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Drug combination therapy increases successful drug repositioning

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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inferredcites →https://doi.org/10.1371/journal.pntd.0002977openalex-snapshot
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inferredcites →https://doi.org/10.18632/oncotarget.5405openalex-snapshot
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Computational polypharmacology comes of age

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.arr.2023.101851openalex-snapshot
Compound combinations targeting longevity: Challenges and perspectives
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102693openalex-snapshot
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies
inferred← citeshttps://doi.org/10.1016/j.bbcan.2019.04.005openalex-snapshot
Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.12.069openalex-snapshot
Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution
inferred← citeshttps://doi.org/10.1016/j.bbrep.2022.101225openalex-snapshot
Drug repurposing for SARS-CoV-2 main protease: Molecular docking and molecular dynamics investigations
inferred← citeshttps://doi.org/10.1016/j.bcp.2019.03.001openalex-snapshot
The FICI paradigm: Correcting flaws in antimicrobial in vitro synergy screens at their inception
inferred← citeshttps://doi.org/10.1016/j.bcp.2019.07.002openalex-snapshot
Olesoxime in neurodegenerative diseases: Scrutinising a promising drug candidate
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116140openalex-snapshot
Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin
inferred← citeshttps://doi.org/10.1016/j.bioorg.2023.106721openalex-snapshot
Small-molecule dual inhibitors targeting heat shock protein 90 for cancer targeted therapy
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.111177openalex-snapshot
A strategy for component-based Chinese medicines design approach of Polygonum orientale L. against hypoxia/reoxygenation based on uniform design-stepwise regression-simulated annealing
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111638openalex-snapshot
Drug repurposing: Iron in the fire for older drugs
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.112911openalex-snapshot
Combined drug triads for synergic neuroprotection in retinal degeneration
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.116084openalex-snapshot
Programmed Co-delivery of tamoxifen and docetaxel using lipid-coated mesoporous silica nanoparticles for overcoming CYP3A4-mediated resistance in triple-negative breast cancer treatment
inferred← citeshttps://doi.org/10.1016/j.bjid.2020.09.001openalex-snapshot
Inhibition of Brazilian ZIKV strain replication in primary human placental chorionic cells and cervical cells treated with nitazoxanide
inferred← citeshttps://doi.org/10.1016/j.cbi.2020.109298openalex-snapshot
Race to arsenal COVID-19 therapeutics: Current alarming status and future directions
inferred← citeshttps://doi.org/10.1016/j.cbi.2022.110333openalex-snapshot
Exploring the repositioning of the amodiaquine as potential drug against visceral leishmaniasis: The in vitro effect against Leishmania infantum is associated with multiple mechanisms, involving mitochondria dysfunction, oxidative stress and loss of cell cycle control
inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111409openalex-snapshot
Multiple mechanisms of action of a triazole-derived salt against Leishmania amazonensis: Apoptosis-like death and autophagy
inferred← citeshttps://doi.org/10.1016/j.clon.2021.08.008openalex-snapshot
Model Selection for the Preclinical Development of New Drug–Radiotherapy Combinations
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2019.05.006openalex-snapshot
DrugR+: A comprehensive relational database for drug repurposing, combination therapy, and replacement therapy
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2023.106671openalex-snapshot
Computational drug repurposing by exploiting large-scale gene expression data: Strategy, methods and applications
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2023.107340openalex-snapshot
BDN-DDI: A bilinear dual-view representation learning framework for drug–drug interaction prediction
inferred← citeshttps://doi.org/10.1016/j.coph.2019.07.006openalex-snapshot
Improving therapy of severe infections through drug repurposing of synergistic combinations
inferred← citeshttps://doi.org/10.1016/j.coph.2019.12.004openalex-snapshot
Next-generation drug repurposing using human genetics and network biology
inferred← citeshttps://doi.org/10.1016/j.csbj.2024.06.012openalex-snapshot
Target repositioning using multi-layer networks and machine learning: The case of prostate cancer
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2023.07.002openalex-snapshot
Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury
inferred← citeshttps://doi.org/10.1016/j.drudis.2020.11.026openalex-snapshot
Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy
inferred← citeshttps://doi.org/10.1016/j.drudis.2021.07.026openalex-snapshot
Advances in the computational landscape for repurposed drugs against COVID-19
inferred← citeshttps://doi.org/10.1016/j.drudis.2021.08.002openalex-snapshot
Evaluating the performance of drug-repurposing technologies
inferred← citeshttps://doi.org/10.1016/j.drudis.2021.09.012openalex-snapshot
Combining repurposed drugs to treat colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.drudis.2022.04.006openalex-snapshot
Machine learning to design antimicrobial combination therapies: Promises and pitfalls
inferred← citeshttps://doi.org/10.1016/j.drudis.2023.103625openalex-snapshot
The recent progress of deep-learning-based in silico prediction of drug combination
inferred← citeshttps://doi.org/10.1016/j.drudis.2024.104201openalex-snapshot
Therapeutic development approaches to treat haploinsufficiency diseases: restoring protein levels
inferred← citeshttps://doi.org/10.1016/j.drudis.2025.104345openalex-snapshot
Computational modeling approaches and regulatory pathways for drug combinations
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116396openalex-snapshot
Privileged small molecules against neglected tropical diseases: A perspective from structure activity relationships
inferred← citeshttps://doi.org/10.1016/j.ejpb.2019.05.004openalex-snapshot
Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176873openalex-snapshot
Emerging pharmacological approaches for Huntington's disease
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177254openalex-snapshot
Aspirin-triggered lipoxin A4 reduces neuropathic pain and anxiety-like behaviours in male diabetic rats: antinociceptive enhancement by cannabinoid receptor agonists
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177480openalex-snapshot
Aspirin enhances the antibacterial activity of colistin against multidrug-resistant Pseudomonas aeruginosa
inferred← citeshttps://doi.org/10.1016/j.ejps.2020.105522openalex-snapshot
Emerging strategies on in silico drug development against COVID-19: challenges and opportunities
inferred← citeshttps://doi.org/10.1016/j.exppara.2023.108655openalex-snapshot
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
inferred← citeshttps://doi.org/10.1016/j.future.2025.107913openalex-snapshot
Drug combination prediction for parasitic diseases through information-augmented hypergraph neural network
inferred← citeshttps://doi.org/10.1016/j.heliyon.2020.e04050openalex-snapshot
Inhibition of human immunodeficiency virus type 1 by niclosamide through mTORC1 inhibition
inferred← citeshttps://doi.org/10.1016/j.ibmed.2023.100101openalex-snapshot
Machine learning for metabolomics research in drug discovery
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.129216openalex-snapshot
Inulin-based formulations as an emerging therapeutic strategy for cancer: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.138809openalex-snapshot
Effect of combination of polyphenols, polysaccharide, and sodium selenite on bortezomib anti-cancer action
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.150985openalex-snapshot
Trypanosoma cruzi carbonic anhydrase inhibitors as a potential antiparasitic agent
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2021.08.007openalex-snapshot
Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2025.100624openalex-snapshot
Evaluation of the inhibitory effects of emodin on Neospora caninum invasion and proliferation in vitro
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2020.120083openalex-snapshot
Resveratrol and artemisinin eudragit-coated liposomes: A strategy to tackle intestinal tumors
inferred← citeshttps://doi.org/10.1016/j.isci.2021.102355openalex-snapshot
Hidden suppressive interactions are common in higher-order drug combinations
inferred← citeshttps://doi.org/10.1016/j.isci.2024.108833openalex-snapshot
Tumor-derived extracellular vesicle drug delivery system for chemo-photothermal-immune combination cancer treatment
inferred← citeshttps://doi.org/10.1016/j.jbo.2020.100321openalex-snapshot
Expression profiling of DNA methyl transferase I (DNMT1) and efficacy of a DNA-hypomethylating agent (decitabine) in combination with chemotherapy in osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.jconrel.2017.08.034openalex-snapshot
Chemotherapy agent-unsaturated fatty acid prodrugs and prodrug-nanoplatforms for cancer chemotherapy
inferred← citeshttps://doi.org/10.1016/j.jconrel.2019.10.054openalex-snapshot
A self-assembled, ROS-responsive Janus-prodrug for targeted therapy of inflammatory bowel disease
inferred← citeshttps://doi.org/10.1016/j.jiph.2020.06.016openalex-snapshot
In silico prediction of potential inhibitors for the main protease of SARS-CoV-2 using molecular docking and dynamics simulation based drug-repurposing
inferred← citeshttps://doi.org/10.1016/j.jpha.2024.101084openalex-snapshot
Exploration of innovative drug repurposing strategies for combating human protozoan diseases: Advances, challenges, and opportunities
inferred← citeshttps://doi.org/10.1016/j.molliq.2023.121253openalex-snapshot
Multi-ligand molecular docking, simulation, free energy calculations and wavelet analysis of the synergistic effects between natural compounds baicalein and cubebin for the inhibition of the main protease of SARS-CoV-2
inferred← citeshttps://doi.org/10.1016/j.molliq.2026.129327openalex-snapshot
Dimeric triazole-chalcone conjugate as multi-target directed β-amyloid inhibitor
inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.143341openalex-snapshot
Chitosan/sodium alginate polymer to deliver hops β-acids and 5-fluorouracil for colorectal cancer chemotherapy: in vitro experiment
inferred← citeshttps://doi.org/10.1016/j.nbd.2020.105227openalex-snapshot
Systematic evaluation of rationally chosen multitargeted drug combinations: a combination of low doses of levetiracetam, atorvastatin and ceftriaxone exerts antiepileptogenic effects in a mouse model of acquired epilepsy
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2022.109366openalex-snapshot
The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside
inferred← citeshttps://doi.org/10.1016/j.partic.2024.06.001openalex-snapshot
Fabrication of micro spherulitic particles of carbamazepine-hesperetin cocrystal via QESD with enhanced manufacturability and dissolution
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.107934openalex-snapshot
New approaches for developing multi-targeted drug combinations for disease modification of complex brain disorders. Does epilepsy prevention become a realistic goal?
inferred← citeshttps://doi.org/10.1016/j.phrs.2018.07.020openalex-snapshot
Dose-dependent target diversion of Danhong injection on the Glu-GLT-1/Gly-GlyRα dynamic balance module of cerebral ischemia
inferred← citeshttps://doi.org/10.1016/j.phymed.2020.153408openalex-snapshot
Synergistic breast cancer suppression efficacy of doxorubicin by combination with glycyrrhetinic acid as an angiogenesis inhibitor
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.156912openalex-snapshot
Brusatol induced ferroptosis in osteosarcoma cells by modulating the Keap1/Nrf2/SLC7A11 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.phyplu.2022.100265openalex-snapshot
In vitro anticancer efficacy of a polyphenolic combination of Quercetin, Curcumin, and Berberine in triple negative breast cancer (TNBC) cells
inferred← citeshttps://doi.org/10.1016/j.saa.2024.124389openalex-snapshot
Vibrational microspectroscopy as a tool to unveil new chemotherapeutic strategies against osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.02.003openalex-snapshot
Turning liabilities into opportunities: Off-target based drug repurposing in cancer
inferred← citeshttps://doi.org/10.1016/j.seppur.2023.124954openalex-snapshot
Sustainable preparation of spherical particles of novel carbamazepine-hesperetin cocrystal via different crystallization strategies: From mechanism to application
inferred← citeshttps://doi.org/10.1016/j.snb.2018.11.162openalex-snapshot
A new circular-shape microfluidic network for generating gradients of multiple substances -design, demonstration and application
inferred← citeshttps://doi.org/10.1016/j.talanta.2026.130129openalex-snapshot
New chemotherapeutic strategies against mesenchymal triple-negative breast cancer: A deeper look at the molecular level
inferred← citeshttps://doi.org/10.1016/j.tim.2018.04.004openalex-snapshot
Drug Repurposing for Viral Infectious Diseases: How Far Are We?
inferred← citeshttps://doi.org/10.1016/j.tips.2021.01.003openalex-snapshot
Drug Repurposing for Rare Diseases
inferred← citeshttps://doi.org/10.1016/j.tranon.2018.06.002openalex-snapshot
Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells
inferred← citeshttps://doi.org/10.1016/j.xcrp.2023.101520openalex-snapshot
Integrating multi-modal deep learning on knowledge graph for the discovery of synergistic drug combinations against infectious diseases
inferred← citeshttps://doi.org/10.1016/j.xgen.2025.101003openalex-snapshot
Network-based drug repurposing for psychiatric disorders using single-cell genomics
inferred← citeshttps://doi.org/10.1016/j.xphs.2023.04.004openalex-snapshot
Review on 505(b)(2) Drug Products Approved by USFDA from 2010 to 2020 Emphasizing Intellectual Property and Regulatory Considerations for Reformulations and New Combinations
inferred← citeshttps://doi.org/10.1017/s0031182019000234openalex-snapshot
Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1017/s0031182020000207openalex-snapshot
Computational approaches for drug discovery against trypanosomatid-caused diseases
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c02636openalex-snapshot
Discovery of Potent PDEδ/NAMPT Dual Inhibitors: Preclinical Evaluation in KRAS Mutant Pancreatic Cancer Cells
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.4c01009openalex-snapshot
Anti-Inflammatory Dimeric and Trimeric Flavonoids from the Roots ofPistacia weinmannifolia
inferred← citeshttps://doi.org/10.1021/acsabm.1c00635openalex-snapshot
Polymeric Nanoparticle Based Diagnosis and Nanomedicine for Treatment and Development of Vaccines for Cerebral Malaria: A Review on Recent Advancement
inferred← citeshttps://doi.org/10.1021/acsinfecdis.0c00886openalex-snapshot
Combination of Subtherapeutic Doses of Tretazicar and Liposomal Amphotericin B Suppresses and Cures Leishmania major-Induced Cutaneous Lesions in Murine Models
inferred← citeshttps://doi.org/10.1021/acsmaterialslett.4c02457openalex-snapshot
Cargo Delivery to Cells Using Laser-Irradiated Carbon-Black-Loaded Polydimethylsiloxane
inferred← citeshttps://doi.org/10.1021/acsomega.5c12226openalex-snapshot
High-Throughput Screening of FDA-Approved Drugs for Antibacterial and Antibiofilm Activities Against Multidrug-resistant Pseudomonas aeruginosa
inferred← citeshttps://doi.org/10.1021/acssuschemeng.2c03982openalex-snapshot
Design of Single and Multicomponent Drug Spherical Particles with Improved Powder Properties in Water Instead of Organic Solvents: A Case Study of Gemfibrozil
inferred← citeshttps://doi.org/10.1038/emi.2016.123openalex-snapshot
Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria
inferred← citeshttps://doi.org/10.1038/nm.4184openalex-snapshot
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
inferred← citeshttps://doi.org/10.1038/s41392-020-00213-8openalex-snapshot
Overcoming cancer therapeutic bottleneck by drug repurposing
inferred← citeshttps://doi.org/10.1038/s41392-022-01248-9openalex-snapshot
Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression
inferred← citeshttps://doi.org/10.1038/s41401-022-00983-7openalex-snapshot
Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines
inferred← citeshttps://doi.org/10.1038/s41416-023-02502-9openalex-snapshot
Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy
inferred← citeshttps://doi.org/10.1038/s41420-024-01819-5openalex-snapshot
Repurposing proteasome inhibitors for improved treatment of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1038/s41467-025-59822-yopenalex-snapshot
Building a unified model for drug synergy analysis powered by large language models
inferred← citeshttps://doi.org/10.1038/s41564-019-0357-1openalex-snapshot
Drug repurposing for antimicrobial discovery
inferred← citeshttps://doi.org/10.1038/s41598-019-39852-5openalex-snapshot
Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells
inferred← citeshttps://doi.org/10.1038/s41598-020-57806-0openalex-snapshot
Novel Analytical Platform For Robust Identification of Cell Migration Inhibitors
inferred← citeshttps://doi.org/10.1038/s41598-020-70280-yopenalex-snapshot
Network-based modeling of drug effects on disease module in systemic sclerosis
inferred← citeshttps://doi.org/10.1038/s41598-020-79472-yopenalex-snapshot
A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants
inferred← citeshttps://doi.org/10.1038/s41598-023-39647-9openalex-snapshot
In vitro synergy screens of FDA-approved drugs reveal novel zidovudine- and azithromycin-based combinations with last-line antibiotics against Klebsiella pneumoniae
inferred← citeshttps://doi.org/10.1038/s41598-025-85947-7openalex-snapshot
DeepDrug as an expert guided and AI driven drug repurposing methodology for selecting the lead combination of drugs for Alzheimer’s disease
inferred← citeshttps://doi.org/10.1038/s41698-020-0122-1openalex-snapshot
Machine learning approaches to drug response prediction: challenges and recent progress
inferred← citeshttps://doi.org/10.1038/s41746-024-01024-9openalex-snapshot
CancerGPT for few shot drug pair synergy prediction using large pretrained language models
inferred← citeshttps://doi.org/10.1038/s43588-020-00007-6openalex-snapshot
Lessons from the COVID-19 pandemic for advancing computational drug repurposing strategies
inferred← citeshttps://doi.org/10.1038/s44259-024-00034-7openalex-snapshot
Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance
inferred← citeshttps://doi.org/10.1039/c8ra09786kopenalex-snapshot
Sodium tanshinone IIA silate increases melanin synthesis by activating the MAPK and PKA pathways and protects melanocytes from H 2 O 2 -induced oxidative stress
inferred← citeshttps://doi.org/10.1039/d1sc01494copenalex-snapshot
Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties
inferred← citeshttps://doi.org/10.1080/07391102.2020.1796804openalex-snapshot
Investigating the binding affinity, interaction, and structure-activity-relationship of 76 prescription antiviral drugs targeting RdRp and Mpro of SARS-CoV-2
inferred← citeshttps://doi.org/10.1080/08982104.2022.2162540openalex-snapshot
Development and validation of HPLC method for simultaneous estimation of erlotinib and niclosamide from liposomes optimized by screening design
inferred← citeshttps://doi.org/10.1080/0954898x.2026.2744620openalex-snapshot
DSCrisk: A dual-view and substructure aware based method for drug-drug interaction risk-level prediction enhanced by contrastive learning
inferred← citeshttps://doi.org/10.1080/1061186x.2024.2424895openalex-snapshot
Overcoming antibiotic resistance: the potential and pitfalls of drug repurposing
inferred← citeshttps://doi.org/10.1080/13543784.2022.2095261openalex-snapshot
ALZT-OP1: an experimental combination regimen for the treatment of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1080/14787210.2022.2082944openalex-snapshot
Drugs repurposing for SARS-CoV-2: new insight of COVID-19 druggability
inferred← citeshttps://doi.org/10.1080/17460441.2020.1704729openalex-snapshot
Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
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