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Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Open‐Space Forced Swim Model of Depression for Mice
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Homer Proteins in Ca 2+ Entry
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Activation of adenosine A1receptor–induced neural stem cell proliferation via MEK/ERK and Akt signaling pathways
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The Role of Glial Adenosine Receptors in Neural Resilience and the Neurobiology of Mood Disorders
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Electroconvulsive therapy: a novel hypothesis for the involvement of purinergic signalling
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Genetically Controlled Upregulation of Adenosine A1 Receptor Expression Enhances the Survival of Primary Cortical Neurons
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Antidepressant-Like Effects of Medial Prefrontal Cortex Deep Brain Stimulation in Rats
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Genome-Wide Association-, Replication-, and Neuroimaging Study Implicates HOMER1 in the Etiology of Major Depression
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Dynamic Network Communication as a Unifying Neural Basis for Cognition, Development, Aging, and Disease
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Sleep deprivation increases A1 adenosine receptor density in the rat brain
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Venlafaxine involves nitric oxide modulatory mechanism in experimental model of chronic behavior despair in mice
inferredcites →https://doi.org/10.1016/j.conb.2006.05.002openalex-snapshot
Homer proteins: implications for neuropsychiatric disorders
inferredcites →https://doi.org/10.1016/j.jbiotec.2011.10.003openalex-snapshot
A rapid, targeted, neuron-selective, in vivo knockdown following a single intracerebroventricular injection of a novel chemically modified siRNA in the adult rat brain
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Neurophysiological mechanisms of electroconvulsive therapy for depression
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Atlas of transgenic Tet-Off Ca2+/calmodulin-dependent protein kinase II and prion protein promoter activity in the mouse brain
inferredcites →https://doi.org/10.1016/j.neuron.2010.11.008openalex-snapshot
Homeostatic Scaling Requires Group I mGluR Activation Mediated by Homer1a
inferredcites →https://doi.org/10.1016/j.neuropharm.2008.07.029openalex-snapshot
An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown
inferredcites →https://doi.org/10.1016/j.neuroscience.2007.09.081openalex-snapshot
Homer1a regulates the activity-induced remodeling of synaptic structures in cultured hippocampal neurons
inferredcites →https://doi.org/10.1016/j.pneurobio.2011.08.006openalex-snapshot
Purinergic signalling: From normal behaviour to pathological brain function
inferredcites →https://doi.org/10.1016/j.yjmcc.2011.08.023openalex-snapshot
Adenosine A1 receptor activation is arrhythmogenic in the developing heart through NADPH oxidase/ERK- and PLC/PKC-dependent mechanisms
inferredcites →https://doi.org/10.1016/s0031-6997(24)01511-4openalex-snapshot
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
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Adenosine and Brain Function
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Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons
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Emotional instability but intact spatial cognition in adenosine receptor 1 knock out mice
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Molecular adaptation to chronic antidepressant treatment: evidence for a more rapid response to the novel α2-adrenoceptor antagonist/5-HT-noradrenaline reuptake inhibitor (SNRI), S35966, compared to the SNRI, venlafaxine
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Structural Sweet Spot for A1Adenosine Receptor Activation by Truncated (N)-Methanocarba Nucleosides: Receptor Docking and Potent Anticonvulsant Activity
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Seizure Activity Produces Differential Changes in Adenosine A1 Receptors within Rat Hippocampus
inferredcites →https://doi.org/10.1038/nm1693openalex-snapshot
Adenosine is crucial for deep brain stimulation–mediated attenuation of tremor
inferredcites →https://doi.org/10.1038/npp.2014.150openalex-snapshot
Association of Adenosine Receptor Gene Polymorphisms and In Vivo Adenosine A1 Receptor Binding in The Human Brain
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Making memories last: the synaptic tagging and capture hypothesis
inferredcites →https://doi.org/10.1038/sj.mp.4001897openalex-snapshot
Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine
inferredcites →https://doi.org/10.1038/sj.npp.1301001openalex-snapshot
Activation of Adenosine A1 Receptors Reduces Anxiety-Like Behavior During Acute Ethanol Withdrawal (Hangover) in Mice
inferredcites →https://doi.org/10.1038/sj.npp.1301612openalex-snapshot
Interleukin-6 Upregulates Neuronal Adenosine A1 Receptors: Implications for Neuromodulation and Neuroprotection
inferredcites →https://doi.org/10.1038/tp.2012.136openalex-snapshot
Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling
inferredcites →https://doi.org/10.1046/j.1460-9568.2002.02122.xopenalex-snapshot
Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate
inferredcites →https://doi.org/10.1073/pnas.0608991104openalex-snapshot
Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors
inferredcites →https://doi.org/10.1073/pnas.0710131104openalex-snapshot
Homer1a is a core brain molecular correlate of sleep loss
inferredcites →https://doi.org/10.1073/pnas.161292398openalex-snapshot
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A 1 receptor
inferredcites →https://doi.org/10.1073/pnas.171317998openalex-snapshot
Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors
inferredcites →https://doi.org/10.1080/15257770600890939openalex-snapshot
The Neuroprotective Adenosine-Activated Signal Transduction Pathway Involves Activation of Phospholipase C
inferredcites →https://doi.org/10.1083/jcb.201110101openalex-snapshot
Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability
inferredcites →https://doi.org/10.1097/fjc.0b013e3182919591openalex-snapshot
Adenosine A1 Receptors Link to Smooth Muscle Contraction Via CYP4a, protein kinase C-α, and ERK1/2
inferredcites →https://doi.org/10.1097/wnr.0b013e3282f262f6openalex-snapshot
Sleep deprivation upregulates A1 adenosine receptors in the rat basal forebrain
inferredcites →https://doi.org/10.1111/j.1460-9568.2005.04165.xopenalex-snapshot
Essential roles of Homer‐1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock
inferredcites →https://doi.org/10.1111/j.1471-4159.2008.05581.xopenalex-snapshot
A gene‐specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant‐like effect in mice
inferredcites →https://doi.org/10.1126/science.1171498openalex-snapshot
Input-Specific Spine Entry of Soma-Derived Vesl-1S Protein Conforms to Synaptic Tagging
inferredcites →https://doi.org/10.1126/science.274.5293.1678openalex-snapshot
Control of Memory Formation Through Regulated Expression of a CaMKII Transgene
inferredcites →https://doi.org/10.1152/ajpheart.01028.2009openalex-snapshot
Myocardial adenosine A1-receptor-mediated adenoprotection involves phospholipase C, PKC-ε, and p38 MAPK, but not HSP27
inferredcites →https://doi.org/10.1159/000328947openalex-snapshot
Sleep Deprivation in Mood Disorders
inferredcites →https://doi.org/10.1176/appi.ajp.2009.10030434openalex-snapshot
Linking Molecules to Mood: New Insight Into the Biology of Depression
inferredcites →https://doi.org/10.1186/gb-2007-8-2-206openalex-snapshot
The Homer family proteins.
inferredcites →https://doi.org/10.1523/jneurosci.1542-11.2011openalex-snapshot
Increase in Cortical Pyramidal Cell Excitability Accompanies Depression-Like Behavior in Mice: A Transcranial Magnetic Stimulation Study
inferredcites →https://doi.org/10.1523/jneurosci.17-13-04956.1997openalex-snapshot
Adenosine A1Receptor-Mediated Activation of Phospholipase C in Cultured Astrocytes Depends on the Level of Receptor Expression
inferredcites →https://doi.org/10.1523/jneurosci.21-11-03797.2001openalex-snapshot
NMDA Receptor Stimulation and Brain-Derived Neurotrophic Factor Upregulate Homer 1a mRNA via the Mitogen-Activated Protein Kinase Cascade in Cultured Cerebellar Granule Cells
inferredcites →https://doi.org/10.1523/jneurosci.3308-11.2012openalex-snapshot
Epigenetic Modulation of Homer1a Transcription Regulation in Amygdala and Hippocampus with Pavlovian Fear Conditioning
inferredcites →https://doi.org/10.1523/jneurosci.3764-05.2005openalex-snapshot
Distinct Roles for Different Homer1 Isoforms in Behaviors and Associated Prefrontal Cortex Function
inferredcites →https://doi.org/10.1523/jneurosci.5066-06.2007openalex-snapshot
Sleep Deprivation Increases A 1 Adenosine Receptor Binding in the Human Brain: A Positron Emission Tomography Study
inferredcites →https://doi.org/10.3389/fnbeh.2013.00224openalex-snapshot
Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
inferredcites →https://doi.org/10.3389/fphar.2013.00161openalex-snapshot
Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
inferredcites →https://doi.org/10.3389/neuro.01.1.1.007.2007openalex-snapshot
Select overexpression of homer1a in dorsal hippocampus impairs spatial working memory
inferredcites →https://doi.org/10.4088/jcp.v64n1211openalex-snapshot
The Economic Burden of Depression in the United States

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Homer1a Undergoes Bimodal Transcriptional Regulation by CREB and the Circadian Clock
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Increased Homer1-mGluR5 mediates chronic stress-induced depressive-like behaviors and glutamatergic dysregulation via activation of PERK-eIF2α
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The mechanistic basis for the rapid antidepressant-like effects of ketamine: From neural circuits to molecular pathways
inferred← citeshttps://doi.org/10.1016/j.scib.2026.02.025openalex-snapshot
Homeostatic adenosine signaling unifies rapid antidepressant actions of ketamine, electroconvulsive therapy and hypoxia
inferred← citeshttps://doi.org/10.1016/j.taap.2017.10.020openalex-snapshot
Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt , Slc6a15 and Adora1 gene expression
inferred← citeshttps://doi.org/10.1016/j.taap.2019.114689openalex-snapshot
Edaravone presents antidepressant-like activity in corticosterone model of depression in mice with possible role of Fkbp5, Comt, Adora1 and Slc6a15 genes
inferred← citeshttps://doi.org/10.1017/neu.2021.18openalex-snapshot
DNA methylation in stress and depression: from biomarker to therapeutics
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01662openalex-snapshot
Design and in Vivo Characterization of A1 Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series
inferred← citeshttps://doi.org/10.1021/acschemneuro.2c00167openalex-snapshot
Rapid Eye Movement Sleep Deprivation Enhances Adenosine Receptor Activation and the CREB1/YAP1/c-Myc Axis to Alleviate Depressive-like Behaviors in Rats
inferred← citeshttps://doi.org/10.1021/acschemneuro.2c00810openalex-snapshot
Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress
inferred← citeshttps://doi.org/10.1021/acschemneuro.4c00640openalex-snapshot
Enhanced Pain Sensitization Induced by Chronic Sleep Deprivation: The Role of Dopamine D2 Receptors-Dependent Homer1a Protein
inferred← citeshttps://doi.org/10.1021/acschemneuro.4c00804openalex-snapshot
Combining Metabolomics and Quantitative Analysis to Investigate Purine Metabolism Disorders in Depression and the Therapeutic Effect of Chaigui Granules
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.3c00315openalex-snapshot
2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A1 Adenosine Receptor Positive Allosteric Modulators
inferred← citeshttps://doi.org/10.1038/mp.2017.188openalex-snapshot
Purinergic system in psychiatric diseases
inferred← citeshttps://doi.org/10.1038/mp.2017.225openalex-snapshot
Engaging homeostatic plasticity to treat depression
inferred← citeshttps://doi.org/10.1038/s12276-018-0025-1openalex-snapshot
Synapse development organized by neuronal activity-regulated immediate-early genes
inferred← citeshttps://doi.org/10.1038/s41380-021-01040-1openalex-snapshot
Update on GPCR-based targets for the development of novel antidepressants
inferred← citeshttps://doi.org/10.1038/s41380-021-01246-3openalex-snapshot
Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors
inferred← citeshttps://doi.org/10.1038/s41380-024-02684-5openalex-snapshot
Rasd2 regulates depression-like behaviors via DRD2 neurons in the prelimbic cortex afferent to nucleus accumbens core circuit
inferred← citeshttps://doi.org/10.1038/s41380-025-03276-7openalex-snapshot
The mPFC molecular clock mediates the effects of sleep deprivation on depression-like behavior and regulates sleep consolidation and homeostasis
inferred← citeshttps://doi.org/10.1038/s41380-026-03594-4openalex-snapshot
Adenosine surges: A step forward in understanding antidepressant actions of ketamine
inferred← citeshttps://doi.org/10.1038/s41386-018-0043-7openalex-snapshot
Prophylactic ketamine alters nucleotide and neurotransmitter metabolism in brain and plasma following stress
inferred← citeshttps://doi.org/10.1038/s41386-021-01241-wopenalex-snapshot
Rapid-acting antidepressants and the circadian clock
inferred← citeshttps://doi.org/10.1038/s41386-022-01356-8openalex-snapshot
Sleep-mediated regulation of reward circuits: implications in substance use disorders
inferred← citeshttps://doi.org/10.1038/s41386-024-01794-6openalex-snapshot
Antidepressant-like effects of psychedelics in a chronic despair mouse model: is the 5-HT2A receptor the unique player?
inferred← citeshttps://doi.org/10.1038/s41392-021-00553-zopenalex-snapshot
From purines to purinergic signalling: molecular functions and human diseases
inferred← citeshttps://doi.org/10.1038/s41392-024-01738-yopenalex-snapshot
Major depressive disorder: hypothesis, mechanism, prevention and treatment
inferred← citeshttps://doi.org/10.1038/s41398-020-00915-1openalex-snapshot
Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression
inferred← citeshttps://doi.org/10.1038/s41398-020-01085-wopenalex-snapshot
ADORA2A variation and adenosine A1 receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation
inferred← citeshttps://doi.org/10.1038/s41398-025-03683-yopenalex-snapshot
Epigenetic aging and DNA methylation biomarker changes following ketamine treatment in patients with MDD and PTSD: a pilot study
inferred← citeshttps://doi.org/10.1038/s41467-023-37601-xopenalex-snapshot
Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula
inferred← citeshttps://doi.org/10.1038/s41467-024-51716-9openalex-snapshot
Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice
inferred← citeshttps://doi.org/10.1038/s41467-025-66774-wopenalex-snapshot
The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action
inferred← citeshttps://doi.org/10.1038/s41467-026-77248-yopenalex-snapshot
The mPFC-reuniens-hippocampus pathway links brain circuitry and neural plasticity in antidepressant response
inferred← citeshttps://doi.org/10.1038/s41586-025-09755-9openalex-snapshot
Adenosine signalling drives antidepressant actions of ketamine and ECT
inferred← citeshttps://doi.org/10.1039/d5sd00170fopenalex-snapshot
Adenosine detection technologies: recent advances and applications in the central nervous system
inferred← citeshttps://doi.org/10.1051/medsci/2024206openalex-snapshot
L’importance de l’horloge circadienne du cortex préfrontal dans la neurobiologie et le traitement de la dépression
inferred← citeshttps://doi.org/10.1073/pnas.1614677114openalex-snapshot
Recovery sleep after extended wakefulness restores elevated A 1 adenosine receptor availability in the human brain
inferred← citeshttps://doi.org/10.1080/00207454.2026.2666245openalex-snapshot
Purinergic signaling: a novel therapeutic target in depression
inferred← citeshttps://doi.org/10.1089/caff.2020.0009openalex-snapshot
Adenosinergic-Dopaminergic Signaling in Mood Disorders: A Mini-Review
inferred← citeshttps://doi.org/10.1093/cercor/bhae399openalex-snapshot
A circuit from lateral hypothalamic to dorsal hippocampal dentate gyrus modulates behavioral despair in mice
inferred← citeshttps://doi.org/10.1093/cercor/bhw078openalex-snapshot
Homer1 Scaffold Proteins Govern Ca2+ Dynamics in Normal and Reactive Astrocytes
inferred← citeshttps://doi.org/10.1096/fj.202202048rropenalex-snapshot
CircHOMER1 inhibits porcine adipogenesis via the miR ‐23b/ SIRT1 axis
inferred← citeshttps://doi.org/10.1101/2021.08.14.456364openalex-snapshot
Clock genes Period 1 and Period 2 in the hippocampal CA1 mediate depression-like behaviors and rapid antidepressant response
inferred← citeshttps://doi.org/10.1101/2021.12.16.472859openalex-snapshot
Effects of ozone on sickness and depressive-like behavioral and biochemical phenotypes and their relations to serum amyloid A and kynurenine in blood
inferred← citeshttps://doi.org/10.1101/2022.10.03.510559openalex-snapshot
Pathological crosstalk between AQP4-dependent ATP/Adenosine release and dopamine neurotransmission underlying depressive behavior during cocaine withdrawal
inferred← citeshttps://doi.org/10.1101/2024.09.10.24313258openalex-snapshot
Ketamine treatment effects on DNA methylation and Epigenetic Biomarkers of aging
inferred← citeshttps://doi.org/10.1101/2025.11.13.688184openalex-snapshot
Gut Microbiota-derived Adenosine Determines the Efficacy of Electroconvulsive Therapy for Depression
inferred← citeshttps://doi.org/10.1111/apha.70043openalex-snapshot
Cav3.1 T‐Type Calcium Channel Acts as a Gateway for GABAergic Excitation in the Medial Prefrontal Cortex That Leads to Chronic Psychological Stress Responses in Mice
inferred← citeshttps://doi.org/10.1111/cpr.12804openalex-snapshot
Rapid anti‐depressant‐like effects of ketamine and other candidates: Molecular and cellular mechanisms
inferred← citeshttps://doi.org/10.1111/ejn.14752openalex-snapshot
Astrocytic equilibrative nucleoside transporter type 1 upregulations in the dorsomedial and dorsolateral striatum distinctly coordinate goal‐directed and habitual ethanol‐seeking behaviours in mice
inferred← citeshttps://doi.org/10.1111/gbb.12511openalex-snapshot
Decoding the transcriptional programs activated by psychotropic drugs in the brain
inferred← citeshttps://doi.org/10.1111/jnc.13724openalex-snapshot
How does adenosine control neuronal dysfunction and neurodegeneration?
inferred← citeshttps://doi.org/10.1111/jnc.14816openalex-snapshot
Adenosine A1 and A2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus
inferred← citeshttps://doi.org/10.1111/jnc.14841openalex-snapshot
The role of adenosine receptors in mood and anxiety disorders
inferred← citeshttps://doi.org/10.1111/jphp.12954openalex-snapshot
The influence of selective A1 and A2A receptor antagonists on the antidepressant-like activity of moclobemide, venlafaxine and bupropion in mice
inferred← citeshttps://doi.org/10.1111/jpi.70095openalex-snapshot
Key Role of the CRE Sequence in the Per1 Promoter in Mediating the Switch Between Unipolar and Bipolar Depression‐Like Behaviors
inferred← citeshttps://doi.org/10.1111/jsr.13597openalex-snapshot
Adenosine, caffeine, and sleep–wake regulation: state of the science and perspectives
inferred← citeshttps://doi.org/10.1124/jpet.116.238121openalex-snapshot
Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression.
inferred← citeshttps://doi.org/10.1124/pharmrev.121.000445openalex-snapshot
International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update
inferred← citeshttps://doi.org/10.1124/pr.116.013227openalex-snapshot
Vitamin D and Depression: Cellular and Regulatory Mechanisms
inferred← citeshttps://doi.org/10.1124/pr.119.018697openalex-snapshot
Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects
inferred← citeshttps://doi.org/10.1126/sciadv.abf0634openalex-snapshot
Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression
inferred← citeshttps://doi.org/10.1126/science.aai8355openalex-snapshot
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
inferred← citeshttps://doi.org/10.1155/2017/9258937openalex-snapshot
Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress
inferred← citeshttps://doi.org/10.1155/2020/1507561openalex-snapshot
Jiao‐Tai‐Wan Ameliorates Depressive‐Like Behavior through the A1R Pathway in Ovariectomized Mice after Unpredictable Chronic Stress
inferred← citeshttps://doi.org/10.1159/000500267openalex-snapshot
Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity
inferred← citeshttps://doi.org/10.1186/s12864-025-11991-2openalex-snapshot
CircHOMER1 in mediating porcine skeletal muscle development
inferred← citeshttps://doi.org/10.1186/s13020-022-00621-8openalex-snapshot
Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress
inferred← citeshttps://doi.org/10.12182/20210160102openalex-snapshot
[A Review of the State of Purinergic Signaling and Psychological Stress].
inferred← citeshttps://doi.org/10.12677/ass.2023.123161openalex-snapshot
Effects of Sleep Deprivation on Depression and Mechanisms of Action
inferred← citeshttps://doi.org/10.1503/jpn.190134openalex-snapshot
Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment
inferred← citeshttps://doi.org/10.1515/hsz-2015-0267openalex-snapshot
Signaling pathways regulating Homer1a expression: implications for antidepressant therapy
inferred← citeshttps://doi.org/10.1523/eneuro.0045-17.2017openalex-snapshot
Stress Models of Depression: A Question of Bad Timing
inferred← citeshttps://doi.org/10.1523/eneuro.0201-16.2016openalex-snapshot
Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice
inferred← citeshttps://doi.org/10.1523/jneurosci.0026-21.2021openalex-snapshot
The Complex Formed by Group I Metabotropic Glutamate Receptor (mGluR) and Homer1a Plays a Central Role in Metaplasticity and Homeostatic Synaptic Scaling
inferred← citeshttps://doi.org/10.1530/jme-17-0165openalex-snapshot
Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?
inferred← citeshttps://doi.org/10.21203/rs.3.rs-9045113/v1openalex-snapshot
Modulation of Depression-like Behaviors by RASD2 through Regulation of Dopaminergic Signaling from the Rostral VTA to D1 Neurons in the NAc Shell
inferred← citeshttps://doi.org/10.2147/nss.s401271openalex-snapshot
Investigating the Role of BDNF in Insomnia: Current Insights
inferred← citeshttps://doi.org/10.21661/r-551967openalex-snapshot
Pills or Sleep Deprivation? Sleep-Deprivation as a Therapeutic Option Intervention in Psychiatry
inferred← citeshttps://doi.org/10.2174/1745017901713010213openalex-snapshot
Relationship Between Brain-Derived Neurotrofic Factor (Bdnf) and Sleep on Depression: A Critical Review
inferred← citeshttps://doi.org/10.21769/bioprotoc.1957openalex-snapshot
Light/Dark Transition Test to Assess Anxiety-like Behavior in Mice
inferred← citeshttps://doi.org/10.21769/bioprotoc.1958openalex-snapshot
Sucrose Preference Test to Measure Anhedonic Behaviour in Mice
inferred← citeshttps://doi.org/10.29254/2077-4214-2022-4-167-76-83openalex-snapshot
ON THE QUESTION OF ADENOSINE SYSTEM PARTICIPATION IN THE PATHOGENESIS OF NEUROSES
inferred← citeshttps://doi.org/10.3389/fnbeh.2017.00041openalex-snapshot
Stress and the Emerging Roles of Chromatin Remodeling in Signal Integration and Stable Transmission of Reversible Phenotypes
inferred← citeshttps://doi.org/10.3389/fncel.2015.00521openalex-snapshot
Depression as a Glial-Based Synaptic Dysfunction
inferred← citeshttps://doi.org/10.3389/fncel.2019.00124openalex-snapshot
Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development
inferred← citeshttps://doi.org/10.3389/fncel.2021.822614openalex-snapshot
Glial Purinergic Signals and Psychiatric Disorders
inferred← citeshttps://doi.org/10.3389/fncir.2021.658343openalex-snapshot
Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement
inferred← citeshttps://doi.org/10.3389/fnins.2018.01015openalex-snapshot
Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus
inferred← citeshttps://doi.org/10.3389/fnmol.2017.00360openalex-snapshot
NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors
inferred← citeshttps://doi.org/10.3389/fphar.2019.00332openalex-snapshot
Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain
inferred← citeshttps://doi.org/10.3389/fphar.2021.652130openalex-snapshot
Guanine-Based Purines as an Innovative Target to Treat Major Depressive Disorder
inferred← citeshttps://doi.org/10.3389/fphar.2022.897436openalex-snapshot
Xiaoyaosan Ameliorates Chronic Restraint Stress-Induced Depression-Like Phenotype by Suppressing A2AR Signaling in the Rat Striatum
inferred← citeshttps://doi.org/10.3389/fphar.2025.1592909openalex-snapshot
Lateral habenula astroglia modulate the potentiating antidepressant-like effects of bright light stimulation in intractable depression
inferred← citeshttps://doi.org/10.3389/fpsyg.2020.00080openalex-snapshot
Effects of Electroconvulsive Therapy on Depression and Its Potential Mechanism
inferred← citeshttps://doi.org/10.3389/fpsyt.2021.599399openalex-snapshot
Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor
inferred← citeshttps://doi.org/10.3389/fpsyt.2023.1228438openalex-snapshot
Effects of electroconvulsive therapy on cerebral A1 adenosine receptor availability: a PET study in patients suffering from treatment-resistant major depressive disorder
inferred← citeshttps://doi.org/10.3390/biom13010106openalex-snapshot
Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas
inferred← citeshttps://doi.org/10.3390/biomedicines10081947openalex-snapshot
Genomic-Analysis-Oriented Drug Repurposing in the Search for Novel Antidepressants
inferred← citeshttps://doi.org/10.3390/brainsci10030160openalex-snapshot
Purinergic Signaling and Related Biomarkers in Depression
inferred← citeshttps://doi.org/10.3390/cells14241967openalex-snapshot
Modulation of Metabotropic Glutamate Receptors as a Strategy to Improve the Efficacy and Safety of Ketamine as an Antidepressant
inferred← citeshttps://doi.org/10.3390/cells9030785openalex-snapshot
Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases
inferred← citeshttps://doi.org/10.3390/cells9040956openalex-snapshot
Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs
inferred← citeshttps://doi.org/10.3390/ijms18010135openalex-snapshot
Treating the Synapse in Major Psychiatric Disorders: The Role of Postsynaptic Density Network in Dopamine-Glutamate Interplay and Psychopharmacologic Drugs Molecular Actions
inferred← citeshttps://doi.org/10.3390/ijms21155555openalex-snapshot
The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted
inferred← citeshttps://doi.org/10.3390/ijms22020937openalex-snapshot
Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype
inferred← citeshttps://doi.org/10.3390/ijms22041840openalex-snapshot
The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies
inferred← citeshttps://doi.org/10.3390/ijms23031219openalex-snapshot
Adenosine Receptors in Neuropsychiatric Disorders: Fine Regulators of Neurotransmission and Potential Therapeutic Targets
inferred← citeshttps://doi.org/10.3390/ijms24021612openalex-snapshot
Effects of Ozone on Sickness and Depressive-like Behavioral and Biochemical Phenotypes and Their Regulation by Serum Amyloid A in Mice
inferred← citeshttps://doi.org/10.3390/ijms24043736openalex-snapshot
Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models
inferred← citeshttps://doi.org/10.3390/ijms26125905openalex-snapshot
Neurobiological Mechanisms of Electroconvulsive Therapy: Molecular Perspectives of Brain Stimulation
inferred← citeshttps://doi.org/10.3390/metabo12070586openalex-snapshot
Effects of Selen on the Antidepressant-like Activity of Agents Affecting the Adenosinergic Neurotransmission
inferred← citeshttps://doi.org/10.3390/metabo14050286openalex-snapshot
Targeted Analysis of Plasma Polar Metabolites in Postmenopausal Depression
inferred← citeshttps://doi.org/10.3390/nu16172920openalex-snapshot
Impact of Coffee Intake on Measures of Wellbeing in Mice
inferred← citeshttps://doi.org/10.3390/vetsci8090189openalex-snapshot
Imipramine Accelerates Nonalcoholic Fatty Liver Disease, Renal Impairment, Diabetic Retinopathy, Insulin Resistance, and Urinary Chromium Loss in Obese Mice
inferred← citeshttps://doi.org/10.3791/62579openalex-snapshot
Animal Models of Depression - Chronic Despair Model (CDM)
inferred← citeshttps://doi.org/10.3892/ijmm.2018.3546openalex-snapshot
An adenosine�A1R-A2aR imbalance regulates low glucose/hypoxia-induced microglial activation, thereby contributing to oligodendrocyte damage through NF-κB and CREB phosphorylation
inferred← citeshttps://doi.org/10.4103/1673-5374.386490openalex-snapshot
Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury
inferred← citeshttps://doi.org/10.5115/acb.22.120openalex-snapshot
Boophone disticha attenuates five day repeated forced swim-induced stress and adult hippocampal neurogenesis impairment in male Balb/c mice
inferred← citeshttps://doi.org/10.53846/goediss-9689openalex-snapshot
Sleep control by TFAP2a and TFAP2b transcription factors in mice
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