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Schisandrae Chinensis Fructus inhibits behavioral deficits induced by sleep deprivation and chronic unpredictable mild stress via increased signaling of brain‐derived neurotrophic factor

https://doi.org/10.1002/ptr.6489
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf00177912openalex-snapshot
The use of a plus-maze to measure anxiety in the mouse
inferredcites →https://doi.org/10.1007/s002130050456openalex-snapshot
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
inferredcites →https://doi.org/10.1007/s00406-016-0693-6openalex-snapshot
Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience
inferredcites →https://doi.org/10.1007/s10571-014-0097-yopenalex-snapshot
Imipramine Ameliorates Pain-related Negative Emotion via Induction of Brain-derived Neurotrophic Factor
inferredcites →https://doi.org/10.1007/s10571-015-0276-5openalex-snapshot
Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
inferredcites →https://doi.org/10.1007/s12031-016-0779-7openalex-snapshot
Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells
inferredcites →https://doi.org/10.1016/bs.vh.2016.10.004openalex-snapshot
BDNF and Hippocampal Synaptic Plasticity
inferredcites →https://doi.org/10.1016/j.apnu.2014.09.006openalex-snapshot
Sleep Disturbances in Patients With Major Depressive Disorder: Incongruence Between Sleep Log and Actigraphy
inferredcites →https://doi.org/10.1016/j.bbr.2016.04.039openalex-snapshot
Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway
inferredcites →https://doi.org/10.1016/j.brainres.2017.02.020openalex-snapshot
Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression
inferredcites →https://doi.org/10.1016/j.brainresbull.2011.06.003openalex-snapshot
Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): A pilot study
inferredcites →https://doi.org/10.1016/j.ejphar.2010.06.043openalex-snapshot
Antidepressant-like effect of scopoletin, a coumarin isolated from Polygala sabulosa (Polygalaceae) in mice: Evidence for the involvement of monoaminergic systems
inferredcites →https://doi.org/10.1016/j.ejphar.2014.09.012openalex-snapshot
Pharmacological evaluation of sedative and hypnotic effects of schizandrin through the modification of pentobarbital-induced sleep behaviors in mice
inferredcites →https://doi.org/10.1016/j.ejphar.2015.05.036openalex-snapshot
Macranthol promotes hippocampal neuronal proliferation in mice via BDNF–TrkB–PI3K/Akt signaling pathway
inferredcites →https://doi.org/10.1016/j.jep.2013.03.015openalex-snapshot
Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice
inferredcites →https://doi.org/10.1016/j.nbd.2015.03.011openalex-snapshot
Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder
inferredcites →https://doi.org/10.1016/j.neuron.2015.07.010openalex-snapshot
Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a
inferredcites →https://doi.org/10.1016/j.neuroscience.2014.11.025openalex-snapshot
Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice
inferredcites →https://doi.org/10.1016/j.pnpbp.2012.12.012openalex-snapshot
Synaptic plasticity in depression: Molecular, cellular and functional correlates
inferredcites →https://doi.org/10.1016/j.pnpbp.2015.01.015openalex-snapshot
Topiramate protects against glutamate excitotoxicity via activating BDNF/TrkB-dependent ERK pathway in rodent hippocampal neurons
inferredcites →https://doi.org/10.1016/j.regpep.2014.11.004openalex-snapshot
Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats
inferredcites →https://doi.org/10.1016/s0140-6736(16)30385-3openalex-snapshot
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis
inferredcites →https://doi.org/10.1016/s0924-977x(15)30085-7openalex-snapshot
S. 16.03 BDNF, depression and sleep: perspectives from animal models
inferredcites →https://doi.org/10.1017/s1461145713000977openalex-snapshot
Activation of signaling pathways downstream of the brain-derived neurotrophic factor receptor, TrkB, in the rat brain by vagal nerve stimulation and antidepressant drugs
inferredcites →https://doi.org/10.1038/srep21089openalex-snapshot
Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder
inferredcites →https://doi.org/10.1093/ijnp/pyu110openalex-snapshot
PI3K/AKT/mTOR Signaling-Mediated Neuropeptide VGF in the Hippocampus of Mice Is Involved in the Rapid Onset Antidepressant-Like Effects of GLYX-13
inferredcites →https://doi.org/10.1177/0269881111424456openalex-snapshot
Involvement of PI3K, GSK-3β and PPARγ in the antidepressant-like effect of folic acid in the forced swimming test in mice
inferredcites →https://doi.org/10.3109/07853890.2015.1131327openalex-snapshot
BDNF in sleep, insomnia, and sleep deprivation
inferredcites →https://doi.org/10.3390/ijms161226105openalex-snapshot
Neuropeptide Trefoil Factor 3 Reverses Depressive-Like Behaviors by Activation of BDNF-ERK-CREB Signaling in Olfactory Bulbectomized Rats
inferredcites →https://doi.org/10.5664/jcsm.4770openalex-snapshot
Improved Sleep Quality is Associated with Reductions in Depression and PTSD Arousal Symptoms and Increases in IGF-1 Concentrations

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4676976openalex-extracted
inferred← citeshttps://doi.org/10.1002/brb3.1592openalex-snapshot
Activation of brain‐derived neurotrophic factor signaling in the basal forebrain reverses acute sleep deprivation‐induced fear memory impairments
inferred← citeshttps://doi.org/10.1002/brb3.3075openalex-snapshot
Effects of chronic sleep restriction on the neuro‐phenotypes of Ctnnd2 knockout mice
inferred← citeshttps://doi.org/10.1002/mnfr.202000869openalex-snapshot
Antidepressant‐like Effects of Degraded Porphyran Isolated fromPorphyra haitanensis
inferred← citeshttps://doi.org/10.1002/ptr.6799openalex-snapshot
Schisandra chinensis ameliorates depressive‐like behaviors by regulating microbiota‐gut‐brain axis via its anti‐inflammation activity
inferred← citeshttps://doi.org/10.1002/ptr.6846openalex-snapshot
The effect of geniposide on chronic unpredictable mild stress‐induced depressive mice through BTK / TLR4 / NF‐κB and BDNF / TrkB signaling pathways
inferred← citeshttps://doi.org/10.1007/s00210-026-05108-zopenalex-snapshot
Adverse drug events and toxicological mechanisms of esketamine: a study based on US Food and Drug Administration Adverse Event Reporting System and network toxicology analysis
inferred← citeshttps://doi.org/10.1007/s00213-025-06910-yopenalex-snapshot
The efficacy and safety of trazodone for sleep problems in depressive patients: a GRADE-assessed systematic review and meta-analysis of clinical trials
inferred← citeshttps://doi.org/10.1007/s11011-022-01124-zopenalex-snapshot
Intricate role of sleep deprivation in modulating depression: focusing on BDNF, VEGF, serotonin, cortisol, and TNF-α
inferred← citeshttps://doi.org/10.1007/s41782-022-00203-6openalex-snapshot
Impact of Sleep Deprivation on Major Neuroinflammatory Signal Transduction Pathways
inferred← citeshttps://doi.org/10.1016/j.bbr.2021.113463openalex-snapshot
Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.175149openalex-snapshot
Sleep deprivation leads to further impairment of hippocampal synaptic plasticity by suppressing melatonin secretion in the pineal gland of chronically unpredictable stress rats
inferred← citeshttps://doi.org/10.1016/j.jad.2023.07.119openalex-snapshot
Sleep deprivation alleviates depression-like behaviors in mice via inhibiting immune and inflammatory pathways and improving neuroplasticity
inferred← citeshttps://doi.org/10.1016/j.jchemneu.2023.102270openalex-snapshot
Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.jpsychires.2022.04.014openalex-snapshot
Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism
inferred← citeshttps://doi.org/10.1016/j.jtcme.2024.11.014openalex-snapshot
Role of IGF1/IGFR signaling pathway in neuroprotective effect of Shengmai Dihuang Decoction on CIH-induced cognitive impairment
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118107openalex-snapshot
Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice
inferred← citeshttps://doi.org/10.1016/j.physbeh.2020.113023openalex-snapshot
The role of sleep disturbances in depressive-like behavior with emphasis on α-ketoglutarate dehydrogenase activity in rats.
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c04565openalex-snapshot
Schisandra chinensis Lignans Exert Antidepressant Effects by Promoting BV2 Microglia Polarization toward the M2 Phenotype through the Activation of the Cannabinoid Receptor Type-2–Signal Transducer and Activator of Transcription 6 Pathway
inferred← citeshttps://doi.org/10.1093/jpp/rgae079openalex-snapshot
Schisandrin B restores M1/M2 balance through miR-124 in lipopolysaccharide-induced BV2 cells
inferred← citeshttps://doi.org/10.11648/j.cnn.20230702.11openalex-snapshot
Role of BDNF-TrkB Signaling in Regulating Anxiety and Depression-Like Behavior in Diverse Brain Regions
inferred← citeshttps://doi.org/10.1177/25424823251391704openalex-snapshot
Effects of sleep deprivation on cognition and synaptic associated proteins in rodents: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1515/tnsci-2020-0198openalex-snapshot
Cryptotanshinone ameliorates CUS-induced depressive-like behaviors in mice
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3687315/v1openalex-snapshot
Role of the Sirt6/Hmgb1 pathway in neuroinflammation of Sleep deprivation-induced depressed mice
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3699810/v1openalex-snapshot
The Impact of Varied Durations of Sleep Deprivation on Anxiety and Depressive-like Behaviors in Mice
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3740670/v1openalex-snapshot
Lithium Carbonate Alleviate Neuronal Apoptosis to Improve Depression Symptoms in Mice by the JNK/c-Jun Signaling Pathway
inferred← citeshttps://doi.org/10.3389/fneur.2022.1053942openalex-snapshot
Sleep deficiency promotes Alzheimer's disease development and progression
inferred← citeshttps://doi.org/10.3389/fneur.2026.1860227openalex-snapshot
Exercise modulation of BDNF/TrkB signaling in Parkinson’s disease: an evidence-calibrated review of neuroprotective mechanisms, biomarker limitations, and translational gaps
inferred← citeshttps://doi.org/10.3389/fphar.2025.1606445openalex-snapshot
Jiannao Pills alleviate depression-like behavior in chronic unpredictable mild stress-induced mice through NF-κB/NLRP3 pathway
inferred← citeshttps://doi.org/10.3390/ijms24010622openalex-snapshot
Fermented Perilla frutescens Ameliorates Depression-like Behavior in Sleep-Deprivation-Induced Stress Model
inferred← citeshttps://doi.org/10.3390/ijms26136230openalex-snapshot
Neuroprotective Effects and Mechanisms of Alpiniae oxyphyllae Fructus, a Medicinal and Edible Homologous Herb: Research Advances
inferred← citeshttps://doi.org/10.3390/nu18050723openalex-snapshot
Evaluation of Therapeutic Effects and Underlying Mechanisms of Baichuan Baile Formula in Rodent Insomnia Models
inferred← citeshttps://doi.org/10.4236/cm.2023.141002openalex-snapshot
Shuganheweitang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behaviors in Rats through the PI3K/AKT/mTOR Pathway: Involvement of Amino Acids, Glycerophospholipids, and Energy Metabolism
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