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Efficient Generation of Astrocytes from Human Pluripotent Stem Cells in Defined Conditions

https://doi.org/10.1002/stem.1334
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Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development
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Cultured neonatal schwann cells contain and secrete neuregulins
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Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
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The topographical distribution of S‐100 and GFA proteins in the adult rat brain: An immunohistochemical study using horseradish peroxidase‐labelled antibodies
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Development of glial cells in the cerebral wall of ferrets: Direct tracing of their transformation from radial glia into astrocytes
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Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors
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Isolation of a glial‐restricted tripotential cell line from embryonic spinal cord cultures
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Oligodendrocyte and astrocyte development in rodents: An in situ and immunohistological analysis during embryonic development
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Region‐specific effects of glia on neuronal induction and differentiation with a focus on dopaminergic neurons
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Chronic alterations in the cellular composition of spinal cord white matter following contusion injury
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NG2 proteoglycan‐expressing cells of the adult rat brain: Possible involvement in the formation of glial scar astrocytes following stab wound
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Cell proliferation and replacement following contusive spinal cord injury
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Distribution of Aquaporin 4 in rodent spinal cord: Relationship with astrocyte markers and chondroitin sulfate proteoglycans
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S100B expression defines a state in which GFAP‐expressing cells lose their neural stem cell potential and acquire a more mature developmental stage
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Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain
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Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)‐regulated glial proliferation
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Uptake of [3H]serotonin and [3H]glutamate by primary astrocyte cultures. I. Effects of different sera and time in culture
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Stem cell‐based cell therapy in neurological diseases: A review
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Nuclear Factor I Isoforms Regulate Gene Expression During the Differentiation of Human Neural Progenitors to Astrocytes
inferredcites →https://doi.org/10.1002/stem.499openalex-snapshot
Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions
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Low-Affinity NGF-Receptor and E-N-CAM Expression Define Two Types of Olfactory Nerve Ensheathing Cells That Share a Common Lineage
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Glial-Restricted Precursors Are Derived from Multipotent Neuroepithelial Stem Cells
inferredcites →https://doi.org/10.1006/dbio.1999.9418openalex-snapshot
Lineage-Restricted Neural Precursors Can Be Isolated from Both the Mouse Neural Tube and Cultured ES Cells
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Characterization of CNS Precursor Subtypes and Radial Glia
inferredcites →https://doi.org/10.1007/978-1-4757-5876-4_4openalex-snapshot
Regulation of the Glial Fibrillary Acidic Protein (GFAP) and of its Encoding mRNA in the Developing Brain and in Cultured Astrocytes
inferredcites →https://doi.org/10.1007/bf00239385openalex-snapshot
Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions
inferredcites →https://doi.org/10.1007/bf01191704openalex-snapshot
H-CAM expression in the human nervous system: Evidence for a role in diverse glial interactions
inferredcites →https://doi.org/10.1016/j.bpobgyn.2004.07.002openalex-snapshot
Therapeutic applications of embryonic stem cells
inferredcites →https://doi.org/10.1016/j.brainresrev.2009.12.001openalex-snapshot
Heterogeneity in astrocyte morphology and physiology
inferredcites →https://doi.org/10.1016/j.cell.2006.11.052openalex-snapshot
CHD5 Is a Tumor Suppressor at Human 1p36
inferredcites →https://doi.org/10.1016/j.cell.2008.02.046openalex-snapshot
Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain Code
inferredcites →https://doi.org/10.1016/j.cell.2008.10.029openalex-snapshot
Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types
inferredcites →https://doi.org/10.1016/j.ejcb.2010.10.014openalex-snapshot
Tropomodulins are negative regulators of neurite outgrowth
inferredcites →https://doi.org/10.1016/j.expneurol.2004.05.043openalex-snapshot
Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration
inferredcites →https://doi.org/10.1016/j.expneurol.2010.10.011openalex-snapshot
Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats
inferredcites →https://doi.org/10.1016/j.neuint.2004.12.007openalex-snapshot
Characterization of cells with proliferative activity after a brain injury
inferredcites →https://doi.org/10.1016/j.neuron.2006.11.019openalex-snapshot
The Transcription Factor NFIA Controls the Onset of Gliogenesis in the Developing Spinal Cord
inferredcites →https://doi.org/10.1016/j.ydbio.2004.08.018openalex-snapshot
CD44 expression identifies astrocyte-restricted precursor cells
inferredcites →https://doi.org/10.1016/j.yexcr.2004.01.026openalex-snapshot
Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity
inferredcites →https://doi.org/10.1016/s0006-8993(00)02922-xopenalex-snapshot
cAMP-induced stellation in primary astrocyte cultures with regional heterogeneity
inferredcites →https://doi.org/10.1016/s0076-6879(06)11009-5openalex-snapshot
[9] TM4 Microarray Software Suite
inferredcites →https://doi.org/10.1016/s0304-3940(00)00981-2openalex-snapshot
Activin promotes astrocytic differentiation of a multipotent neural stem cell line and an astrocyte progenitor cell line from murine central nervous system
inferredcites →https://doi.org/10.1016/s0378-1119(00)00140-2openalex-snapshot
Roles of the NFI/CTF gene family in transcription and development
inferredcites →https://doi.org/10.1016/s0896-6273(00)80193-2openalex-snapshot
Bone Morphogenetic Proteins Promote Astroglial Lineage Commitment by Mammalian Subventricular Zone Progenitor Cells
inferredcites →https://doi.org/10.1016/s0896-6273(00)80960-5openalex-snapshot
Isolation of Lineage-Restricted Neuronal Precursors from Multipotent Neuroepithelial Stem Cells
inferredcites →https://doi.org/10.1016/s1044-7431(03)00210-0openalex-snapshot
NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS
inferredcites →https://doi.org/10.1017/s1740925x04000213openalex-snapshot
Differential fate of multipotent and lineage-restricted neural precursors following transplantation into the adult CNS
inferredcites →https://doi.org/10.1021/bi060641sopenalex-snapshot
Analysis of the Structure and Function of the Transcriptional Coregulator HOP,
inferredcites →https://doi.org/10.1038/35055553openalex-snapshot
Neurons derived from radial glial cells establish radial units in neocortex
inferredcites →https://doi.org/10.1038/37284openalex-snapshot
TGF-β signalling from cell membrane to nucleus through SMAD proteins
inferredcites →https://doi.org/10.1038/nature04139openalex-snapshot
Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube
inferredcites →https://doi.org/10.1038/nature09611openalex-snapshot
Developmental genetics of vertebrate glial–cell specification
inferredcites →https://doi.org/10.1038/nbt.1877openalex-snapshot
Specification of transplantable astroglial subtypes from human pluripotent stem cells
inferredcites →https://doi.org/10.1038/sj.onc.1203527openalex-snapshot
STATs in oncogenesis
inferredcites →https://doi.org/10.1038/sj.onc.1206211openalex-snapshot
CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system
inferredcites →https://doi.org/10.1046/j.1440-169x.1998.00003.xopenalex-snapshot
Combinatorial expression patterns of individual TLE proteins during cell determination and differentiation suggest non‐redundant functions for mammalian homologs of Drosophila Groucho
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Pharmacology of Sodium‐Dependent High‐Affinity l ‐[3H]Glutamate Transport in Glial Cultures
inferredcites →https://doi.org/10.1046/j.1471-4159.1997.69051859.xopenalex-snapshot
Neonatal Oligodendrocytes Contain and Secrete Neuregulins In Vitro
inferredcites →https://doi.org/10.1073/pnas.0407893101openalex-snapshot
Radial glia give rise to adult neural stem cells in the subventricular zone
inferredcites →https://doi.org/10.1073/pnas.0605843103openalex-snapshot
Evolution of increased glia–neuron ratios in the human frontal cortex
inferredcites →https://doi.org/10.1073/pnas.1101109108openalex-snapshot
Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus
inferredcites →https://doi.org/10.1073/pnas.91.20.9387openalex-snapshot
Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes.
inferredcites →https://doi.org/10.1073/pnas.95.7.3996openalex-snapshot
A tripotential glial precursor cell is present in the developing spinal cord
inferredcites →https://doi.org/10.1073/pnas.96.21.11946openalex-snapshot
Disruption of the murine nuclear factor I-A gene ( Nfia ) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum
inferredcites →https://doi.org/10.1074/jbc.274.24.17209openalex-snapshot
ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases
inferredcites →https://doi.org/10.1074/jbc.m110.152421openalex-snapshot
The Unique Transcriptional Activation Domain of Nuclear Factor-I-X3 Is Critical to Specifically Induce Marker Gene Expression in Astrocytes
inferredcites →https://doi.org/10.1074/jbc.m402169200openalex-snapshot
Thrombospondin-1-induced Focal Adhesion Disassembly in Fibroblasts Requires Thy-1 Surface Expression, Lipid Raft Integrity, and Src Activation
inferredcites →https://doi.org/10.1074/jbc.m404596200openalex-snapshot
The Herbicide Paraquat Induces Dopaminergic Nigral Apoptosis through Sustained Activation of the JNK Pathway
inferredcites →https://doi.org/10.1074/jbc.m805897200openalex-snapshot
S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase
inferredcites →https://doi.org/10.1096/fj.05-5460revopenalex-snapshot
Thy‐1 as a regulator of cell‐cell and cell‐matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis
inferredcites →https://doi.org/10.1097/00005072-199307000-00009openalex-snapshot
CD44 Expression in Human Astrocytes and Oligodendrocytes in Culture
inferredcites →https://doi.org/10.1111/j.1432-0436.2006.00051.xopenalex-snapshot
Characterization and in vitro differentiation potential of a new human embryonic stem cell line, ReliCell®hES1
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Nuclear factor‐I regulates glial fibrillary acidic protein gene expression in astrocytes differentiated from cortical precursor cells
inferredcites →https://doi.org/10.1126/science.278.5337.477openalex-snapshot
Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway
inferredcites →https://doi.org/10.1126/science.284.5413.479openalex-snapshot
Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300
inferredcites →https://doi.org/10.1128/jvi.74.14.6433-6441.2000openalex-snapshot
Human T-Cell Lymphotropic Virus Type 1-Infected T Lymphocytes Impair Catabolism and Uptake of Glutamate by Astrocytes via Tax-1 and Tumor Necrosis Factor Alpha
inferredcites →https://doi.org/10.1128/mcb.02293-06openalex-snapshot
Nuclear Factor I X Deficiency Causes Brain Malformation and Severe Skeletal Defects
inferredcites →https://doi.org/10.1128/mcb.11.2.906openalex-snapshot
The Gene Encoding the Oligodendrocyte-Myelin Glycoprotein Is Embedded within the Neurofibromatosis Type 1 Gene
inferredcites →https://doi.org/10.1146/annurev.neuro.25.112701.142916openalex-snapshot
Transcriptional Codes and the Control of Neuronal Identity
inferredcites →https://doi.org/10.1159/000048721openalex-snapshot
Neuregulin: An Oligodendrocyte Growth Factor Absent in Active Multiple Sclerosis Lesions
inferredcites →https://doi.org/10.1182/blood-2007-03-082586openalex-snapshot
Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling
inferredcites →https://doi.org/10.1186/1471-213x-8-102openalex-snapshot
Expression profiling of human glial precursors
inferredcites →https://doi.org/10.1186/1471-213x-8-52openalex-snapshot
The transcription factor Nfixis essential for normal brain development
inferredcites →https://doi.org/10.1186/1749-8104-3-13openalex-snapshot
Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP
inferredcites →https://doi.org/10.1242/dev.127.24.5253openalex-snapshot
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
inferredcites →https://doi.org/10.1242/dev.129.6.1327openalex-snapshot
Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains
inferredcites →https://doi.org/10.1242/jcs.108.10.3181openalex-snapshot
In vitro differentiation of embryonic stem cells into glial cells and functional neurons
inferredcites →https://doi.org/10.1371/journal.pone.0006233openalex-snapshot
Xeno-Free Defined Conditions for Culture of Human Embryonic Stem Cells, Neural Stem Cells and Dopaminergic Neurons Derived from Them
inferredcites →https://doi.org/10.1371/journal.pone.0024515openalex-snapshot
CHD5, a Brain-Specific Paralog of Mi2 Chromatin Remodeling Enzymes, Regulates Expression of Neuronal Genes
inferredcites →https://doi.org/10.1385/1-59259-186-8:029openalex-snapshot
Isolation of Stem and Precursor Cells from Fetal Tissue
inferredcites →https://doi.org/10.1523/jneurosci.1624-07.2007openalex-snapshot
Late-Stage Neuronal Progenitors in the Retina Are Radial Muller Glia That Function as Retinal Stem Cells
inferredcites →https://doi.org/10.1523/jneurosci.21-18-07153.2001openalex-snapshot
Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus
inferredcites →https://doi.org/10.1523/jneurosci.2175-05.2005openalex-snapshot
Transplantation of Neuronal and Glial Restricted Precursors into Contused Spinal Cord Improves Bladder and Motor Functions, Decreases Thermal Hypersensitivity, and Modifies Intraspinal Circuitry
inferredcites →https://doi.org/10.1523/jneurosci.4178-07.2008openalex-snapshot
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
inferredcites →https://doi.org/10.1634/stemcells.2004-0189openalex-snapshot
Unique Gene Expression Signature by Human Embryonic Stem Cells Cultured Under Serum-Free Conditions Correlates with Their Enhanced and Prolonged Growth in an Undifferentiated Stage

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Disease in a Dish: Cellular Models to Understand Human Conditions
inferred← citeshttps://doi.org/10.1016/b978-0-12-818084-6.00006-4openalex-snapshot
The therapeutic potential of exogenous adult stem cells for the injured central nervous system
inferred← citeshttps://doi.org/10.1016/b978-0-12-823577-5.00021-0openalex-snapshot
Functional genomics of psychiatric disease risk using genome engineering
inferred← citeshttps://doi.org/10.1016/b978-0-12-823808-0.00010-9openalex-snapshot
Use of human induced pluripotent stem cells (hiPSC)-derived neuronal models to study the neuropathogenesis of the protozoan parasite, Toxoplasma gondii
inferred← citeshttps://doi.org/10.1016/b978-0-323-85545-7.00005-3openalex-snapshot
Human induced pluripotent stem cell–derived astrocytes progenitors as discovery platforms
inferred← citeshttps://doi.org/10.1016/b978-0-323-85654-6.00040-xopenalex-snapshot
Toxic/metabolic diseases of the nervous system
inferred← citeshttps://doi.org/10.1016/b978-0-323-85764-2.00006-5openalex-snapshot
Human induced pluripotent stem cell– based modeling of Alzheimer’s disease, a glial perspective
inferred← citeshttps://doi.org/10.1016/b978-0-323-85764-2.00009-0openalex-snapshot
Studying non–cell-autonomous neurodegeneration in Parkinson’s disease with induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2016.08.003openalex-snapshot
Mitochondria in Multiple Sclerosis: Molecular Mechanisms of Pathogenesis
inferred← citeshttps://doi.org/10.1016/j.addr.2018.09.009openalex-snapshot
Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting
inferred← citeshttps://doi.org/10.1016/j.ajhg.2018.10.009openalex-snapshot
Human Models Are Needed for Studying Human Neurodevelopmental Disorders
inferred← citeshttps://doi.org/10.1016/j.alcohol.2018.03.008openalex-snapshot
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook
inferred← citeshttps://doi.org/10.1016/j.brainres.2015.07.048openalex-snapshot
Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes
inferred← citeshttps://doi.org/10.1016/j.brainres.2015.09.020openalex-snapshot
iPSC-based drug screening for Huntington׳s disease
inferred← citeshttps://doi.org/10.1016/j.cell.2025.08.038openalex-snapshot
Multiscale proteomic modeling reveals protein networks driving Alzheimer’s disease pathogenesis
inferred← citeshttps://doi.org/10.1016/j.celrep.2013.06.021openalex-snapshot
Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.04.011openalex-snapshot
Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107732openalex-snapshot
Variable Outcomes in Neural Differentiation of Human PSCs Arise from Intrinsic Differences in Developmental Signaling Pathways
inferred← citeshttps://doi.org/10.1016/j.cels.2020.09.004openalex-snapshot
EpiMogrify Models H3K4me3 Data to Identify Signaling Molecules that Improve Cell Fate Control and Maintenance
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2025.110100openalex-snapshot
Precision medicine approach for in vitro modeling and computational screening of anti-epileptic drugs in pediatric epilepsy patients with SCN2A (R1629L) mutation
inferred← citeshttps://doi.org/10.1016/j.drudis.2018.01.011openalex-snapshot
Astrocytes as targets for drug discovery
inferred← citeshttps://doi.org/10.1016/j.ejcb.2024.151458openalex-snapshot
Paving the way to a neural fate – RNA signatures in naive and trans-differentiating mesenchymal stem cells
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109231openalex-snapshot
ApoE maintains neuronal integrity via microRNA and H3K27me3-mediated repression
inferred← citeshttps://doi.org/10.1016/j.jare.2023.01.006openalex-snapshot
Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2014.07.453openalex-snapshot
Production of neural stem cells from human pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.jchemneu.2020.101892openalex-snapshot
Cerebral and cerebellar histological changes in the rat animal model of rotenone induced parkinsonism can be ameliorated by bone marrow derived stem cell conditioned media
inferred← citeshttps://doi.org/10.1016/j.jconrel.2018.07.017openalex-snapshot
Cell reprogramming approaches in gene- and cell-based therapies for Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.jcyt.2018.03.037openalex-snapshot
Illustrating the potency of current Good Manufacturing Practice–compliant induced pluripotent stem cell lines as a source of multiple cell lineages using standardized protocols
inferred← citeshttps://doi.org/10.1016/j.jneumeth.2021.109284openalex-snapshot
Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2020.577425openalex-snapshot
Modelling multiple sclerosis using induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.mcn.2015.11.011openalex-snapshot
Human pluripotent stem cell models of Fragile X syndrome
inferred← citeshttps://doi.org/10.1016/j.mcn.2020.103532openalex-snapshot
Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics
inferred← citeshttps://doi.org/10.1016/j.mcn.2020.103533openalex-snapshot
Models of the blood-brain barrier using iPSC-derived cells
inferred← citeshttps://doi.org/10.1016/j.molmed.2015.09.003openalex-snapshot
Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases
inferred← citeshttps://doi.org/10.1016/j.nbd.2019.104562openalex-snapshot
Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs
inferred← citeshttps://doi.org/10.1016/j.nbd.2020.104788openalex-snapshot
Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) risk
inferred← citeshttps://doi.org/10.1016/j.nbd.2023.106230openalex-snapshot
An overall view of the most common experimental models for multiple sclerosis
inferred← citeshttps://doi.org/10.1016/j.neulet.2019.134681openalex-snapshot
Rapid differentiation of astrocytes from human embryonic stem cells
inferred← citeshttps://doi.org/10.1016/j.neulet.2020.135028openalex-snapshot
Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery
inferred← citeshttps://doi.org/10.1016/j.neuro.2014.10.007openalex-snapshot
Compounds with species and cell type specific toxicity identified in a 2000 compound drug screen of neural stem cells and rat mixed cortical neurons
inferred← citeshttps://doi.org/10.1016/j.neuro.2019.02.010openalex-snapshot
An industry perspective: A streamlined screening strategy using alternative models for chemical assessment of developmental neurotoxicity
inferred← citeshttps://doi.org/10.1016/j.neuron.2017.07.035openalex-snapshot
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1016/j.neuron.2022.02.010openalex-snapshot
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons
inferred← citeshttps://doi.org/10.1016/j.nsa.2026.107000openalex-snapshot
Special characteristics of human astrocytes and their roles in brain homeostasis
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2015.09.009openalex-snapshot
Human induced pluripotent stem cells in Parkinson's disease: A novel cell source of cell therapy and disease modeling
inferred← citeshttps://doi.org/10.1016/j.scr.2015.05.014openalex-snapshot
Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors
inferred← citeshttps://doi.org/10.1016/j.scr.2021.102458openalex-snapshot
Reliable Generation of Glial Enriched Progenitors from Human Fibroblast-Derived iPSCs
inferred← citeshttps://doi.org/10.1016/j.semcdb.2018.05.020openalex-snapshot
Decoding cell signalling and regulation of oligodendrocyte differentiation
inferred← citeshttps://doi.org/10.1016/j.stem.2016.10.015openalex-snapshot
Neural Subtype Specification from Human Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1016/j.stem.2021.12.008openalex-snapshot
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
inferred← citeshttps://doi.org/10.1016/j.stemcr.2014.12.002openalex-snapshot
Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors
inferred← citeshttps://doi.org/10.1016/j.stemcr.2017.05.011openalex-snapshot
Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1016/j.stemcr.2017.06.018openalex-snapshot
An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1016/j.stemcr.2017.12.021openalex-snapshot
Astrocytes Attenuate Mitochondrial Dysfunctions in Human Dopaminergic Neurons Derived from iPSC
inferred← citeshttps://doi.org/10.1016/j.stemcr.2018.01.021openalex-snapshot
Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models
inferred← citeshttps://doi.org/10.1016/j.stemcr.2018.08.019openalex-snapshot
Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1016/j.stemcr.2020.05.003openalex-snapshot
Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
inferred← citeshttps://doi.org/10.1016/j.stemcr.2021.09.013openalex-snapshot
Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3
inferred← citeshttps://doi.org/10.1016/j.ymthe.2021.01.001openalex-snapshot
The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.0c00067openalex-snapshot
A Defined and Scalable Peptide-Based Platform for the Generation of Human Pluripotent Stem Cell-Derived Astrocytes
inferred← citeshttps://doi.org/10.1021/acschemneuro.5c00197openalex-snapshot
Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media
inferred← citeshttps://doi.org/10.1038/cddis.2017.89openalex-snapshot
Aberrant iPSC-derived human astrocytes in Alzheimer's disease
inferred← citeshttps://doi.org/10.1038/ncomms3196openalex-snapshot
hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury
inferred← citeshttps://doi.org/10.1038/nrneurol.2016.171openalex-snapshot
Neuroinflammation — using big data to inform clinical practice
inferred← citeshttps://doi.org/10.1038/s41380-019-0468-3openalex-snapshot
Modeling Alzheimer’s disease with iPSC-derived brain cells
inferred← citeshttps://doi.org/10.1038/s41380-020-0786-5openalex-snapshot
N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells
inferred← citeshttps://doi.org/10.1038/s41380-020-0824-3openalex-snapshot
MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis
inferred← citeshttps://doi.org/10.1038/s41398-019-0535-1openalex-snapshot
Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes
inferred← citeshttps://doi.org/10.1038/s41551-018-0219-9openalex-snapshot
Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons
inferred← citeshttps://doi.org/10.1038/s41582-021-00578-6openalex-snapshot
Dissecting the complexities of Alzheimer disease with in vitro models of the human brain
inferred← citeshttps://doi.org/10.1038/s41597-024-03823-xopenalex-snapshot
A single-cell transcriptomic dataset of pluripotent stem cell-derived astrocytes via NFIB/SOX9 overexpression
inferred← citeshttps://doi.org/10.1038/s41598-018-38395-5openalex-snapshot
Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells
inferred← citeshttps://doi.org/10.1038/s41598-019-53414-9openalex-snapshot
Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system
inferred← citeshttps://doi.org/10.1038/s41598-021-99059-5openalex-snapshot
Soft surfaces promote astrocytic differentiation of mouse embryonic neural stem cells via dephosphorylation of MRLC in the absence of serum
inferred← citeshttps://doi.org/10.1038/s42256-021-00333-yopenalex-snapshot
Simultaneous deep generative modelling and clustering of single-cell genomic data
inferred← citeshttps://doi.org/10.1038/srep09205openalex-snapshot
A platform for rapid generation of single and multiplexed reporters in human iPSC lines
inferred← citeshttps://doi.org/10.1038/srep32025openalex-snapshot
Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation
inferred← citeshttps://doi.org/10.1042/ns20210027openalex-snapshot
3D hydrogel models of the neurovascular unit to investigate blood–brain barrier dysfunction
inferred← citeshttps://doi.org/10.1074/jbc.ra120.013352openalex-snapshot
The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene
inferred← citeshttps://doi.org/10.1080/17590914.2026.2673257openalex-snapshot
CD44 Knockout Alters the Cellular Response and Improves Locomotor Outcome After Spinal Cord Injury
inferred← citeshttps://doi.org/10.1089/aivt.2018.0025openalex-snapshot
Neurovascular Organotypic Culture Models Using Induced Pluripotent Stem Cells to Assess Adverse Chemical Exposure Outcomes
inferred← citeshttps://doi.org/10.1089/cell.2021.0172openalex-snapshot
Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming
inferred← citeshttps://doi.org/10.1089/scd.2013.0412openalex-snapshot
Genome Wide Profiling of Dopaminergic Neurons Derived from Human Embryonic and Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1089/scd.2014.0151openalex-snapshot
“Footprint-Free” Human Induced Pluripotent Stem Cell-Derived Astrocytes for In Vivo Cell-Based Therapy
inferred← citeshttps://doi.org/10.1089/scd.2015.0244openalex-snapshot
Enrichment of Oligodendrocyte Progenitors from Differentiated Neural Precursors by Clonal Sphere Preparations
inferred← citeshttps://doi.org/10.1089/scd.2017.0003openalex-snapshot
Paving the Way Toward Complex Blood-Brain Barrier Models Using Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1089/scd.2019.0007openalex-snapshot
Human Pluripotent Stem Cells as Tools for Predicting Developmental Neural Toxicity of Chemicals: Strategies, Applications, and Challenges
inferred← citeshttps://doi.org/10.1089/scd.2020.0138openalex-snapshot
Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells
inferred← citeshttps://doi.org/10.1093/hmg/ddaa003openalex-snapshot
Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics
inferred← citeshttps://doi.org/10.1093/hmg/ddx155openalex-snapshot
APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes
inferred← citeshttps://doi.org/10.1093/med/9780197549469.003.0064openalex-snapshot
New Models for Assessment of Antiseizure Activity
inferred← citeshttps://doi.org/10.1093/toxsci/kfae037openalex-snapshot
Pluripotent stem cells for target organ developmental toxicity testing
inferred← citeshttps://doi.org/10.1097/wnr.0000000000000064openalex-snapshot
Modeling astrocytic contribution toward neurodegeneration with pluripotent stem cells
inferred← citeshttps://doi.org/10.1098/rstb.2017.0214openalex-snapshot
Generation of defined neural populations from pluripotent stem cells
inferred← citeshttps://doi.org/10.1101/2020.08.17.254730openalex-snapshot
Simultaneous deep generative modeling and clustering of single cell genomic data
inferred← citeshttps://doi.org/10.1101/2023.08.23.554346openalex-snapshot
Altered metabolic function induced by amyloid-beta oligomers and PSEN1-mutations in iPSC-derived astrocytes
inferred← citeshttps://doi.org/10.1101/2023.11.24.568451openalex-snapshot
Increased FAN1 expression by mRNA-LNP attenuates CAG repeat expansion in Huntington patients’ iPSC-derived astrocytes
inferred← citeshttps://doi.org/10.1101/2024.03.14.585115openalex-snapshot
Impact of genomic background and developmental state on signaling pathways and response to therapy in glioblastoma patient-derived cells
inferred← citeshttps://doi.org/10.1101/2024.11.01.621156openalex-snapshot
Astrocytes control UP state and slow oscillation periodicity in human cortical networks
inferred← citeshttps://doi.org/10.1101/2025.05.30.657119openalex-snapshot
Detection of astrocyte epigenetic memory in in vitro systems, experimental autoimmune encephalomyelitis and multiple sclerosis samples
inferred← citeshttps://doi.org/10.1101/523233openalex-snapshot
Human and mouse iPSC-derived astrocyte subtypes reveal vulnerability in Vanishing White Matter
inferred← citeshttps://doi.org/10.1111/jnc.16014openalex-snapshot
Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC ‐derived models of Alzheimer's disease
inferred← citeshttps://doi.org/10.1111/jnc.16267openalex-snapshot
Altered metabolic function induced by Aβ‐oligomers and PSEN1 mutations in iPSC ‐derived astrocytes
inferred← citeshttps://doi.org/10.1113/jp270658openalex-snapshot
Stem cell‐derived astrocytes: are they physiologically credible?
inferred← citeshttps://doi.org/10.1126/scitranslmed.aaz6747openalex-snapshot
Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents
inferred← citeshttps://doi.org/10.1134/s1819712420040066openalex-snapshot
Generation and Characteristics of Glial Cells from Induced Human Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1142/9789814623186_0018openalex-snapshot
Neural Stem Cell Therapy for Spinal Cord Injury
inferred← citeshttps://doi.org/10.1142/9789814623186_0019openalex-snapshot
Generating Different Neural Cell Types from iPSCs for Screening and Cell Therapy for CNS Disorders
inferred← citeshttps://doi.org/10.1152/physiolgenomics.00130.2014openalex-snapshot
Identification of stable reference genes in differentiating human pluripotent stem cells
inferred← citeshttps://doi.org/10.1155/2019/7420189openalex-snapshot
Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1177/09636897211017829openalex-snapshot
Differentiation of Human Pluripotent Stem Cells Into Specific Neural Lineages
inferred← citeshttps://doi.org/10.1177/10738584211001753openalex-snapshot
Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches
inferred← citeshttps://doi.org/10.1177/1087057113501869openalex-snapshot
Functional Screening Assays with Neurons Generated from Pluripotent Stem Cell–Derived Neural Stem Cells
inferred← citeshttps://doi.org/10.1177/1087057115610055openalex-snapshot
Establishment of a Human Neuronal Network Assessment System by Using a Human Neuron/Astrocyte Co-Culture Derived from Fetal Neural Stem/Progenitor Cells
inferred← citeshttps://doi.org/10.1186/s11658-025-00765-zopenalex-snapshot
NT2-derived astrocyte–neuron co-culture reflects physiological relevance and offers research validity
inferred← citeshttps://doi.org/10.1186/s12575-024-00257-yopenalex-snapshot
Assessment and Evaluation of Contemporary Approaches for Astrocyte Differentiation from hiPSCs: A Modeling Paradigm for Alzheimer's Disease
inferred← citeshttps://doi.org/10.1186/s12915-020-00770-yopenalex-snapshot
Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation
inferred← citeshttps://doi.org/10.1186/s12974-019-1553-xopenalex-snapshot
Neuroinflammatory astrocytes generated from cord blood-derived human induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1186/s12974-023-02919-2openalex-snapshot
Human iPSC-derived glia models for the study of neuroinflammation
inferred← citeshttps://doi.org/10.1186/s12987-019-0147-4openalex-snapshot
Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood–brain barrier model
inferred← citeshttps://doi.org/10.1186/s13041-020-00658-6openalex-snapshot
Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia
inferred← citeshttps://doi.org/10.1186/s13287-025-04580-3openalex-snapshot
Small molecule-mediated rapid generation of functional human astrocytes: unveiling AKT1-STAT1/3 signaling in astrocyte development
inferred← citeshttps://doi.org/10.1201/9781315402185-7openalex-snapshot
6 Huntington’s Disease and Stem Cells
inferred← citeshttps://doi.org/10.12688/f1000research.12596.1openalex-snapshot
Recent advances in lineage differentiation from stem cells: hurdles and opportunities?
inferred← citeshttps://doi.org/10.1364/boe.524356openalex-snapshot
DHM/SERS reveals cellular morphology and molecular changes during iPSCs-derived activation of astrocytes
inferred← citeshttps://doi.org/10.1371/journal.pone.0073548openalex-snapshot
The Cytoskeletal Protein RHAMM and ERK1/2 Activity Maintain the Pluripotency of Murine Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0096139openalex-snapshot
Comparison of the Gene Expression Profiles of Human Fetal Cortical Astrocytes with Pluripotent Stem Cell Derived Neural Stem Cells Identifies Human Astrocyte Markers and Signaling Pathways and Transcription Factors Active in Human Astrocytes
inferred← citeshttps://doi.org/10.1371/journal.pone.0157276openalex-snapshot
The Regulation of rRNA Gene Transcription during Directed Differentiation of Human Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0214156openalex-snapshot
Amelioration of Huntington’s disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington’s disease monkeys
inferred← citeshttps://doi.org/10.1371/journal.pone.0315171openalex-snapshot
Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment
inferred← citeshttps://doi.org/10.1517/14712598.2014.922533openalex-snapshot
Self-renewal and cell lineage differentiation strategies in human embryonic stem cells and induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1517/17460441.2013.805199openalex-snapshot
Neural stem cells as tools for drug discovery: novel platforms and approaches
inferred← citeshttps://doi.org/10.15283/ijsc22008openalex-snapshot
Direct Conversion to Achieve Glial Cell Fates: Oligodendrocytes and Schwann Cells
inferred← citeshttps://doi.org/10.17343/sdutfd.743932openalex-snapshot
KLİNİK YÖNLERİYLE BİRLİKTE PLURİPOTENT KÖK HÜCRELERDEN SİNİR HÜCRELERİNE FARKLILAŞMA
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2348325/v1openalex-snapshot
Heparan Sulfate Proteoglycans as Markers in Human Neural Progenitor Cell Line Short-Term Lineage Differentiation
inferred← citeshttps://doi.org/10.2174/1389201020666191129103730openalex-snapshot
Approach to Neurotoxicity using Human iPSC Neurons: Consortium for Safety Assessment using Human iPS Cells
inferred← citeshttps://doi.org/10.21769/bioprotoc.4936openalex-snapshot
Generation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Astrocytes for Amyotrophic Lateral Sclerosis and Other Neurodegenerative Disease Studies
inferred← citeshttps://doi.org/10.2217/fnl-2017-0029openalex-snapshot
Pathological Human Astroglia in Alzheimer's Disease: Opening New Horizons with Stem Cell Technology
inferred← citeshttps://doi.org/10.25122/jml-2022-0346openalex-snapshot
Differentiation of neurosphere after transplantation into the damaged spinal cord
inferred← citeshttps://doi.org/10.26508/lsa.202201542openalex-snapshot
Building in vitro models of the brain to understand the role ofAPOEin Alzheimer’s disease
inferred← citeshttps://doi.org/10.29245/2578-2940/2018/1.1114openalex-snapshot
Modeling human pregnancy-associated developmental neurotoxicity in vitro using pluripotent stem cell-derived neurons and astrocytes
inferred← citeshttps://doi.org/10.31083/j.jin2002055openalex-snapshot
Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease
inferred← citeshttps://doi.org/10.3233/jad-230739openalex-snapshot
Systems Medicine as a Strategy to Deal with Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3233/jhd-160199openalex-snapshot
Induced Pluripotent Stem Cells in Huntington’s Disease Research: Progress and Opportunity
inferred← citeshttps://doi.org/10.3389/fcell.2017.00117openalex-snapshot
The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening
inferred← citeshttps://doi.org/10.3389/fcell.2020.544043openalex-snapshot
Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture Models
inferred← citeshttps://doi.org/10.3389/fcell.2023.1226604openalex-snapshot
Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons
inferred← citeshttps://doi.org/10.3389/fendo.2021.668517openalex-snapshot
Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective
inferred← citeshttps://doi.org/10.3389/fgene.2023.1198129openalex-snapshot
From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome
inferred← citeshttps://doi.org/10.3389/fnagi.2021.736580openalex-snapshot
Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease
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