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Discovery of new analogs of the marine biotoxin azaspiracid in blue mussels ( Mytilus edulis ) by ultra‐performance liquid chromatography/tandem mass spectrometry

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1522-7189(199905/06)7:3<99::aid-nt46>3.0.co;2-lopenalex-snapshot
Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland
inferredcites →https://doi.org/10.1002/ange.200460696openalex-snapshot
Structural Revision and Total Synthesis of Azaspiracid‐1, Part 2: Definition of the ABCD Domain and Total Synthesis
inferredcites →https://doi.org/10.1002/anie.200351825openalex-snapshot
Total Synthesis of the Proposed Azaspiracid‐1 Structure, Part 1: Construction of the Enantiomerically Pure C1–C20, C21–C27, and C28–C40 Fragments
inferredcites →https://doi.org/10.1002/anie.200460696openalex-snapshot
Structural Revision and Total Synthesis of Azaspiracid‐1, Part 2: Definition of the ABCD Domain and Total Synthesis
inferredcites →https://doi.org/10.1002/rcm.2501openalex-snapshot
Discovery of fatty acid ester metabolites of spirolide toxins in mussels from Norway using liquid chromatography/tandem mass spectrometry
inferredcites →https://doi.org/10.1002/rcm.863openalex-snapshot
Studies on azaspiracid biotoxins. II. Mass spectral behavior and structural elucidation of azaspiracid analogs
inferredcites →https://doi.org/10.1016/s0040-4020(01)96469-5openalex-snapshot
Diarrhetic shellfish toxins
inferredcites →https://doi.org/10.1016/s0041-0101(02)00082-xopenalex-snapshot
First evidence of an extensive northern European distribution of azaspiracid poisoning (AZP) toxins in shellfish
inferredcites →https://doi.org/10.1016/s0041-0101(02)00244-1openalex-snapshot
Ubiquitous ‘benign’ alga emerges as the cause of shellfish contamination responsible for the human toxic syndrome, azaspiracid poisoning
inferredcites →https://doi.org/10.1016/s0041-0101(02)00288-xopenalex-snapshot
Detection of five new hydroxyl analogues of azaspiracids in shellfish using multiple tandem mass spectrometry
inferredcites →https://doi.org/10.1016/s0041-0101(03)00105-3openalex-snapshot
The first identification of azaspiracids in shellfish from France and Spain
inferredcites →https://doi.org/10.1021/ja981413ropenalex-snapshot
Azaspiracid, a New Marine Toxin Having Unique Spiro Ring Assemblies, Isolated from Irish Mussels, Mytilus edulis
inferredcites →https://doi.org/10.1021/jf060396jopenalex-snapshot
Identification of Fatty Acid Esters of Pectenotoxin-2 Seco Acid in Blue Mussels (Mytilus edulis) from Ireland
inferredcites →https://doi.org/10.1271/bbb.65.740openalex-snapshot
Structures of Azaspiracid Analogs, Azaspiracid-4 and Azaspiracid-5, Causative Toxins of Azaspiracid Poisoning in Europe
inferredcites →https://doi.org/10.2983/0730-8000(2006)25[1067:fdoaim]2.0.co;2openalex-snapshot
FIRST DETECTION OF AZASPIRACIDS IN MUSSELS IN NORTH WEST AFRICA

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Assessing Escherichia Coli and Coliform Bacteria in Mussel Mytella Strigata (Hanley, 1843) Collected in Tangub Misamis Occidental and Baroy Lanao Del Norte
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Pathological clues of phycotoxin ingestion
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The Determination of Marine Biotoxins in Seafood
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Harmful Algal Blooms and Shellfish
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Biomimetic Syntheses of Alkaloids with a Non‐Amino Acid Origin
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Monoclonal Antibodies with Orthogonal Azaspiracid Epitopes
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Marine Toxins in Italy: The More You Look, the More You Find
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Current literature in mass spectrometry
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Food contaminant analysis at ultra‐high mass resolution: application of hybrid linear ion trap – orbitrap mass spectrometry for the determination of the polyether toxins, azaspiracids, in shellfish
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Simultaneous determination of biotoxins DSP and AZAs in bivalve molluscs and fish by liquid chromatography/tandem mass spectrometry
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Marine Dinoflagellates-Associated Human Poisoning
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Phycotoxins: chemistry, mechanisms of action and shellfish poisoning
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Azaspiracid Toxins: Toxicological Profile
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Effect of Dilution Rate on Azadinium spinosum and Azaspiracid (AZA) Production in Pilot Scale Photobioreactors for the Harvest of AZA1 and -2
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Azaspiracid Toxins: Toxicological Profile
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Algal Blooms: Basic Concepts
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LC-MS-MS aboard ship: tandem mass spectrometry in the search for phycotoxins and novel toxigenic plankton from the North Sea
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The development of a rapid method for the isolation of four azaspiracids for use as reference materials for quantitative LC–MS–MS methods
inferred← citeshttps://doi.org/10.1007/s00216-010-4161-2openalex-snapshot
The preparation of certified calibration solutions for azaspiracid-1, -2, and -3, potent marine biotoxins found in shellfish
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A mussel tissue certified reference material for multiple phycotoxins. Part 3: homogeneity and stability
inferred← citeshttps://doi.org/10.1007/s00216-012-5849-2openalex-snapshot
Quantitative analysis of azaspiracids in Azadinium spinosum cultures
inferred← citeshttps://doi.org/10.1007/s00216-014-8250-5openalex-snapshot
A mussel (Mytilus edulis) tissue certified reference material for the marine biotoxins azaspiracids
inferred← citeshttps://doi.org/10.1007/s00216-016-0037-4openalex-snapshot
Mediterranean Azadinium dexteroporum (Dinophyceae) produces six novel azaspiracids and azaspiracid-35: a structural study by a multi-platform mass spectrometry approach
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Cardiovascular Toxicity from Marine Envenomation
inferred← citeshttps://doi.org/10.1016/b978-0-12-811515-2.00007-xopenalex-snapshot
Occurrence of Natural Toxins in Seafood
inferred← citeshttps://doi.org/10.1016/b978-0-443-36320-7.00005-3openalex-snapshot
Comprehensive applications of marine biotoxins resources
inferred← citeshttps://doi.org/10.1016/bs.coac.2017.07.004openalex-snapshot
Marine Toxins Analysis for Consumer Protection
inferred← citeshttps://doi.org/10.1016/bs.coac.2017.08.002openalex-snapshot
Structural Diversity of Microalgal Marine Toxins
inferred← citeshttps://doi.org/10.1016/bs.coac.2017.08.005openalex-snapshot
LC/MS Analysis of Marine Toxins
inferred← citeshttps://doi.org/10.1016/j.ab.2013.10.035openalex-snapshot
Microsphere-based immunoassay for the detection of azaspiracids
inferred← citeshttps://doi.org/10.1016/j.aca.2010.11.036openalex-snapshot
Screening of lipophilic marine toxins in shellfish and algae: Development of a library using liquid chromatography coupled to orbitrap mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.aquatox.2012.08.016openalex-snapshot
Effect of Azadinium spinosum on the feeding behaviour and azaspiracid accumulation of Mytilus edulis
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2025.144502openalex-snapshot
Bioaccumulations and biotransformations of azaspiracids from Amphidoma languida in the mussel Mytilus edulis
inferred← citeshttps://doi.org/10.1016/j.chroma.2008.10.123openalex-snapshot
Determination of dissolved domoic acid in seawater with reversed-phase extraction disks and rapid resolution liquid chromatography tandem mass spectrometry with head-column trapping
inferred← citeshttps://doi.org/10.1016/j.chroma.2008.12.099openalex-snapshot
Liquid chromatography–tandem mass spectrometry method for the detection of marine lipophilic toxins under alkaline conditions
inferred← citeshttps://doi.org/10.1016/j.chroma.2009.03.062openalex-snapshot
Sensitive method for the determination of lipophilic marine biotoxins in extracts of mussels and processed shellfish by high-performance liquid chromatography–tandem mass spectrometry based on enrichment by solid-phase extraction
inferred← citeshttps://doi.org/10.1016/j.chroma.2010.09.020openalex-snapshot
Strategies for the elimination of matrix effects in the liquid chromatography tandem mass spectrometry analysis of the lipophilic toxins okadaic acid and azaspiracid-1 in molluscan shellfish
inferred← citeshttps://doi.org/10.1016/j.chroma.2011.09.017openalex-snapshot
Derivatization of azaspiracid biotoxins for analysis by liquid chromatography with fluorescence detection
inferred← citeshttps://doi.org/10.1016/j.envres.2026.124339openalex-snapshot
Monitoring of regulated and non-regulated biotoxins in marine organisms using liquid-phase microextraction and liquid chromatography coupled with high-resolution mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.hal.2008.06.003openalex-snapshot
Characterization of azaspiracids in plankton size-fractions and isolation of an azaspiracid-producing dinoflagellate from the North Sea
inferred← citeshttps://doi.org/10.1016/j.hal.2011.06.010openalex-snapshot
The role of Azadinium spinosum (Dinophyceae) in the production of azaspiracid shellfish poisoning in mussels
inferred← citeshttps://doi.org/10.1016/j.hal.2012.05.004openalex-snapshot
Blooms of Azadinium cf. spinosum Elbrächter et Tillmann (Dinophyceae) in northern shelf waters of Argentina, Southwestern Atlantic
inferred← citeshttps://doi.org/10.1016/j.hal.2012.11.009openalex-snapshot
Morphology, phylogeny and azaspiracid profile of Azadinium poporum (Dinophyceae) from the China Sea
inferred← citeshttps://doi.org/10.1016/j.hal.2018.12.005openalex-snapshot
Two novel azaspiracids from Azadinium poporum, and a comprehensive compilation of azaspiracids produced by Amphidomataceae, (Dinophyceae)
inferred← citeshttps://doi.org/10.1016/j.jfca.2025.108684openalex-snapshot
A two-step LC-HRMS strategy for targeted and suspect screening of lipophilic marine biotoxins in bivalve molluscs
inferred← citeshttps://doi.org/10.1016/j.jprot.2009.02.008openalex-snapshot
Proteomic response of human neuroblastoma cells to azaspiracid-1
inferred← citeshttps://doi.org/10.1016/j.tiv.2017.09.018openalex-snapshot
Whole genome mRNA transcriptomics analysis reveals different modes of action of the diarrheic shellfish poisons okadaic acid and dinophysis toxin-1 versus azaspiracid-1 in Caco-2 cells
inferred← citeshttps://doi.org/10.1016/j.toxcx.2020.100059openalex-snapshot
Fatty acid esters of azaspiracids identified in mussels (Mytilus edulis) using liquid chromatography-high resolution mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.toxicon.2009.01.010openalex-snapshot
A convenient and cost-effective method for monitoring marine algal toxins with passive samplers
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Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin
inferred← citeshttps://doi.org/10.1016/j.toxicon.2009.02.015openalex-snapshot
Performance of the EU-harmonised mouse bioassay for lipophilic toxins for the detection of azaspiracids in naturally contaminated mussel (Mytilus edulis) hepatopancreas tissue homogenates characterised by liquid chromatography coupled to tandem mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.toxicon.2009.07.014openalex-snapshot
First identification of azaspiracid and spirolides in Mesodesma donacium and Mulinia edulis from Northern Chile
inferred← citeshttps://doi.org/10.1016/j.toxicon.2009.09.009openalex-snapshot
Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations
inferred← citeshttps://doi.org/10.1016/j.toxicon.2009.10.020openalex-snapshot
First evidence of azaspiracids (AZAs): A family of lipophilic polyether marine toxins in scallops (Argopecten purpuratus) and mussels (Mytilus chilensis) collected in two regions of Chile
inferred← citeshttps://doi.org/10.1016/j.toxicon.2012.04.351openalex-snapshot
Azaspiracid accumulation, detoxification and biotransformation in blue mussels (Mytilus edulis) experimentally fed Azadinium spinosum
inferred← citeshttps://doi.org/10.1016/j.toxicon.2012.05.007openalex-snapshot
New azaspiracids in Amphidomataceae (Dinophyceae)
inferred← citeshttps://doi.org/10.1016/j.toxicon.2013.01.010openalex-snapshot
Dissolved azaspiracids are absorbed and metabolized by blue mussels (Mytilus edulis)
inferred← citeshttps://doi.org/10.1016/j.toxicon.2014.10.012openalex-snapshot
Confirmation of extensive natural distribution of azaspiracids in the tissue compartments of mussels (Mytilus edulis)
inferred← citeshttps://doi.org/10.1016/j.toxicon.2017.12.040openalex-snapshot
Accumulation and transformation of azaspiracids in scallops ( Chlamys farreri ) and mussels ( Mytilus galloprovincialis ) fed with Azadinium poporum, and response of antioxidant enzymes
inferred← citeshttps://doi.org/10.1016/j.toxicon.2021.06.010openalex-snapshot
Complex profiles of azaspiracid analogues in two culture strains of Azadinium poporum (Amphidomataceae, Dinophyceae) isolated from Japanese coastal waters determined by LC-MS/MS
inferred← citeshttps://doi.org/10.1016/j.toxlet.2017.10.016openalex-snapshot
Toxic equivalency factors (TEFs) after acute oral exposure of azaspiracid 1, −2 and −3 in mice
inferred← citeshttps://doi.org/10.1017/s0950268810000853openalex-snapshot
Shellfish toxicity: human health implications of marine algal toxins
inferred← citeshttps://doi.org/10.1021/ac801506dopenalex-snapshot
Evaluation of Various pH and Temperature Conditions on the Stability of Azaspiracids and Their Importance in Preparative Isolation and Toxicological Studies
inferred← citeshttps://doi.org/10.1021/acs.jafc.1c03831openalex-snapshot
In Vitro Metabolism of Azaspiracids 1–3 with a Hepatopancreatic Fraction from Blue Mussels (Mytilus edulis)
inferred← citeshttps://doi.org/10.1021/acs.jafc.5b01320openalex-snapshot
Structure Elucidation, Relative LC–MS Response and In Vitro Toxicity of Azaspiracids 7–10 Isolated from Mussels (Mytilus edulis)
inferred← citeshttps://doi.org/10.1021/acs.jafc.5b04609openalex-snapshot
Effects of Heating on Proportions of Azaspiracids 1–10 in Mussels (Mytilus edulis) and Identification of Carboxylated Precursors for Azaspiracids 5, 10, 13, and 15
inferred← citeshttps://doi.org/10.1021/acs.jafc.8b00346openalex-snapshot
Selective Extraction and Purification of Azaspiracids from Blue Mussels (Mytilus edulis) Using Boric Acid Gel
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.7b00973openalex-snapshot
Identification of 21,22-Dehydroazaspiracids in Mussels (Mytilus edulis) and in Vitro Toxicity of Azaspiracid-26
inferred← citeshttps://doi.org/10.1021/es103612copenalex-snapshot
Mussels Increase Xenobiotic (Azaspiracid) Toxicity Using a Unique Bioconversion Mechanism
inferred← citeshttps://doi.org/10.1021/np500555kopenalex-snapshot
Isolation, Structure Elucidation, Relative LC-MS Response, and in Vitro Toxicity of Azaspiracids from the Dinoflagellate Azadinium spinosum
inferred← citeshttps://doi.org/10.1021/tx200553popenalex-snapshot
Comparative Effects of the Marine Algal Toxins Azaspiracid-1, -2, and -3 on Jurkat T Lymphocyte Cells
inferred← citeshttps://doi.org/10.1021/tx3001785openalex-snapshot
Induction of Apoptosis Pathways in Several Cell Lines following Exposure to the Marine Algal Toxin Azaspiracid
inferred← citeshttps://doi.org/10.1021/tx300283topenalex-snapshot
Marine Algal Toxin Azaspiracid Is an Open-State Blocker of hERG Potassium Channels
inferred← citeshttps://doi.org/10.1021/tx400434bopenalex-snapshot
Epimers of Azaspiracids: Isolation, Structural Elucidation, Relative LC-MS Response, and in Vitro Toxicity of 37-epi-Azaspiracid-1
inferred← citeshttps://doi.org/10.1021/tx800165copenalex-snapshot
Azaspiracid Substituent at C1 Is Relevant to in Vitro Toxicity
inferred← citeshttps://doi.org/10.1080/00288330.2021.1953083openalex-snapshot
Molecular detection and distribution of the genera Amphidoma and Azadinium (Amphidomataceae, Dinophyceae) in the coastal waters of Aotearoa/New Zealand
inferred← citeshttps://doi.org/10.1080/09670260802578534openalex-snapshot
Azadinium spinosumgen. et sp. nov. (Dinophyceae) identified as a primary producer of azaspiracid toxins
inferred← citeshttps://doi.org/10.1080/19440049.2017.1368720openalex-snapshot
Screening for the presence of lipophilic marine biotoxins in shellfish samples using the neuro-2a bioassay
inferred← citeshttps://doi.org/10.1093/chromsci/bmu054openalex-snapshot
Solid-Phase Extraction-Based Ultra-Sensitive Detection of Four Lipophilic Marine Biotoxins in Bivalves by High-Performance Liquid Chromatography-Tandem Mass Spectrometry
inferred← citeshttps://doi.org/10.1093/plankt/fbw099openalex-snapshot
Identification ofAzadinium poporum(Dinophyceae) in the Southeast Pacific: morphology, molecular phylogeny, and azaspiracid profile characterization
inferred← citeshttps://doi.org/10.1093/toxsci/kfp246openalex-snapshot
Cell Volume Decrease as a Link between Azaspiracid-Induced Cytotoxicity and c-Jun-N-Terminal Kinase Activation in Cultured Neurons
inferred← citeshttps://doi.org/10.1111/j.1742-4658.2008.06713.xopenalex-snapshot
Marine toxins and the cytoskeleton: azaspiracids
inferred← citeshttps://doi.org/10.1111/pre.12133openalex-snapshot
Revisiting the 1991 algal bloom in shelf waters off Argentina: Azadinium luciferelloides sp. nov. (Amphidomataceae, Dinophyceae) as the causative species in a diverse community of other amphidomataceans
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Towards tailored assays for cell-based approaches to toxicity testing
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A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems
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Algal toxins and their detection
inferred← citeshttps://doi.org/10.21427/d7c30nopenalex-snapshot
Optimisation of Isolation Methods for the AZA Group of Marine Biotoxins and the Development of Accurate and Precise Methods of Analysis
inferred← citeshttps://doi.org/10.2174/1389203715666140221120219openalex-snapshot
High-Throughput Proteomics: A New Tool for Quality and Safety in Fishery Products
inferred← citeshttps://doi.org/10.2216/ph09-35.1openalex-snapshot
Azadinium obesum (Dinophyceae), a new nontoxic species in the genus that can produce azaspiracid toxins
inferred← citeshttps://doi.org/10.2903/j.efsa.2008.723openalex-snapshot
Marine biotoxins in shellfish – Azaspiracid group ‐ Scientific Opinion of the Panel on Contaminants in the Food chain
inferred← citeshttps://doi.org/10.2903/j.efsa.2021.6422openalex-snapshot
Evaluation of the shucking of certain species of scallops contaminated with lipophilic toxins with a view to the production of edible parts meeting the safety requirements foreseen in the Union legislation
inferred← citeshttps://doi.org/10.2903/j.efsa.2021.6809openalex-snapshot
Evaluation of the shucking of certain species of scallops contaminated with domoic acid with a view to the production of edible parts meeting the safety requirements foreseen in the Union legislation
inferred← citeshttps://doi.org/10.3390/md10061360openalex-snapshot
Production and Isolation of Azaspiracid-1 and -2 from Azadinium spinosum Culture in Pilot Scale Photobioreactors
inferred← citeshttps://doi.org/10.3390/md13116687openalex-snapshot
Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum
inferred← citeshttps://doi.org/10.3390/md17090489openalex-snapshot
Effects of Temperature, Growth Media, and Photoperiod on Growth and Toxin Production of Azadinium spinosum
inferred← citeshttps://doi.org/10.3390/md6020039openalex-snapshot
Azaspiracid Shellfish Poisoning: A Review on the Chemistry, Ecology, and Toxicology with an Emphasis on Human Health Impacts
inferred← citeshttps://doi.org/10.3390/md8040881openalex-snapshot
Impact of Marine Drugs on Cytoskeleton-Mediated Reproductive Events
inferred← citeshttps://doi.org/10.3390/s21072499openalex-snapshot
Current Trends and Challenges for Rapid SMART Diagnostics at Point-of-Site Testing for Marine Toxins
inferred← citeshttps://doi.org/10.3390/s91109414openalex-snapshot
Use of Biosensors as Alternatives to Current Regulatory Methods for Marine Biotoxins
inferred← citeshttps://doi.org/10.3390/toxins10010002openalex-snapshot
Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Detection of Pacific Ciguatoxins in Toxic Samples from Nuku Hiva Island (French Polynesia)
inferred← citeshttps://doi.org/10.3390/toxins11010058openalex-snapshot
The Incidence of Marine Toxins and the Associated Seafood Poisoning Episodes in the African Countries of the Indian Ocean and the Red Sea
inferred← citeshttps://doi.org/10.3390/toxins11070394openalex-snapshot
LC–MS/MS Analysis of the Emerging Toxin Pinnatoxin-G and High Levels of Esterified OA Group Toxins in Galician Commercial Mussels
inferred← citeshttps://doi.org/10.3390/toxins2040878openalex-snapshot
Marine Toxins: Chemistry, Toxicity, Occurrence and Detection, with Special Reference to the Dutch Situation
inferred← citeshttps://doi.org/10.3987/com-08-11555openalex-snapshot
Synthesis of Open-Chain C21-C40 Fragment of Azaspiracid-1
inferred← citeshttps://doi.org/10.5772/intechopen.82438openalex-snapshot
Instrumental Methods for Detection of Lipophilic Marine Toxins in Endemic Species from Pacific Austral Fjords
inferred← citeshttps://doi.org/10.70675/5b31fd9dzc5eez4355z8e0dz130fcee1227copenalex-snapshot
Analyse non ciblée des biotoxines marines dans les produits de la pêche
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