis
inferred← citeshttps://doi.org/10.1007/s00018-024-05289-xopenalex-snapshot
Proximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury
inferred← citeshttps://doi.org/10.1007/s00109-010-0683-5openalex-snapshot
Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma
inferred← citeshttps://doi.org/10.1007/s00109-016-1439-7openalex-snapshot
Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2
inferred← citeshttps://doi.org/10.1007/s00210-026-05202-2openalex-snapshot
Targeting the GSK-3β/mTOR axis: a novel pharmacological strategy for preeclampsia prevention and treatment
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Pharmacological modulation of HIF-1 in the treatment of neuropsychiatric disorders
inferred← citeshttps://doi.org/10.1007/s10067-019-04635-wopenalex-snapshot
Impact of the gene-gene interactions related to the HIF-1α signaling pathway with the knee osteoarthritis development
inferred← citeshttps://doi.org/10.1007/s10456-011-9201-9openalex-snapshot
GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions
inferred← citeshttps://doi.org/10.1007/s10571-012-9803-9openalex-snapshot
Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia
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The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies
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Transcriptome analysis demonstrates that long noncoding RNA is involved in the hypoxic response in Larimichthys crocea
inferred← citeshttps://doi.org/10.1007/s11427-015-4801-zopenalex-snapshot
The hypoxia signaling pathway and hypoxic adaptation in fishes
inferred← citeshttps://doi.org/10.1007/s12035-026-05935-4openalex-snapshot
Mild Cognitive Impairment Associated with Obstructive Sleep Apnoea: A Pilot Study on Oxygen-Related Plasma Biomarkers and Network Analysis
inferred← citeshttps://doi.org/10.1007/s12094-007-0055-yopenalex-snapshot
Hypoxia-inducible factors and cancer
inferred← citeshttps://doi.org/10.1007/s12195-016-0453-8openalex-snapshot
Interrogating Canonical Wnt Signaling Pathway in Human Pluripotent Stem Cell Fate Decisions Using CRISPR-Cas9
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The microtubule as a breast cancer target
inferred← citeshttps://doi.org/10.1007/s12672-024-01484-1openalex-snapshot
Glucose deprivation impairs hypoxia-inducible factor-1α synthesis
inferred← citeshttps://doi.org/10.1016/b978-0-12-394274-6.00005-4openalex-snapshot
Hypoxia, Therapeutic Resistance, and Sphingosine 1-Phosphate
inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.00039-6openalex-snapshot
Hypoxia
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Therapeutic targeting of glycogen synthase kinase-3: Strategy to address neurodegenerative diseases
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Crosstalks of GSK3 signaling with the mTOR network and effects on targeted therapy of cancer
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Induction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2011.10.089openalex-snapshot
Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice
inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.12.020openalex-snapshot
GSK3β negatively regulates HIF1α mRNA stability via nucleolin in the MG63 osteosarcoma cell line
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.01.005openalex-snapshot
Ubiquitination is absolutely required for the degradation of hypoxia-inducible factor - 1 alpha protein in hypoxic conditions
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.01.047openalex-snapshot
Alternative regulation of HIF-1α stability through Phosphorylation on Ser451
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Building on a foundation of VEGF and mTOR targeted agents in renal cell carcinoma
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A partnership with the proteasome; the destructive nature of GSK3
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The role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma
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HIF-1α serves as a co-linker between AD and T2DM
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Temporal Rac1 – HIF-1 crosstalk modulates hypoxic survival of aged neurons
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Hypoxia-inducible factors: Crosstalk between their protein stability and protein degradation
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Reactive oxygen species and HIF-1 signalling in cancer
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Decreased production of vascular endothelial growth factor in adriamycin-resistant breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.canlet.2011.10.033openalex-snapshot
ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer
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Inhibition of T-antigen expression promoting glycogen synthase kinase 3 impairs merkel cell carcinoma cell growth
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HIF-1α: A potential therapeutic opportunity in renal fibrosis
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Intermittent fasting along with hydroalcoholic extract of Centella-asiatica ameliorates sub-acute hypoxia-induced ischemic stroke in adult zebrafish
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CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation
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MKP-1 negatively regulates LPS-mediated IL-1β production through p38 activation and HIF-1α expression
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d-lactate-induced ETosis in cattle polymorphonuclear leucocytes is dependent on the release of mitochondrial reactive oxygen species and the PI3K/Akt/HIF-1 and GSK-3β pathways
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The hypoxia‐inducible factor is stabilized in circulating hematopoietic stem cells under normoxic conditions
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δ‐catenin overexpression promotes angiogenic potential of CWR22Rv‐1 prostate cancer cells via HIF‐1α and VEGF
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Reactive oxygen species produced by the knockdown of manganese-superoxide dismutase up-regulate hypoxia-inducible factor-1α expression in oral squamous cell carcinoma cells
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Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke
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Cerebrolysin protects PC12 cells from CoCl2‐induced hypoxia employing GSK3β signaling
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Low-dose photodynamic therapy promotes angiogenic potential and increases immunogenicity of human mesenchymal stromal cells
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Therapeutic potentials of Apatinib in cancer treatment: Possible mechanisms and clinical relevance
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Feedback regulation between AMPK and HIF-1α contributes to color stability via energy metabolism and mitochondrial efficiency regulation of yak meat
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Is intractable epilepsy a tauopathy?
inferred← citeshttps://doi.org/10.1016/j.neuro.2015.01.001openalex-snapshot
A not cytotoxic nickel concentration alters the expression of neuronal differentiation markers in NT2 cells
inferred← citeshttps://doi.org/10.1016/j.niox.2010.12.010openalex-snapshot
Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease
inferred← citeshttps://doi.org/10.1016/j.peptides.2021.170507openalex-snapshot
The hypoxia response and nutritional peptides
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2010.02.003openalex-snapshot
Dehydroepiandrosterone: A new treatment for vascular remodeling diseases including pulmonary arterial hypertension
inferred← citeshttps://doi.org/10.1016/j.placenta.2010.04.009openalex-snapshot
Inhibition of the PI3K-Akt Pathway Suppresses sFlt1 Expression in Human Placental Hypoxia Models In Vitro
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2013.01.003openalex-snapshot
The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients
inferred← citeshttps://doi.org/10.1016/j.redox.2022.102243openalex-snapshot
ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCP
inferred← citeshttps://doi.org/10.1016/j.redox.2026.104220openalex-snapshot
HIF inhibition: Current strategies and clinical challenges
inferred← citeshttps://doi.org/10.1016/j.tibs.2008.08.002openalex-snapshot
HIF-1 regulation: not so easy come, easy go
inferred← citeshttps://doi.org/10.1016/j.trecan.2019.08.005openalex-snapshot
DUBs, Hypoxia, and Cancer
inferred← citeshttps://doi.org/10.1016/j.yexcr.2017.03.041openalex-snapshot
A compendium of proteins that interact with HIF-1α
inferred← citeshttps://doi.org/10.1021/pr9007927openalex-snapshot
Quantitative Phosphoproteomic Analysis of the STAT3/IL-6/HIF1α Signaling Network: An Initial Study in GSC11 Glioblastoma Stem Cells
inferred← citeshttps://doi.org/10.1038/emm.2013.87openalex-snapshot
Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state
inferred← citeshttps://doi.org/10.1038/labinvest.2010.207openalex-snapshot
Vhl is required for normal pancreatic β cell function and the maintenance of β cell mass with age in mice
inferred← citeshttps://doi.org/10.1038/onc.2010.366openalex-snapshot
Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1
inferred← citeshttps://doi.org/10.1038/onc.2011.174openalex-snapshot
Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway
inferred← citeshttps://doi.org/10.1038/s12276-025-01602-1openalex-snapshot
EGLN1 (PHD2) role in tumor microenvironment: insights for therapeutic targeting
inferred← citeshttps://doi.org/10.1038/s41388-021-01915-1openalex-snapshot
Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors
inferred← citeshttps://doi.org/10.1038/s41388-023-02659-wopenalex-snapshot
Hypoxia switches TET1 from being tumor-suppressive to oncogenic
inferred← citeshttps://doi.org/10.1038/s41398-018-0270-zopenalex-snapshot
GSK3β: a plausible mechanism of cognitive and hippocampal changes induced by erythropoietin treatment in mood disorders?
inferred← citeshttps://doi.org/10.1038/s41419-022-04897-4openalex-snapshot
Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia
inferred← citeshttps://doi.org/10.1038/s41467-024-51882-wopenalex-snapshot
Citrullination modulation stabilizes HIF-1α to promote tumour progression
inferred← citeshttps://doi.org/10.1038/s41598-024-65537-9openalex-snapshot
Cathepsins L and B target HIF1α for oxygen-independent proteolytic cleavage
inferred← citeshttps://doi.org/10.1038/sj.bmt.1705872openalex-snapshot
How lithium treatment generates neutrophilia by enhancing phosphorylation of GSK-3, increasing HIF-1 levels and how this path is important during engraftment
inferred← citeshttps://doi.org/10.1038/srep19118openalex-snapshot
CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS
inferred← citeshttps://doi.org/10.1039/c6mb00657dopenalex-snapshot
Erythropoietin and co.: intrinsic structure and functional disorder
inferred← citeshttps://doi.org/10.1039/c6md00432fopenalex-snapshot
Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories
inferred← citeshttps://doi.org/10.1073/pnas.1412840111openalex-snapshot
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
inferred← citeshttps://doi.org/10.1073/pnas.1807112115openalex-snapshot
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
inferred← citeshttps://doi.org/10.1073/pnas.2209933119openalex-snapshot
Input integration by the circadian clock exhibits nonadditivity and fold-change detection
inferred← citeshttps://doi.org/10.1073/pnas.2408104121openalex-snapshot
Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α
inferred← citeshttps://doi.org/10.1074/jbc.m109.016170openalex-snapshot
Mechanism of Hypoxia-induced GCM1 Degradation
inferred← citeshttps://doi.org/10.1074/jbc.m110.160325openalex-snapshot
Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1α
inferred← citeshttps://doi.org/10.1074/jbc.m110.166462openalex-snapshot
Regulation of PTEN Stability and Activity by Plk3
inferred← citeshttps://doi.org/10.1074/jbc.m111.264598openalex-snapshot
Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator
inferred← citeshttps://doi.org/10.1074/jbc.m113.507194openalex-snapshot
Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)
inferred← citeshttps://doi.org/10.1074/jbc.m116.767178openalex-snapshot
Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel
inferred← citeshttps://doi.org/10.1080/15384101.2017.1320005openalex-snapshot
The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia
inferred← citeshttps://doi.org/10.1080/15384101.2017.1373224openalex-snapshot
Polo-like kinase 3, hypoxic responses, and tumorigenesis
inferred← citeshttps://doi.org/10.1080/17460441.2019.1613370openalex-snapshot
The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy
inferred← citeshttps://doi.org/10.1089/ars.2009.2929openalex-snapshot
Neuroprotective Multifunctional Iron Chelators: From Redox-Sensitive Process to Novel Therapeutic Opportunities
inferred← citeshttps://doi.org/10.1089/ars.2009.3014openalex-snapshot
The Hypoxia-Inducible Factor-2α Is Stabilized by Oxidative Stress Involving NOX4
inferred← citeshttps://doi.org/10.1089/cbr.2024.0025openalex-snapshot
GSK-3: An “Ace” Among Kinases
inferred← citeshttps://doi.org/10.1091/mbc.e08-01-0042openalex-snapshot
Transcriptional Regulation of Serine/Threonine Kinase-15 (STK15) Expression by Hypoxia and HIF-1
inferred← citeshttps://doi.org/10.1093/carcin/bgp070openalex-snapshot
Metabolic transformation in cancer
inferred← citeshttps://doi.org/10.1093/ndt/gfad051openalex-snapshot
Tubulovascular protection from protease-activated receptor-1 depletion during AKI-to-CKD transition
inferred← citeshttps://doi.org/10.1096/fj.201902426ropenalex-snapshot
Regulation of stanniocalcin‐1 secretion by BeWo cells and first trimester human placental tissue from normal pregnancies and those at increased risk of developing preeclampsia
inferred← citeshttps://doi.org/10.1100/tsw.2009.93openalex-snapshot
Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin
inferred← citeshttps://doi.org/10.1101/2025.04.03.647116openalex-snapshot
GSK3B inhibition partially reverses brain ethanol-induced transcriptomic changes in C57BL/6J mice: Expression network co-analysis with human genome-wide association studies
inferred← citeshttps://doi.org/10.1111/apm.12569openalex-snapshot
Hypoxic inactivation of glycogen synthase kinase‐3β promotes gastric tumor growth and angiogenesis by facilitating hypoxia‐inducible factor‐1 signaling
inferred← citeshttps://doi.org/10.1111/cas.13483openalex-snapshot
Regulatory mechanisms of hypoxia‐inducible factor 1 activity: Two decades of knowledge
inferred← citeshttps://doi.org/10.1111/febs.15222openalex-snapshot
Hypoxia‐inducible factors in metabolic reprogramming during sepsis
inferred← citeshttps://doi.org/10.1111/febs.70334openalex-snapshot
Oxygen‐independent expression of HIF ‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia
inferred← citeshttps://doi.org/10.1111/imr.12029openalex-snapshot
Metabolic control of the Treg/Th17 axis
inferred← citeshttps://doi.org/10.1111/j.1745-7254.2008.00904.xopenalex-snapshot
Hypoxia confers protection against apoptosis via the PI3K/Akt pathway in endothelial progenitor cells
inferred← citeshttps://doi.org/10.1111/jpi.70029openalex-snapshot
Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia
inferred← citeshttps://doi.org/10.1111/wrr.12253openalex-snapshot
Hyperbaric oxygen therapy activates hypoxia‐inducible factor 1 ( HIF ‐1), which contributes to improved wound healing in diabetic mice
inferred← citeshttps://doi.org/10.1113/ep090685openalex-snapshot
Inhibition of the glycogen synthase kinase 3β–hypoxia‐inducible factor 1α pathway alleviates NLRP3‐mediated pyroptosis induced by high glucose in renal tubular epithelial cells
inferred← citeshttps://doi.org/10.1113/jp288798openalex-snapshot
Hypoxia‐inducible factor‐2 stabilization is not sufficient to induce erythropoietin production in deeper medullary fibroblasts
inferred← citeshttps://doi.org/10.1126/scisignal.aaf0583openalex-snapshot
Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1
inferred← citeshttps://doi.org/10.1126/scitranslmed.adp5088openalex-snapshot
Dual PI3K/mTOR inhibition is required to combat resistance to CDK4/6 inhibitor and endocrine therapy in PIK3CA -mutant breast cancer
inferred← citeshttps://doi.org/10.1128/mcb.00773-08openalex-snapshot
Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation
inferred← citeshttps://doi.org/10.1136/annrheumdis-2017-212647openalex-snapshot
Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation
inferred← citeshttps://doi.org/10.1152/ajpendo.00427.2015openalex-snapshot
Insulin-induced cytokine production in macrophages causes insulin resistance in hepatocytes
inferred← citeshttps://doi.org/10.1152/ajplung.00153.2017openalex-snapshot
Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signaling
inferred← citeshttps://doi.org/10.1152/ajprenal.00155.2013openalex-snapshot
Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis
inferred← citeshttps://doi.org/10.1152/ajprenal.00253.2019openalex-snapshot
Renal oxygenation during the early stages of adenine-induced chronic kidney disease
inferred← citeshttps://doi.org/10.1158/0008-5472.can-07-6182openalex-snapshot
Polo-like Kinase 3 Functions as a Tumor Suppressor and Is a Negative Regulator of Hypoxia-Inducible Factor-1α under Hypoxic Conditions
inferred← citeshttps://doi.org/10.1158/0008-5472.can-08-0917openalex-snapshot
Sphingosine Kinase 1: A New Modulator of Hypoxia Inducible Factor 1α during Hypoxia in Human Cancer Cells
inferred← citeshttps://doi.org/10.1159/000350078openalex-snapshot
Isoflurane Preconditioning Increases Survival of Rat Skin Random-Pattern Flaps by Induction of HIF-1a Expression
inferred← citeshttps://doi.org/10.1161/01.res.0000338259.37472.b6openalex-snapshot
Overcoming an Energy Crisis?
inferred← citeshttps://doi.org/10.1161/atvbaha.109.185280openalex-snapshot
Sphingosine-1-Phosphate
inferred← citeshttps://doi.org/10.1177/15230864261467594openalex-snapshot
Itaconate Ameliorates Skin Fibrosis Through Inhibition of HIF-1α/LDHA-Driven Aerobic Glycolysis
inferred← citeshttps://doi.org/10.1182/blood-2011-08-375014openalex-snapshot
GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α
inferred← citeshttps://doi.org/10.1186/1423-0127-19-67openalex-snapshot
The ubiquitin–proteasome system and signal transduction pathways regulating Epithelial Mesenchymal transition of cancer
inferred← citeshttps://doi.org/10.1186/2049-3002-2-3openalex-snapshot
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways
inferred← citeshttps://doi.org/10.1186/2162-3619-1-5openalex-snapshot
Roles of Polo-like kinase 3 in suppressing tumor angiogenesis
inferred← citeshttps://doi.org/10.1186/s12864-025-11743-2openalex-snapshot
Integrating SNP data to reveal the adaptive selection features of goat populations in extreme environments
inferred← citeshttps://doi.org/10.1186/s12885-022-09508-1openalex-snapshot
OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1α/CA9 axis
inferred← citeshttps://doi.org/10.1186/s12943-024-01975-3openalex-snapshot
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling
inferred← citeshttps://doi.org/10.1186/s12964-023-01143-yopenalex-snapshot
Adiponectin affects the migration ability of bone marrow-derived mesenchymal stem cells via the regulation of hypoxia inducible factor 1α
inferred← citeshttps://doi.org/10.1186/s12964-025-02514-3openalex-snapshot
USP13 promotes colorectal cancer progression by deubiquitinating and stabilizing HIF-1α
inferred← citeshttps://doi.org/10.1186/s13046-022-02578-wopenalex-snapshot
Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth
inferred← citeshttps://doi.org/10.1242/jcs.068122openalex-snapshot
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
inferred← citeshttps://doi.org/10.1242/jcs.106682openalex-snapshot
Hypoxia causes triglyceride accumulation via HIF-1-mediated stimulation of lipin 1 expression
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1006478openalex-snapshot
Genotype-phenotype relations of the von Hippel-Lindau tumor suppressor inferred from a large-scale analysis of disease mutations and interactors
inferred← citeshttps://doi.org/10.1371/journal.pgen.1001285openalex-snapshot
Evolutionary Conserved Regulation of HIF-1β by NF-κB
inferred← citeshttps://doi.org/10.1371/journal.pgen.1003314openalex-snapshot
The Archipelago Ubiquitin Ligase Subunit Acts in Target Tissue to Restrict Tracheal Terminal Cell Branching and Hypoxic-Induced Gene Expression
inferred← citeshttps://doi.org/10.1371/journal.pone.0010522openalex-snapshot
Inhibition of Hypoxia-Inducible Factor-1α (HIF-1α) Protein Synthesis by DNA Damage Inducing Agents
inferred← citeshttps://doi.org/10.1371/journal.pone.0034050openalex-snapshot
H2O2 Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling
inferred← citeshttps://doi.org/10.1371/journal.pone.0107914openalex-snapshot
GSK3β-Dependent Phosphorylation Alters DNA Binding, Transactivity and Half-Life of the Transcription Factor USF2
inferred← citeshttps://doi.org/10.1371/journal.pone.0112580openalex-snapshot
Hypoxia-Inducible Factors Modulate the Stemness and Malignancy of Colon Cancer Cells by Playing Opposite Roles in Canonical Wnt Signaling
inferred← citeshttps://doi.org/10.1371/journal.pone.0113865openalex-snapshot
Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2
inferred← citeshttps://doi.org/10.1371/journal.pone.0147038openalex-snapshot
Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α
inferred← citeshttps://doi.org/10.1371/journal.pone.0154309openalex-snapshot
Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle
inferred← citeshttps://doi.org/10.1371/journal.pone.0246531openalex-snapshot
The regulation of Hypoxia-Inducible Factor-1 (HIF-1alpha) expression by Protein Disulfide Isomerase (PDI)
inferred← citeshttps://doi.org/10.14336/ad.2015.0929openalex-snapshot
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
inferred← citeshttps://doi.org/10.1530/erc-11-0211openalex-snapshot
RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells
inferred← citeshttps://doi.org/10.1615/critrevoncog.v20.i5-6.130openalex-snapshot
Hypoxia-Induced Signaling Promotes Prostate Cancer Progression: Exosomes Role as Messenger of Hypoxic Response in Tumor Microenvironment
inferred← citeshttps://doi.org/10.1681/asn.2013040350openalex-snapshot
Delayed Administration of a Single Dose of Lithium Promotes Recovery from AKI
inferred← citeshttps://doi.org/10.18632/oncotarget.3186openalex-snapshot
A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells
inferred← citeshttps://doi.org/10.2147/dddt.s274980openalex-snapshot
HIF-1α is a Potential Molecular Target for Herbal Medicine to Treat Diseases
inferred← citeshttps://doi.org/10.2147/hp.s60703openalex-snapshot
Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β
inferred← citeshttps://doi.org/10.2147/hp.s96366openalex-snapshot
The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth
inferred← citeshttps://doi.org/10.2174/138161209789649358openalex-snapshot
Kinases as Upstream Regulators of the HIF System: Their Emerging Potential as Anti-Cancer Drug Targets
inferred← citeshttps://doi.org/10.2174/138161213804581837openalex-snapshot
Wnt/beta-Catenin Signaling and Small Molecule Inhibitors
inferred← citeshttps://doi.org/10.2174/1381612825666191210152156openalex-snapshot
Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC
inferred← citeshttps://doi.org/10.2174/1570161121666230913093441openalex-snapshot
MDMB-FUBINACA Influences Brain Angiogenesis and the Expression of VEGF, ANG-1, and ANG-2
inferred← citeshttps://doi.org/10.2492/inflammregen.33.203openalex-snapshot
Post-translational modifications of proteins in gene regulation under hypoxic conditions
inferred← citeshttps://doi.org/10.3109/10409238.2013.838205openalex-snapshot
Transcriptional regulation by hypoxia inducible factors
inferred← citeshttps://doi.org/10.3389/fcell.2016.00011openalex-snapshot
Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity
inferred← citeshttps://doi.org/10.3389/fcell.2021.646687openalex-snapshot
Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy
inferred← citeshttps://doi.org/10.3389/fcell.2022.862791openalex-snapshot
Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis
inferred← citeshttps://doi.org/10.3389/fcell.2023.1250000openalex-snapshot
Protein kinase B/AKT phosphorylates hypoxia-inducible factor-3α1 in response to insulin, promoting cell growth and migration
inferred← citeshttps://doi.org/10.3389/fendo.2022.1103075openalex-snapshot
Hypoxia signaling pathway: A central mediator in endocrine tumors
inferred← citeshttps://doi.org/10.3389/fncel.2014.00001openalex-snapshot
Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer’s disease risk factor
inferred← citeshttps://doi.org/10.3389/fnmol.2011.00040openalex-snapshot
GSK-3: Functional Insights from Cell Biology and Animal Models
inferred← citeshttps://doi.org/10.3389/fnmol.2012.00001openalex-snapshot
GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder
inferred← citeshttps://doi.org/10.3389/fonc.2022.984525openalex-snapshot
Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer
inferred← citeshttps://doi.org/10.3389/fphar.2022.998574openalex-snapshot
NLRP3-mediated pyroptosis in diabetic nephropathy
inferred← citeshttps://doi.org/10.3390/ani11113021openalex-snapshot
Genetics Responses to Hypoxia and Reoxygenation Stress in Larimichthys crocea Revealed via Transcriptome Analysis and Weighted Gene Co-Expression Network
inferred← citeshttps://doi.org/10.3390/antiox11112277openalex-snapshot
Irregular Expression of Cellular Stress Response Markers in the Placenta of Women with Chronic Venous Disease
inferred← citeshttps://doi.org/10.3390/biomedicines8020032openalex-snapshot
Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for Medicine
inferred← citeshttps://doi.org/10.3390/cancers14071791openalex-snapshot
Vitamin D and Hypoxia: Points of Interplay in Cancer
inferred← citeshttps://doi.org/10.3390/cells6040045openalex-snapshot
The Role of Hypoxia in Glioblastoma Invasion
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