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Adiposity‐Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/oby.20625openalex-snapshot
Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog
inferredcites →https://doi.org/10.1007/s10620-011-1641-yopenalex-snapshot
Validation of a New Physical Activity Questionnaire for a Sedentary Population
inferredcites →https://doi.org/10.1007/s11892-013-0421-9openalex-snapshot
Race/Ethnic Difference in Diabetes and Diabetic Complications
inferredcites →https://doi.org/10.1016/0026-0495(79)90024-6openalex-snapshot
The effect of aging on carbohydrate metabolism: A review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly
inferredcites →https://doi.org/10.1016/0026-0495(82)90059-2openalex-snapshot
Hormonal control of glucose homeostasis during development and ageing in mice
inferredcites →https://doi.org/10.1016/j.exger.2015.01.003openalex-snapshot
Characterization of age-associated changes in peripheral organ and brain region weights in C57BL/6 mice
inferredcites →https://doi.org/10.1038/nature16151openalex-snapshot
Depletion of fat-resident Treg cells prevents age-associated insulin resistance
inferredcites →https://doi.org/10.1038/oby.2009.229openalex-snapshot
Fat Distribution, Aerobic Fitness, Blood Lipids, and Insulin Sensitivity in African‐American and European‐American Women
inferredcites →https://doi.org/10.1038/oby.2010.212openalex-snapshot
Age‐Related Changes in Insulin Sensitivity and β‐Cell Function Among European‐American and African‐American Women
inferredcites →https://doi.org/10.1038/srep00134openalex-snapshot
The metabolic footprint of aging in mice
inferredcites →https://doi.org/10.1096/fasebj.2.12.3044905openalex-snapshot
Aging and glucose homeostasis in C57BL/6J male mice
inferredcites →https://doi.org/10.1097/01.gim.0000076971.55421.adopenalex-snapshot
Determination and use of haplotypes: Ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans
inferredcites →https://doi.org/10.1111/acel.12481openalex-snapshot
Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age‐related insulin resistance
inferredcites →https://doi.org/10.1111/j.1365-2362.1991.tb01352.xopenalex-snapshot
Peripheral and hepatic insulin sensitivity in healthy elderly human subjects
inferredcites →https://doi.org/10.1111/j.1474-9726.2011.00786.xopenalex-snapshot
Essential role of protein tyrosine phosphatase 1B in obesity‐induced inflammation and peripheral insulin resistance during aging
inferredcites →https://doi.org/10.1126/science.1082889openalex-snapshot
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
inferredcites →https://doi.org/10.1152/ajpendo.00366.2002openalex-snapshot
Aging and insulin secretion
inferredcites →https://doi.org/10.1152/ajpendo.00406.2014openalex-snapshot
Comparison of the physiological relevance of systemic vs. portal insulin delivery to evaluate whole body glucose flux during an insulin clamp
inferredcites →https://doi.org/10.1152/ajpendo.1979.237.3.e214openalex-snapshot
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
inferredcites →https://doi.org/10.1159/000355958openalex-snapshot
Dialysis Dose and Intradialytic Hypotension: Results from the HEMO Study
inferredcites →https://doi.org/10.1161/01.cir.103.1.78openalex-snapshot
Evidence for Joint Genetic Control of Insulin Sensitivity and Systolic Blood Pressure in Hispanic Families With a Hypertensive Proband
inferredcites →https://doi.org/10.1172/jci.insight.91863openalex-snapshot
Insulin’s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion
inferredcites →https://doi.org/10.1177/019262339502300503openalex-snapshot
Longevity, Body Weight, and Neoplasia in Ad Libitum-Fed and Diet-Restricted C57BL6 Mice Fed NIH-31 Open Formula Diet
inferredcites →https://doi.org/10.1210/jc.2015-2892openalex-snapshot
Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans
inferredcites →https://doi.org/10.1210/jc.75.4.1125openalex-snapshot
Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age
inferredcites →https://doi.org/10.1210/jc.83.9.3350openalex-snapshot
Age-Related Reduction in Glucose Elimination Is Accompanied by Reduced Glucose Effectiveness and Increased Hepatic Insulin Extraction in Man
inferredcites →https://doi.org/10.1210/jcem-60-1-13openalex-snapshot
Pathogenesis of Age-Related Glucose Intolerance in Man: Insulin Resistance and Decreased β-Cell Function*
inferredcites →https://doi.org/10.1210/jcem-67-5-951openalex-snapshot
Insulin Resistance andβ-Cell Dysfunction in Aging: The Importance of Dietary Carbohydrate*
inferredcites →https://doi.org/10.1210/jcem.83.9.5107openalex-snapshot
Age-Related Reduction in Glucose Elimination Is Accompanied by Reduced Glucose Effectiveness and Increased Hepatic Insulin Extraction in Man1
inferredcites →https://doi.org/10.1242/dmm.006239openalex-snapshot
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
inferredcites →https://doi.org/10.1249/00005768-199301000-00011openalex-snapshot
Compendium of Physical Activities: classification of energy costs of human physical activities
inferredcites →https://doi.org/10.1371/journal.pone.0166263openalex-snapshot
Insulin Clearance Is Associated with Hepatic Lipase Activity and Lipid and Adiposity Traits in Mexican Americans
inferredcites →https://doi.org/10.18632/aging.101059openalex-snapshot
A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated
inferredcites →https://doi.org/10.2169/internalmedicine.53.1580openalex-snapshot
Effects of Age on Insulin Resistance and Secretion in Subjects without Diabetes
inferredcites →https://doi.org/10.2307/2531248openalex-snapshot
Longitudinal Data Analysis for Discrete and Continuous Outcomes
inferredcites →https://doi.org/10.2337/db05-1692openalex-snapshot
Effects of Age and Sex on Postprandial Glucose Metabolism
inferredcites →https://doi.org/10.2337/db09-0591openalex-snapshot
Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function
inferredcites →https://doi.org/10.2337/db11-1300openalex-snapshot
The Critical Role of Metabolic Pathways in Aging
inferredcites →https://doi.org/10.2337/db12-0339openalex-snapshot
Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice
inferredcites →https://doi.org/10.2337/db14-0020openalex-snapshot
Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions
inferredcites →https://doi.org/10.2337/dc12-0101openalex-snapshot
Relationship of Insulin Sensitivity, Insulin Secretion, and Adiposity With Insulin Clearance in a Multiethnic Population
inferredcites →https://doi.org/10.2337/diab.27.5.563openalex-snapshot
Inhibition of Insulin Secretion by Exogenous Insulin in Normal Man as Demonstrated by C-peptide Assay
inferredcites →https://doi.org/10.2337/diab.28.12.1095openalex-snapshot
Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin
inferredcites →https://doi.org/10.2337/diab.31.10.851openalex-snapshot
Influence of Age on Clearance of Insulin in Man
inferredcites →https://doi.org/10.2337/diab.44.5.555openalex-snapshot
Skeletal Muscle GLUT4 Protein Concentration and Aging in Humans
inferredcites →https://doi.org/10.2337/diab.45.7.947openalex-snapshot
Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR)
inferredcites →https://doi.org/10.2337/diabetes.52.7.1738openalex-snapshot
Mechanisms of the Age-Associated Deterioration in Glucose Tolerance
inferredcites →https://doi.org/10.2337/diabetes.52.8.1888openalex-snapshot
Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity
inferredcites →https://doi.org/10.2337/diabetes.53.11.2867openalex-snapshot
Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and β-Cell Function
inferredcites →https://doi.org/10.2337/diabetes.54.4.1222openalex-snapshot
Variation in the Gene for Muscle-Specific AMP Deaminase Is Associated With Insulin Clearance, a Highly Heritable Trait
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Unlocking Regenerative Potential: Beta-Cell Neogenesis and Novel Myokines Involved in Adaptation to Insulin Resistance in Mice
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Analysis of energy expenditure and behavioral characteristics in different mouse strains under normal and disease conditions
inferred← citeshttps://doi.org/10.1002/oby.22422openalex-snapshot
Hidden Figures in Age‐Associated Regulation of Glucose Metabolism: Insulin Secretion and Plasma Clearance
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The Assessment of Glucose Homeostasis in Rodents: Glucose, Insulin and Pyruvate Tolerance Tests
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Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice
inferred← citeshttps://doi.org/10.1007/s13679-025-00672-6openalex-snapshot
Muscle Insulin Resistance Elicits Muscle Atrophy in Obesity
inferred← citeshttps://doi.org/10.1016/b978-0-443-15500-0.00012-8openalex-snapshot
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Endocrinological and pathophysiological perspectives of diabetes in aging
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inferred← citeshttps://doi.org/10.1016/j.mad.2025.112068openalex-snapshot
Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice
inferred← citeshttps://doi.org/10.1016/j.metabol.2020.154352openalex-snapshot
Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101414openalex-snapshot
Increased glycolysis affects β-cell function and identity in aging and diabetes
inferred← citeshttps://doi.org/10.1016/j.physbeh.2026.115372openalex-snapshot
Effects of high-fat diet and age on locomotor activity and lipid metabolism in mice
inferred← citeshttps://doi.org/10.1016/j.xpro.2025.103774openalex-snapshot
Protocol for in vivo assessment of glucose control and insulin secretion and sensitivity in the pig
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Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
inferred← citeshttps://doi.org/10.1038/s41598-025-10436-wopenalex-snapshot
Vitamin E intake mediates the associations of triglyceride-glucose index and its related parameters with phenotypic age acceleration in middle-aged and elderly population
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Skeletal muscle mitochondrial dysfunction is associated with increased Gdf15 expression and circulating GDF15 levels in aged mice
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The Effects of Aging on Male Mouse Pancreatic β-Cell Function Involve Multiple Events in the Regulation of Secretion: Influence of Insulin Sensitivity
inferred← citeshttps://doi.org/10.1093/gerona/glad126openalex-snapshot
Insulin Sensitivity Initially Worsens but Later Improves With Aging in Male C57BL/6N Mice
inferred← citeshttps://doi.org/10.1111/1753-0407.70280openalex-snapshot
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Biological aging mediates the associations of metabolic score for insulin resistance with all‐cause and cardiovascular disease mortality among US adults: A nationwide cohort study
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Additional file 1 of T cells accumulate in non-diabetic islets during ageing
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Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters
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