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Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway

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1 of the 44 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1016/j.omtn.2019.08.024 (notice 2024-05-18).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/advs.202000925openalex-snapshot
Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2‐ERK Signaling to Suppress Esophageal Cancer Metastasis
inferredcites →https://doi.org/10.1002/ijc.22862openalex-snapshot
Activation of PI3K‐Akt signaling pathway promotes prostate cancer cell invasion
inferredcites →https://doi.org/10.1002/ijc.30262openalex-snapshot
Dosing targeted and cytotoxic two‐drug combinations: Lessons learned from analysis of 24,326 patients reported 2010 through 2013
inferredcites →https://doi.org/10.1002/jcb.26783openalex-snapshot
Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116
inferredcites →https://doi.org/10.1002/jcp.26406openalex-snapshot
Oxaliplatin resistance in colorectal cancer cells is mediated via activation of ABCG2 to alleviate ER stress induced apoptosis
inferredcites →https://doi.org/10.1002/jcp.27221openalex-snapshot
The role of microRNAs in 5‐FU resistance of colorectal cancer: Possible mechanisms
inferredcites →https://doi.org/10.1002/wnan.1353openalex-snapshot
Combinatorial nanomedicines for colon cancer therapy
inferredcites →https://doi.org/10.1007/s10072-017-2854-4openalex-snapshot
Treatment with telmisartan, a long-acting angiotensin II receptor blocker, prevents migraine attacks in Japanese non-responders to lomerizine
inferredcites →https://doi.org/10.1016/j.biopha.2018.06.103openalex-snapshot
Naringin suppresses the growth and motility of hypertrophic scar fibroblasts by inhibiting the kinase activity of Akt
inferredcites →https://doi.org/10.1016/j.canlet.2018.03.039openalex-snapshot
IGF2 induces CD133 expression in esophageal cancer cells to promote cancer stemness
inferredcites →https://doi.org/10.1016/j.ceb.2009.11.014openalex-snapshot
Mammalian autophagy: core molecular machinery and signaling regulation
inferredcites →https://doi.org/10.1016/j.drudis.2016.05.015openalex-snapshot
Drug combination therapy increases successful drug repositioning
inferredcites →https://doi.org/10.1016/j.drudis.2019.06.014openalex-snapshot
Drug repurposing: a promising tool to accelerate the drug discovery process
inferredcites →https://doi.org/10.1016/j.jconrel.2020.01.019openalex-snapshot
Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells
inferredcites →https://doi.org/10.1016/j.kint.2015.11.021openalex-snapshot
Autophagy in acute kidney injury
inferredcites →https://doi.org/10.1016/j.omtn.2019.08.024openalex-snapshot
RETRACTED: circIFT80 Functions as a ceRNA of miR-1236-3p to Promote Colorectal Cancer Progression
inferredcites →https://doi.org/10.1016/j.phrs.2017.07.013openalex-snapshot
Drug repurposing in cancer
inferredcites →https://doi.org/10.1016/s1470-2045(14)71199-4openalex-snapshot
Adjuvant chemotherapy after preoperative (chemo)radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data
inferredcites →https://doi.org/10.1021/acs.jafc.8b04020openalex-snapshot
Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling
inferredcites →https://doi.org/10.1038/nature12912openalex-snapshot
Discovery and saturation analysis of cancer genes across 21 tumour types
inferredcites →https://doi.org/10.1038/ncomms14399openalex-snapshot
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
inferredcites →https://doi.org/10.1038/nrd.2018.168openalex-snapshot
Drug repurposing: progress, challenges and recommendations
inferredcites →https://doi.org/10.1038/nrm1835openalex-snapshot
Complex networks orchestrate epithelial–mesenchymal transitions
inferredcites →https://doi.org/10.1038/s41419-020-2730-7openalex-snapshot
Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis
inferredcites →https://doi.org/10.1038/s41568-019-0216-7openalex-snapshot
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
inferredcites →https://doi.org/10.1093/annonc/mdu260openalex-snapshot
Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
inferredcites →https://doi.org/10.1093/carcin/bgy186openalex-snapshot
Melatonin-mediated downregulation of thymidylate synthase as a novel mechanism for overcoming 5-fluorouracil associated chemoresistance in colorectal cancer cells
inferredcites →https://doi.org/10.1111/cpr.12202openalex-snapshot
MicroRNAs predict and modulate responses to chemotherapy in colorectal cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-1595openalex-snapshot
The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment
inferredcites →https://doi.org/10.1158/1078-0432.ccr-15-1196openalex-snapshot
Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance
inferredcites →https://doi.org/10.1158/2159-8290.cd-14-0362openalex-snapshot
Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations
inferredcites →https://doi.org/10.1172/jci73941openalex-snapshot
The role for autophagy in cancer
inferredcites →https://doi.org/10.1182/blood-2004-09-3706openalex-snapshot
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival
inferredcites →https://doi.org/10.1186/s13045-017-0436-9openalex-snapshot
Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment
inferredcites →https://doi.org/10.1186/s13046-019-1355-0openalex-snapshot
Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation
inferredcites →https://doi.org/10.1615/critrevoncog.2018027211openalex-snapshot
A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics
inferredcites →https://doi.org/10.18632/oncotarget.16333openalex-snapshot
Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy
inferredcites →https://doi.org/10.18632/oncotarget.2596openalex-snapshot
Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway
inferredcites →https://doi.org/10.21037/jgo.2019.09.04openalex-snapshot
Managing elderly with colorectal cancer
inferredcites →https://doi.org/10.3389/fphar.2017.00736openalex-snapshot
Pharmacogenomics DNA Biomarkers in Colorectal Cancer: Current Update
inferredcites →https://doi.org/10.3748/wjg.v24.i41.4643openalex-snapshot
Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma
inferredcites →https://doi.org/10.3858/emm.2011.43.5.032openalex-snapshot
Frontier of Epilepsy Research - mTOR signaling pathway
inferredcites →https://doi.org/10.7150/thno.30372openalex-snapshot
Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance
inferredcites →https://doi.org/10.7150/thno.48698openalex-snapshot
Anti-allergic drug azelastine suppresses colon tumorigenesis by directly targeting ARF1 to inhibit IQGAP1-ERK-Drp1-mediated mitochondrial fission

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4671341openalex-extracted
Lomerizine Promotes Ferroptosis by Targeting CACNA1b Mediated JAK2/STAT3 Pathway Activation and Reverses Cisplatin Resistance of HNSCC
inferred← citeshttps://doi.org/10.1002/advs.202202528openalex-snapshot
Blockade of Nuclear β‐Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis
inferred← citeshttps://doi.org/10.1002/mco2.200openalex-snapshot
Vascular calcification: Molecular mechanisms and therapeutic interventions
inferred← citeshttps://doi.org/10.1002/mco2.70295openalex-snapshot
PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment
inferred← citeshttps://doi.org/10.1002/tox.24197openalex-snapshot
MiR ‐2110 induced by chemically synthesized cinobufagin functions as a tumor‐metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma
inferred← citeshttps://doi.org/10.1007/s10067-024-06871-1openalex-snapshot
Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis
inferred← citeshttps://doi.org/10.1007/s12672-024-01250-3openalex-snapshot
Autophagy regulates apoptosis of colorectal cancer cells based on signaling pathways
inferred← citeshttps://doi.org/10.1016/j.apsb.2023.07.013openalex-snapshot
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer
inferred← citeshttps://doi.org/10.1016/j.bioorg.2023.106701openalex-snapshot
Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118524openalex-snapshot
Autophagy in colorectal cancer: Current understanding of mechanisms and future therapeutic directions
inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216225openalex-snapshot
Regulatory network and targeted interventions for CCDC family in tumor pathogenesis
inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.175186openalex-snapshot
FXYD5 promotes sorafenib resistance through the Akt/mTOR signaling pathway in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.envres.2023.115721openalex-snapshot
Rational targeting of autophagy in colorectal cancer therapy: From molecular interactions to pharmacological compounds
inferred← citeshttps://doi.org/10.1016/j.expneurol.2025.115366openalex-snapshot
Effect of activated autophagy on an animal model of vestibular migraine-like attacks
inferred← citeshttps://doi.org/10.1016/j.nantod.2024.102589openalex-snapshot
Rapamycin-loaded nanoparticles elicit local liver immunosuppressive and remote anti-tumor efficacy
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154593openalex-snapshot
Paeonol ameliorates endometrial hyperplasia in mice via inhibiting PI3K/AKT pathway-related ferroptosis
inferred← citeshttps://doi.org/10.1038/s41421-023-00570-yopenalex-snapshot
Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance
inferred← citeshttps://doi.org/10.1038/s41422-023-00793-4openalex-snapshot
Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner
inferred← citeshttps://doi.org/10.1371/journal.pone.0311308openalex-snapshot
Autophagy-associated biomarkers ULK2, UVRAG, and miRNAs miR-21, miR-126, and miR-374: Prognostic significance in glioma patients
inferred← citeshttps://doi.org/10.2147/pgpm.s398522openalex-snapshot
Discovery of Drug-Responsive Phenomic Alteration-Related Driver Genes in the Treatment of Coronary Heart Disease
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1150940openalex-snapshot
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β
inferred← citeshttps://doi.org/10.3390/cells14080574openalex-snapshot
Lysosomes and LAMPs as Autophagy Drivers of Drug Resistance in Colorectal Cancer
inferred← citeshttps://doi.org/10.7150/ijbs.70679openalex-snapshot
Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest
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