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Doxorubicin‐induced cardiotoxicity involves IFNγ‐mediated metabolic reprogramming in cardiomyocytes

https://doi.org/10.1002/path.5192
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Doxorubicin induces specific immune functions and cytokine expression in peritoneal cells
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inferredcites →https://doi.org/10.1016/j.ajpath.2014.08.019openalex-snapshot
Interferon-γ Safeguards Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis
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Current prospects of type II interferon γ signaling and autoimmunity
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A concise description of cardioprotective strategies in doxorubicin-induced cardiotoxicityThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.
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Anthracycline Cardiotoxicity
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inferredcites →https://doi.org/10.1200/jco.2011.40.1273openalex-snapshot
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Correction: Toll-Like Receptor (TLR) 2 and TLR4 Differentially Regulate Doxorubicin Induced Cardiomyopathy in Mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes
inferred← citeshttps://doi.org/10.1002/jbt.22829openalex-snapshot
Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF‐κB intricate network in experimentally doxorubicin‐induced cardiotoxicity in rats: The role of curcumin
inferred← citeshttps://doi.org/10.1002/ptr.7965openalex-snapshot
Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases
inferred← citeshttps://doi.org/10.1007/s00210-024-03073-zopenalex-snapshot
2-Methoxyestradiol ameliorates doxorubicin-induced cardiotoxicity by regulating the expression of GLUT4 and CPT-1B in female rats
inferred← citeshttps://doi.org/10.1007/s10875-021-01000-yopenalex-snapshot
Rare Pathogenic Variants in Mitochondrial and Inflammation-Associated Genes May Lead to Inflammatory Cardiomyopathy in Chagas Disease
inferred← citeshttps://doi.org/10.1007/s12012-021-09710-wopenalex-snapshot
Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-κB, and TNF-α in Rats
inferred← citeshttps://doi.org/10.1007/s12012-023-09820-7openalex-snapshot
The Role of mTOR in Doxorubicin-Altered Cardiac Metabolism: A Promising Therapeutic Target of Natural Compounds
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110587openalex-snapshot
Temporary blockade of interferon-γ ameliorates doxorubicin-induced cardiotoxicity without influencing the anti-tumor effect
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117720openalex-snapshot
Endoplasmic reticulum stress in intestinal microecology: A controller of antineoplastic drug-related cardiovascular toxicity
inferred← citeshttps://doi.org/10.1016/j.ejphar.2019.172818openalex-snapshot
Effects of doxorubicin on the heart: From molecular mechanisms to intervention strategies
inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.173884openalex-snapshot
Aldose reductase regulates doxorubicin-induced immune and inflammatory responses by activating mitochondrial biogenesis
inferred← citeshttps://doi.org/10.1016/j.jacbts.2023.02.014openalex-snapshot
IFN-γ-STAT1-ERK Pathway Mediates Protective Effects of Invariant Natural Killer T Cells Against Doxorubicin-Induced Cardiomyocyte Death
inferred← citeshttps://doi.org/10.1016/j.jep.2021.114936openalex-snapshot
Ethanol extracts of Rhaponticum uniflorum (L.) DC flowers attenuate doxorubicin-induced cardiotoxicity via alleviating apoptosis and regulating mitochondrial dynamics in H9c2 cells
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.05.030openalex-snapshot
IL-17A-stimulated endothelial fatty acid β-oxidation promotes tumor angiogenesis
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119760openalex-snapshot
An update of the molecular mechanisms underlying doxorubicin plus trastuzumab induced cardiotoxicity
inferred← citeshttps://doi.org/10.1016/j.semcancer.2025.05.009openalex-snapshot
Metabolic reprogramming in cancer therapy-related cardiovascular toxicity: Mechanisms and intervention strategies
inferred← citeshttps://doi.org/10.1038/s44161-024-00507-yopenalex-snapshot
Cytotoxic T cells drive doxorubicin-induced cardiac fibrosis and systolic dysfunction
inferred← citeshttps://doi.org/10.1093/eurheartj/ehae188openalex-snapshot
Rescue of cardiac dysfunction during chemotherapy in acute myeloid leukaemia by blocking IL-1α
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Zinc dyshomeostasis: an emerging hallmark of cancer
inferred← citeshttps://doi.org/10.1101/2023.04.28.538426openalex-snapshot
Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis
inferred← citeshttps://doi.org/10.1139/cjpp-2020-0404openalex-snapshot
Impact of ellagic acid application on doxorubicin-induced cardiovascular toxicity model
inferred← citeshttps://doi.org/10.1152/ajpheart.00187.2026openalex-snapshot
Interplay of oxidative stress and inflammatory mechanisms in doxorubicin-induced cardiomyopathy
inferred← citeshttps://doi.org/10.1155/2019/7901735openalex-snapshot
Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway
inferred← citeshttps://doi.org/10.1155/2020/5347204openalex-snapshot
Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice
inferred← citeshttps://doi.org/10.1155/2021/6628957openalex-snapshot
Protection against Doxorubicin‐Induced Cardiotoxicity through Modulating iNOS/ARG 2 Balance by Electroacupuncture at PC6
inferred← citeshttps://doi.org/10.1155/2022/7176282openalex-snapshot
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inferred← citeshttps://doi.org/10.1161/circresaha.119.314681openalex-snapshot
Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy
inferred← citeshttps://doi.org/10.1161/circulationaha.122.062551openalex-snapshot
Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis
inferred← citeshttps://doi.org/10.1161/circulationaha.124.071217openalex-snapshot
Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy
inferred← citeshttps://doi.org/10.1177/15353702231220658openalex-snapshot
Inflammation and mitochondria in the pathogenesis of chronic Chagas disease cardiomyopathy
inferred← citeshttps://doi.org/10.1186/s12967-023-04498-5openalex-snapshot
Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
inferred← citeshttps://doi.org/10.1186/s12967-024-05623-8openalex-snapshot
The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes
inferred← citeshttps://doi.org/10.2147/jir.s358471openalex-snapshot
Doxorubicin-Induced Cardiotoxicity May Be Alleviated by Bone Marrow Mesenchymal Stem Cell-Derived Exosomal lncRNA via Inhibiting Inflammation
inferred← citeshttps://doi.org/10.2147/jir.s444600openalex-snapshot
Analysis and Validation of Critical Signatures and Immune Cell Infiltration Characteristics in Doxorubicin-Induced Cardiotoxicity by Integrating Bioinformatics and Machine Learning
inferred← citeshttps://doi.org/10.2174/011573403x322928241021100631openalex-snapshot
Unveiling the Complexities: Exploring Mechanisms of Anthracyclineinduced Cardiotoxicity
inferred← citeshttps://doi.org/10.29413/abs.2021-6.4.3openalex-snapshot
Genetic basis of anthracyclines cardiotoxicity: Literature review
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Metabolomic profiling and biomarker identification for early detection and therapeutic targeting of doxorubicin-induced cardiotoxicity
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Early vs. Late Onset Cardiac Injury and Mortality in Hospitalized COVID-19 Patients in Wuhan
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RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study
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Identification of novel biomarkers involved in doxorubicin-induced acute and chronic cardiotoxicity, respectively, by integrated bioinformatics
inferred← citeshttps://doi.org/10.3389/fcvm.2025.1566782openalex-snapshot
Bioinformatics analysis of ferroptosis-related biomarkers and potential drug predictions in doxorubicin-induced cardiotoxicity
inferred← citeshttps://doi.org/10.3389/fimmu.2021.755782openalex-snapshot
Impairment of Multiple Mitochondrial Energy Metabolism Pathways in the Heart of Chagas Disease Cardiomyopathy Patients
inferred← citeshttps://doi.org/10.3389/fimmu.2021.755862openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/biom14080922openalex-snapshot
Complex Interplay between DNA Damage and Autophagy in Disease and Therapy
inferred← citeshttps://doi.org/10.3390/biomedicines10092215openalex-snapshot
Chagas Disease Megaesophagus Patients Carrying Variant MRPS18B P260A Display Nitro-Oxidative Stress and Mitochondrial Dysfunction in Response to IFN-γ Stimulus
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The Innate Immune System in Cardiovascular Diseases and Its Role in Doxorubicin-Induced Cardiotoxicity
inferred← citeshttps://doi.org/10.3390/ijms25105303openalex-snapshot
Nicotinamide Mononucleotide Supplementation Alleviates Doxorubicin-Induced Multi-Organ Fibrosis
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Role of Oxidative Stress and Inflammation in Doxorubicin-Induced Cardiotoxicity: A Brief Account
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Reply to Trela, B.A.; Guffroy, M.R. Comment on “AlAsmari et al. Venetoclax Induces Cardiotoxicity Through Modulation of Oxidative-Stress-Mediated Cardiac Inflammation and Apoptosis via NF-κB and BCL-2 Pathway. Int. J. Mol. Sci. 2022, 23, 6260”
inferred← citeshttps://doi.org/10.3390/nu13072158openalex-snapshot
The Effects of Bergamot Polyphenolic Fraction, Cynara cardunculus, and Olea europea L. Extract on Doxorubicin-Induced Cardiotoxicity
inferred← citeshttps://doi.org/10.3390/ph14100970openalex-snapshot
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Integrated microarray analysis to identify potential biomarkers and therapeutic targets in dilated cardiomyopathy
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