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Unlocking Regenerative Potential: Beta-Cell Neogenesis and Novel Myokines Involved in Adaptation to Insulin Resistance in Mice

https://doi.org/10.2139/ssrn.4789208
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1 of the 61 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1074/jbc.m113.529925 (notice 2016-07-01).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/oby.22418openalex-extracted
Adiposity‐Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans
inferredcites →https://doi.org/10.1007/s00125-010-1809-6openalex-extracted
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
inferredcites →https://doi.org/10.1007/s00125-019-05038-xopenalex-extracted
Heterozygous deletion of Seipin in islet beta cells of male mice has an impact on insulin synthesis and secretion through reduced PPARγ expression
inferredcites →https://doi.org/10.1016/j.ando.2019.10.003openalex-extracted
Lipodystrophic syndromes: From diagnosis to treatment
inferredcites →https://doi.org/10.1016/j.arr.2022.101674openalex-extracted
The pancreatic β-cell in ageing: Implications in age-related diabetes
inferredcites →https://doi.org/10.1016/j.bbrc.2010.06.070openalex-extracted
S961, an insulin receptor antagonist causes hyperinsulinemia, insulin-resistance and depletion of energy stores in rats
inferredcites →https://doi.org/10.1016/j.cell.2007.12.015openalex-extracted
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
inferredcites →https://doi.org/10.1016/j.celrep.2021.110213openalex-extracted
Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes
inferredcites →https://doi.org/10.1016/j.celrep.2022.111074openalex-extracted
Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming
inferredcites →https://doi.org/10.1016/j.cmet.2015.07.025openalex-extracted
Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function
inferredcites →https://doi.org/10.1016/j.cmet.2016.04.002openalex-extracted
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
inferredcites →https://doi.org/10.1016/j.cmet.2016.08.018openalex-extracted
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes
inferredcites →https://doi.org/10.1016/j.cmet.2017.03.015openalex-extracted
β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance
inferredcites →https://doi.org/10.1016/j.devcel.2009.11.003openalex-extracted
Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth
inferredcites →https://doi.org/10.1016/j.molmet.2022.101438openalex-extracted
Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction
inferredcites →https://doi.org/10.1016/j.stem.2021.08.003openalex-extracted
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas
inferredcites →https://doi.org/10.1016/s0092-8674(00)81896-6openalex-extracted
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles
inferredcites →https://doi.org/10.1038/mt.2015.29openalex-extracted
Overcoming Insulin Insufficiency by Forced Follistatin Expression in β -cells of db/db Mice
inferredcites →https://doi.org/10.1038/nm.2513openalex-extracted
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
inferredcites →https://doi.org/10.1038/nm.4054openalex-extracted
p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
inferredcites →https://doi.org/10.1038/s41587-019-0201-4openalex-extracted
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
inferredcites →https://doi.org/10.1038/s41598-018-36289-0openalex-extracted
Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice
inferredcites →https://doi.org/10.1038/srep31553openalex-extracted
Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance
inferredcites →https://doi.org/10.1038/srep34885openalex-extracted
Intra-islet lesions and lobular variations in β-cell mass expansion in ob/ob mice revealed by 3D imaging of intact pancreas
inferredcites →https://doi.org/10.1055/s-0030-1269896openalex-extracted
Morphofunctional Alterations in Endocrine Pancreas of Short- and Long-term Dexamethasone-treated Rats
inferredcites →https://doi.org/10.1073/pnas.0607966104openalex-extracted
FSTL3 deletion reveals roles for TGF-β family ligands in glucose and fat homeostasis in adults
inferredcites →https://doi.org/10.1073/pnas.1410854111openalex-extracted
Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature
inferredcites →https://doi.org/10.1073/pnas.1524200113openalex-extracted
G rowth factors and medium hyperglycemia induce Sox9 + ductal cell differentiation into β cells in mice with reversal of diabetes
inferredcites →https://doi.org/10.1073/pnas.1621069114openalex-extracted
Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice
inferredcites →https://doi.org/10.1074/jbc.m113.529925openalex-extracted
Myostatin Induces Insulin Resistance via Casitas B-Lineage Lymphoma b (Cblb)-mediated Degradation of Insulin Receptor Substrate 1 (IRS1) Protein in Response to High Calorie Diet Intake
inferredcites →https://doi.org/10.1074/jbc.m610986200openalex-extracted
Glucose Is Necessary for Embryonic Pancreatic Endocrine Cell Differentiation
inferredcites →https://doi.org/10.1080/08977190500233367openalex-extracted
Effect of epiregulin on pancreatic beta cell growth and insulin secretion
inferredcites →https://doi.org/10.1093/bib/bbs046openalex-extracted
A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis
inferredcites →https://doi.org/10.1093/bioinformatics/btu638openalex-extracted
HTSeq—a Python framework to work with high-throughput sequencing data
inferredcites →https://doi.org/10.1093/nar/28.1.27openalex-extracted
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/gkaa1074openalex-extracted
The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets
inferredcites →https://doi.org/10.1096/fj.201700061rropenalex-extracted
Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy
inferredcites →https://doi.org/10.1152/ajpendo.00353.2017openalex-extracted
Do skeletal muscle-secreted factors influence the function of pancreatic β-cells?
inferredcites →https://doi.org/10.1155/2017/1328573openalex-extracted
Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion
inferredcites →https://doi.org/10.1172/jci.insight.99576openalex-extracted
Human duct cells contribute to β cell compensation in insulin resistance
inferredcites →https://doi.org/10.1172/jci119175openalex-extracted
Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.
inferredcites →https://doi.org/10.1172/jci66323openalex-extracted
No evidence for β cell neogenesis in murine adult pancreas
inferredcites →https://doi.org/10.1172/jci8339openalex-extracted
Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines
inferredcites →https://doi.org/10.1186/2045-3701-4-12openalex-extracted
Microenvironmental stimuli for proliferation of functional islet β-cells
inferredcites →https://doi.org/10.1210/endocr/bqab019openalex-extracted
FSTL3-Neutralizing Antibodies Enhance Glucose-Responsive Insulin Secretion in Dysfunctional Male Mouse and Human Islets
inferredcites →https://doi.org/10.1210/me.2014-1265openalex-extracted
Increasing β-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand
inferredcites →https://doi.org/10.1242/dev.056499openalex-extracted
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
inferredcites →https://doi.org/10.1242/dmm.045351openalex-extracted
3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
inferredcites →https://doi.org/10.1530/joe-13-0189openalex-extracted
β-cell adaptation in a mouse model of glucocorticoid-induced metabolic syndrome
inferredcites →https://doi.org/10.1530/joe-14-0373openalex-extracted
Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes
inferredcites →https://doi.org/10.2337/db06-0017openalex-extracted
Regulation of Pancreatic β-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse
inferredcites →https://doi.org/10.2337/db08-1198openalex-extracted
Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age
inferredcites →https://doi.org/10.2337/db13-1013openalex-extracted
Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
inferredcites →https://doi.org/10.2337/db17-1314openalex-extracted
Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance
inferredcites →https://doi.org/10.2337/db20-0290openalex-extracted
Generation and Characterization of a Novel Mouse Model That Allows Spatiotemporal Quantification of Pancreatic β-Cell Proliferation
inferredcites →https://doi.org/10.2337/db22-0019openalex-extracted
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion
inferredcites →https://doi.org/10.2337/dc12-0421openalex-extracted
β-Cell Mass and Turnover in Humans
inferredcites →https://doi.org/10.2337/diabetes.52.9.2304openalex-extracted
Increased β-Cell Apoptosis Prevents Adaptive Increase in β-Cell Mass in Mouse Model of Type 2 Diabetes
inferredcites →https://doi.org/10.3389/fendo.2022.836344openalex-extracted
Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg
inferredcites →https://doi.org/10.3390/ijms22020623openalex-extracted
Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
inferredcites →https://doi.org/10.3390/nu12123846openalex-extracted
Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.