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Schwarzinicine A inhibits transient receptor potential canonical channels and exhibits overt vasorelaxation effects

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.201411511openalex-snapshot

(−)‐Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

inferredcites →https://doi.org/10.1002/ptr.7489openalex-snapshot

Schwarzinicine A inhibits transient receptor potential canonical channels and exhibits overt vasorelaxation effects

inferredcites →https://doi.org/10.1007/978-94-007-0265-3_4openalex-snapshot

Synthetic Modulators of TRP Channel Activity

inferredcites →https://doi.org/10.1007/s00210-015-1140-3openalex-snapshot

Contractile function of smooth muscle retained after overnight storage

inferredcites →https://doi.org/10.1007/s00223-020-00673-8openalex-snapshot

Modulation of Transient Receptor Potential Channels 3 and 6 Regulates Osteoclast Function with Impact on Trabecular Bone Loss

inferredcites →https://doi.org/10.1007/s00418-004-0720-yopenalex-snapshot

Expression of TRPC homologs in endothelial cells and smooth muscle layers of human arteries

inferredcites →https://doi.org/10.1007/s11427-014-4713-3openalex-snapshot

Imbalance and dysfunction of transient receptor potential channels contribute to the pathogenesis of hypertension

inferredcites →https://doi.org/10.1016/j.bmcl.2018.03.056openalex-snapshot

Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6)

inferredcites →https://doi.org/10.1016/j.ceca.2016.03.012openalex-snapshot

Mechanisms of lipid regulation and lipid gating in TRPC channels

inferredcites →https://doi.org/10.1016/j.cophys.2020.06.005openalex-snapshot

Mechanisms and significance of Ca2+ entry through TRPC channels

inferredcites →https://doi.org/10.1016/j.dib.2018.04.033openalex-snapshot

Data on the Lignosus rhinocerotis water soluble sclerotial extract affecting intracellular calcium level in rat dorsal root ganglion cells

inferredcites →https://doi.org/10.1016/j.ejphar.2006.05.014openalex-snapshot

2-Aminoethoxydiphenyl borate inhibits KCl-induced vascular smooth muscle contraction

inferredcites →https://doi.org/10.1016/j.pharmthera.2020.107497openalex-snapshot

TRPC channels: Structure, function, regulation and recent advances in small molecular probes

inferredcites →https://doi.org/10.1016/s0092-8674(00)81233-7openalex-snapshot

trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry

inferredcites →https://doi.org/10.1021/acs.jnatprod.7b01037openalex-snapshot

Ribemansides A and B, TRPC6 Inhibitors from Ribes manshuricum That Suppress TGF-β1-Induced Fibrogenesis in HK-2 Cells

inferredcites →https://doi.org/10.1021/acs.jnatprod.9b01160openalex-snapshot

Schwarzinicines A–G, 1,4-Diarylbutanoid–Phenethylamine Conjugates from the Leaves of Ficus schwarzii

inferredcites →https://doi.org/10.1038/16711openalex-snapshot

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

inferredcites →https://doi.org/10.1038/24890openalex-snapshot

Functional interaction between InsP3 receptors and store-operated Htrp3 channels

inferredcites →https://doi.org/10.1038/s42003-020-01437-8openalex-snapshot

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

inferredcites →https://doi.org/10.1038/sj.jid.5700352openalex-snapshot

TRPC7 Is a Receptor-Operated DAG-Activated Channel in Human Keratinocytes

inferredcites →https://doi.org/10.1039/d0cb00126kopenalex-snapshot

Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels

inferredcites →https://doi.org/10.1042/bj2710515openalex-snapshot

SK&F 96365, a novel inhibitor of receptor-mediated calcium entry

inferredcites →https://doi.org/10.1073/pnas.0808793106openalex-snapshot

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

inferredcites →https://doi.org/10.1073/pnas.102596199openalex-snapshot

Subunit composition of mammalian transient receptor potential channels in living cells

inferredcites →https://doi.org/10.1074/jbc.272.47.29672openalex-snapshot

Cloning and Expression of a Novel Mammalian Homolog ofDrosophila Transient Receptor Potential (Trp) Involved in Calcium Entry Secondary to Activation of Receptors Coupled by the Gq Class of G Protein

inferredcites →https://doi.org/10.1074/jbc.273.17.10279openalex-snapshot

Molecular Cloning and Functional Characterization of a Novel Receptor-activated TRP Ca2+ Channel from Mouse Brain

inferredcites →https://doi.org/10.1074/jbc.m510301200openalex-snapshot

Sensing of Lysophospholipids by TRPC5 Calcium Channel

inferredcites →https://doi.org/10.1080/14786419.2021.1903005openalex-snapshot

Concise synthesis of the vasorelaxant alkaloids schwarzinicines A and B

inferredcites →https://doi.org/10.1111/bph.14791openalex-snapshot

Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative

inferredcites →https://doi.org/10.1111/j.1582-4934.2009.00890.xopenalex-snapshot

Increased rhythmicity in hypertensive arterial smooth muscle is linked to transient receptor potential canonical channels

inferredcites →https://doi.org/10.1113/jp273327openalex-snapshot

Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension

inferredcites →https://doi.org/10.1128/mcb.25.16.6980-6989.2005openalex-snapshot

Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice

inferredcites →https://doi.org/10.1152/ajpcell.00283.2001openalex-snapshot

TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells

inferredcites →https://doi.org/10.1152/ajpheart.00861.2004openalex-snapshot

TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries

inferredcites →https://doi.org/10.1152/ajplung.00452.2003openalex-snapshot

Overexpression ofTRPC1enhances pulmonary vasoconstriction induced by capacitative Ca2+entry

inferredcites →https://doi.org/10.1152/ajprenal.00338.2003openalex-snapshot

Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation

inferredcites →https://doi.org/10.1152/physrev.00026.2014openalex-snapshot

Transient Receptor Potential Channels in the Vasculature

inferredcites →https://doi.org/10.1159/000342461openalex-snapshot

Role of TRPC1 and TRPC3 Channels in Contraction and Relaxation of Mouse Thoracic Aorta

inferredcites →https://doi.org/10.1161/01.res.0000225284.36490.a2openalex-snapshot

A Sphingosine-1–Phosphate-Activated Calcium Channel Controlling Vascular Smooth Muscle Cell Motility

inferredcites →https://doi.org/10.1161/01.res.88.3.325openalex-snapshot

The Transient Receptor Potential Protein Homologue TRP6 Is the Essential Component of Vascular α1-Adrenoceptor–Activated Ca2+-Permeable Cation Channel

inferredcites →https://doi.org/10.1161/circresaha.108.188748openalex-snapshot

TRPC1 Associates With BK Ca Channel to Form a Signal Complex in Vascular Smooth Muscle Cells

inferredcites →https://doi.org/10.1161/hh0302.105662openalex-snapshot

Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries

inferredcites →https://doi.org/10.1371/journal.pone.0121634openalex-snapshot

Dissecting out the Complex Ca2+-Mediated Phenylephrine-Induced Contractions of Mouse Aortic Segments

inferredcites →https://doi.org/10.1371/journal.pone.0191225openalex-snapshot

Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

inferredcites →https://doi.org/10.3390/cells7060052openalex-snapshot

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease

inferredcites →https://doi.org/10.3390/cells7110218openalex-snapshot

Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels

inferredcites →https://doi.org/10.3390/cells9010126openalex-snapshot

TRPC Channels in the SOCE Scenario

inferredcites →https://doi.org/10.3390/ijms21176125openalex-snapshot

TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease

inferredcites →https://doi.org/10.7554/elife.53311openalex-snapshot

Structural basis for pharmacological modulation of the TRPC6 channel

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4662872openalex-extracted

Total Synthesis of Natural Alkaloids Schwarzinicines A-D

inferred← citeshttps://doi.org/10.1016/j.phytol.2023.11.007openalex-snapshot

Vasorelaxant effect of a phenylethylamine analogue based on schwarzinicine A an alkaloid isolated from the leaves of Ficus schwarzii

inferred← citeshttps://doi.org/10.1016/j.tet.2024.133909openalex-snapshot

Total synthesis of natural alkaloids Schwarzinicines A-D

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.3c00707openalex-snapshot

Preparation and Preliminary Structure–Activity Relationship Studies of Schwarzinicine A Analogs as Vasorelaxant Agents

inferred← citeshttps://doi.org/10.1039/d5ra00619hopenalex-snapshot

Corey–Fuchs reaction enabled synthesis of natural products: a review

inferred← citeshttps://doi.org/10.6023/cjoc202605029openalex-snapshot

Application of Amide Reductive Alkynylation and Reductive Alkylation in the Rapid Synthesis of Schwarzinicines A~C and Ficusnotins B, F

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