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Therapeutic prospects of naturally occurring p38 MAPK inhibitors tanshinone IIA and pinocembrin for the treatment of SARS‐CoV ‐2‐induced CNS complications

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2 of the 147 references listed on this page are in the Retraction Watch database as retracted (export 2026-11-11): 10.1007/s00210-021-02067-5 (notice 2023-09-28), 10.3892/mmr.2016.5916 (notice 2024-12-02).

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Tanshinone IIA Exhibits Anticonvulsant Activity in Zebrafish and Mouse Seizure Models

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Mechanisms and functions of p38 MAPK signalling

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An updated patent review of p38 MAP kinase inhibitors (2014-2019)

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Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

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Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

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Tanshinone IIA: A Promising Natural Cardioprotective Agent

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Protective Effects of p38 MAPK Inhibitor SB202190 against Hippocampal Apoptosis and Spatial Learning and Memory Deficits in a Rat Model of Vascular Dementia

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Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities

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Tanshinone IIA Inhibits Glutamate‐Induced Oxidative Toxicity through Prevention of Mitochondrial Dysfunction and Suppression of MAPK Activation in SH‐SY5Y Human Neuroblastoma Cells

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HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-κB-MyD88 Signaling Pathway and Disrupting Mitochondrial Function

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Sodium Tanshinone IIA Sulfonate Ameliorates Injury‐Induced Oxidative Stress and Intervertebral Disc Degeneration in Rats by Inhibiting p38 MAPK Signaling Pathway

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Tanshinone IIA Accomplished Protection against Radiation-Induced Cardiomyocyte Injury by Regulating the p38/p53 Pathway

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Tanshinone IIA Inhibits miR-1 Expression through p38 MAPK Signal Pathway in Post-infarction Rat Cardiomyocytes

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Tanshinone IIA Inhibits Tissue Factor Expression Induced by Thrombin in Human Umbilical Vein Endothelial Cells via PAR-1 and p38 MAPK Signaling Pathway

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Tanshinone IIA Ameliorates Spatial Learning and Memory Deficits by Inhibiting the Activity of ERK and GSK-3β

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Anwulignan Improves d -Galactose-Induced Learning and Memory Impairment via Regulating P38 MAPK-Nrf2-HO-1 Pathway in Mice

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Characteristics of compounds that cross the blood-brain barrier

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Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis

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A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model

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The Mesobuthus martensii genome reveals the molecular diversity of scorpion toxins

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Pinocembrin suppresses TGF-β1-induced epithelial-mesenchymal transition and metastasis of human Y-79 retinoblastoma cells through inactivating αvβ3 integrin/FAK/p38α signaling pathway

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Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis

inferredcites →https://doi.org/10.1186/s12974-020-01981-4openalex-snapshot

Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro

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Signal Transduction in SARS‐CoV‐Infected Cells

inferredcites →https://doi.org/10.1371/journal.pone.0038381openalex-snapshot

Tanshinone IIA Attenuates the Inflammatory Response and Apoptosis after Traumatic Injury of the Spinal Cord in Adult Rats

inferredcites →https://doi.org/10.1371/journal.pone.0103229openalex-snapshot

Inhibitory Effect of Tanshinone IIA on Rat Hepatic Stellate Cells

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The efficacy and safety of pinocembrin in a sheep model of bleomycin-induced pulmonary fibrosis

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Glia as a Therapeutic Target: Selective Suppression of Human Amyloid-β-Induced Upregulation of Brain Proinflammatory Cytokine Production Attenuates Neurodegeneration

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Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling

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Tanshinone IIA Promotes M2 Microglia by ERβ/IL-10 Pathway and Attenuates Neuronal Loss in Mouse TBI Model

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p38 MAP Kinase Inhibitors as Potential Therapeutic Drugs for Neural Diseases

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Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion

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Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion

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Pinocembrin Decreases Atrial Fibrillation Susceptibility in a Rodent Model of Depression

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Comparative Review of SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza A Respiratory Viruses

inferredcites →https://doi.org/10.3389/fnmol.2020.570586openalex-snapshot

Functions of p38 MAP Kinases in the Central Nervous System

inferredcites →https://doi.org/10.3389/fphar.2018.00263openalex-snapshot

Sodium Tanshinone IIA Sulfonate Decreases Cigarette Smoke-Induced Inflammation and Oxidative Stress via Blocking the Activation of MAPK/HIF-1α Signaling Pathway

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Efficacy and Safety of Sodium Tanshinone IIA Sulfonate Injection on Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

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Anti–SARS-CoV-2 Natural Products as Potentially Therapeutic Agents

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Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities

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Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review

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