On the public citation graph

Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors

https://doi.org/10.1007/128_2011_183

0 signed · 170 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1521-3773(19991216)38:24<3743::aid-anie3743>3.0.co;2-uopenalex-snapshot

The Design of Leadlike Combinatorial Libraries

inferredcites →https://doi.org/10.1002/3527608761openalex-snapshot

Fragment‐based Approaches in Drug Discovery

inferredcites →https://doi.org/10.1002/ana.20889openalex-snapshot

Amyloid load and cerebral atrophy in Alzheimer's disease: An 11C‐PIB positron emission tomography study

inferredcites →https://doi.org/10.1002/ana.410430316openalex-snapshot

Molecular mapping of alzheimer‐type dementia in Down's syndrome

inferredcites →https://doi.org/10.1002/anie.200462457openalex-snapshot

Virtual Exploration of the Small‐Molecule Chemical Universe below 160 Daltons

inferredcites →https://doi.org/10.1002/cmdc.200800132openalex-snapshot

Group Efficiency: A Guideline for Hits‐to‐Leads Chemistry

inferredcites →https://doi.org/10.1002/cmdc.200900251openalex-snapshot

Fragment‐Based Drug Discovery: A Practical Approach. Edited by Edward R. Zartler and Michael J. Shapiro.

inferredcites →https://doi.org/10.1002/cmdc.200900386openalex-snapshot

Thermodynamic Optimisation in Drug Discovery: A Case Study using Carbonic Anhydrase Inhibitors

inferredcites →https://doi.org/10.1002/cmr.a.20121openalex-snapshot

Theoretical analysis of the competition ligand‐based NMR experiments and selected applications to fragment screening and binding constant measurements

inferredcites →https://doi.org/10.1002/ddr.20289openalex-snapshot

Progress toward the development of a viable BACE‐1 inhibitor

inferredcites →https://doi.org/10.1002/mrc.1381openalex-snapshot

Competition STD NMR for the detection of high‐affinity ligands and NMR‐based screening

inferredcites →https://doi.org/10.1006/mcne.1999.0811openalex-snapshot

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

inferredcites →https://doi.org/10.1007/s10822-009-9264-5openalex-snapshot

Design of compound libraries for fragment screening

inferredcites →https://doi.org/10.1007/s10822-009-9280-5openalex-snapshot

Lessons for fragment library design: analysis of output from multiple screening campaigns

inferredcites →https://doi.org/10.1016/0006-8993(91)91553-dopenalex-snapshot

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

inferredcites →https://doi.org/10.1016/0006-8993(92)90778-8openalex-snapshot

Evidence for a substance P containing subpopulation in the primate suprachiasmatic nucleus

inferredcites →https://doi.org/10.1016/j.bmcl.2007.05.038openalex-snapshot

The role of molecular size in ligand efficiency

inferredcites →https://doi.org/10.1016/j.bmcl.2008.01.032openalex-snapshot

Tyramine fragment binding to BACE-1

inferredcites →https://doi.org/10.1016/j.bmcl.2010.06.089openalex-snapshot

Fragment-based discovery and optimization of BACE1 inhibitors

inferredcites →https://doi.org/10.1016/j.cbpa.2004.04.003openalex-snapshot

Pursuing the leadlikeness concept in pharmaceutical research

inferredcites →https://doi.org/10.1016/j.cbpa.2007.07.010openalex-snapshot

Fragment-based screening using X-ray crystallography and NMR spectroscopy

inferredcites →https://doi.org/10.1016/j.cbpa.2010.02.010openalex-snapshot

Drugging challenging targets using fragment-based approaches

inferredcites →https://doi.org/10.1016/j.copbio.2006.10.007openalex-snapshot

Fragment-based lead discovery: a chemical update

inferredcites →https://doi.org/10.1016/j.coph.2009.04.009openalex-snapshot

Recent progress in fragment-based lead discovery

inferredcites →https://doi.org/10.1016/j.ddtec.2010.11.003openalex-snapshot

Ligand efficiency as a guide in fragment hit selection and optimization

inferredcites →https://doi.org/10.1016/j.ddtec.2010.11.010openalex-snapshot

Fragment library design: efficiently hunting drugs in chemical space

inferredcites →https://doi.org/10.1016/j.ddtec.2010.11.012openalex-snapshot

Surface Plasmon Resonance biosensor analysis as a useful tool in FBDD

inferredcites →https://doi.org/10.1016/j.drudis.2008.07.005openalex-snapshot

Do enthalpy and entropy distinguish first in class from best in class?

inferredcites →https://doi.org/10.1016/j.drudis.2008.10.006openalex-snapshot

Two ‘Golden Ratio’ indices in fragment-based drug discovery

inferredcites →https://doi.org/10.1016/j.drudis.2008.11.007openalex-snapshot

Ligand efficiency and fragment-based drug discovery

inferredcites →https://doi.org/10.1016/j.drudis.2009.03.009openalex-snapshot

Transforming fragments into candidates: small becomes big in medicinal chemistry

inferredcites →https://doi.org/10.1016/j.drudis.2009.04.007openalex-snapshot

From fragment to clinical candidate—a historical perspective

inferredcites →https://doi.org/10.1016/j.drudis.2009.07.013openalex-snapshot

NMR methods in fragment screening: theory and a comparison with other biophysical techniques

inferredcites →https://doi.org/10.1016/j.drudis.2010.08.004openalex-snapshot

Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation

inferredcites →https://doi.org/10.1016/j.drudis.2010.08.013openalex-snapshot

Thermodynamics guided lead discovery and optimization

inferredcites →https://doi.org/10.1016/j.jalz.2007.11.008openalex-snapshot

The amyloid cascade hypothesis

inferredcites →https://doi.org/10.1016/j.jns.2006.02.006openalex-snapshot

Aβ42 gene vaccination reduces brain amyloid plaque burden in transgenic mice

inferredcites →https://doi.org/10.1016/j.sbi.2010.04.003openalex-snapshot

Structural biology in fragment-based drug design

inferredcites →https://doi.org/10.1016/s0079-6468(08)70097-3openalex-snapshot

7 Isothermal Titration Calorimetry in Drug Discovery

inferredcites →https://doi.org/10.1016/s0896-6273(03)00294-0openalex-snapshot

Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

inferredcites →https://doi.org/10.1016/s0896-6273(03)00810-9openalex-snapshot

BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

inferredcites →https://doi.org/10.1016/s0969-9961(03)00104-9openalex-snapshot

BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

inferredcites →https://doi.org/10.1016/s1359-6446(03)02831-9openalex-snapshot

A ‘Rule of Three’ for fragment-based lead discovery?

inferredcites →https://doi.org/10.1016/s1359-6446(04)03069-7openalex-snapshot

Ligand efficiency: a useful metric for lead selection

inferredcites →https://doi.org/10.1016/s1359-6446(05)03386-6openalex-snapshot

Ligand efficiency indices as guideposts for drug discovery

inferredcites →https://doi.org/10.1021/bi051040oopenalex-snapshot

Characterization of Autocatalytic Conversion of Precursor BACE1 by Heteronuclear NMR Spectroscopy

inferredcites →https://doi.org/10.1021/bi900017qopenalex-snapshot

Fragment-Based Discovery of Nonpeptidic BACE-1 Inhibitors Using Tethering

inferredcites →https://doi.org/10.1021/bi901061aopenalex-snapshot

Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays

inferredcites →https://doi.org/10.1021/ci000403iopenalex-snapshot

Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery

inferredcites →https://doi.org/10.1021/ci010366aopenalex-snapshot

Is There a Difference between Leads and Drugs? A Historical Perspective

inferredcites →https://doi.org/10.1021/ci049806zopenalex-snapshot

Design and Characterization of Libraries of Molecular Fragments for Use in NMR Screening against Protein Targets

inferredcites →https://doi.org/10.1021/ci600423uopenalex-snapshot

Virtual Exploration of the Chemical Universe up to 11 Atoms of C, N, O, F: Assembly of 26.4 Million Structures (110.9 Million Stereoisomers) and Analysis for New Ring Systems, Stereochemistry, Physicochemical Properties, Compound Classes, and Drug Discovery

inferredcites →https://doi.org/10.1021/ci900094mopenalex-snapshot

Simple Size-Independent Measure of Ligand Efficiency

inferredcites →https://doi.org/10.1021/ja000300gopenalex-snapshot

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)

inferredcites →https://doi.org/10.1021/ja000350lopenalex-snapshot

NMR-Based Screening of Proteins Containing 13C-Labeled Methyl Groups

inferredcites →https://doi.org/10.1021/ja0100120openalex-snapshot

Group Epitope Mapping by Saturation Transfer Difference NMR To Identify Segments of a Ligand in Direct Contact with a Protein Receptor

inferredcites →https://doi.org/10.1021/ja038128eopenalex-snapshot

A General NMR Method for Rapid, Efficient, and Reliable Biochemical Screening

inferredcites →https://doi.org/10.1021/ja0425942openalex-snapshot

Screening of Protein Kinases by ATP-STD NMR Spectroscopy

inferredcites →https://doi.org/10.1021/jm021053popenalex-snapshot

A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs

inferredcites →https://doi.org/10.1021/jm040031vopenalex-snapshot

Fragment-Based Drug Discovery

inferredcites →https://doi.org/10.1021/jm060511hopenalex-snapshot

Fragment-Based Drug Design: How Big Is Too Big?

inferredcites →https://doi.org/10.1021/jm0611962openalex-snapshot

Application of Fragment Screening by X-ray Crystallography to β-Secretase

inferredcites →https://doi.org/10.1021/jm061197uopenalex-snapshot

Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase

inferredcites →https://doi.org/10.1021/jm061242yopenalex-snapshot

Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

inferredcites →https://doi.org/10.1021/jm070825kopenalex-snapshot

Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation

inferredcites →https://doi.org/10.1021/jm070829popenalex-snapshot

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency

inferredcites →https://doi.org/10.1021/jm100009zopenalex-snapshot

Fragment-Based Deconstruction of Bcl-x L Inhibitors

inferredcites →https://doi.org/10.1021/jm100118xopenalex-snapshot

An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs

inferredcites →https://doi.org/10.1021/jm701122qopenalex-snapshot

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

inferredcites →https://doi.org/10.1021/jm701255bopenalex-snapshot

Ligand Binding Efficiency: Trends, Physical Basis, and Implications

inferredcites →https://doi.org/10.1021/jm8000373openalex-snapshot

Recent Developments in Fragment-Based Drug Discovery

inferredcites →https://doi.org/10.1021/jm801220aopenalex-snapshot

Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping

inferredcites →https://doi.org/10.1021/jm901408popenalex-snapshot

Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and Validation

inferredcites →https://doi.org/10.1021/jm901472uopenalex-snapshot

Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors

inferredcites →https://doi.org/10.1023/b:jnmr.0000032509.81283.d3openalex-snapshot

Letter to the Editor: Backbone Resonance Assignments of the 45.3 kDa Catalytic Domain of Human BACE1

inferredcites →https://doi.org/10.1038/85059openalex-snapshot

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

inferredcites →https://doi.org/10.1038/990107openalex-snapshot

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

inferredcites →https://doi.org/10.1038/990114openalex-snapshot

Purification and cloning of amyloid precursor protein β-secretase from human brain

inferredcites →https://doi.org/10.1038/nchem.217openalex-snapshot

The rise of fragment-based drug discovery

inferredcites →https://doi.org/10.1038/nchembio.163openalex-snapshot

Impact of linker strain and flexibility in the design of a fragment-based inhibitor

inferredcites →https://doi.org/10.1038/nm0706-780openalex-snapshot

Alzheimer disease: progress or profit?

inferredcites →https://doi.org/10.1038/nn1335openalex-snapshot

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

inferredcites →https://doi.org/10.1038/nrd1467openalex-snapshot

Fragment-based lead discovery

inferredcites →https://doi.org/10.1038/nrd2220openalex-snapshot

A decade of fragment-based drug design: strategic advances and lessons learned

inferredcites →https://doi.org/10.1038/nrd2314openalex-snapshot

Therapies for Alzheimer's disease

inferredcites →https://doi.org/10.1038/nrd2445openalex-snapshot

The influence of drug-like concepts on decision-making in medicinal chemistry

inferredcites →https://doi.org/10.1038/nrd2796openalex-snapshot

The influence of lead discovery strategies on the properties of drug candidates

inferredcites →https://doi.org/10.1038/nrd3054openalex-snapshot

Adding calorimetric data to decision making in lead discovery: a hot tip

inferredcites →https://doi.org/10.1038/nrm2101openalex-snapshot

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

inferredcites →https://doi.org/10.1042/bj3110001openalex-snapshot

The toxicity in vitro of β-amyloid protein

inferredcites →https://doi.org/10.1073/pnas.160115697openalex-snapshot

BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein

inferredcites →https://doi.org/10.1073/pnas.91.25.12243openalex-snapshot

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

inferredcites →https://doi.org/10.1093/brain/92.1.147openalex-snapshot

PRESENILE DEMENTIA AND ALZHEIMER'S DISEASE IN MONGOLISM

inferredcites →https://doi.org/10.1111/j.1365-2559.1988.tb02018.xopenalex-snapshot

Alzheimer's disease and Down's syndrome

inferredcites →https://doi.org/10.1126/science.1072994openalex-snapshot

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

inferredcites →https://doi.org/10.1126/science.1132341openalex-snapshot

Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

inferredcites →https://doi.org/10.1126/science.274.5292.1531openalex-snapshot

Discovering High-Affinity Ligands for Proteins: SAR by NMR

inferredcites →https://doi.org/10.1126/science.286.5440.735openalex-snapshot

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

inferredcites →https://doi.org/10.1126/science.286.5443.1255aopenalex-snapshot

BACE Maps to Chromosome 11 and a BACE Homolog, BACE2 , Reside in the Obligate Down Syndrome Region of Chromosome 21

inferredcites →https://doi.org/10.1126/science.290.5489.150openalex-snapshot

Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

inferredcites →https://doi.org/10.1126/science.7638621openalex-snapshot

A Familial Alzheimer's Disease Locus on Chromosome 1

inferredcites →https://doi.org/10.1152/physrev.2001.81.2.741openalex-snapshot

Alzheimer's Disease: Genes, Proteins, and Therapy

inferredcites →https://doi.org/10.1212/01.wnl.0000148604.77591.67openalex-snapshot

Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD

inferredcites →https://doi.org/10.1212/01.wnl.0000159740.16984.3copenalex-snapshot

Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial

inferredcites →https://doi.org/10.1212/01.wnl.0000159743.08996.99openalex-snapshot

Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease

inferredcites →https://doi.org/10.1523/jneurosci.2440-08.2008openalex-snapshot

BACE1 Knock-Outs Display Deficits in Activity-Dependent Potentiation of Synaptic Transmission at Mossy Fiber to CA3 Synapses in the Hippocampus

inferredcites →https://doi.org/10.1586/14737175.6.5.653openalex-snapshot

Immunization therapy in Alzheimer's disease

inferredcites →https://doi.org/10.1586/14737175.6.6.897openalex-snapshot

Therapeutic options in Alzheimer’s disease

inferredcites →https://doi.org/10.2174/092986710791111224openalex-snapshot

Contributions of Computational Chemistry and Biophysical Techniques to Fragment-Based Drug Discovery

inferredcites →https://doi.org/10.2174/138161206778793001openalex-snapshot

Vaccine Development for Alzheimers Disease

inferredcites →https://doi.org/10.2174/156720506775697098openalex-snapshot

Has the Amyloid Cascade Hypothesis for Alzheimers Disease been Proved?

inferredcites →https://doi.org/10.2174/1568026033392606openalex-snapshot

Design of Small Molecule Libraries for NMR Screening and Other Applications in Drug Discovery

inferredcites →https://doi.org/10.2174/156802607782341082openalex-snapshot

Fragment-Based Drug Discovery: What has it Achieved so Far?

inferredcites →https://doi.org/10.2174/978160805201110703010171openalex-snapshot

Fragment-Based Approaches to Lead Discovery

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/9780470559277.ch130118openalex-snapshot

Saturation Transfer Difference NMR for Fragment Screening

inferred← citeshttps://doi.org/10.1002/9781118681121.ch14openalex-snapshot

NMR Studies of Protein–Small Molecule Interactions for Drug Discovery

inferred← citeshttps://doi.org/10.1002/9781119099512.ch9openalex-snapshot

Protein‐Based NMR Methods Applied to Drug Discovery

inferred← citeshttps://doi.org/10.1002/9781119627784.ch4openalex-snapshot

Finding Cures for Alzheimer's Disease

inferred← citeshttps://doi.org/10.1002/9783527677016.ch6openalex-snapshot

Hit and Lead Identification from Fragments

inferred← citeshttps://doi.org/10.1002/9783527683604.ch14openalex-snapshot

BACE Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.201500441openalex-snapshot

High‐Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH

inferred← citeshttps://doi.org/10.1002/cmdc.202000756openalex-snapshot

Using NMR Spectroscopy in the Fragment‐Based Drug Discovery of Small‐Molecule Anticancer Targeted Therapies

inferred← citeshttps://doi.org/10.1007/128_2011_179openalex-snapshot

Fragment Screening Using X-Ray Crystallography

inferred← citeshttps://doi.org/10.1007/128_2011_180openalex-snapshot

Introduction to Fragment-Based Drug Discovery

inferred← citeshttps://doi.org/10.1007/128_2011_265openalex-snapshot

Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery

inferred← citeshttps://doi.org/10.1007/978-1-4939-2269-7_16openalex-snapshot

NMR Screening in Fragment-Based Drug Design: A Practical Guide

inferred← citeshttps://doi.org/10.1007/978-81-322-2172-2_25openalex-snapshot

Plant Pharmacogenomics: From Drug Discovery to Personalized Ethnomedicine

inferred← citeshttps://doi.org/10.1007/978-981-19-1953-4_5openalex-snapshot

Emerging Role of Structural and Systems Biology in Anticancer Therapeutics

inferred← citeshttps://doi.org/10.1007/s10822-013-9683-1openalex-snapshot

The importance of molecular complexity in the design of screening libraries

inferred← citeshttps://doi.org/10.1007/s10822-018-0160-8openalex-snapshot

In silico fragment-mapping method: a new tool for fragment-based/structure-based drug discovery

inferred← citeshttps://doi.org/10.1007/s12195-015-0421-8openalex-snapshot

Per-Residue Energy Footprints-Based Pharmacophore Modeling as an Enhanced In Silico Approach in Drug Discovery: A Case Study on the Identification of Novel β-Secretase1 (BACE1) Inhibitors as Anti-Alzheimer Agents

inferred← citeshttps://doi.org/10.1016/b978-0-12-396521-9.00004-8openalex-snapshot

Structural Biology and Anticancer Drug Design

inferred← citeshttps://doi.org/10.1016/b978-0-443-45105-8.00006-8openalex-snapshot

Approaches of computer-aided drug design/artificial intelligence in drug discovery

inferred← citeshttps://doi.org/10.1016/j.biochi.2012.02.002openalex-snapshot

Fragment-based design of small RNA binders: Promising developments and contribution of NMR

inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.08.028openalex-snapshot

Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations

inferred← citeshttps://doi.org/10.1016/j.jpha.2020.02.002openalex-snapshot

Drug target discovery by magnetic nanoparticles coupled mass spectrometry

inferred← citeshttps://doi.org/10.1016/j.pep.2017.11.009openalex-snapshot

Expression and purification of the human epidermal growth factor receptor extracellular domain

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01917openalex-snapshot

Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01195openalex-snapshot

Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.7b00483openalex-snapshot

HTS by NMR for the Identification of Potent and Selective Inhibitors of Metalloenzymes

inferred← citeshttps://doi.org/10.1021/cb300436copenalex-snapshot

Fragment Screening of GPCRs Using Biophysical Methods: Identification of Ligands of the Adenosine A2A Receptor with Novel Biological Activity

inferred← citeshttps://doi.org/10.1021/cr300314qopenalex-snapshot

Integrated Approach to Structure-Based Enzymatic Drug Design: Molecular Modeling, Spectroscopy, and Experimental Bioactivity

inferred← citeshttps://doi.org/10.1021/cr500043bopenalex-snapshot

NMR-Based Approaches for the Identification and Optimization of Inhibitors of Protein–Protein Interactions

inferred← citeshttps://doi.org/10.1021/jm301448popenalex-snapshot

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

inferred← citeshttps://doi.org/10.1021/jm301659nopenalex-snapshot

Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1038/srep11322openalex-snapshot

Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer’s mice

inferred← citeshttps://doi.org/10.1071/ch13255openalex-snapshot

Fragment-based Drug Discovery: the Shape of Things to Come

inferred← citeshttps://doi.org/10.1080/07391102.2017.1337590openalex-snapshot

Fragment-based virtual screening approach and molecular dynamics simulation studies for identification of BACE1 inhibitor leads

inferred← citeshttps://doi.org/10.1093/abbs/gmt050openalex-snapshot

Structure–activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease

inferred← citeshttps://doi.org/10.1111/cbdd.13489openalex-snapshot

Design, synthesis, and biological evaluation of 4‐aminopyrimidine or 4,6‐diaminopyrimidine derivatives as beta amyloid cleaving enzyme‐1 inhibitors

inferred← citeshttps://doi.org/10.11144/javeriana.10554.1567openalex-snapshot

Estudio de las propensiones conformacionales del amino acido l-glutamato en regiones altamente estructuradas de proteínas resueltas por cristalografía de rayos x

inferred← citeshttps://doi.org/10.11606/d.60.2016.tde-07062016-094346openalex-snapshot

Desenvolvimento de uma plataforma modelo para a busca de ligantes com potencial leishmanicida baseado na inibição seletiva da enzima diidroorotato desidrogenase

inferred← citeshttps://doi.org/10.1177/1087057112462237openalex-snapshot

Development and Characterization of a Novel Membrane Assay for Full-Length BACE-1 at pH 6.0

inferred← citeshttps://doi.org/10.1177/1087057113482138openalex-snapshot

Development of a Novel β-Secretase Binding Assay Using the AlphaScreen Platform

inferred← citeshttps://doi.org/10.1515/dmpt-2022-0109openalex-snapshot

Application of vibrational spectroscopy and nuclear magnetic resonance methods for drugs pharmacokinetics research

inferred← citeshttps://doi.org/10.1517/13543776.2014.859246openalex-snapshot

N-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-phenyl)-amides as BACE1 inhibitors: a patent evaluation of WO2013041499

inferred← citeshttps://doi.org/10.2147/dnnd.s41056openalex-snapshot

Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease

inferred← citeshttps://doi.org/10.2174/1568026615666150519102459openalex-snapshot

High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists

inferred← citeshttps://doi.org/10.2174/1568026622666220726092034openalex-snapshot

OMICs Technologies for Natural Compounds-based Drug Development

inferred← citeshttps://doi.org/10.24966/and-9608/100001openalex-snapshot

Enhancement of sAPPα as a Therapeutic Strategy for Alzheimer’s and Other Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.24966/and-9608/vol1iss1openalex-snapshot

inferred← citeshttps://doi.org/10.3109/14756366.2012.733384openalex-snapshot

Ligand design, synthesis and biological anti-HCV evaluations for genotypes 1b and 4a of certain 4-(3- & 4-[3-(3,5-dibromo-4-hydroxyphenyl)-propylamino]phenyl) butyric acids and 3-(3,5-dibromo-4-hydroxyphenyl)-propylamino-acetamidobenzoic acid esters

inferred← citeshttps://doi.org/10.3233/jad-2012-121537openalex-snapshot

Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes

inferred← citeshttps://doi.org/10.3389/fmolb.2020.00180openalex-snapshot

Application of Fragment-Based Drug Discovery to Versatile Targets

inferred← citeshttps://doi.org/10.3390/ijms131012857openalex-snapshot

Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls

inferred← citeshttps://doi.org/10.3390/molecules25204597openalex-snapshot

NMR as a “Gold Standard” Method in Drug Design and Discovery

inferred← citeshttps://doi.org/10.3410/f.717970223.793469655openalex-snapshot

Faculty Opinions recommendation of Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.

inferred← citeshttps://doi.org/10.4155/fmc.14.20openalex-snapshot

Halogen-Enriched Fragment Libraries as Chemical Probes for Harnessing Halogen Bonding in Fragment-Based Lead Discovery

inferred← citeshttps://doi.org/10.53846/goediss-9806openalex-snapshot

Structure-based Search for novel c-di-AMP Synthase Inhibiting Fragments

inferred← citeshttps://doi.org/10.70675/125f61bcza5b1z4576z81adz8851275eb661openalex-snapshot

Etude d'interactions protéine-ADN : Interactions Ku70/Ku80-ADN au sein de la voie NHEJ et caractérisation d'inhibiteurs d'une interaction protéine-ADN cible dans un contexte de recherche de médicaments

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.