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Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons

https://doi.org/10.1002/stem.1415
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1 of the 51 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1016/j.stem.2010.03.001 (notice 2023-06-01).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/stem.1060openalex-snapshot
Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC‐Derived Neural Cells in a Primate Model of Parkinson's Disease
inferredcites →https://doi.org/10.1002/stem.1152openalex-snapshot
Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells
inferredcites →https://doi.org/10.1002/stem.211openalex-snapshot
CD15, CD24, and CD29 Define a Surface Biomarker Code for Neural Lineage Differentiation of Stem Cells
inferredcites →https://doi.org/10.1002/stem.662openalex-snapshot
Development of Histocompatible Primate‐Induced Pluripotent Stem Cells for Neural Transplantation
inferredcites →https://doi.org/10.1006/exnr.2002.7891openalex-snapshot
Modeling Parkinson's Disease in Rats: An Evaluation of 6-OHDA Lesions of the Nigrostriatal Pathway
inferredcites →https://doi.org/10.1016/0014-2999(68)90164-7openalex-snapshot
6-hydroxy-dopamine induced degeneration of central monoamine neurons
inferredcites →https://doi.org/10.1016/0306-4522(84)90134-9openalex-snapshot
Dopamine and cholecystokinin immunoreactive neurones in mesencephalic grafts reinnervating the neostriatum: Evidence for selective growth regulation
inferredcites →https://doi.org/10.1016/0896-6273(95)90062-4openalex-snapshot
Induction of midbrain dopaminergic neurons by Sonic hedgehog
inferredcites →https://doi.org/10.1016/j.cell.2009.02.013openalex-snapshot
Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors
inferredcites →https://doi.org/10.1016/j.celrep.2012.04.009openalex-snapshot
Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions
inferredcites →https://doi.org/10.1016/j.expneurol.2005.01.007openalex-snapshot
Effect of intrastriatal 6-OHDA lesion on dopaminergic innervation of the rat cortex and globus pallidus
inferredcites →https://doi.org/10.1016/j.mcn.2010.06.017openalex-snapshot
Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid
inferredcites →https://doi.org/10.1016/j.nbd.2009.05.018openalex-snapshot
The blood–brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates—Evidence from in vivo neuroimaging studies
inferredcites →https://doi.org/10.1016/j.scr.2008.08.001openalex-snapshot
CD marker expression profiles of human embryonic stem cells and their neural derivatives, determined using flow-cytometric analysis, reveal a novel CD marker for exclusion of pluripotent stem cells
inferredcites →https://doi.org/10.1016/j.stem.2008.11.012openalex-snapshot
Isolation and Production of Cells Suitable for Human Therapy: Challenges Ahead
inferredcites →https://doi.org/10.1016/j.stem.2009.04.005openalex-snapshot
Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins
inferredcites →https://doi.org/10.1016/j.stem.2010.03.001openalex-snapshot
RETRACTED: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells
inferredcites →https://doi.org/10.1016/s0092-8674(00)81437-3openalex-snapshot
FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate
inferredcites →https://doi.org/10.1034/j.1399-3089.2003.01130.xopenalex-snapshot
Immune parameters relevant to neural xenograft survival in the primate brain
inferredcites →https://doi.org/10.1038/nature05934openalex-snapshot
Generation of germline-competent induced pluripotent stem cells
inferredcites →https://doi.org/10.1038/nature07863openalex-snapshot
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
inferredcites →https://doi.org/10.1038/nature07864openalex-snapshot
Virus-free induction of pluripotency and subsequent excision of reprogramming factors
inferredcites →https://doi.org/10.1038/nature09342openalex-snapshot
Epigenetic memory in induced pluripotent stem cells
inferredcites →https://doi.org/10.1038/nature10135openalex-snapshot
Immunogenicity of induced pluripotent stem cells
inferredcites →https://doi.org/10.1038/nature10648openalex-snapshot
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
inferredcites →https://doi.org/10.1038/nbt.1529openalex-snapshot
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
inferredcites →https://doi.org/10.1046/j.1440-169x.1997.t01-5-00009.xopenalex-snapshot
Expressions ofPDGF receptor alpha, c‐KitandFlk1genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells
inferredcites →https://doi.org/10.1073/pnas.022438099openalex-snapshot
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
inferredcites →https://doi.org/10.1073/pnas.1010209107openalex-snapshot
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats
inferredcites →https://doi.org/10.1074/jbc.m602632200openalex-snapshot
Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells
inferredcites →https://doi.org/10.1089/scd.2009.1806.ediopenalex-snapshot
Mitochondria: Determinants of Stem Cell Fate?
inferredcites →https://doi.org/10.1093/brain/awh510openalex-snapshot
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease
inferredcites →https://doi.org/10.1126/science.1172482openalex-snapshot
Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences
inferredcites →https://doi.org/10.1126/scitranslmed.3000976openalex-snapshot
Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson’s Patients with Neural Transplants
inferredcites →https://doi.org/10.1126/scitranslmed.3003985openalex-snapshot
Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease
inferredcites →https://doi.org/10.1172/jci58767openalex-snapshot
Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment
inferredcites →https://doi.org/10.1242/dev.02181openalex-snapshot
A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
inferredcites →https://doi.org/10.1242/dev.02879openalex-snapshot
Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells
inferredcites →https://doi.org/10.1258/0023677053739783openalex-snapshot
A novel method for activity monitoring in small non-human primates
inferredcites →https://doi.org/10.1371/journal.pone.0016734openalex-snapshot
Induction and Enhancement of Cardiac Cell Differentiation from Mouse and Human Induced Pluripotent Stem Cells with Cyclosporin-A
inferredcites →https://doi.org/10.1371/journal.pone.0017540openalex-snapshot
Cell-Surface Marker Signatures for the Isolation of Neural Stem Cells, Glia and Neurons Derived from Human Pluripotent Stem Cells
inferredcites →https://doi.org/10.1523/jneurosci.1676-05.2005openalex-snapshot
Identification of Dopaminergic Neurons of Nigral and Ventral Tegmental Area Subtypes in Grafts of Fetal Ventral Mesencephalon Based on Cell Morphology, Protein Expression, and Efferent Projections
inferredcites →https://doi.org/10.1634/stemcells.2004-0172openalex-snapshot
Long‐Term Survival of Dopamine Neurons Derived from Parthenogenetic Primate Embryonic Stem Cells (Cyno‐1) After Transplantation
inferredcites →https://doi.org/10.1634/stemcells.2005-0393openalex-snapshot
Transplantation of Human Embryonic Stem Cell-Derived Cells to a Rat Model of Parkinson's Disease: Effect of In Vitro Differentiation on Graft Survival and Teratoma Formation
inferredcites →https://doi.org/10.1634/stemcells.2006-0380openalex-snapshot
Enhanced Yield of Neuroepithelial Precursors and Midbrain-Like Dopaminergic Neurons from Human Embryonic Stem Cells Using the Bone Morphogenic Protein Antagonist Noggin
inferredcites →https://doi.org/10.1634/stemcells.2006-0744openalex-snapshot
Markers and Methods for Cell Sorting of Human Embryonic Stem Cell-Derived Neural Cell Populations
inferredcites →https://doi.org/10.1634/stemcells.2007-0996openalex-snapshot
Embryonic Stem Cell-Derived Pitx3-Enhanced Green Fluorescent Protein Midbrain Dopamine Neurons Survive Enrichment by Fluorescence-Activated Cell Sorting and Function in an Animal Model of Parkinson's Disease
inferredcites →https://doi.org/10.2217/rme.10.58openalex-snapshot
Similarly Derived and Cultured HEsc Lines Show Variation in their Developmental Potential Towards Neuronal Cells in Long-Term Culture
inferredcites →https://doi.org/10.2967/jnumed.109.066811openalex-snapshot
Dopamine Cell Implantation in Parkinson's Disease: Long-Term Clinical and 18F-FDOPA PET Outcomes
inferredcites →https://doi.org/10.3727/096368910x527266openalex-snapshot
Markers of Pluripotency and Differentiation in Human Neural Precursor Cells Derived from Embryonic Stem Cells and CNS Tissue
inferredcites →https://doi.org/10.3727/096368912x647144openalex-snapshot
Intracerebral Transplantation of Differentiated Human Embryonic Stem Cells to Hemiparkinsonian Monkeys

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4818803openalex-extracted
Roles of Ipsc in Advancing Treatments for Neurological Disorders
inferred← citeshttps://doi.org/10.1002/9781118308295.ch1openalex-snapshot
Neural Differentiation of Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1002/advs.202103827openalex-snapshot
Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: A Longitudinal Study in a Macaque Model of Parkinson's Disease
inferred← citeshttps://doi.org/10.1002/bies.202400118openalex-snapshot
The history and status of dopamine cell therapies for Parkinson's disease
inferred← citeshttps://doi.org/10.1002/cne.23617openalex-snapshot
Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell–derived neural progenitor cells
inferred← citeshttps://doi.org/10.1002/cpz1.88openalex-snapshot
Autologous Induced Pluripotent Stem Cell–Based Cell Therapies: Promise, Progress, and Challenges
inferred← citeshttps://doi.org/10.1002/ibra.12189openalex-snapshot
Somatic cell reprogramming for Parkinson's disease treatment
inferred← citeshttps://doi.org/10.1002/inmd.70137openalex-snapshot
The regulation of stem cell fate and its application in neural regeneration
inferred← citeshttps://doi.org/10.1002/jcp.27182openalex-snapshot
Stem cell‐based therapy for Parkinson’s disease with a focus on human endometrium‐derived mesenchymal stem cells
inferred← citeshttps://doi.org/10.1002/jcp.29800openalex-snapshot
Induced pluripotent stem cells (iPSCs) as game‐changing tools in the treatment of neurodegenerative disease: Mirage or reality?
inferred← citeshttps://doi.org/10.1002/mds.26113openalex-snapshot
Stem cell reprogramming: Basic implications and future perspective for movement disorders
inferred← citeshttps://doi.org/10.1002/sctm.18-0036openalex-snapshot
Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons
inferred← citeshttps://doi.org/10.1002/stem.1708openalex-snapshot
Wnt/β-Catenin Signaling Is Required to Rescue Midbrain Dopaminergic Progenitors and Promote Neurorepair in Ageing Mouse Model of Parkinson’s Disease
inferred← citeshttps://doi.org/10.1002/stem.2450openalex-snapshot
Concise Review: Human Embryonic Stem Cells—What Have We Done? What Are We Doing? Where Are We Going?
inferred← citeshttps://doi.org/10.1002/stem.2992openalex-snapshot
Interaction Between Sympk and Oct4 Promotes Mouse Embryonic Stem Cell Proliferation
inferred← citeshttps://doi.org/10.1007/7651_2014_159openalex-snapshot
Induced Pluripotent Stem Cells from Nonhuman Primates
inferred← citeshttps://doi.org/10.1007/978-1-0716-0655-1_3openalex-snapshot
Engraftable Induced Pluripotent Stem Cell-Derived Neural Precursors for Brain Repair
inferred← citeshttps://doi.org/10.1007/978-1-4939-9007-8_8openalex-snapshot
Midbrain Dopaminergic Neurons Differentiated from Human-Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1007/978-3-030-45493-7_1openalex-snapshot
Modeling Neurodevelopmental Deficits in Tuberous Sclerosis Complex with Stem Cell Derived Neural Precursors and Neurons
inferred← citeshttps://doi.org/10.1007/978-3-030-97641-5_3openalex-snapshot
Cell-Based Therapy and Genome Editing in Parkinson’s Disease: Quo Vadis?
inferred← citeshttps://doi.org/10.1007/978-3-031-89307-0_13openalex-snapshot
Dopaminergic-Induced Pluripotent Stem Cells for Parkinson’s Disease
inferred← citeshttps://doi.org/10.1007/978-3-319-29149-9_4openalex-snapshot
Stem Cells in Diseases of Aging
inferred← citeshttps://doi.org/10.1007/978-3-319-30582-0_12openalex-snapshot
Derivation of Dopaminergic Neurons from Human Pluripotent Stem Cells Using a Defined System and/or Small Molecules
inferred← citeshttps://doi.org/10.1007/978-3-319-53889-1_23openalex-snapshot
Stem Cell Technology for (Epi)genetic Brain Disorders
inferred← citeshttps://doi.org/10.1007/978-81-322-2110-4_1openalex-snapshot
Promises of Stem Cell Research and Therapeutics
inferred← citeshttps://doi.org/10.1007/978-981-15-4370-8_3openalex-snapshot
Stem Cell Therapy for Parkinson’s Disease
inferred← citeshttps://doi.org/10.1007/978-981-99-2452-3_17openalex-snapshot
Stem Cells Therapy for Cartilage Regeneration in Clinic: Challenges and Opportunities
inferred← citeshttps://doi.org/10.1007/s00018-015-2028-6openalex-snapshot
Canonical and noncanonical Wnt signaling in neural stem/progenitor cells
inferred← citeshttps://doi.org/10.1007/s00702-017-1708-9openalex-snapshot
The role of nonhuman primate models in the development of cell-based therapies for Parkinson’s disease
inferred← citeshttps://doi.org/10.1007/s00702-017-1722-yopenalex-snapshot
Non-human primate models of PD to test novel therapies
inferred← citeshttps://doi.org/10.1007/s10561-020-09896-3openalex-snapshot
Stem cell-based therapy as a promising approach in Alzheimer's disease: current perspectives on novel treatment
inferred← citeshttps://doi.org/10.1007/s10571-014-0071-8openalex-snapshot
Repression of SIRT1 Promotes the Differentiation of Mouse Induced Pluripotent Stem Cells into Neural Stem Cells
inferred← citeshttps://doi.org/10.1007/s11064-019-02781-wopenalex-snapshot
In Vivo Phenotyping of Familial Parkinson’s Disease with Human Induced Pluripotent Stem Cells: A Proof-of-Concept Study
inferred← citeshttps://doi.org/10.1007/s12015-015-9623-7openalex-snapshot
Comparison of Human Primary with Human iPS Cell-Derived Dopaminergic Neuron Grafts in the Rat Model for Parkinson’s Disease
inferred← citeshttps://doi.org/10.1007/s12015-017-9717-5openalex-snapshot
Understanding Parkinson’s Disease through the Use of Cell Reprogramming
inferred← citeshttps://doi.org/10.1007/s12015-019-09906-2openalex-snapshot
A Gutsy Move for Cell-Based Regenerative Medicine in Parkinson’s Disease: Targeting the Gut Microbiome to Sequester Inflammation and Neurotoxicity
inferred← citeshttps://doi.org/10.1007/s12015-021-10262-3openalex-snapshot
Review of the Current Trends in Clinical Trials Involving Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1007/s12035-018-1232-4openalex-snapshot
Misfolded Protein Linked Strategies Toward Biomarker Development for Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.1007/s12035-018-1419-8openalex-snapshot
Cellular and Molecular Aspects of Parkinson Treatment: Future Therapeutic Perspectives
inferred← citeshttps://doi.org/10.1016/b978-0-12-410396-2.00029-3openalex-snapshot
The Application and Future of Neural Stem Cells in Regenerative Medicine
inferred← citeshttps://doi.org/10.1016/b978-0-12-822228-7.00002-3openalex-snapshot
Induced pluripotent stem cells from nonhuman primates
inferred← citeshttps://doi.org/10.1016/b978-0-12-822229-4.00005-xopenalex-snapshot
iPSCs and cell therapy for Parkinson’s disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-822277-5.00002-xopenalex-snapshot
Differentiation of Purkinje cells from pluripotent stem cells for disease phenotyping in vitro
inferred← citeshttps://doi.org/10.1016/b978-0-12-823882-0.00006-0openalex-snapshot
Applications of human induced pluripotent stem cell and human embryonic stem cell models for substance use disorders
inferred← citeshttps://doi.org/10.1016/b978-0-323-85764-2.00005-3openalex-snapshot
Investigating the pathophysiology of anorexia nervosa using induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/b978-0-323-85765-9.00008-4openalex-snapshot
Human induced pluripotent stem cell modeling of neurofibromatosis type 1
inferred← citeshttps://doi.org/10.1016/b978-0-323-90120-8.00010-1openalex-snapshot
Autologous vs heterologous cell replacement strategies for Parkinson disease and other neurologic diseases
inferred← citeshttps://doi.org/10.1016/bs.pbr.2016.11.002openalex-snapshot
Mechanisms and use of neural transplants for brain repair
inferred← citeshttps://doi.org/10.1016/bs.pbr.2016.11.003openalex-snapshot
Ex vivo gene therapy for the treatment of neurological disorders
inferred← citeshttps://doi.org/10.1016/bs.pbr.2017.02.008openalex-snapshot
Strategies for bringing stem cell-derived dopamine neurons to the clinic—The NYSTEM trial
inferred← citeshttps://doi.org/10.1016/j.bbagen.2014.11.010openalex-snapshot
Oxidative stress, redox regulation and diseases of cellular differentiation
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.12.188openalex-snapshot
Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons
inferred← citeshttps://doi.org/10.1016/j.brainres.2015.06.054openalex-snapshot
Cell therapy for Parkinson׳s disease: Functional role of the host immune response on survival and differentiation of dopaminergic neuroblasts
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2025.111297openalex-snapshot
Advantages and challenges of using allogeneic vs. autologous sources for neuronal cell replacement in Parkinson’s disease: Insights from non-human primate studies
inferred← citeshttps://doi.org/10.1016/j.ejphar.2015.03.041openalex-snapshot
From mice to mind: Strategies and progress in translating neuroregeneration
inferred← citeshttps://doi.org/10.1016/j.expneurol.2014.01.007openalex-snapshot
Neonatal immune-tolerance in mice does not prevent xenograft rejection
inferred← citeshttps://doi.org/10.1016/j.inat.2026.102291openalex-snapshot
Neurosurgical treatments for Parkinson's disease: A narrative review
inferred← citeshttps://doi.org/10.1016/j.jconrel.2018.07.017openalex-snapshot
Cell reprogramming approaches in gene- and cell-based therapies for Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.jcyt.2015.02.001openalex-snapshot
Human induced pluripotent stem cell–derived neurons improve motor asymmetry in a 6-hydroxydopamine–induced rat model of Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.jcyt.2018.02.371openalex-snapshot
Intrastriatal transplantation of stem cells from human exfoliated deciduous teeth reduces motor defects in Parkinsonian rats
inferred← citeshttps://doi.org/10.1016/j.jneumeth.2015.01.027openalex-snapshot
X-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation
inferred← citeshttps://doi.org/10.1016/j.mcn.2015.10.002openalex-snapshot
Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice
inferred← citeshttps://doi.org/10.1016/j.molmed.2016.05.010openalex-snapshot
iPSCs: On the Road to Reprogramming Aging
inferred← citeshttps://doi.org/10.1016/j.nbd.2015.04.003openalex-snapshot
Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.nbd.2021.105587openalex-snapshot
Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons
inferred← citeshttps://doi.org/10.1016/j.nbt.2014.05.001openalex-snapshot
Application of human induced pluripotent stem cells for modeling and treating neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.neuint.2022.105324openalex-snapshot
Therapeutic function of iPSCs-derived primitive neuroepithelial cells in a rat model of Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.neulet.2014.04.019openalex-snapshot
Brn4 and TH synergistically promote the differentiation of neural stem cells into dopaminergic neurons
inferred← citeshttps://doi.org/10.1016/j.neulet.2016.05.032openalex-snapshot
Efficient generation of dopaminergic-like neurons by overexpression of Nurr1 and Pitx3 in mouse induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1016/j.neures.2021.08.002openalex-snapshot
Modeling schizophrenia with iPS cell technology and disease mouse models
inferred← citeshttps://doi.org/10.1016/j.neuron.2015.02.023openalex-snapshot
Cell-Based Screening: Extracting Meaning from Complex Data
inferred← citeshttps://doi.org/10.1016/j.neuron.2015.03.002openalex-snapshot
Moving Stem Cells to the Clinic: Potential and Limitations for Brain Repair
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2015.10.008openalex-snapshot
Purinergic receptors in embryonic and adult neurogenesis
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2017.03.035openalex-snapshot
Recovery from experimental parkinsonism by intrastriatal application of erythropoietin or EPO-releasing neural precursors
inferred← citeshttps://doi.org/10.1016/j.nsa.2026.106988openalex-snapshot
Differentiation of human iPSCs into dopaminergic neurons: comparative analysis of 2D and 3D protocols for disease modeling and pharmacology
inferred← citeshttps://doi.org/10.1016/j.parkreldis.2015.05.011openalex-snapshot
First-in-human cell transplant trials in Parkinson's disease: The need for an improved informed consent process
inferred← citeshttps://doi.org/10.1016/j.pbb.2020.173060openalex-snapshot
Classic and evolving animal models in Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2015.09.009openalex-snapshot
Human induced pluripotent stem cells in Parkinson's disease: A novel cell source of cell therapy and disease modeling
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2018.04.005openalex-snapshot
Pluripotent stem cell-based therapy for Parkinson’s disease: Current status and future prospects
inferred← citeshttps://doi.org/10.1016/j.reprotox.2021.06.009openalex-snapshot
Evaluation of atrazine neurodevelopment toxicity in vitro-application of hESC-based neural differentiation model
inferred← citeshttps://doi.org/10.1016/j.scr.2016.08.013openalex-snapshot
Advantages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.scr.2020.101908openalex-snapshot
Mesenchymal stem cells modulate misfolded α-synuclein in parkinsonian disorders: A multitarget disease-modifying strategy
inferred← citeshttps://doi.org/10.1016/j.stem.2015.01.018openalex-snapshot
Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease
inferred← citeshttps://doi.org/10.1016/j.stem.2016.12.014openalex-snapshot
Seq-ing Markers of Midbrain Dopamine Neurons
inferred← citeshttps://doi.org/10.1016/j.stem.2020.02.011openalex-snapshot
Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery
inferred← citeshttps://doi.org/10.1016/j.stem.2021.01.005openalex-snapshot
Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use
inferred← citeshttps://doi.org/10.1016/j.stemcr.2013.08.007openalex-snapshot
Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate
inferred← citeshttps://doi.org/10.1016/j.stemcr.2014.01.013openalex-snapshot
Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation
inferred← citeshttps://doi.org/10.1016/j.stemcr.2014.03.001openalex-snapshot
Detailed Analysis of the Genetic and Epigenetic Signatures of iPSC-Derived Mesodiencephalic Dopaminergic Neurons
inferred← citeshttps://doi.org/10.1016/j.stemcr.2016.02.008openalex-snapshot
Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1
inferred← citeshttps://doi.org/10.1016/j.stemcr.2017.02.003openalex-snapshot
Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives
inferred← citeshttps://doi.org/10.1016/j.stemcr.2017.08.002openalex-snapshot
A PITX3 -EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1016/j.stemcr.2018.11.021openalex-snapshot
Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation
inferred← citeshttps://doi.org/10.1016/j.ymthe.2017.06.015openalex-snapshot
Efficient Generation of Dopamine Neurons by Synthetic Transcription Factor mRNAs
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.9b01585openalex-snapshot
Gelator Length Precisely Tunes Supramolecular Hydrogel Stiffness and Neuronal Phenotype in 3D Culture
inferred← citeshttps://doi.org/10.1021/acschemneuro.8b00389openalex-snapshot
Progress in Dopaminergic Cell Replacement and Regenerative Strategies for Parkinson’s Disease
inferred← citeshttps://doi.org/10.1038/celldisc.2015.12openalex-snapshot
Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model
inferred← citeshttps://doi.org/10.1038/s41380-018-0018-4openalex-snapshot
Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin
inferred← citeshttps://doi.org/10.1038/s41380-021-01273-0openalex-snapshot
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
inferred← citeshttps://doi.org/10.1038/s41419-019-2133-9openalex-snapshot
Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors
inferred← citeshttps://doi.org/10.1038/s41420-020-00351-6openalex-snapshot
22(R)-hydroxycholesterol for dopaminergic neuronal specification of MSCs and amelioration of Parkinsonian symptoms in rats
inferred← citeshttps://doi.org/10.1038/s41422-024-00971-yopenalex-snapshot
Past, present, and future of cell replacement therapy for parkinson’s disease: a novel emphasis on host immune responses
inferred← citeshttps://doi.org/10.1038/s41467-021-23113-zopenalex-snapshot
16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro
inferred← citeshttps://doi.org/10.1038/s41536-019-0066-7openalex-snapshot
Combination of stem cell and gene therapy ameliorates symptoms in Huntington’s disease mice
inferred← citeshttps://doi.org/10.1038/s41536-020-00100-4openalex-snapshot
Global trends in clinical trials involving pluripotent stem cells: a systematic multi-database analysis
inferred← citeshttps://doi.org/10.1038/s41576-019-0100-zopenalex-snapshot
Induced pluripotent stem cells in disease modelling and drug discovery
inferred← citeshttps://doi.org/10.1038/s41583-019-0257-7openalex-snapshot
The future of stem cell therapies for Parkinson disease
inferred← citeshttps://doi.org/10.1038/s41593-018-0221-2openalex-snapshot
Selective vulnerability in neurodegenerative diseases
inferred← citeshttps://doi.org/10.1038/s41598-018-19291-4openalex-snapshot
Using intracellular markers to identify a novel set of surface markers for live cell purification from a heterogeneous hIPSC culture
inferred← citeshttps://doi.org/10.1038/s41598-022-22158-4openalex-snapshot
Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons
inferred← citeshttps://doi.org/10.1038/s41598-025-85811-8openalex-snapshot
MRI-guided focused ultrasound for treating Parkinson’s disease with human mesenchymal stem cells
inferred← citeshttps://doi.org/10.1038/s42005-023-01242-9openalex-snapshot
Morphogenesis in space offers challenges and opportunities for soft matter and biophysics
inferred← citeshttps://doi.org/10.1038/srep40573openalex-snapshot
Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform
inferred← citeshttps://doi.org/10.1039/c4ra13835jopenalex-snapshot
Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine
inferred← citeshttps://doi.org/10.1073/pnas.1501989112openalex-snapshot
Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors
inferred← citeshttps://doi.org/10.1080/10408363.2019.1571478openalex-snapshot
Dental stem cells as a promising source for cell therapies in neurological diseases
inferred← citeshttps://doi.org/10.1080/21655979.2020.1870074openalex-snapshot
The importance of cell culture parameter standardization: an assessment of the robustness of the 2102Ep reference cell line
inferred← citeshttps://doi.org/10.1088/2516-1091/acce12openalex-snapshot
The potential of in vitro neuronal networks cultured on micro electrode arrays for biomedical research
inferred← citeshttps://doi.org/10.1089/cell.2016.0034openalex-snapshot
Recent Advances in Therapeutic Applications of Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1089/scd.2015.0394openalex-snapshot
Fail-Safe Therapy by Gamma-Ray Irradiation Against Tumor Formation by Human-Induced Pluripotent Stem Cell-Derived Neural Progenitors
inferred← citeshttps://doi.org/10.1093/hmg/ddz184openalex-snapshot
Intravenous infusion of iPSC-derived neural precursor cells increases acid β-glucosidase function in the brain and lessens the neuronopathic phenotype in a mouse model of Gaucher disease
inferred← citeshttps://doi.org/10.1097/wnr.0000000000000058openalex-snapshot
Human foetal brain tissue as quality control when developing stem cells towards cell replacement therapy for neurological diseases
inferred← citeshttps://doi.org/10.1098/rstb.2014.0370openalex-snapshot
Treatment of Parkinson's disease using cell transplantation
inferred← citeshttps://doi.org/10.1101/2020.07.08.192591openalex-snapshot
Human embryonic stem cells-derived dopaminergic neurons transplanted in parkinsonian monkeys recover dopamine levels and motor behavior
inferred← citeshttps://doi.org/10.1101/2020.10.28.359224openalex-snapshot
Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity
inferred← citeshttps://doi.org/10.1101/2025.10.26.684610openalex-snapshot
Recapitulating Parkinson’s pathology in human iPSC dopaminergic neurons reveals new mechanistic insights into Lewy body formation and heterogeneity
inferred← citeshttps://doi.org/10.1101/741108openalex-snapshot
Brunner Syndrome associated MAOA dysfunction in human induced dopaminergic neurons results in dysregulated NMDAR expression and increased network activity
inferred← citeshttps://doi.org/10.1111/cpr.12229openalex-snapshot
Induced pluripotent stem cells and Parkinson's disease: modelling and treatment
inferred← citeshttps://doi.org/10.1111/ejn.13504openalex-snapshot
In vitro differentiation of neural stem cells derived from human olfactory bulb into dopaminergic‐like neurons
inferred← citeshttps://doi.org/10.1111/joim.12415openalex-snapshot
Clinical translation of stem cell transplantation in Parkinson's disease
inferred← citeshttps://doi.org/10.1111/joim.12475openalex-snapshot
Brain repair and reprogramming: the route to clinical translation
inferred← citeshttps://doi.org/10.1126/sciadv.aed8851openalex-snapshot
Modeling Parkinson’s pathology in human iPSC dopaminergic neurons uncovers key mechanisms of Lewy body formation and heterogeneity
inferred← citeshttps://doi.org/10.1136/jnnp-2015-312036openalex-snapshot
Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges
inferred← citeshttps://doi.org/10.1142/9789814623186_0019openalex-snapshot
Generating Different Neural Cell Types from iPSCs for Screening and Cell Therapy for CNS Disorders
inferred← citeshttps://doi.org/10.1155/2016/5683097openalex-snapshot
The Preclinical Research Progress of Stem Cells Therapy in Parkinson’s Disease
inferred← citeshttps://doi.org/10.1155/2016/6484713openalex-snapshot
The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside
inferred← citeshttps://doi.org/10.1155/2017/5472752openalex-snapshot
Hyperbolic Modeling of Subthalamic Nucleus Cells to Investigate the Effect of Dopamine Depletion
inferred← citeshttps://doi.org/10.1166/jbt.2023.3341openalex-snapshot
A Modified Differentiation Protocol In Vitro to Generate Dopaminergic Neurons from Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1177/1759091416676147openalex-snapshot
Grafted Neural Precursors Integrate Into Mouse Striatum, Differentiate and Promote Recovery of Function Through Release of Erythropoietin in MPTP-Treated Mice
inferred← citeshttps://doi.org/10.1186/s10020-023-00691-wopenalex-snapshot
TERC haploid cell reprogramming: a novel therapeutic strategy for aplastic anemia
inferred← citeshttps://doi.org/10.1186/s13287-025-04614-wopenalex-snapshot
Mesenchymal stem cell therapies for ARDS: translational promise and challenges
inferred← citeshttps://doi.org/10.1186/s40035-015-0039-8openalex-snapshot
Development of stem cell-based therapy for Parkinson’s disease
inferred← citeshttps://doi.org/10.1186/s40035-019-0180-xopenalex-snapshot
Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease
inferred← citeshttps://doi.org/10.1186/s41702-017-0004-5openalex-snapshot
Direct conversion from skin fibroblasts to functional dopaminergic neurons for biomedical application
inferred← citeshttps://doi.org/10.1201/9781315402185-7openalex-snapshot
6 Huntington’s Disease and Stem Cells
inferred← citeshttps://doi.org/10.1242/dev.097394openalex-snapshot
How to make a midbrain dopaminergic neuron
inferred← citeshttps://doi.org/10.13005/bbra/1600openalex-snapshot
Stem Cell-Based Therapy in Human Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.13052/ijts2246-8765.2015.005openalex-snapshot
Stem Cell Therapy for Brain Tumors
inferred← citeshttps://doi.org/10.1371/journal.pone.0087388openalex-snapshot
Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons
inferred← citeshttps://doi.org/10.1371/journal.pone.0101185openalex-snapshot
Transplantation of Induced Pluripotent Stem Cells Improves Functional Recovery in Huntington's Disease Rat Model
inferred← citeshttps://doi.org/10.1371/journal.pone.0193195openalex-snapshot
Optimization of culture conditions for the derivation and propagation of baboon (Papio anubis) induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1515/revneuro-2015-0054openalex-snapshot
Recent approaches and challenges in iPSCs: modeling and cell-based therapy of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1517/14712598.2014.876986openalex-snapshot
Advances in stem-cell–generated transplantation therapy for Parkinson's disease
inferred← citeshttps://doi.org/10.1586/14737175.2015.1091727openalex-snapshot
Treating non-motor symptoms of Parkinson’s disease with transplantation of stem cells
inferred← citeshttps://doi.org/10.1684/abc.2020.1611openalex-snapshot
Dental stem cells: myth or hope in neuroregenerative medicine?
inferred← citeshttps://doi.org/10.17352/sscrt.000002openalex-snapshot
Stem Cell Therapy for Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.18679/cn11-6030/r.2015.009openalex-snapshot
Differentiated Cells Derived from Fetal Neural Stem Cells Improve Motor Deficits in a Rat Model of Parkinson's Disease
inferred← citeshttps://doi.org/10.21037/atm.2019.11.16openalex-snapshot
A compendious summary of Parkinson’s disease patient-derived iPSCs in the first decade
inferred← citeshttps://doi.org/10.21037/jtd.2017.02.77openalex-snapshot
Induced pluripotent stem cells, form in vitro tissue engineering to in vivo allogeneic transplantation
inferred← citeshttps://doi.org/10.21037/sci.2017.06.08openalex-snapshot
Cell replacement therapy is the remedial solution for treating Parkinson’s disease
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3266974/v1openalex-snapshot
APCDD1 outperforms other dopaminergic cell surface markers in benchmarking study
inferred← citeshttps://doi.org/10.2174/011574888x374086250602050549openalex-snapshot
Therapeutic Potential of PSC-derived Cell Transplantation in Parkinson's Disease: A Systematic Review and Meta-analysis of Preclinical Studies
inferred← citeshttps://doi.org/10.2174/1381612827666211115154450openalex-snapshot
Polyphenols and Stem Cells for Neuroregeneration in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
inferred← citeshttps://doi.org/10.2174/1389450120666181211164147openalex-snapshot
Potential Applications of Induced Pluripotent Stem Cells for Cardiovascular Diseases
inferred← citeshttps://doi.org/10.2217/nmt.14.26openalex-snapshot
The Potential of Alternate Sources of Cells for Neural Grafting in Parkinson’s and Huntington’s Disease
inferred← citeshttps://doi.org/10.2217/nnm-2017-0001openalex-snapshot
Gold Nanoparticles Enhance the Differentiation of Embryonic Stem Cells into Dopaminergic Neurons Via mTOR/p70S6K Pathway
inferred← citeshttps://doi.org/10.2217/rme-2018-0081openalex-snapshot
The Management of Risk and Investment in Cell Therapy Process Development: A Case Study for Neurodegenerative Disease
inferred← citeshttps://doi.org/10.2217/rme-2019-0076openalex-snapshot
From Protocol to Product: Ventral Midbrain Dopaminergic Neuron Differentiation for the Treatment of Parkinson’s Disease
inferred← citeshttps://doi.org/10.2217/rme.14.43openalex-snapshot
Stem Cell Therapies for Parkinson’s Disease: Are Trials Just Around the Corner?
inferred← citeshttps://doi.org/10.30565/medalanya.1459470openalex-snapshot
Effects of Collagen Coating, Fetal Bovine Serum Concentration, Differentiation Agents, and Neurotoxin Application on In Vitro Modeling of Parkinson's Disease Using SH-SY5Y Cell Culture
inferred← citeshttps://doi.org/10.3233/jpd-179002openalex-snapshot
Replacing Dopamine Neurons in Parkinson’s Disease: How did it happen?
inferred← citeshttps://doi.org/10.3233/jpd-212920openalex-snapshot
Human Embryonic Stem Cell-Derived Dopaminergic Grafts Alleviate L-DOPA Induced Dyskinesia
inferred← citeshttps://doi.org/10.33425/2639-9512.1059openalex-snapshot
Treating Parkinson Disease with Autologous Telomerase-Positive Stem Cells, Update 2021
inferred← citeshttps://doi.org/10.3389/fcell.2020.00443openalex-snapshot
Toward Generating Subtype-Specific Mesencephalic Dopaminergic Neurons in vitro
inferred← citeshttps://doi.org/10.3389/fcell.2020.00729openalex-snapshot
Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities
inferred← citeshttps://doi.org/10.3389/fnagi.2016.00117openalex-snapshot
A Compendium of Preparation and Application of Stem Cells in Parkinson's Disease: Current Status and Future Prospects
inferred← citeshttps://doi.org/10.3389/fnagi.2021.695718openalex-snapshot
Modeling Parkinson’s Disease: Not Only Rodents?
inferred← citeshttps://doi.org/10.3389/fnagi.2024.1354164openalex-snapshot
Human stem cell transplantation models of Alzheimer’s disease
inferred← citeshttps://doi.org/10.3389/fncel.2015.00097openalex-snapshot
Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson’s disease
inferred← citeshttps://doi.org/10.3389/fncel.2020.00058openalex-snapshot
Advantages and Recent Developments of Autologous Cell Therapy for Parkinson’s Disease Patients
inferred← citeshttps://doi.org/10.3389/fncel.2020.00146openalex-snapshot
Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective
inferred← citeshttps://doi.org/10.3389/fncel.2022.817198openalex-snapshot
Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase
inferred← citeshttps://doi.org/10.3389/fnins.2014.00016openalex-snapshot
Adult subventricular zone neural stem cells as a potential source of dopaminergic replacement neurons
inferred← citeshttps://doi.org/10.3389/fnins.2020.558532openalex-snapshot
Current Status of Stem Cell-Derived Therapies for Parkinson’s Disease: From Cell Assessment and Imaging Modalities to Clinical Trials
inferred← citeshttps://doi.org/10.3389/fsurg.2025.1504563openalex-snapshot
A review of regenerative medicine and tissue engineering with a focus on wound healing and anti-aging
inferred← citeshttps://doi.org/10.3390/bioengineering10040449openalex-snapshot
Human-Derived Cortical Neurospheroids Coupled to Passive, High-Density and 3D MEAs: A Valid Platform for Functional Tests
inferred← citeshttps://doi.org/10.3390/biom12030344openalex-snapshot
Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.3390/biomedicines12030549openalex-snapshot
Some Novel Therapies in Parkinson’s Disease: A Promising Path Forward or Not Yet? A Systematic Review of the Literature
inferred← citeshttps://doi.org/10.3390/cells10092319openalex-snapshot
Induced Pluripotent Stem Cells (iPSCs)—Roles in Regenerative Therapies, Disease Modelling and Drug Screening
inferred← citeshttps://doi.org/10.3390/cells10102558openalex-snapshot
Cell Transdifferentiation and Reprogramming in Disease Modeling: Insights into the Neuronal and Cardiac Disease Models and Current Translational Strategies
inferred← citeshttps://doi.org/10.3390/cells12232738openalex-snapshot
Human Embryonic Stem Cell-Derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Monkeys
inferred← citeshttps://doi.org/10.3390/cells8111438openalex-snapshot
iPSCs-Based Neural 3D Systems: A Multidimensional Approach for Disease Modeling and Drug Discovery
inferred← citeshttps://doi.org/10.3390/ijms21155467openalex-snapshot
Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies
inferred← citeshttps://doi.org/10.3390/ijms22073381openalex-snapshot
Current State-of-the-Art and Unresolved Problems in Using Human Induced Pluripotent Stem Cell-Derived Dopamine Neurons for Parkinson’s Disease Drug Development
inferred← citeshttps://doi.org/10.3390/ijms22169047openalex-snapshot
Combination of Drugs and Cell Transplantation: More Beneficial Stem Cell-Based Regenerative Therapies Targeting Neurological Disorders
inferred← citeshttps://doi.org/10.3390/ijms222212141openalex-snapshot
The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells
inferred← citeshttps://doi.org/10.3390/ijms24032523openalex-snapshot
From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson’s Disease Modeling and Regenerative Therapy
inferred← citeshttps://doi.org/10.3390/pharmaceutics15122656openalex-snapshot
Cell Therapy for Parkinson’s Disease
inferred← citeshttps://doi.org/10.3402/arb.v3.31772openalex-snapshot
Drug discovery toward successful cell transplantation therapy for Parkinson's disease using human pluripotent stem cells
inferred← citeshttps://doi.org/10.34172/jlms.2022.28openalex-snapshot
Photobiomodulation Therapy and Cell Therapy Improved Parkinson’s Diseases by Neuro-regeneration and Tremor Inhibition
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