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The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes

https://doi.org/10.2139/ssrn.4781335
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Human EHMT2/G9a activates p53 through methylation-independent mechanism
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p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer
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Conservation and divergence of the p53 gene regulatory network between mice and humans
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ETV7 regulates breast cancer stem-like cell features by repressing IFN-response genes
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p53 dynamics vary between tissues and are linked with radiation sensitivity
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c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1
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Foxo3a Regulates Apoptosis by Negatively Targeting miR-21
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The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage
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TP53INP1s and Homeodomain-interacting Protein Kinase-2 (HIPK2) Are Partners in Regulating p53 Activity
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p53 Induces NF-κB Activation by an IκB Kinase-independent Mechanism Involving Phosphorylation of p65 by Ribosomal S6 Kinase 1
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Editor’s Highlight: The Altered DNA Methylome of Chronic Doxorubicin Exposure in Sprague Dawley Rats
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Regulation of Interferon-Inducible Proteins by Doxorubicin via Interferon γ-Janus Tyrosine Kinase-Signal Transducer and Activator of Transcription Signaling in Tumor Cells
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Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex
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Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression
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Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1
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Stimulation of p53 DNA Binding by c-Abl Requires the p53 C Terminus and Tetramerization
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c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination
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Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence
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Phosphorylation-Dependent Degradation of p300 by Doxorubicin-Activated p38 Mitogen-Activated Protein Kinase in Cardiac Cells
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Central endothelin: effects on vasopressin and the arterial baroreflex in doxorubicin heart failure ratsThis article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin.
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HIF-1α expression follows microvascular loss in advanced murine adriamycin nephrosis
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Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage
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Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes
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EGF (Epidermal Growth Factor) Receptor Ligands in Atrial Fibrillation
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Tissue Resident CCR2− and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury
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Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-Induced Cardiomyopathy Through the SR-A1-c-Myc Axis
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Foxo Transcription Factors Blunt Cardiac Hypertrophy by Inhibiting Calcineurin Signaling
inferredcites →https://doi.org/10.1161/circulationaha.109.906610openalex-extracted
Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury
inferredcites →https://doi.org/10.1161/circulationaha.111.021352openalex-extracted
Controlled and Cardiac-Restricted Overexpression of the Arginine Vasopressin V1A Receptor Causes Reversible Left Ventricular Dysfunction Through Gαq-Mediated Cell Signaling
inferredcites →https://doi.org/10.1161/circulationaha.119.042474openalex-extracted
Regulatory RNAs in Heart Failure
inferredcites →https://doi.org/10.1161/jaha.118.008853openalex-extracted
Role of Semaphorin Signaling During Cardiovascular Development
inferredcites →https://doi.org/10.1172/jci.insight.125437openalex-extracted
Antiinflammatory activity of ANGPTL4 facilitates macrophage polarization to induce cardiac repair
inferredcites →https://doi.org/10.1172/jci36308openalex-extracted
Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
inferredcites →https://doi.org/10.1172/jci88353openalex-extracted
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy
inferredcites →https://doi.org/10.1186/1471-2164-9-324openalex-extracted
Topoisomerase II inhibition involves characteristic chromosomal expression patterns
inferredcites →https://doi.org/10.1186/s13630-018-0058-zopenalex-extracted
Evidence of primary cilia in the developing rat heart
inferredcites →https://doi.org/10.1210/en.2012-1061openalex-extracted
Minireview: G Protein-Coupled Estrogen Receptor-1, GPER-1: Its Mechanism of Action and Role in Female Reproductive Cancer, Renal and Vascular Physiology
inferredcites →https://doi.org/10.1247/csf.21.101openalex-extracted
Differentiation of Beating Cardiac Muscle Cells from a Derivative of P19 Embryonal Carcinoma Cells.
inferredcites →https://doi.org/10.1247/csf.31.1openalex-extracted
ErbB and HB-EGF Signaling in Heart Development and Function
inferredcites →https://doi.org/10.1258/la.2011.011021openalex-extracted
A simple procedure for estimation of total body surface area and determination of a new value of Meeh's constant in rats
inferredcites →https://doi.org/10.1371/journal.pgen.1001000openalex-extracted
A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy
inferredcites →https://doi.org/10.1371/journal.pone.0010236openalex-extracted
The Coordinated P53 and Estrogen Receptor Cis-Regulation at an FLT1 Promoter SNP Is Specific to Genotoxic Stress and Estrogenic Compound
inferredcites →https://doi.org/10.1371/journal.pone.0037401openalex-extracted
Secretogranin II; a Protein Increased in the Myocardium and Circulation in Heart Failure with Cardioprotective Properties
inferredcites →https://doi.org/10.1371/journal.pone.0037505openalex-extracted
Increased Expression of Fatty-Acid and Calcium Metabolism Genes in Failing Human Heart
inferredcites →https://doi.org/10.1371/journal.pone.0078728openalex-extracted
NF-κB-Induced IL-6 Ensures STAT3 Activation and Tumor Aggressiveness in Glioblastoma
inferredcites →https://doi.org/10.1371/journal.pone.0078870openalex-extracted
A Cross-Platform Comparison of Affymetrix and Agilent Microarrays Reveals Discordant miRNA Expression in Lung Tumors of c-Raf Transgenic Mice
inferredcites →https://doi.org/10.1371/journal.pone.0100920openalex-extracted
Dicer Cooperates with p53 to Suppress DNA Damage and Skin Carcinogenesis in Mice
inferredcites →https://doi.org/10.1371/journal.pone.0130940openalex-extracted
Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes
inferredcites →https://doi.org/10.1371/journal.pone.0135988openalex-extracted
G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion
inferredcites →https://doi.org/10.1385/ct:1:4:267openalex-extracted
Molecular Mechanisms of Cardiac Hypertrophy Induced by Toxicants
inferredcites →https://doi.org/10.1538/expanim.21-0060openalex-extracted
Downregulation of interferon-induced protein with tetratricopeptide repeats 3 relieves the inflammatory response and myocardial fibrosis of mice with myocardial infarction and improves their cardiac function
inferredcites →https://doi.org/10.15420/ecr.2017:17:2openalex-extracted
Cardio-oncology: A Focus on Cardiotoxicity
inferredcites →https://doi.org/10.18632/oncotarget.1556openalex-extracted
Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancer
inferredcites →https://doi.org/10.18632/oncotarget.1845openalex-extracted
ΔN-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites
inferredcites →https://doi.org/10.18632/oncotarget.5387openalex-extracted
The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding
inferredcites →https://doi.org/10.2174/138945008785909347openalex-extracted
Thrombospondin and Apoptosis: Molecular Mechanisms and Use for Design of Complementation Treatments
inferredcites →https://doi.org/10.2337/db16-0014openalex-extracted
DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes
inferredcites →https://doi.org/10.2353/ajpath.2007.060906openalex-extracted
Interferon-γ Induces Chronic Active Myocarditis and Cardiomyopathy in Transgenic Mice
inferredcites →https://doi.org/10.3109/00313028609059479openalex-extracted
Contraction-band necrosis: patterns of distribution in the myocardium and their diagnostic usefulness in sudden cardiac death
inferredcites →https://doi.org/10.3389/fcvm.2019.00140openalex-extracted
The Role of the TGF-β Superfamily in Myocardial Infarction
inferredcites →https://doi.org/10.3389/fphys.2021.633058openalex-extracted
Is Upregulation of Sarcolipin Beneficial or Detrimental to Muscle Function?
inferredcites →https://doi.org/10.3390/cells9061395openalex-extracted
Microtubule Organization in Striated Muscle Cells
inferredcites →https://doi.org/10.3390/ijms20030748openalex-extracted
Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells
inferredcites →https://doi.org/10.3390/ijms20225554openalex-extracted
RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells
inferredcites →https://doi.org/10.3390/ijms21114099openalex-extracted
Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury
inferredcites →https://doi.org/10.4049/jimmunol.171.6.2797openalex-extracted
CCL9 Is Secreted by the Follicle-Associated Epithelium and Recruits Dome Region Peyer’s Patch CD11b+ Dendritic Cells
inferredcites →https://doi.org/10.4049/jimmunol.173.3.2084openalex-extracted
MIP-1γ Promotes Receptor Activator of NF-κB Ligand-Induced Osteoclast Formation and Survival
inferredcites →https://doi.org/10.7150/ijbs.38835openalex-extracted
EHMT2/G9a Inhibits Aortic Smooth Muscle Cell Death by Suppressing Autophagy Activation
inferredcites →https://doi.org/10.7326/0003-4819-91-5-710openalex-extracted
Risk Factors for Doxorubicin-lnduced Congestive Heart Failure
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