On the public citation graph

A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?

https://doi.org/10.1007/7854_2016_57

0 signed · 370 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archgenpsychiatry.2011.49openalex-snapshot

Effects of Adrenal Sensitivity, Stress- and Cue-Induced Craving, and Anxiety on Subsequent Alcohol Relapse and Treatment Outcomes

inferredcites →https://doi.org/10.1002/(sici)1098-2396(199603)22:3<195::aid-syn1>3.0.co;2-7openalex-snapshot

Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events

inferredcites →https://doi.org/10.1002/cne.1105openalex-snapshot

Orbitomedial prefrontal cortical projections to hypothalamus in the rat

inferredcites →https://doi.org/10.1002/cne.1190openalex-snapshot

Differential expression of orexin receptors 1 and 2 in the rat brain

inferredcites →https://doi.org/10.1002/cne.20859openalex-snapshot

Afferents to the orexin neurons of the rat brain

inferredcites →https://doi.org/10.1002/cne.21420openalex-snapshot

Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and γ‐aminobutyric acid neurons

inferredcites →https://doi.org/10.1006/appe.1996.0059openalex-snapshot

Drug Self-Administration Viewed as Ingestive Behaviour

inferredcites →https://doi.org/10.1007/7854_2016_55openalex-snapshot

The Role of Orexins/Hypocretins in Alcohol Use and Abuse

inferredcites →https://doi.org/10.1007/7854_2016_56openalex-snapshot

Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders

inferredcites →https://doi.org/10.1007/978-1-4612-4812-5_6openalex-snapshot

Intravenous Drug Self-Administration: A Special Case of Positive Reinforcement

inferredcites →https://doi.org/10.1007/bf02245266openalex-snapshot

Conditioned responses to cocaine-related stimuli in cocaine abuse patients

inferredcites →https://doi.org/10.1007/bf03033808openalex-snapshot

Dopamine and reward: The anhedonia hypothesis 30 years on

inferredcites →https://doi.org/10.1007/s00213-002-1157-4openalex-snapshot

Second-order schedules of drug self-administration in animals

inferredcites →https://doi.org/10.1007/s00213-002-1200-5openalex-snapshot

The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat

inferredcites →https://doi.org/10.1007/s00213-002-1224-xopenalex-snapshot

The reinstatement model of drug relapse: history, methodology and major findings

inferredcites →https://doi.org/10.1007/s00213-004-2036-yopenalex-snapshot

Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats

inferredcites →https://doi.org/10.1007/s00213-006-0668-9openalex-snapshot

Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits

inferredcites →https://doi.org/10.1007/s00213-010-1792-0openalex-snapshot

Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA

inferredcites →https://doi.org/10.1007/s00213-010-2048-8openalex-snapshot

Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration

inferredcites →https://doi.org/10.1007/s00213-012-2681-5openalex-snapshot

Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats

inferredcites →https://doi.org/10.1007/s00213-012-2899-2openalex-snapshot

The behavioral economics of drug self-administration: A review and new analytical approach for within-session procedures

inferredcites →https://doi.org/10.1007/s00213-012-2902-yopenalex-snapshot

Role of orexin/hypocretin in conditioned sucrose-seeking in rats

inferredcites →https://doi.org/10.1007/s00429-013-0626-3openalex-snapshot

Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks

inferredcites →https://doi.org/10.1007/s40263-014-0150-xopenalex-snapshot

Assessment of the Abuse Liability of a Dual Orexin Receptor Antagonist: A Crossover Study of Almorexant and Zolpidem in Recreational Drug Users

inferredcites →https://doi.org/10.1007/s40263-014-0179-xopenalex-snapshot

Orexin/Hypocretin Based Pharmacotherapies for the Treatment of Addiction: DORA or SORA?

inferredcites →https://doi.org/10.1016/0006-8993(88)90606-3openalex-snapshot

Burst firing induced in midbrain dopamine neurons by stimulation of the medial prefrontal and anterior cingulate cortices

inferredcites →https://doi.org/10.1016/0006-8993(94)90780-3openalex-snapshot

N-methyl-d-aspartic acid biphasically regulates the biochemical and electrophysiological response of A10 dopamine neurons in the ventral tegmental area: in vivo microdialysis and in vitro electrophysiological studies

inferredcites →https://doi.org/10.1016/0361-9230(82)90145-9openalex-snapshot

The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde tracer and immunofluorescence study in the rat

inferredcites →https://doi.org/10.1016/b978-0-444-59489-1.00007-0openalex-snapshot

Multiple roles for orexin/hypocretin in addiction

inferredcites →https://doi.org/10.1016/b978-0-444-59489-1.00009-4openalex-snapshot

Orexin, stress, and anxiety/panic states

inferredcites →https://doi.org/10.1016/j.bbr.2007.05.025openalex-snapshot

Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward

inferredcites →https://doi.org/10.1016/j.bbr.2013.05.021openalex-snapshot

Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice

inferredcites →https://doi.org/10.1016/j.bbr.2014.04.012openalex-snapshot

Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement

inferredcites →https://doi.org/10.1016/j.biopsych.2007.02.002openalex-snapshot

Stimuli Linked to Ethanol Availability Activate Hypothalamic CART and Orexin Neurons in a Reinstatement Model of Relapse

inferredcites →https://doi.org/10.1016/j.biopsych.2008.03.006openalex-snapshot

Orexin Mediates the Expression of Precipitated Morphine Withdrawal and Concurrent Activation of the Nucleus Accumbens Shell

inferredcites →https://doi.org/10.1016/j.biopsych.2009.01.018openalex-snapshot

Reinstatement of Cocaine Seeking by Hypocretin (Orexin) in the Ventral Tegmental Area: Independence from the Local Corticotropin-Releasing Factor Network

inferredcites →https://doi.org/10.1016/j.biopsych.2011.06.025openalex-snapshot

Hypocretin/Orexin Signaling in the Hypothalamic Paraventricular Nucleus is Essential for the Expression of Nicotine Withdrawal

inferredcites →https://doi.org/10.1016/j.biopsych.2015.04.021openalex-snapshot

Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S

inferredcites →https://doi.org/10.1016/j.brainres.2008.05.060openalex-snapshot

Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity

inferredcites →https://doi.org/10.1016/j.brainres.2009.09.106openalex-snapshot

Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction

inferredcites →https://doi.org/10.1016/j.brainres.2009.11.054openalex-snapshot

The role of hypocretin in driving arousal and goal-oriented behaviors

inferredcites →https://doi.org/10.1016/j.brainres.2011.03.045openalex-snapshot

The orexin1 receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats

inferredcites →https://doi.org/10.1016/j.brainres.2011.11.003openalex-snapshot

Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss–Webster mice

inferredcites →https://doi.org/10.1016/j.brainres.2014.12.024openalex-snapshot

Differential roles of medial prefrontal subregions in the regulation of drug seeking

inferredcites →https://doi.org/10.1016/j.brainres.2016.10.018openalex-snapshot

Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats

inferredcites →https://doi.org/10.1016/j.celrep.2014.03.055openalex-snapshot

Coreleased Orexin and Glutamate Evoke Nonredundant Spike Outputs and Computations in Histamine Neurons

inferredcites →https://doi.org/10.1016/j.conb.2013.01.003openalex-snapshot

Recent developments in animal models of drug relapse

inferredcites →https://doi.org/10.1016/j.conb.2014.07.006openalex-snapshot

Hypocretin (orexin) neuromodulation of stress and reward pathways

inferredcites →https://doi.org/10.1016/j.ejphar.2005.09.024openalex-snapshot

Neuropsychopharmacology of drug seeking: Insights from studies with second-order schedules of drug reinforcement

inferredcites →https://doi.org/10.1016/j.jsat.2008.06.005openalex-snapshot

The relevance and treatment of cue-induced cravings in tobacco dependence

inferredcites →https://doi.org/10.1016/j.neubiorev.2009.11.011openalex-snapshot

How conditioned stimuli acquire the ability to activate VTA dopamine cells: A proposed neurobiological component of reward-related learning

inferredcites →https://doi.org/10.1016/j.neures.2006.11.009openalex-snapshot

Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats

inferredcites →https://doi.org/10.1016/j.neuroimage.2007.09.059openalex-snapshot

Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues

inferredcites →https://doi.org/10.1016/j.neuron.2005.03.010openalex-snapshot

Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice

inferredcites →https://doi.org/10.1016/j.neuron.2005.04.035openalex-snapshot

Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

inferredcites →https://doi.org/10.1016/j.neuron.2006.01.016openalex-snapshot

Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine

inferredcites →https://doi.org/10.1016/j.neuron.2007.03.021openalex-snapshot

Coordinated Accumbal Dopamine Release and Neural Activity Drive Goal-Directed Behavior

inferredcites →https://doi.org/10.1016/j.neuropharm.2004.06.032openalex-snapshot

Dopamine and drug addiction: the nucleus accumbens shell connection

inferredcites →https://doi.org/10.1016/j.neuropharm.2009.06.042openalex-snapshot

Orexin/hypocretin is necessary for context-driven cocaine-seeking

inferredcites →https://doi.org/10.1016/j.neuropharm.2011.04.022openalex-snapshot

Activation of orexin neurons in dorsomedial/perifornical hypothalamus and antidepressant reversal in a rodent model of depression

inferredcites →https://doi.org/10.1016/j.neuropharm.2013.05.040openalex-snapshot

On the motivational properties of reward cues: Individual differences

inferredcites →https://doi.org/10.1016/j.neuropharm.2014.12.021openalex-snapshot

Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference

inferredcites →https://doi.org/10.1016/j.neuropharm.2016.07.006openalex-snapshot

Nucleus incertus Orexin2 receptors mediate alcohol seeking in rats

inferredcites →https://doi.org/10.1016/j.neuroscience.2007.01.063openalex-snapshot

The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking

inferredcites →https://doi.org/10.1016/j.neuroscience.2007.11.018openalex-snapshot

Renewal of extinguished cocaine-seeking

inferredcites →https://doi.org/10.1016/j.neuroscience.2010.02.002openalex-snapshot

The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats

inferredcites →https://doi.org/10.1016/j.neuroscience.2011.08.014openalex-snapshot

The science of making drug-addicted animals

inferredcites →https://doi.org/10.1016/j.neuroscience.2011.09.047openalex-snapshot

Propensity to 'relapse’ following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei

inferredcites →https://doi.org/10.1016/j.neuroscience.2012.01.004openalex-snapshot

Regional c-Fos and FosB/ΔFosB expression associated with chronic methamphetamine self-administration and methamphetamine-seeking behavior in rats

inferredcites →https://doi.org/10.1016/j.neuroscience.2012.08.036openalex-snapshot

Selective Fos induction in hypothalamic orexin/hypocretin, but not melanin-concentrating hormone neurons, by a learned food-cue that stimulates feeding in sated rats

inferredcites →https://doi.org/10.1016/j.neuroscience.2014.11.026openalex-snapshot

Appetitive associative learning recruits a distinct network with cortical, striatal, and hypothalamic regions

inferredcites →https://doi.org/10.1016/j.peptides.2004.10.014openalex-snapshot

Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro

inferredcites →https://doi.org/10.1016/j.peptides.2009.04.018openalex-snapshot

Electrophysiological effects of orexin/hypocretin on nucleus accumbens shell neurons in rats: An in vitro study

inferredcites →https://doi.org/10.1016/j.peptides.2010.10.023openalex-snapshot

Electrophysiological effects of orexin-B and dopamine on rat nucleus accumbens shell neurons in vitro

inferredcites →https://doi.org/10.1016/j.physbeh.2012.04.016openalex-snapshot

Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network

inferredcites →https://doi.org/10.1016/j.physbeh.2013.10.005openalex-snapshot

Optogenetic examination identifies a context-specific role for orexins/hypocretins in anxiety-related behavior

inferredcites →https://doi.org/10.1016/j.regpep.2003.10.003openalex-snapshot

Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity

inferredcites →https://doi.org/10.1016/j.regpep.2003.12.014openalex-snapshot

Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons

inferredcites →https://doi.org/10.1016/j.resp.2009.03.006openalex-snapshot

CO2 activates orexin-containing neurons in mice

inferredcites →https://doi.org/10.1016/j.tins.2006.08.002openalex-snapshot

Arousal and reward: a dichotomy in orexin function

inferredcites →https://doi.org/10.1016/s0006-8993(99)01136-1openalex-snapshot

Feeding response to central orexins

inferredcites →https://doi.org/10.1016/s0014-5793(98)01266-6openalex-snapshot

Distribution of orexin receptor mRNA in the rat brain

inferredcites →https://doi.org/10.1016/s0092-8674(00)80949-6openalex-snapshot

Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

inferredcites →https://doi.org/10.1016/s0092-8674(00)81973-xopenalex-snapshot

Narcolepsy in orexin Knockout Mice

inferredcites →https://doi.org/10.1016/s0140-6736(99)05582-8openalex-snapshot

Hypocretin (orexin) deficiency in human narcolepsy

inferredcites →https://doi.org/10.1016/s0165-0173(00)00024-2openalex-snapshot

Stress-induced relapse to heroin and cocaine seeking in rats: a review

inferredcites →https://doi.org/10.1016/s0165-0173(98)00019-8openalex-snapshot

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

inferredcites →https://doi.org/10.1016/s0165-0173(99)00023-5openalex-snapshot

The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking

inferredcites →https://doi.org/10.1016/s0167-0115(00)00199-3openalex-snapshot

A selective orexin-1 receptor antagonist reduces food consumption in male and female rats

inferredcites →https://doi.org/10.1016/s0301-0082(96)00070-6openalex-snapshot

PHARMACOLOGICAL ASPECTS OF HUMAN AND CANINE NARCOLEPSY

inferredcites →https://doi.org/10.1016/s0306-4522(02)00017-9openalex-snapshot

Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area

inferredcites →https://doi.org/10.1016/s0306-4522(03)00238-0openalex-snapshot

Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats

inferredcites →https://doi.org/10.1016/s0306-4522(03)00334-8openalex-snapshot

Fos immunoreactivity in hypocretin-synthesizing and hypocretin-1 receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration

inferredcites →https://doi.org/10.1016/s0306-4522(03)00461-5openalex-snapshot

Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat

inferredcites →https://doi.org/10.1016/s0893-133x(99)00133-5openalex-snapshot

Persistent Increase in the Motivation to Take Heroin in Rats with a History of Drug Escalation

inferredcites →https://doi.org/10.1016/s1474-4422(14)70053-5openalex-snapshot

Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial

inferredcites →https://doi.org/10.1017/s1461145711000423openalex-snapshot

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking

inferredcites →https://doi.org/10.1017/s1461145712000193openalex-snapshot

The dual orexin receptor antagonist almorexant, alone and in combination with morphine, cocaine and amphetamine, on conditioned place preference and locomotor sensitization in the rat

inferredcites →https://doi.org/10.1017/s1461145713000333openalex-snapshot

Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats

inferredcites →https://doi.org/10.1021/cn500246jopenalex-snapshot

Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1

inferredcites →https://doi.org/10.1037/0033-295x.115.1.186openalex-snapshot

Economic demand and essential value.

inferredcites →https://doi.org/10.1037/bne0000112openalex-snapshot

Differential roles of orexin receptors within the dentate gyrus in stress- and drug priming-induced reinstatement of conditioned place preference in rats.

inferredcites →https://doi.org/10.1038/79690openalex-snapshot

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

inferredcites →https://doi.org/10.1038/nature01476openalex-snapshot

Subsecond dopamine release promotes cocaine seeking

inferredcites →https://doi.org/10.1038/nature04071openalex-snapshot

A role for lateral hypothalamic orexin neurons in reward seeking

inferredcites →https://doi.org/10.1038/nature06310openalex-snapshot

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

inferredcites →https://doi.org/10.1038/ncomms12199openalex-snapshot

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

inferredcites →https://doi.org/10.1038/ncomms7266openalex-snapshot

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses

inferredcites →https://doi.org/10.1038/nm.2075openalex-snapshot

A key role for orexin in panic anxiety

inferredcites →https://doi.org/10.1038/nn.3810openalex-snapshot

Motivational activation: a unifying hypothesis of orexin/hypocretin function

inferredcites →https://doi.org/10.1038/npp.2008.195openalex-snapshot

Behavioral Economic Assessment of Price and Cocaine Consumption Following Self-Administration Histories that Produce Escalation of Either Final Ratios or Intake

inferredcites →https://doi.org/10.1038/npp.2012.37openalex-snapshot

The Motivation to Self-Administer is Increased After a History of Spiking Brain Levels of Cocaine

inferredcites →https://doi.org/10.1038/npp.2012.76openalex-snapshot

Yohimbine Depresses Excitatory Transmission in BNST and Impairs Extinction of Cocaine Place Preference Through Orexin-Dependent, Norepinephrine-Independent Processes

inferredcites →https://doi.org/10.1038/npp.2013.62openalex-snapshot

An Orexin Hotspot in Ventral Pallidum Amplifies Hedonic ‘Liking’ for Sweetness

inferredcites →https://doi.org/10.1038/npp.2013.72openalex-snapshot

A Role for Hypocretin/Orexin Receptor-1 in Cue-Induced Reinstatement of Nicotine-Seeking Behavior

inferredcites →https://doi.org/10.1038/npp.2016.10openalex-snapshot

Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose ‘Liking’ and Intake but Scopolamine in Caudal Shell Shifts ‘Liking’ Toward ‘Disgust’ and ‘Fear’

inferredcites →https://doi.org/10.1038/nrn3837openalex-snapshot

The role of orexin in motivated behaviours

inferredcites →https://doi.org/10.1038/sj.bjp.0706789openalex-snapshot

The orexin system regulates alcohol‐seeking in rats

inferredcites →https://doi.org/10.1038/sj.npp.1300011openalex-snapshot

Critical Role for Ventral Tegmental Glutamate in Preference for a Cocaine-Conditioned Environment

inferredcites →https://doi.org/10.1038/sj.npp.1300391openalex-snapshot

Pharmacological Blockade of α2-Adrenoceptors Induces Reinstatement of Cocaine-Seeking Behavior in Squirrel Monkeys

inferredcites →https://doi.org/10.1038/sj.npp.1300619openalex-snapshot

Rapid Dopamine Signaling in the Nucleus Accumbens during Contingent and Noncontingent Cocaine Administration

inferredcites →https://doi.org/10.1038/sj.npp.1301650openalex-snapshot

Prominent Activation of Brainstem and Pallidal Afferents of the Ventral Tegmental Area by Cocaine

inferredcites →https://doi.org/10.1073/pnas.0507480102openalex-snapshot

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior

inferredcites →https://doi.org/10.1073/pnas.0802687105openalex-snapshot

Adaptive sugar sensors in hypothalamic feeding circuits

inferredcites →https://doi.org/10.1073/pnas.0808023105openalex-snapshot

Insular hypocretin transmission regulates nicotine reward

inferredcites →https://doi.org/10.1073/pnas.1004100107openalex-snapshot

Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system

inferredcites →https://doi.org/10.1073/pnas.1315542111openalex-snapshot

Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

inferredcites →https://doi.org/10.1073/pnas.1406324111openalex-snapshot

Economic demand predicts addiction-like behavior and therapeutic efficacy of oxytocin in the rat

inferredcites →https://doi.org/10.1073/pnas.95.1.322openalex-snapshot

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

inferredcites →https://doi.org/10.1080/09595230601036960openalex-snapshot

Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications

inferredcites →https://doi.org/10.1097/fbp.0b013e328343d761openalex-snapshot

Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward

inferredcites →https://doi.org/10.1097/wnr.0000000000000120openalex-snapshot

Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking

inferredcites →https://doi.org/10.1101/lm.1041309openalex-snapshot

Extinction circuits for fear and addiction overlap in prefrontal cortex

inferredcites →https://doi.org/10.1111/adb.12139openalex-snapshot

Anterior thalamic paraventricular nucleus is involved in intermittent access ethanol drinking: role of orexin receptor 2

inferredcites →https://doi.org/10.1111/adb.12251openalex-snapshot

Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats

inferredcites →https://doi.org/10.1111/adb.12323openalex-snapshot

Individual differences in orexin‐I receptor modulation of motivation for the opioid remifentanil

inferredcites →https://doi.org/10.1111/bph.12415openalex-snapshot

The hypocretins/orexins: integrators of multiple physiological functions

inferredcites →https://doi.org/10.1111/bph.12639openalex-snapshot

Orexin/hypocretin role in reward: implications for opioid and other addictions

inferredcites →https://doi.org/10.1111/ejn.12866openalex-snapshot

Orexin‐1 receptor signaling increases motivation for cocaine‐associated cues

inferredcites →https://doi.org/10.1111/ejn.13170openalex-snapshot

Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner

inferredcites →https://doi.org/10.1111/j.1369-1600.2012.00480.xopenalex-snapshot

N ‐(2‐methyl‐6‐benzoxazolyl)‐ N ′‐1,5‐naphthyridin‐4‐yl urea ( SB 334867), a hypocretin receptor‐1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking

inferredcites →https://doi.org/10.1111/j.1460-9568.1993.tb00479.xopenalex-snapshot

Tonic Activation of NMDA Receptors Causes Spontaneous Burst Discharge of Rat Midbrain Dopamine Neurons In Vivo

inferredcites →https://doi.org/10.1111/j.1460-9568.2004.03093.xopenalex-snapshot

Activation of a subpopulation of orexin/hypocretin‐containing hypothalamic neurons by GABAA receptor‐mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment

inferredcites →https://doi.org/10.1111/j.1460-9568.2008.06074.xopenalex-snapshot

Neural correlates of arousal‐induced circadian clock resetting: hypocretin/orexin and the intergeniculate leaflet

inferredcites →https://doi.org/10.1111/j.1460-9568.2008.06397.xopenalex-snapshot

Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons

inferredcites →https://doi.org/10.1111/j.1460-9568.2008.06453.xopenalex-snapshot

Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons

inferredcites →https://doi.org/10.1111/j.1460-9568.2009.06844.xopenalex-snapshot

Orexin/hypocretin signaling at the orexin 1 receptor regulates cue‐elicited cocaine‐seeking

inferredcites →https://doi.org/10.1111/j.1460-9568.2009.06952.xopenalex-snapshot

Hypocretin /orexin contributes to the expression of some but not all forms of stress and arousal

inferredcites →https://doi.org/10.1111/j.1460-9568.2009.07065.xopenalex-snapshot

The hypocretin–orexin system regulates cocaine self‐administration via actions on the mesolimbic dopamine system

inferredcites →https://doi.org/10.1111/j.1460-9568.2012.08013.xopenalex-snapshot

Orexin / hypocretin 1 receptor antagonist reduces heroin self‐administration and cue‐induced heroin seeking

inferredcites →https://doi.org/10.1111/j.1460-9568.2012.08057.xopenalex-snapshot

Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area

inferredcites →https://doi.org/10.1111/j.1476-5381.2010.01088.xopenalex-snapshot

Discrete cue‐conditioned alcohol‐seeking after protracted abstinence: pattern of neural activation and involvement of orexin1 receptors

inferredcites →https://doi.org/10.1111/j.1749-6632.1992.tb25966.xopenalex-snapshot

Neural Mechanisms of Drug Reinforcementa

inferredcites →https://doi.org/10.1111/j.1749-6632.1992.tb25984.xopenalex-snapshot

Classical Conditioning in Drug‐Dependent Humansa

inferredcites →https://doi.org/10.1113/jphysiol.2012.230268openalex-snapshot

Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus

inferredcites →https://doi.org/10.1113/jphysiol.2012.246983openalex-snapshot

Repeated in vivo exposure of cocaine induces long‐lasting synaptic plasticity in hypocretin/orexin‐producing neurons in the lateral hypothalamus in mice

inferredcites →https://doi.org/10.1124/jpet.111.187567openalex-snapshot

Orexin-1 Receptor Mediation of Cocaine Seeking in Male and Female Rats

inferredcites →https://doi.org/10.1124/jpet.116.235945openalex-snapshot

Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2

inferredcites →https://doi.org/10.1126/science.1077349openalex-snapshot

Discrete Coding of Reward Probability and Uncertainty by Dopamine Neurons

inferredcites →https://doi.org/10.1177/0269881109353464openalex-snapshot

Induction of c-Fos in ‘panic/defence’-related brain circuits following brief hypercarbic gas exposure

inferredcites →https://doi.org/10.1371/journal.pone.0012980openalex-snapshot

Cocaine- and Amphetamine-Regulated Transcript (CART) Signaling within the Paraventricular Thalamus Modulates Cocaine-Seeking Behaviour

inferredcites →https://doi.org/10.1371/journal.pone.0044726openalex-snapshot

The Dual Orexin/Hypocretin Receptor Antagonist, Almorexant, in the Ventral Tegmental Area Attenuates Ethanol Self-Administration

inferredcites →https://doi.org/10.1523/jneurosci.0706-12.2012openalex-snapshot

Optogenetic Probing of Fast Glutamatergic Transmission from Hypocretin/Orexin to Histamine NeuronsIn Situ

inferredcites →https://doi.org/10.1523/jneurosci.0784-11.2011openalex-snapshot

Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice

inferredcites →https://doi.org/10.1523/jneurosci.18-23-09996.1998openalex-snapshot

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

inferredcites →https://doi.org/10.1523/jneurosci.1887-05.2005openalex-snapshot

Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

inferredcites →https://doi.org/10.1523/jneurosci.21-05-01656.2001openalex-snapshot

Fos Expression in Orexin Neurons Varies with Behavioral State

inferredcites →https://doi.org/10.1523/jneurosci.21-15-05841.2001openalex-snapshot

Blockade of D1 Dopamine Receptors in the Ventral Tegmental Area Decreases Cocaine Reward: Possible Role for Dendritically Released Dopamine

inferredcites →https://doi.org/10.1523/jneurosci.21-19-j0003.2001openalex-snapshot

Orexin (Hypocretin) Neurons Contain Dynorphin

inferredcites →https://doi.org/10.1523/jneurosci.22-15-06742.2002openalex-snapshot

Differential Activation of Orexin Neurons by Antipsychotic Drugs Associated with Weight Gain

inferredcites →https://doi.org/10.1523/jneurosci.2277-12.2012openalex-snapshot

Fos Activation of Selective Afferents to Ventral Tegmental Area during Cue-Induced Reinstatement of Cocaine Seeking in Rats

inferredcites →https://doi.org/10.1523/jneurosci.23-01-00007.2003openalex-snapshot

Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins

inferredcites →https://doi.org/10.1523/jneurosci.23-08-03106.2003openalex-snapshot

Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal

inferredcites →https://doi.org/10.1523/jneurosci.23-30-09913.2003openalex-snapshot

Correlated Coding of Motivation and Outcome of Decision by Dopamine Neurons

inferredcites →https://doi.org/10.1523/jneurosci.2761-05.2006openalex-snapshot

Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine

inferredcites →https://doi.org/10.1523/jneurosci.2871-10.2010openalex-snapshot

Orexin/Hypocretin Modulates Response of Ventral Tegmental Dopamine Neurons to Prefrontal Activation: Diurnal Influences

inferredcites →https://doi.org/10.1523/jneurosci.3323-12.2013openalex-snapshot

Mu-Opioid Stimulation in Rat Prefrontal Cortex Engages Hypothalamic Orexin/Hypocretin-Containing Neurons, and Reveals Dissociable Roles of Nucleus Accumbens and Hypothalamus in Cortically Driven Feeding

inferredcites →https://doi.org/10.1523/jneurosci.3459-04.2004openalex-snapshot

Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response

inferredcites →https://doi.org/10.1523/jneurosci.3542-07.2007openalex-snapshot

Orexin Signaling in the Ventral Tegmental Area Is Required for High-Fat Appetite Induced by Opioid Stimulation of the Nucleus Accumbens

inferredcites →https://doi.org/10.1523/jneurosci.3903-15.2016openalex-snapshot

Orexin Neurons Respond Differentially to Auditory Cues Associated with Appetitive versus Aversive Outcomes

inferredcites →https://doi.org/10.1523/jneurosci.3917-11.2012openalex-snapshot

Lateral Hypothalamic Orexin/Hypocretin Neurons That Project to Ventral Tegmental Area Are Differentially Activated with Morphine Preference

inferredcites →https://doi.org/10.1523/jneurosci.4017-11.2011openalex-snapshot

Highly Specific Role of Hypocretin (Orexin) Neurons: Differential Activation as a Function of Diurnal Phase, Operant Reinforcement versus Operant Avoidance and Light Level

inferredcites →https://doi.org/10.1523/jneurosci.4121-06.2007openalex-snapshot

A Role for Hypocretin (Orexin) in Male Sexual Behavior

inferredcites →https://doi.org/10.1523/jneurosci.4561-11.2012openalex-snapshot

A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

inferredcites →https://doi.org/10.1523/jneurosci.4933-09.2010openalex-snapshot

Accumbens Shell–Hypothalamus Interactions Mediate Extinction of Alcohol Seeking

inferredcites →https://doi.org/10.1523/jneurosci.5194-08.2009openalex-snapshot

Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking

inferredcites →https://doi.org/10.1523/jneurosci.5724-09.2010openalex-snapshot

Hypocretins Regulate the Anxiogenic-Like Effects of Nicotine and Induce Reinstatement of Nicotine-Seeking Behavior

inferredcites →https://doi.org/10.1523/jneurosci.6096-08.2009openalex-snapshot

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

inferredcites →https://doi.org/10.3389/fnbeh.2012.00047openalex-snapshot

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence

inferredcites →https://doi.org/10.3389/fnbeh.2012.00075openalex-snapshot

Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry?

inferredcites →https://doi.org/10.3389/fnbeh.2012.00081openalex-snapshot

Glutamate and GABA as rapid effectors of hypothalamic “peptidergic” neurons

inferredcites →https://doi.org/10.3389/fnbeh.2013.00018openalex-snapshot

What about me…? The PVT: a role for the paraventricular thalamus (PVT) in drug-seeking behavior

inferredcites →https://doi.org/10.3389/fnbeh.2013.00144openalex-snapshot

Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference

inferredcites →https://doi.org/10.3389/fnbeh.2014.00244openalex-snapshot

Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats

inferredcites →https://doi.org/10.3389/fnbeh.2014.00280openalex-snapshot

Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART)

inferredcites →https://doi.org/10.3389/fnins.2014.00036openalex-snapshot

Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls

inferredcites →https://doi.org/10.3389/fnins.2015.00065openalex-snapshot

Recruitment of hypothalamic orexin neurons after formalin injections in adult male rats exposed to a neonatal immune challenge

inferredcites →https://doi.org/10.4172/2155-6105.s4-008openalex-snapshot

Insights for Developing Pharmacological Treatments for Psychostimulant Relapse Targeting Hypothalamic Peptide Systems

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4193399openalex-extracted

inferred← citeshttps://doi.org/10.1002/cmdc.201900074openalex-snapshot

Structure–Activity Relationships of 1‐Benzoylazulenes at the OX1 and OX2 Orexin Receptors

inferred← citeshttps://doi.org/10.1002/eat.24181openalex-snapshot

Evaluating the efficacy of the selective orexin 1 receptor antagonist nivasorexant in an animal model of binge‐eating disorder

inferred← citeshttps://doi.org/10.1007/164_2018_100openalex-snapshot

Contribution of Dynorphin and Orexin Neuropeptide Systems to the Motivational Effects of Alcohol

inferred← citeshttps://doi.org/10.1007/978-3-030-21573-6_208-1openalex-snapshot

Orexins

inferred← citeshttps://doi.org/10.1007/978-3-319-57535-3openalex-snapshot

Behavioral Neuroscience of Orexin/Hypocretin

inferred← citeshttps://doi.org/10.1007/978-90-368-2524-5_16openalex-snapshot

Middelgerelateerde en verslavingsstoornissen

inferred← citeshttps://doi.org/10.1007/978-981-16-0123-1_21openalex-snapshot

Sleep and Substance-Use Disorder

inferred← citeshttps://doi.org/10.1007/s00213-017-4709-3openalex-snapshot

Role of hypocretin/orexin receptor blockade on drug-taking and ultrasonic vocalizations (USVs) associated with low-effort self-administration of cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV) in rats

inferred← citeshttps://doi.org/10.1007/s00213-018-4871-2openalex-snapshot

The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders

inferred← citeshttps://doi.org/10.1007/s00406-025-01999-wopenalex-snapshot

A new direction for adjunctive therapy of difficult-to-treat depression: examining the role of orexin receptor antagonists

inferred← citeshttps://doi.org/10.1007/s00429-017-1544-6openalex-snapshot

CART neurons in the lateral hypothalamus communicate with the nucleus accumbens shell via glutamatergic neurons in paraventricular thalamic nucleus to modulate reward behavior

inferred← citeshttps://doi.org/10.1007/s00429-021-02449-8openalex-snapshot

Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens

inferred← citeshttps://doi.org/10.1007/s11064-022-03793-9openalex-snapshot

The Role of Orexin-1 Receptors Within the Hippocampal CA1 Area in the Extinction and Reinstatement of Methamphetamine-Seeking Behaviors

inferred← citeshttps://doi.org/10.1007/s12035-018-1453-6openalex-snapshot

Regulation of Brain DNA Methylation Factors and of the Orexinergic System by Cocaine and Food Self-Administration

inferred← citeshttps://doi.org/10.1007/s40263-022-00974-6openalex-snapshot

Orexin Receptor Antagonists in the Treatment of Depression: A Leading Article Summarising Pre-clinical and Clinical Studies

inferred← citeshttps://doi.org/10.1007/s40265-020-01373-1openalex-snapshot

Non-Opioid Treatments for Opioid Use Disorder: Rationales and Data to Date

inferred← citeshttps://doi.org/10.1007/s40675-024-00294-9openalex-snapshot

Insomnia and the Orexinergic Pathway in the Link with Psychopathology: Effects of DORAs in Insomnia Comorbid with Mental Disturbances

inferred← citeshttps://doi.org/10.1007/s40801-023-00356-4openalex-snapshot

Factors Associated with Prescriptions for an Orexin Receptor Antagonist Among Japanese Patients with Insomnia: Analysis of a Nationwide Japanese Claims Database

inferred← citeshttps://doi.org/10.1016/b978-0-12-813751-2.00001-2openalex-snapshot

Hypocretins (Orexins): Twenty Years of Dissecting Arousal Circuits

inferred← citeshttps://doi.org/10.1016/b978-0-12-813751-2.00002-4openalex-snapshot

Pharmacology of Orexin/Hypocretin Receptors

inferred← citeshttps://doi.org/10.1016/b978-0-12-813751-2.00004-8openalex-snapshot

Orexins and Control of Feeding by Learned Cues

inferred← citeshttps://doi.org/10.1016/b978-0-12-816658-1.00016-8openalex-snapshot

Hypocretin (Orexin): What It Does and How It Links With Narcolepsy and Food Choices

inferred← citeshttps://doi.org/10.1016/b978-0-12-820107-7.00022-7openalex-snapshot

Pleasure, addiction, and hypocretin (orexin)

inferred← citeshttps://doi.org/10.1016/bs.apha.2021.09.002openalex-snapshot

Potential therapeutic targets for the treatment of opioid abuse and pain

inferred← citeshttps://doi.org/10.1016/bs.irn.2020.11.002openalex-snapshot

Drug addiction co-morbidity with alcohol: Neurobiological insights

inferred← citeshttps://doi.org/10.1016/j.addicn.2022.100011openalex-snapshot

Actions of feeding-related peptides on the mesolimbic dopamine system in regulation of natural and drug rewards

inferred← citeshttps://doi.org/10.1016/j.addicn.2022.100018openalex-snapshot

Four hypothalamic peptides and their impact on drug-seeking behaviour: A prefrontal cortex view

inferred← citeshttps://doi.org/10.1016/j.addicn.2023.100126openalex-snapshot

Recent advances in drug discovery efforts targeting the sigma 1 receptor system: Implications for novel medications designed to reduce excessive drug and food seeking

inferred← citeshttps://doi.org/10.1016/j.aichem.2023.100040openalex-snapshot

Machine learning models to predict ligand binding affinity for the orexin 1 receptor

inferred← citeshttps://doi.org/10.1016/j.alcohol.2021.02.004openalex-snapshot

Increased alcohol consumption in sleep-restricted rats is mediated by delta FosB induction

inferred← citeshttps://doi.org/10.1016/j.appet.2022.106146openalex-snapshot

Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2017.09.008openalex-snapshot

Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling

inferred← citeshttps://doi.org/10.1016/j.bbr.2023.114497openalex-snapshot

Dual orexin/hypocretin receptor antagonism attenuates NMDA receptor hypofunction-induced attentional impairments in a rat model of schizophrenia

inferred← citeshttps://doi.org/10.1016/j.bbr.2025.115754openalex-snapshot

The effects of nicotine on sleep in female C57BL/6J mice

inferred← citeshttps://doi.org/10.1016/j.bbr.2026.116430openalex-snapshot

Modulatory role of the mPFC orexin-2 receptors in the acquisition and expression in two paradigms of the natural- and drug-induced conditioned place preference in the rats

inferred← citeshttps://doi.org/10.1016/j.bcp.2018.08.040openalex-snapshot

When orexins meet cannabinoids: Bidirectional functional interactions

inferred← citeshttps://doi.org/10.1016/j.biopha.2018.10.033openalex-snapshot

Co-administration of the low dose of orexin and nitrergic antagonists induces an antidepressant-like effect in mice

inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118098openalex-snapshot

Duloxetine improves hyperosmia in mice with pancreatic cancer by increasing dopamine levels in the olfactory bulb

inferred← citeshttps://doi.org/10.1016/j.biopsych.2017.01.010openalex-snapshot

Orexin/Hypocretin, Central Amygdala, and Escalation of Cocaine Intake

inferred← citeshttps://doi.org/10.1016/j.biopsych.2018.07.022openalex-snapshot

Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin/Hypocretin Neurons Underlies the Expression of an Addicted State in Rats

inferred← citeshttps://doi.org/10.1016/j.bmc.2023.117325openalex-snapshot

Azulene as a biphenyl mimetic in orexin/hypocretin receptor agonists

inferred← citeshttps://doi.org/10.1016/j.brainres.2018.08.018openalex-snapshot

Orexin/hypocretin and dysregulated eating: Promotion of foraging behavior

inferred← citeshttps://doi.org/10.1016/j.brainres.2018.08.031openalex-snapshot

Activation of medial hypothalamic orexin neurons during a Go/No-Go task

inferred← citeshttps://doi.org/10.1016/j.brainres.2018.11.023openalex-snapshot

The potential role of the orexin reward system in future treatments for opioid drug abuse

inferred← citeshttps://doi.org/10.1016/j.brainres.2018.12.036openalex-snapshot

Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy

inferred← citeshttps://doi.org/10.1016/j.brainres.2019.02.026openalex-snapshot

Cocaine abuse and midbrain circuits: Functional anatomy of hypocretin/orexin transmission and therapeutic prospect

inferred← citeshttps://doi.org/10.1016/j.brainres.2019.04.017openalex-snapshot

The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task

inferred← citeshttps://doi.org/10.1016/j.brainres.2019.146359openalex-snapshot

Preliminary examination of the orexin system on relapse-related factors in cocaine use disorder

inferred← citeshttps://doi.org/10.1016/j.brainres.2019.146461openalex-snapshot

Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil

inferred← citeshttps://doi.org/10.1016/j.brainres.2020.146665openalex-snapshot

Introduction to the Special Issue: “Making orexin-based therapies for addiction a reality: What are the steps from here?”

inferred← citeshttps://doi.org/10.1016/j.brainres.2020.147013openalex-snapshot

Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender

inferred← citeshttps://doi.org/10.1016/j.brainresbull.2022.05.006openalex-snapshot

Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems

inferred← citeshttps://doi.org/10.1016/j.cub.2019.07.069openalex-snapshot

Orexin in the Posterior Paraventricular Thalamus Mediates Hunger-Related Signals in the Nucleus Accumbens Core

inferred← citeshttps://doi.org/10.1016/j.drugalcdep.2021.108719openalex-snapshot

Age-specific treatment effects of orexin/hypocretin-receptor antagonism on methamphetamine-seeking behavior

inferred← citeshttps://doi.org/10.1016/j.drugalcdep.2021.108930openalex-snapshot

The dual orexin receptor antagonist almorexant blocks the sleep-disrupting and daytime stimulant effects of methamphetamine in rhesus monkeys

inferred← citeshttps://doi.org/10.1016/j.drugalcdep.2024.112434openalex-snapshot

Suvorexant enhances oxycodone-induced respiratory depression in male rats

inferred← citeshttps://doi.org/10.1016/j.dscb.2026.100318openalex-snapshot

Chronic fatigue syndrome in MS: an endogenous response pattern to an immunological challenge mediated by orexin/hypocretin?

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110210openalex-snapshot

Future perspectives of emerging novel drug targets and immunotherapies to control drug addiction

inferred← citeshttps://doi.org/10.1016/j.jpsychires.2024.02.051openalex-snapshot

The role of orexin receptors within the CA1 area in the acquisition and expression of methamphetamine place preference

inferred← citeshttps://doi.org/10.1016/j.medidd.2020.100059openalex-snapshot

Counterbalanced microcircuits for Orx1 and Orx2 regulation of stress reactivity

inferred← citeshttps://doi.org/10.1016/j.neubiorev.2021.10.043openalex-snapshot

New directions in modelling dysregulated reward seeking for food and drugs

inferred← citeshttps://doi.org/10.1016/j.neubiorev.2022.104674openalex-snapshot

Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts

inferred← citeshttps://doi.org/10.1016/j.neubiorev.2022.104832openalex-snapshot

Sleep loss and addiction

inferred← citeshttps://doi.org/10.1016/j.neubiorev.2023.105440openalex-snapshot

Modeling methamphetamine use disorder and relapse in animals: Short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain

inferred← citeshttps://doi.org/10.1016/j.neuro.2021.02.005openalex-snapshot

Effect of suvorexant on morphine tolerance and dependence in mice: Role of NMDA, AMPA, ERK and CREB proteins

inferred← citeshttps://doi.org/10.1016/j.neuron.2019.03.003openalex-snapshot

A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.09.016openalex-snapshot

Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.09.033openalex-snapshot

Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.11.017openalex-snapshot

To eat or to sleep: That is a lateral hypothalamic question

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2020.108013openalex-snapshot

Recent perspectives on orexin/hypocretin promotion of addiction-related behaviors

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2020.108359openalex-snapshot

The orexin (hypocretin) neuropeptide system is a target for novel therapeutics to treat cocaine use disorder with alcohol coabuse

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2025.110703openalex-snapshot

Central and peripheral monoamine changes in a rat model of Gaming Disorder

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2019.10.013openalex-snapshot

CCL2/CCR2 Chemokine System in Embryonic Hypothalamus: Involvement in Sexually Dimorphic Stimulatory Effects of Prenatal Ethanol Exposure on Peptide-Expressing Neurons

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2020.11.025openalex-snapshot

Sex- and Brain Region-specific Changes in Gene Expression in Male and Female Rats as Consequences of Methamphetamine Self-administration and Abstinence

inferred← citeshttps://doi.org/10.1016/j.npep.2022.102259openalex-snapshot

Neural correlates and potential targets for the contribution of orexin to addiction in cortical and subcortical areas

inferred← citeshttps://doi.org/10.1016/j.nsa.2023.103922openalex-snapshot

The role of the orexin system in the neurobiology of anxiety disorders: Potential for a novel treatment target

inferred← citeshttps://doi.org/10.1016/j.pbb.2020.173088openalex-snapshot

The neurobiology of abstinence-induced reward-seeking in males and females

inferred← citeshttps://doi.org/10.1016/j.pbb.2022.173466openalex-snapshot

Suvorexant Maintenance Enhances the Reinforcing But Not Subjective and Physiological Effects of Intravenous Cocaine in Humans

inferred← citeshttps://doi.org/10.1016/j.pbb.2024.173952openalex-snapshot

Emerging medications and pharmacological treatment approaches for substance use disorders

inferred← citeshttps://doi.org/10.1016/j.peptides.2017.12.017openalex-snapshot

Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats

inferred← citeshttps://doi.org/10.1016/j.peptides.2020.170368openalex-snapshot

Evaluation of the relationship between the gene expression level of orexin-1 receptor in the rat blood and prefrontal cortex, novelty-seeking, and proneness to methamphetamine dependence: A candidate biomarker

inferred← citeshttps://doi.org/10.1016/j.peptides.2023.171044openalex-snapshot

Effect of different doses of almorexant on learning and memory in 8-month-old APP/PS1 (AD) mice

inferred← citeshttps://doi.org/10.1016/j.phrs.2019.02.014openalex-snapshot

The paraventricular thalamic nucleus: A key hub of neural circuits underlying drug addiction

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2018.01.002openalex-snapshot

Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2022.110517openalex-snapshot

Orexin deficiency affects sensorimotor gating and its amphetamine-induced impairment

inferred← citeshttps://doi.org/10.1016/j.psychres.2018.04.010openalex-snapshot

Orexin A in men with heroin use disorder undergoing methadone maintenance treatment

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2023.106080openalex-snapshot

Blockade of orexin receptor 1 attenuates morphine protracted abstinence-induced anxiety-like behaviors in male mice

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2025.107570openalex-snapshot

Effects of suvorexant on diurnal cortisol and patient-reported stress during opioid withdrawal in a randomized trial

inferred← citeshttps://doi.org/10.1016/j.sleep.2025.02.037openalex-snapshot

Determinants of substance use patterns in patients with narcolepsy type 1: A multi-center comparative cross-sectional study

inferred← citeshttps://doi.org/10.1016/j.sleep.2025.106640openalex-snapshot

Narcolepsy and cardiovascular health: A big picture perspective

inferred← citeshttps://doi.org/10.1016/j.tins.2021.09.002openalex-snapshot

Orexin (hypocretin) and addiction

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00841openalex-snapshot

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists

inferred← citeshttps://doi.org/10.1038/npp.2017.250openalex-snapshot

Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence

inferred← citeshttps://doi.org/10.1038/s41380-025-02895-4openalex-snapshot

Genetic associations between orexin genes and phenotypes related to behavioral regulation in humans, including substance use

inferred← citeshttps://doi.org/10.1038/s41380-025-03406-1openalex-snapshot

Sleep regulates drug seeking and relapse – a perspective

inferred← citeshttps://doi.org/10.1038/s41386-019-0420-xopenalex-snapshot

The role of orexin-1 receptor signaling in demand for the opioid fentanyl

inferred← citeshttps://doi.org/10.1038/s41386-019-0465-xopenalex-snapshot

Drugs, sleep, and the addicted brain

inferred← citeshttps://doi.org/10.1038/s41386-020-0619-xopenalex-snapshot

Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: why sleep on this any longer?

inferred← citeshttps://doi.org/10.1038/s41386-021-01173-5openalex-snapshot

Orexin-1 receptor signaling in ventral tegmental area mediates cue-driven demand for cocaine

inferred← citeshttps://doi.org/10.1038/s41386-022-01356-8openalex-snapshot

Sleep-mediated regulation of reward circuits: implications in substance use disorders

inferred← citeshttps://doi.org/10.1038/s41386-024-02017-8openalex-snapshot

Orexinergic modulation of chronic jet lag-induced deficits in mouse cognitive flexibility

inferred← citeshttps://doi.org/10.1038/s41398-022-02161-zopenalex-snapshot

Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking

inferred← citeshttps://doi.org/10.1038/s41398-025-03571-5openalex-snapshot

Found in translation: orexin receptor antagonism for the treatment of opioid use disorder

inferred← citeshttps://doi.org/10.1038/s41598-021-95707-yopenalex-snapshot

Sexually dimorphic and asymmetric effects of embryonic ethanol exposure on hypocretin/orexin neurons as related to behavioral changes in zebrafish

inferred← citeshttps://doi.org/10.1038/s41598-023-28369-7openalex-snapshot

Neuronal chemokine concentration gradients mediate effects of embryonic ethanol exposure on ectopic hypocretin/orexin neurons and behavior in zebrafish

inferred← citeshttps://doi.org/10.1038/s41598-023-35432-wopenalex-snapshot

Subpopulations of hypocretin/orexin neurons differ in measures of their cell proliferation, dynorphin co-expression, projections, and response to embryonic ethanol exposure

inferred← citeshttps://doi.org/10.1039/d3md00573aopenalex-snapshot

Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure–activity–relationship, and sleep-promoting properties in rats

inferred← citeshttps://doi.org/10.1073/pnas.1910495116openalex-snapshot

Identifying roles for peptidergic signaling in mice

inferred← citeshttps://doi.org/10.1080/13543776.2017.1344221openalex-snapshot

Orexin research: patent news from 2016

inferred← citeshttps://doi.org/10.1093/ijnp/pyaa040openalex-snapshot

Sex Differences in Demand for Highly Palatable Foods: Role of the Orexin System

inferred← citeshttps://doi.org/10.1093/ijnp/pyz050openalex-snapshot

Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking

inferred← citeshttps://doi.org/10.1093/oso/9780190671051.003.0018openalex-snapshot

Orexins in Food and Addiction

inferred← citeshttps://doi.org/10.1093/oxfordhb/9780197618431.013.12openalex-snapshot

Opioid Effects on Sleep

inferred← citeshttps://doi.org/10.1093/oxfordhb/9780197618431.013.6openalex-snapshot

The Neurobiology of Opioid Use

inferred← citeshttps://doi.org/10.1097/fbp.0000000000000609openalex-snapshot

Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin-seeking behavior in rats

inferred← citeshttps://doi.org/10.1101/2020.04.25.061887openalex-snapshot

The dual orexin/hypocretin receptor antagonist suvorexant reduces addiction-like behaviors for the opioid fentanyl

inferred← citeshttps://doi.org/10.1101/2023.02.05.527043openalex-snapshot

Dual Orexin/Hypocretin Receptor Antagonism Attenuates Attentional Impairments in an Nmda Receptor Hypofunction Model of Schizophrenia

inferred← citeshttps://doi.org/10.1101/2023.09.22.559044openalex-snapshot

Opiate anticipation,opiate induced anatomical changes in hypocretin (Hcrt, orexin) neurons and opiate induced microglial activation are blocked by the dual Hcrt receptor antagonist suvorexant, while opiate analgesia is maintained

inferred← citeshttps://doi.org/10.1101/675603openalex-snapshot

Identifying Novel Roles for Peptidergic Signaling in Mice

inferred← citeshttps://doi.org/10.1101/cshperspect.a039628openalex-snapshot

Neural Substrates and Circuits of Drug Addiction

inferred← citeshttps://doi.org/10.1111/acer.14126openalex-snapshot

Embryonic Ethanol Exposure Affects the Early Development, Migration, and Location of Hypocretin/Orexin Neurons in Zebrafish

inferred← citeshttps://doi.org/10.1111/adb.12643openalex-snapshot

Circulating orexin changes during withdrawal are associated with nicotine craving and risk for smoking relapse

inferred← citeshttps://doi.org/10.1111/adb.12795openalex-snapshot

The number of lateral hypothalamus orexin/hypocretin neurons contributes to individual differences in cocaine demand

inferred← citeshttps://doi.org/10.1111/adb.12946openalex-snapshot

Intermittent self‐administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system

inferred← citeshttps://doi.org/10.1111/adb.13238openalex-snapshot

Embryonic ethanol exposure induces ectopic Hcrt and MCH neurons outside hypothalamus in rats and zebrafish: Role in ethanol‐induced behavioural disturbances

inferred← citeshttps://doi.org/10.1111/adb.70173openalex-snapshot

The Orexin System Modulates Stress‐Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence

inferred← citeshttps://doi.org/10.1111/ejn.14166openalex-snapshot

Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin/hypocretin‐1 receptor antagonist in rats

inferred← citeshttps://doi.org/10.1111/fcp.12723openalex-snapshot

Orexin receptors: Targets and applications

inferred← citeshttps://doi.org/10.1111/jnc.15301openalex-snapshot

A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

inferred← citeshttps://doi.org/10.11144/javeriana.umed63-1.basuopenalex-snapshot

Consumo de basuco: aspectos relevantes para su tratamiento

inferred← citeshttps://doi.org/10.1124/pharmrev.123.000953openalex-snapshot

International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology

inferred← citeshttps://doi.org/10.1134/s1990750822010085openalex-snapshot

Increase in the Level of Orexin Receptor 1 (OX1R) mRNA in the Brain Structures of Rats Prone to Impulsivity in Behavior

inferred← citeshttps://doi.org/10.1155/2018/9492453openalex-snapshot

The Effect of Detoxification on Sleep: How Does Sleep Quality Change during Qualified Detoxification Treatment?

inferred← citeshttps://doi.org/10.1159/000514965openalex-snapshot

The Insomnia-Addiction Positive Feedback Loop: Role of the Orexin System

inferred← citeshttps://doi.org/10.1186/s13041-019-0514-8openalex-snapshot

Pharmacological and chemogenetic orexin/hypocretin intervention ameliorates Hipp-dependent memory impairment in the A53T mice model of Parkinson’s disease

inferred← citeshttps://doi.org/10.1186/s13293-026-00858-0openalex-snapshot

Social defeat stress responses in the stress alternative model are dependent on sex and anterior basolateral amygdala orexin 2 receptors

inferred← citeshttps://doi.org/10.1242/dmm.047217openalex-snapshot

The darkness and the light: diurnal rodent models for seasonal affective disorder

inferred← citeshttps://doi.org/10.1371/journal.pone.0304461openalex-snapshot

Insomnia symptoms and neurofunctional correlates among adults receiving buprenorphine for opioid use disorder

inferred← citeshttps://doi.org/10.1523/eneuro.0283-20.2020openalex-snapshot

Sleep Deprivation Enhances Cocaine Conditioned Place Preference in an Orexin Receptor-Modulated Manner

inferred← citeshttps://doi.org/10.1523/eneuro.0433-17.2018openalex-snapshot

Brain Activity during Methamphetamine Anticipation in a Non-Invasive Self-Administration Paradigm in Mice

inferred← citeshttps://doi.org/10.1523/jneurosci.0255-19.2019openalex-snapshot

Orexin-1 Receptor Signaling in Ventral Pallidum Regulates Motivation for the Opioid Remifentanil

inferred← citeshttps://doi.org/10.1523/jneurosci.1557-21.2021openalex-snapshot

Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome

inferred← citeshttps://doi.org/10.1556/2006.8.2019.65openalex-snapshot

Increase of orexin A in the peripheral blood of adolescents with Internet gaming disorder

inferred← citeshttps://doi.org/10.15789/1563-0625-tca-2105openalex-snapshot

Tumor cell apoptosis mediated by the orexins

inferred← citeshttps://doi.org/10.18097/pbmc20216705411openalex-snapshot

Increase in the level of orexin receptor 1 (OX1R) mRNA in the brain structures of rats prone to impulsivity in behavior

inferred← citeshttps://doi.org/10.18632/aging.205884openalex-snapshot

The protective effects of orexin-A in alleviating cell senescence against interleukin-1β (IL-1β) in chondrocytes

inferred← citeshttps://doi.org/10.2147/nss.s201994openalex-snapshot

Targeting Orexin Receptors for the Treatment of Insomnia: From Physiological Mechanisms to Current Clinical Evidence and Recommendations

inferred← citeshttps://doi.org/10.2217/bmm-2021-0291openalex-snapshot

Potential Biomarkers of Addiction Identified By Real-Time Pcr in Human Peripheral Blood Lymphocytes: A Narrative Review

inferred← citeshttps://doi.org/10.23880/nnoaj-16000141openalex-snapshot

Endocrinology of Sleep and Appetite

inferred← citeshttps://doi.org/10.2478/ahem-2021-0007openalex-snapshot

Orexin receptor blockers: A tool for lowering alcohol intake and alcohol addictive behavior in the light of preclinical studies

inferred← citeshttps://doi.org/10.24875/ric.23000117openalex-snapshot

Addiction to Tobacco Smoking and Vaping

inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-7l33topenalex-snapshot

Computational Analysis of Fully Activated Orexin Receptor 2 Across Various Thermodynamic Ensembles with Surface Tension Monitoring

inferred← citeshttps://doi.org/10.29399/npa.28383openalex-snapshot

Orexin Receptor Antagonists as an Adjunct for the Treatment of Depression: A mini meta-analysis

inferred← citeshttps://doi.org/10.3389/fnbeh.2021.720592openalex-snapshot

Editorial: Role of the Thalamus in Motivated Behavior

inferred← citeshttps://doi.org/10.3389/fnbeh.2022.1085882openalex-snapshot

Alternative use of suvorexant (Belsomra®) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence

inferred← citeshttps://doi.org/10.3389/fnins.2019.00088openalex-snapshot

Nucleus Accumbens Shell Orexin-1 Receptors Are Critical Mediators of Binge Intake in Excessive-Drinking Individuals

inferred← citeshttps://doi.org/10.3389/fnins.2019.00702openalex-snapshot

Chemogenetic Modulation of Orexin Neurons Reverses Changes in Anxiety and Locomotor Activity in the A53T Mouse Model of Parkinson’s Disease

inferred← citeshttps://doi.org/10.3389/fphys.2017.00357openalex-snapshot

Orexin System: The Key for a Healthy Life

inferred← citeshttps://doi.org/10.3389/fpsyt.2022.900135openalex-snapshot

Reduction of Orexin-A Is Associated With Anxiety and the Level of Depression of Male Methamphetamine Users During the Initial Withdrawal Period

inferred← citeshttps://doi.org/10.3390/brainsci10040226openalex-snapshot

Targeting the Orexin System for Prescription Opioid Use Disorder

inferred← citeshttps://doi.org/10.3390/brainsci12020150openalex-snapshot

Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone

inferred← citeshttps://doi.org/10.3390/cells12101399openalex-snapshot

Role of Chemokine Cxcl12a in Mediating the Stimulatory Effects of Ethanol on Embryonic Development of Subpopulations of Hypocretin/Orexin Neurons and Their Projections

inferred← citeshttps://doi.org/10.3390/genes12081263openalex-snapshot

Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction

inferred← citeshttps://doi.org/10.3390/ijerph19148353openalex-snapshot

Physiological Role of Orexinergic System for Health

inferred← citeshttps://doi.org/10.3390/jcm9062015openalex-snapshot

Sleep Quality and Sleep Disturbance Perception in Dual Disorder Patients

inferred← citeshttps://doi.org/10.34172/ahj.2024.1491openalex-snapshot

The Role of Orexin Receptor Antagonists in Inhibiting Drug Addiction: A Review Article

inferred← citeshttps://doi.org/10.35946/arcr.v44.1.02openalex-snapshot

Sleep-Related Predictors of Risk for Alcohol Use and Related Problems in Adolescents and Young Adults

inferred← citeshttps://doi.org/10.4103/0366-6999.246068openalex-snapshot

Orexin might Predict Status of Alcohol Dependence

inferred← citeshttps://doi.org/10.5152/pcp.2021.20011openalex-snapshot

Plasma Orexin Levels Related to Altered Brain Activity During Abstinence in Patients with Alcohol Dependence

inferred← citeshttps://doi.org/10.51731/cjht.2023.624openalex-snapshot

Lemborexant (Dayvigo)

inferred← citeshttps://doi.org/10.70675/dabd8862z2623z4c01za6b5z4dc6777dee16openalex-snapshot

Alteration in the expression of genes involved in DNA methylation and circadian rhythms by cocaine and natural reinforcers : potential role of epigenetics in two partially overlapping neuronal networks

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.