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The role of orexin in motivated behaviours
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inferredcites →https://doi.org/10.1001/archneurpsyc.1955.02330080005003openalex-snapshot
EXPERIMENTAL DATA ON ROLE OF HYPOTHALAMUS IN MECHANISM OF EMOTIONAL BEHAVIOR
inferredcites →https://doi.org/10.1002/(sici)1096-9861(19981228)402:4<442::aid-cne2>3.0.co;2-ropenalex-snapshot
Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
inferredcites →https://doi.org/10.1002/ana.21825openalex-snapshot
Abnormal activity in reward brain circuits in human narcolepsy with cataplexy
inferredcites →https://doi.org/10.1002/ana.21881openalex-snapshot
Reduced amygdala activity during aversive conditioning in human narcolepsy
inferredcites →https://doi.org/10.1002/cmdc.201300003openalex-snapshot
Discovery and Characterization of ACT‐335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist
inferredcites →https://doi.org/10.1002/cne.1190openalex-snapshot
Differential expression of orexin receptors 1 and 2 in the rat brain
inferredcites →https://doi.org/10.1002/cne.20859openalex-snapshot
Afferents to the orexin neurons of the rat brain
inferredcites →https://doi.org/10.1002/cne.21420openalex-snapshot
Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and γ‐aminobutyric acid neurons
inferredcites →https://doi.org/10.1002/da.20292openalex-snapshot
Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder
inferredcites →https://doi.org/10.1002/oby.20045openalex-snapshot
High and low activity rats: Elevated intrinsic physical activity drives resistance to diet‐induced obesity in non‐bred rats
inferredcites →https://doi.org/10.1002/syn.10086openalex-snapshot
Conditioned‐fear stress increases Fos expression in monoaminergic and GABAergic neurons of the locus coeruleus and dorsal raphe nuclei
inferredcites →https://doi.org/10.1006/bbrc.1999.1998openalex-snapshot
Inhibition of Food Intake by Central Injection of Anti-orexin Antibody in Fasted Rats
inferredcites →https://doi.org/10.1006/exnr.1998.6787openalex-snapshot
Neuropharmacological Characterization of Basal Forebrain Cholinergic Stimulated Cataplexy in Narcoleptic Canines
inferredcites →https://doi.org/10.1006/nlme.1996.0067openalex-snapshot
Norepinephrine Release in the Amygdala in Response to Footshock Stimulation
inferredcites →https://doi.org/10.1007/s00213-010-1792-0openalex-snapshot
Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA
inferredcites →https://doi.org/10.1007/s00213-010-2048-8openalex-snapshot
Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration
inferredcites →https://doi.org/10.1007/s00213-010-2127-xopenalex-snapshot
Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement
inferredcites →https://doi.org/10.1007/s00213-012-2736-7openalex-snapshot
The brain orexin system and almorexant in fear-conditioned startle reactions in the rat
inferredcites →https://doi.org/10.1016/b978-0-444-59489-1.00002-1openalex-snapshot
Overview of orexin/hypocretin system
inferredcites →https://doi.org/10.1016/b978-0-444-59489-1.00007-0openalex-snapshot
Multiple roles for orexin/hypocretin in addiction
inferredcites →https://doi.org/10.1016/j.alcohol.2009.07.002openalex-snapshot
Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol–preferring Sprague–Dawley rats
inferredcites →https://doi.org/10.1016/j.biopsych.2007.02.002openalex-snapshot
Stimuli Linked to Ethanol Availability Activate Hypothalamic CART and Orexin Neurons in a Reinstatement Model of Relapse
inferredcites →https://doi.org/10.1016/j.biopsych.2009.12.035openalex-snapshot
Orexin Signaling Via the Orexin 1 Receptor Mediates Operant Responding for Food Reinforcement
inferredcites →https://doi.org/10.1016/j.bmcl.2003.08.038openalex-snapshot
N- Acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist
inferredcites →https://doi.org/10.1016/j.bmcl.2004.06.032openalex-snapshot
Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX2R) antagonists
inferredcites →https://doi.org/10.1016/j.bmcl.2011.08.093openalex-snapshot
Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists
inferredcites →https://doi.org/10.1016/j.brainres.2005.05.045openalex-snapshot
Orexin A in the nucleus accumbens stimulates feeding and locomotor activity
inferredcites →https://doi.org/10.1016/j.brainres.2009.01.022openalex-snapshot
Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis
inferredcites →https://doi.org/10.1016/j.brainres.2009.09.106openalex-snapshot
Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction
inferredcites →https://doi.org/10.1016/j.brainres.2009.10.068openalex-snapshot
Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction
inferredcites →https://doi.org/10.1016/j.brainres.2009.12.035openalex-snapshot
Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization
inferredcites →https://doi.org/10.1016/j.cmet.2008.10.010openalex-snapshot
Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity
inferredcites →https://doi.org/10.1016/j.cmet.2009.09.013openalex-snapshot
Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System
inferredcites →https://doi.org/10.1016/j.ejphar.2006.02.021openalex-snapshot
Activation of orexin neurons by acute nicotine
inferredcites →https://doi.org/10.1016/j.neuint.2009.08.012openalex-snapshot
The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization
inferredcites →https://doi.org/10.1016/j.neulet.2005.01.046openalex-snapshot
Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions
inferredcites →https://doi.org/10.1016/j.neures.2006.11.009openalex-snapshot
Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats
inferredcites →https://doi.org/10.1016/j.neuron.2005.03.010openalex-snapshot
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
inferredcites →https://doi.org/10.1016/j.neuron.2006.01.016openalex-snapshot
Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine
inferredcites →https://doi.org/10.1016/j.neuron.2008.06.012openalex-snapshot
A Role for Brain Stress Systems in Addiction
inferredcites →https://doi.org/10.1016/j.neuron.2011.08.027openalex-snapshot
Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids
inferredcites →https://doi.org/10.1016/j.neuron.2012.03.017openalex-snapshot
Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons
inferredcites →https://doi.org/10.1016/j.neuron.2014.02.010openalex-snapshot
Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate
inferredcites →https://doi.org/10.1016/j.neuropharm.2008.06.060openalex-snapshot
Role of lateral hypothalamic orexin neurons in reward processing and addiction
inferredcites →https://doi.org/10.1016/j.neuropharm.2009.06.042openalex-snapshot
Orexin/hypocretin is necessary for context-driven cocaine-seeking
inferredcites →https://doi.org/10.1016/j.neuropharm.2009.07.008openalex-snapshot
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure
inferredcites →https://doi.org/10.1016/j.neuroscience.2007.07.016openalex-snapshot
Nitric oxide and GABA mediate bi-directional cardiovascular effects of orexin in the nucleus tractus solitarii of rats
inferredcites →https://doi.org/10.1016/j.neuroscience.2010.02.002openalex-snapshot
The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats
inferredcites →https://doi.org/10.1016/j.neuroscience.2010.11.067openalex-snapshot
Hypocretin-1 (orexin A) prevents the effects of hypoxia/hypercapnia and enhances the GABAergic pathway from the lateral paragigantocellular nucleus to cardiac vagal neurons in the nucleus ambiguus
inferredcites →https://doi.org/10.1016/j.neuroscience.2012.08.036openalex-snapshot
Selective Fos induction in hypothalamic orexin/hypocretin, but not melanin-concentrating hormone neurons, by a learned food-cue that stimulates feeding in sated rats
inferredcites →https://doi.org/10.1016/j.neuroscience.2013.07.054openalex-snapshot
Co-localization of hypocretin-1 and leucine-enkephalin in hypothalamic neurons projecting to the nucleus of the solitary tract and their effect on arterial pressure
inferredcites →https://doi.org/10.1016/j.physbeh.2004.04.034openalex-snapshot
Mind versus metabolism in the control of food intake and energy balance
inferredcites →https://doi.org/10.1016/j.physbeh.2010.03.009openalex-snapshot
Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity
inferredcites →https://doi.org/10.1016/j.physbeh.2012.04.016openalex-snapshot
Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network
inferredcites →https://doi.org/10.1016/j.regpep.2003.12.014openalex-snapshot
Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons
inferredcites →https://doi.org/10.1016/j.sleep.2009.02.009openalex-snapshot
Obstructive sleep apnea in narcolepsy
inferredcites →https://doi.org/10.1016/j.tins.2006.08.002openalex-snapshot
Arousal and reward: a dichotomy in orexin function
inferredcites →https://doi.org/10.1016/j.tips.2011.03.007openalex-snapshot
Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal
inferredcites →https://doi.org/10.1016/j.yhbeh.2010.09.006openalex-snapshot
Lesions of orexin neurons block conditioned place preference for sexual behavior in male rats
inferredcites →https://doi.org/10.1016/s0006-3223(03)00412-8openalex-snapshot
Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma
inferredcites →https://doi.org/10.1016/s0006-8993(00)02043-6openalex-snapshot
Orexin-induced food intake involves neuropeptide Y pathway
inferredcites →https://doi.org/10.1016/s0006-8993(00)02555-5openalex-snapshot
Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system11Published on the World Wide Web on 27 June 2000.
inferredcites →https://doi.org/10.1016/s0006-8993(03)03002-6openalex-snapshot
Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats
inferredcites →https://doi.org/10.1016/s0006-8993(99)01136-1openalex-snapshot
Feeding response to central orexins
inferredcites →https://doi.org/10.1016/s0006-8993(99)01336-0openalex-snapshot
Distribution of orexin neurons in the adult rat brain
inferredcites →https://doi.org/10.1016/s0006-8993(99)01457-2openalex-snapshot
Cardiovascular regulatory actions of the hypocretins in brain
inferredcites →https://doi.org/10.1016/s0006-8993(99)01824-7openalex-snapshot
Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action1This study was presented in part at the 28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA, in November 1998.1
inferredcites →https://doi.org/10.1016/s0031-9384(00)00341-3openalex-snapshot
Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons
inferredcites →https://doi.org/10.1016/s0092-8674(00)80949-6openalex-snapshot
Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
inferredcites →https://doi.org/10.1016/s0092-8674(00)81965-0openalex-snapshot
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
inferredcites →https://doi.org/10.1016/s0092-8674(00)81973-xopenalex-snapshot
Narcolepsy in orexin Knockout Mice
inferredcites →https://doi.org/10.1016/s0140-6736(05)74704-8openalex-snapshot
Increased body-mass index in patients with narcolepsy
inferredcites →https://doi.org/10.1016/s0167-0115(00)00199-3openalex-snapshot
A selective orexin-1 receptor antagonist reduces food consumption in male and female rats
inferredcites →https://doi.org/10.1016/s0896-6273(01)00293-8openalex-snapshot
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
inferredcites →https://doi.org/10.1016/s0896-6273(03)00331-3openalex-snapshot
Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
inferredcites →https://doi.org/10.1016/s0896-6273(04)00251-xopenalex-snapshot
Physiological Properties of Hypothalamic MCH Neurons Identified with Selective Expression of Reporter Gene after Recombinant Virus Infection
inferredcites →https://doi.org/10.1016/s0960-894x(01)00343-2openalex-snapshot
1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor
inferredcites →https://doi.org/10.1016/s1389-9457(00)00056-3openalex-snapshot
Narcolepsy and obesity: remission of severe cataplexy with sibutramine
inferredcites →https://doi.org/10.1017/s1461145711000423openalex-snapshot
Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
inferredcites →https://doi.org/10.1021/jm100541copenalex-snapshot
Discovery of the Dual Orexin Receptor Antagonist [(7 R )-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2 H -1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia
inferredcites →https://doi.org/10.1038/bjp.2008.3openalex-snapshot
Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high‐fat food self‐administration and reinstatement of food seeking in rats
inferredcites →https://doi.org/10.1038/nature04071openalex-snapshot
A role for lateral hypothalamic orexin neurons in reward seeking
inferredcites →https://doi.org/10.1038/ncomms2461openalex-snapshot
Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction
inferredcites →https://doi.org/10.1038/nm.2075openalex-snapshot
A key role for orexin in panic anxiety
inferredcites →https://doi.org/10.1038/nm1544openalex-snapshot
Promotion of sleep by targeting the orexin system in rats, dogs and humans
inferredcites →https://doi.org/10.1038/npp.2013.72openalex-snapshot
A Role for Hypocretin/Orexin Receptor-1 in Cue-Induced Reinstatement of Nicotine-Seeking Behavior
inferredcites →https://doi.org/10.1038/nrn2092openalex-snapshot
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
inferredcites →https://doi.org/10.1038/sj.bjp.0705610openalex-snapshot
Characterisation of the binding of [3H]‐SB‐674042, a novel nonpeptide antagonist, to the human orexin‐1 receptor
inferredcites →https://doi.org/10.1038/sj.bjp.0706789openalex-snapshot
The orexin system regulates alcohol‐seeking in rats
inferredcites →https://doi.org/10.1046/j.1365-2826.2001.00655.xopenalex-snapshot
Central Orexin‐A Activates Hypothalamic‐Pituitary‐Adrenal Axis and Stimulates Hypothalamic Corticotropin Releasing Factor and Arginine Vasopressin Neurones in Conscious Rats
inferredcites →https://doi.org/10.1073/pnas.0507480102openalex-snapshot
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
inferredcites →https://doi.org/10.1073/pnas.0702676104openalex-snapshot
Control of hypothalamic orexin neurons by acid and CO 2
inferredcites →https://doi.org/10.1073/pnas.0808023105openalex-snapshot
Insular hypocretin transmission regulates nicotine reward
inferredcites →https://doi.org/10.1073/pnas.1012456108openalex-snapshot
Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice
inferredcites →https://doi.org/10.1073/pnas.1312804110openalex-snapshot
Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbits
inferredcites →https://doi.org/10.1073/pnas.1320325110openalex-snapshot
Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus
inferredcites →https://doi.org/10.1073/pnas.95.1.322openalex-snapshot
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
inferredcites →https://doi.org/10.1073/pnas.96.2.748openalex-snapshot
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
inferredcites →https://doi.org/10.1093/sleep/11.1.1openalex-snapshot
Distribution of Choline Acetyltransferase Immunoreactive Somata in the Feline Brainstem: Implications for REM Sleep Generation
inferredcites →https://doi.org/10.1093/sleep/26.5.558openalex-snapshot
Emotional Information Processing in Patients with Narcolepsy: A Psychophysiologic Investigation
inferredcites →https://doi.org/10.1097/fbp.0b013e328343d761openalex-snapshot
Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward
inferredcites →https://doi.org/10.1111/bph.12296openalex-snapshot
Orexin/hypocretin receptor signalling: a functional perspective
inferredcites →https://doi.org/10.1111/bph.12324openalex-snapshot
Orexin/hypocretin receptor signalling cascades
inferredcites →https://doi.org/10.1111/j.1365-2869.2007.00587.xopenalex-snapshot
Amygdala dysfunction in narcolepsy‐cataplexy
inferredcites →https://doi.org/10.1111/j.1460-9568.2009.06844.xopenalex-snapshot
Orexin/hypocretin signaling at the orexin 1 receptor regulates cue‐elicited cocaine‐seeking
inferredcites →https://doi.org/10.1111/j.1460-9568.2009.06952.xopenalex-snapshot
Hypocretin /orexin contributes to the expression of some but not all forms of stress and arousal
inferredcites →https://doi.org/10.1111/j.1460-9568.2009.07065.xopenalex-snapshot
The hypocretin–orexin system regulates cocaine self‐administration via actions on the mesolimbic dopamine system
inferredcites →https://doi.org/10.1111/j.1460-9568.2012.08013.xopenalex-snapshot
Orexin / hypocretin 1 receptor antagonist reduces heroin self‐administration and cue‐induced heroin seeking
inferredcites →https://doi.org/10.1111/j.1476-5381.2010.01088.xopenalex-snapshot
Discrete cue‐conditioned alcohol‐seeking after protracted abstinence: pattern of neural activation and involvement of orexin1 receptors
inferredcites →https://doi.org/10.1111/j.1476-5381.2011.01694.xopenalex-snapshot
Orexin A in rat rostral ventrolateral medulla is pressor, sympatho‐excitatory, increases barosensitivity and attenuates the somato‐sympathetic reflex
inferredcites →https://doi.org/10.1113/jphysiol.2005.085829openalex-snapshot
Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy
inferredcites →https://doi.org/10.1113/jphysiol.2008.168260openalex-snapshot
Antagonism of orexin receptor‐1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness
inferredcites →https://doi.org/10.1113/jphysiol.2010.195099openalex-snapshot
Orexin neurons are indispensable for stress-induced thermogenesis in mice
inferredcites →https://doi.org/10.1113/jphysiol.2011.217000openalex-snapshot
Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels
inferredcites →https://doi.org/10.1124/dmd.110.035386openalex-snapshot
Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans
inferredcites →https://doi.org/10.1124/jpet.110.167791openalex-snapshot
Orexins Depolarize Rostral Ventrolateral Medulla Neurons and Increase Arterial Pressure and Heart Rate in Rats Mainly via Orexin 2 Receptors
inferredcites →https://doi.org/10.1124/mol.110.064584openalex-snapshot
Mapping the Binding Pocket of Dual Antagonist Almorexant to Human Orexin 1 and Orexin 2 Receptors: Comparison with the Selective OX1 Antagonist SB-674042 and the Selective OX2 Antagonist N-Ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA)
inferredcites →https://doi.org/10.1146/annurev.neuro.24.1.429openalex-snapshot
To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness
inferredcites →https://doi.org/10.1152/ajpheart.00877.2002openalex-snapshot
Cardiovascular effects of hypocretin-1 in nucleus of the solitary tract
inferredcites →https://doi.org/10.1152/ajpregu.00263.2012openalex-snapshot
Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses
inferredcites →https://doi.org/10.1152/ajpregu.00344.2002openalex-snapshot
Regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation
inferredcites →https://doi.org/10.1152/ajpregu.00496.2006openalex-snapshot
Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress
inferredcites →https://doi.org/10.1152/ajpregu.00671.2002openalex-snapshot
Attenuated defense response and low basal blood pressure in orexin knockout mice
inferredcites →https://doi.org/10.1152/ajpregu.00704.2005openalex-snapshot
Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice
inferredcites →https://doi.org/10.1152/ajpregu.00737.2004openalex-snapshot
Orexin A-induced feeding is augmented by caloric challenge
inferredcites →https://doi.org/10.1152/ajpregu.1999.277.6.r1780openalex-snapshot
Sympathetic and cardiovascular actions of orexins in conscious rats
inferredcites →https://doi.org/10.1210/en.2003-1582openalex-snapshot
Circulating Triglycerides Impact on Orexigenic Peptides and Neuronal Activity in Hypothalamus
inferredcites →https://doi.org/10.1210/en.2008-0293openalex-snapshot
Orexin-A Hyperphagia: Hindbrain Participation in Consummatory Feeding Responses
inferredcites →https://doi.org/10.1242/jeb.100.1.159openalex-snapshot
The Defence-Arousal System and its Relevance for Circulatory and Respiratory Control
inferredcites →https://doi.org/10.1371/journal.pone.0016406openalex-snapshot
Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists
inferredcites →https://doi.org/10.1385/endo:14:2:269openalex-snapshot
Neuropeptide Y in Central Control
inferredcites →https://doi.org/10.1385/mn:32:3:285openalex-snapshot
Stress and Arousal: The Corticotrophin-Releasing Factor/Hypocretin Circuitry
inferredcites →https://doi.org/10.1515/bmc-2011-0066openalex-snapshot
Orexin modulates brown adipose tissue thermogenesis
inferredcites →https://doi.org/10.1523/jneurosci.1130-13.2013openalex-snapshot
Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-Dependent Fear Memory Consolidation
inferredcites →https://doi.org/10.1523/jneurosci.18-23-09996.1998openalex-snapshot
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
inferredcites →https://doi.org/10.1523/jneurosci.21-19-j0003.2001openalex-snapshot
Orexin (Hypocretin) Neurons Contain Dynorphin
inferredcites →https://doi.org/10.1523/jneurosci.23-08-03106.2003openalex-snapshot
Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal
inferredcites →https://doi.org/10.1523/jneurosci.2761-05.2006openalex-snapshot
Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine
inferredcites →https://doi.org/10.1523/jneurosci.3459-04.2004openalex-snapshot
Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response
inferredcites →https://doi.org/10.1523/jneurosci.3542-07.2007openalex-snapshot
Orexin Signaling in the Ventral Tegmental Area Is Required for High-Fat Appetite Induced by Opioid Stimulation of the Nucleus Accumbens
inferredcites →https://doi.org/10.1523/jneurosci.3917-11.2012openalex-snapshot
Lateral Hypothalamic Orexin/Hypocretin Neurons That Project to Ventral Tegmental Area Are Differentially Activated with Morphine Preference
inferredcites →https://doi.org/10.1523/jneurosci.4458-07.2008openalex-snapshot
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System
inferredcites →https://doi.org/10.1523/jneurosci.4561-11.2012openalex-snapshot
A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference
inferredcites →https://doi.org/10.1523/jneurosci.4925-04.2005openalex-snapshot
Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin NeuronsIn Situ
inferredcites →https://doi.org/10.1523/jneurosci.6096-08.2009openalex-snapshot
Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers
inferredcites →https://doi.org/10.1523/jneurosci.6506-10.2011openalex-snapshot
Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non-REM and REM Sleep
inferredcites →https://doi.org/10.3181/00379727-77-18766openalex-snapshot
Localization of a "Feeding Center" in the Hypothalamus of the Rat
inferredcites →https://doi.org/10.3389/fnbeh.2012.00075openalex-snapshot
Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry?
inferredcites →https://doi.org/10.3389/fnins.2014.00008openalex-snapshot
Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/advs.202200640openalex-snapshot
Motivational and Valence‐Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes
inferred← citeshttps://doi.org/10.1002/advs.202411858openalex-snapshot
Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction
inferred← citeshttps://doi.org/10.1002/advs.202413817openalex-snapshot
Genetics‐Based Targeting Strategies for Precise Neuromodulation
inferred← citeshttps://doi.org/10.1002/ajmg.a.37749openalex-snapshot
Higher plasma orexin A levels in children with Prader–Willi syndrome compared with healthy unrelated sibling controls
inferred← citeshttps://doi.org/10.1002/ajmg.a.37777openalex-snapshot
Higher plasma orexin a levels in children with Prader–Willi syndrome compared with healthy unrelated sibling controls
inferred← citeshttps://doi.org/10.1002/alz.71291openalex-snapshot
Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/ar.24265openalex-snapshot
A Preliminary Description of the Sleep‐Related Neural Systems in the Brain of the Blue Wildebeest, Connochaetes taurinus
inferred← citeshttps://doi.org/10.1002/bies.202400190openalex-snapshot
The Art of Chilling Out: How Neurons Regulate Torpor
inferred← citeshttps://doi.org/10.1002/cne.24638openalex-snapshot
Age‐related central regulation of orexin and NPY in the short‐lived African killifish Nothobranchius furzeri
inferred← citeshttps://doi.org/10.1002/cphy.c190031openalex-snapshot
Leptin: Master Regulator of Biological Functions that Affects Breathing
inferred← citeshttps://doi.org/10.1002/hipo.23376openalex-snapshot
Orexin (hypocretin) mediates light‐dependent fluctuation of hippocampal function in a diurnal rodent
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2020.tb00137.xopenalex-snapshot
Leptin: Master Regulator of Biological Functions that Affects Breathing
inferred← citeshttps://doi.org/10.1002/jdn.70102openalex-snapshot
Effects of Maternal High‐Fat Diet During Pregnancy and Lactation on Behaviour and Hypothalamic Orexin Neurons in Mice Offspring
inferred← citeshttps://doi.org/10.1002/jnr.23975openalex-snapshot
Orexin‐A increases the firing activity of hippocampal CA1 neurons through orexin‐1 receptors
inferred← citeshttps://doi.org/10.1002/npr2.70079openalex-snapshot
Longitudinal Associations of Serum Orexin‐A With Physical Activity and Sleep in Schizophrenia: A Preliminary Study
inferred← citeshttps://doi.org/10.1002/pmic.201600478openalex-snapshot
Proteomic profiling of the hypothalamus in two mouse models of narcolepsy
inferred← citeshttps://doi.org/10.1002/wsbm.1536openalex-snapshot
Orexin, serotonin, and energy balance
inferred← citeshttps://doi.org/10.1007/164_2018_100openalex-snapshot
Contribution of Dynorphin and Orexin Neuropeptide Systems to the Motivational Effects of Alcohol
inferred← citeshttps://doi.org/10.1007/7854_2015_381openalex-snapshot
Regulation of the Motivation to Eat
inferred← citeshttps://doi.org/10.1007/7854_2016_45openalex-snapshot
Orexin/Hypocretin and Organizing Principles for a Diversity of Wake-Promoting Neurons in the Brain
inferred← citeshttps://doi.org/10.1007/7854_2016_46openalex-snapshot
Orexin and Central Modulation of Cardiovascular and Respiratory Function
inferred← citeshttps://doi.org/10.1007/7854_2016_47openalex-snapshot
Orexin OX2 Receptor Antagonists as Sleep Aids
inferred← citeshttps://doi.org/10.1007/7854_2016_57openalex-snapshot
A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?
inferred← citeshttps://doi.org/10.1007/7854_2016_59openalex-snapshot
The Hypocretin/Orexin Neuronal Networks in Zebrafish
inferred← citeshttps://doi.org/10.1007/978-3-030-41878-6_13openalex-snapshot
The Hypothalamus, the Preoptic Area, and Hypothalamohypophysial Systems
inferred← citeshttps://doi.org/10.1007/978-3-030-62263-3_17openalex-snapshot
Narcolepsy, Idiopathic Hypersomnia, and Dysautonomia
inferred← citeshttps://doi.org/10.1007/978-3-319-23078-8_16openalex-snapshot
Orexin and Circadian Influences in Sleep and Psychiatric Disorders: A Review of Experimental and Computational Modelling Studies
inferred← citeshttps://doi.org/10.1007/978-3-319-23078-8_21openalex-snapshot
Orexin Regulates Glucose Homeodynamics with Daily Rhythm
inferred← citeshttps://doi.org/10.1007/978-3-319-23078-8_4openalex-snapshot
Physiological Roles of Orexin Receptors on Sleep/Wakefulness Regulation
inferred← citeshttps://doi.org/10.1007/978-3-319-30572-1_13openalex-snapshot
REM Sleep: Food for Thought?
inferred← citeshttps://doi.org/10.1007/978-3-319-40764-7_6openalex-snapshot
Role of Astrocytes in Central Respiratory Chemoreception
inferred← citeshttps://doi.org/10.1007/978-3-319-60492-3_24openalex-snapshot
Should an Artificial Window Substitute a Natural One?
inferred← citeshttps://doi.org/10.1007/978-981-15-5167-3_3openalex-snapshot
Chemistry of Neurochemicals: Psychopharmaceuticals and Neuropeptides
inferred← citeshttps://doi.org/10.1007/978-981-97-2681-3_4openalex-snapshot
Central Nervous System Regulation of Eating and Brain Functions
inferred← citeshttps://doi.org/10.1007/s00213-018-4871-2openalex-snapshot
The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders
inferred← citeshttps://doi.org/10.1007/s00213-020-05651-4openalex-snapshot
The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues
inferred← citeshttps://doi.org/10.1007/s00429-017-1466-3openalex-snapshot
The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization
inferred← citeshttps://doi.org/10.1007/s10571-017-0487-zopenalex-snapshot
The Orexin System and Hypertension
inferred← citeshttps://doi.org/10.1007/s10695-022-01107-yopenalex-snapshot
Effect of winter feeding frequency on growth performance, biochemical blood parameters, oxidative stress, and appetite-related genes in Takifugu rubripes
inferred← citeshttps://doi.org/10.1007/s10989-019-09943-yopenalex-snapshot
Alteration of Phospholipase C Expression in Rat Visual Cortical Neurons by Chronic Blockade of Orexin Receptor 1
inferred← citeshttps://doi.org/10.1007/s11033-021-06198-zopenalex-snapshot
RF-amide related peptide-3 (RFRP-3): a novel neuroendocrine regulator of energy homeostasis, metabolism, and reproduction
inferred← citeshttps://doi.org/10.1007/s11055-019-00846-5openalex-snapshot
An Immunohistochemical Study of the Pathways of the Influence of Dopamine on Orexinergic Neurons in the Perifornical Area of the Hypothalamus
inferred← citeshttps://doi.org/10.1007/s11154-026-10036-7openalex-snapshot
Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions
inferred← citeshttps://doi.org/10.1007/s12017-018-8506-xopenalex-snapshot
Central Orexin A Affects Reproductive Axis by Modulation of Hypothalamic Kisspeptin/Neurokinin B/Dynorphin Secreting Neurons in the Male Wistar Rats
inferred← citeshttps://doi.org/10.1007/s12264-015-1564-2openalex-snapshot
Dissecting the hypothalamic pathways that underlie innate behaviors
inferred← citeshttps://doi.org/10.1007/s12264-019-00447-9openalex-snapshot
Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders
inferred← citeshttps://doi.org/10.1007/s13105-019-00719-yopenalex-snapshot
HYPOTHesizing about central comBAT against obesity
inferred← citeshttps://doi.org/10.1007/s13311-019-00726-3openalex-snapshot
Neurophysiological and Behavioral Effects of Anti-Orexinergic Treatments in a Mouse Model of Huntington's Disease
inferred← citeshttps://doi.org/10.1007/s40265-024-02096-3openalex-snapshot
Orexin Receptor Antagonists for the Prevention and Treatment of Alzheimer’s Disease and Associated Sleep Disorders
inferred← citeshttps://doi.org/10.1007/s40675-026-00362-2openalex-snapshot
Targeting Orexinergic and Histaminergic Wake-Promoting Circuits: Effects on Sleep and Mental Health
inferred← citeshttps://doi.org/10.1007/s41782-017-0032-7openalex-snapshot
Neurobiological Role of Hypocretin in Regulation of Psychiatric Disorders
inferred← citeshttps://doi.org/10.1007/s41782-020-00103-7openalex-snapshot
Inhibition of Orexin-1/2 Receptors Disrupts Goal-Oriented Locomotor Activity During Motivated Behaviour in Male Rats
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12442-4openalex-snapshot
Orexin Receptor Antagonists
inferred← citeshttps://doi.org/10.1016/b978-0-12-813743-7.00024-4openalex-snapshot
Sleep in Fish Models
inferred← citeshttps://doi.org/10.1016/b978-0-12-813751-2.00004-8openalex-snapshot
Orexins and Control of Feeding by Learned Cues
inferred← citeshttps://doi.org/10.1016/b978-0-12-813751-2.00007-3openalex-snapshot
Orexins and Cognition: Neuroanatomical and Neurochemical Substrates
inferred← citeshttps://doi.org/10.1016/b978-0-12-816093-0.00018-5openalex-snapshot
Regulation of the Energy Balance
inferred← citeshttps://doi.org/10.1016/b978-0-12-819973-2.00025-3openalex-snapshot
Sleep disorders and the hypothalamus
inferred← citeshttps://doi.org/10.1016/b978-0-323-54856-4.00014-6openalex-snapshot
When Food Is an Addiction
inferred← citeshttps://doi.org/10.1016/b978-0-44-345008-2.00019-9openalex-snapshot
The brain's ‘Allow, Restrain, Amplify, Respond’ (ARAR) architecture
inferred← citeshttps://doi.org/10.1016/bs.pbr.2016.06.001openalex-snapshot
Fatigue with up- vs downregulated brain arousal should not be confused
inferred← citeshttps://doi.org/10.1016/bs.vh.2024.06.006openalex-snapshot
Modulation of respiration and hypothalamus
inferred← citeshttps://doi.org/10.1016/j.alcohol.2025.01.006openalex-snapshot
Effects of daridorexant on rest/wake activity patterns and drinking in adult rats exposed to chronic ethanol vapor in adolescence
inferred← citeshttps://doi.org/10.1016/j.appet.2016.09.032openalex-snapshot
Plasma kisspeptin and ghrelin levels are independently correlated with physical activity in patients with anorexia nervosa
inferred← citeshttps://doi.org/10.1016/j.autneu.2020.102712openalex-snapshot
Orexin A and B in the rat superior salivatory nucleus
inferred← citeshttps://doi.org/10.1016/j.autneu.2025.103248openalex-snapshot
Diencephalic and brainstem circuit mechanisms underlying autonomic cardiovascular adjustments to exercise: Recent insights from rodent studies
inferred← citeshttps://doi.org/10.1016/j.bbr.2017.02.021openalex-snapshot
Injections of the of the α1-adrenoceptor antagonist prazosin into the median raphe nucleus increase food intake and Fos expression in orexin neurons of free-feeding rats
inferred← citeshttps://doi.org/10.1016/j.bbr.2017.12.002openalex-snapshot
Dose-dependent and opposite effects of orexin A on prepulse inhibition response in sleep-deprived and non-sleep-deprived rats
inferred← citeshttps://doi.org/10.1016/j.bbr.2018.04.010openalex-snapshot
Orexin A in the ventral tegmental area enhances saccharin-induced conditioned flavor preference: The role of D1 receptors in central nucleus of amygdala
inferred← citeshttps://doi.org/10.1016/j.bbr.2019.112155openalex-snapshot
Involvement of orexin receptors within the hippocampal dentate gyrus in morphine-induced reinstatement in food-deprived rats
inferred← citeshttps://doi.org/10.1016/j.bbr.2022.113791openalex-snapshot
Intracerebroventricular infusion of the selective orexin 1 receptor antagonist SB-334867 impairs cognitive flexibility in a sex-dependent manner
inferred← citeshttps://doi.org/10.1016/j.bbr.2023.114491openalex-snapshot
Nasal administration of orexin A partially rescues dizocilpine-induced cognitive impairments in female C57BL/6 J mice
inferred← citeshttps://doi.org/10.1016/j.bbr.2025.115686openalex-snapshot
The effect of different training intensities on Orexin-1 receptor protein expression in the nucleus accumbens and physical activity drive in male wistar rats
inferred← citeshttps://doi.org/10.1016/j.bbr.2025.116010openalex-snapshot
Differential modulation of contextual fear conditioning by orexin receptors in the dorsal hippocampus
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.10.146openalex-snapshot
Transmembrane peptide 4 and 5 of APJ are essential for its heterodimerization with OX1R
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.112925openalex-snapshot
Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1
inferred← citeshttps://doi.org/10.1016/j.biopsych.2025.11.004openalex-snapshot
Functional Plasticity of Orexin/Hypocretin Neurons Balances Stress States
inferred← citeshttps://doi.org/10.1016/j.bjao.2025.100415openalex-snapshot
Systemic role of orexin A, substance P, bradykinin, and DABK in severe COVID-19 and 2.5-yr follow-ups: an observational study
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.03.010openalex-snapshot
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring
inferred← citeshttps://doi.org/10.1016/j.bmc.2023.117325openalex-snapshot
Azulene as a biphenyl mimetic in orexin/hypocretin receptor agonists
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.07.011openalex-snapshot
Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.04.044openalex-snapshot
Synthesis and biological evaluation of F-18 labeled tetrahydroisoquinoline derivatives targeting orexin 1 receptor
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.07.039openalex-snapshot
Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.126893openalex-snapshot
Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group
inferred← citeshttps://doi.org/10.1016/j.bmcl.2021.128098openalex-snapshot
Synthesis and biological evaluation of novel 18F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain
inferred← citeshttps://doi.org/10.1016/j.bmcl.2022.128530openalex-snapshot
Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton
inferred← citeshttps://doi.org/10.1016/j.bmcl.2022.128550openalex-snapshot
Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives
inferred← citeshttps://doi.org/10.1016/j.bmcl.2023.129151openalex-snapshot
Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton
inferred← citeshttps://doi.org/10.1016/j.bpsc.2026.03.006openalex-snapshot
Motivational Subdomains in Neurodevelopmental Disorders: A Heuristic Circuit Framework for Translational Validation
inferred← citeshttps://doi.org/10.1016/j.brainres.2016.01.049openalex-snapshot
The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice
inferred← citeshttps://doi.org/10.1016/j.brainres.2016.07.024openalex-snapshot
Reduced spontaneous neuronal activity in the insular cortex and thalamus in healthy adults with insomnia symptoms
inferred← citeshttps://doi.org/10.1016/j.brainres.2016.10.018openalex-snapshot
Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats
inferred← citeshttps://doi.org/10.1016/j.brainres.2017.07.006openalex-snapshot
Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus
inferred← citeshttps://doi.org/10.1016/j.brainres.2018.04.002openalex-snapshot
A comparison of the orexin receptor distribution in the brain between diurnal Nile grass rats ( Arvicanthis niloticus ) and nocturnal mice ( Mus musculus )
inferred← citeshttps://doi.org/10.1016/j.brainres.2018.07.026openalex-snapshot
The contribution of orexins to sex differences in the stress response
inferred← citeshttps://doi.org/10.1016/j.brainres.2018.09.011openalex-snapshot
How orexin signals bias action: Hypothalamic and accumbal circuits
inferred← citeshttps://doi.org/10.1016/j.brainres.2018.11.032openalex-snapshot
Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit
inferred← citeshttps://doi.org/10.1016/j.brainres.2018.12.036openalex-snapshot
Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy
inferred← citeshttps://doi.org/10.1016/j.brainres.2020.147199openalex-snapshot
Orexin deficiency affects sociability and the acquisition, expression, and extinction of conditioned social fear
inferred← citeshttps://doi.org/10.1016/j.brainres.2025.149491openalex-snapshot
Modulation of noradrenergic signalling reverses stress-induced changes in the hippocampus: Involvement of orexinergic systems
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2018.06.016openalex-snapshot
Role of orexin-1 and orexin-2 receptors in the CA1 region of hippocampus in the forced swim stress- and food deprivation-induced reinstatement of morphine seeking behaviors in rats
inferred← citeshttps://doi.org/10.1016/j.cellsig.2015.03.026openalex-snapshot
The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism
inferred← citeshttps://doi.org/10.1016/j.cellsig.2020.109743openalex-snapshot
A novel phosphorylation site on orexin receptor 1 regulating orexinA-induced GRK2-biased signaling
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107779openalex-snapshot
Brain Circuit of Claustrophobia-like Behavior in Mice Identified by Upstream Tracing of Sighing
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107790openalex-snapshot
Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene
inferred← citeshttps://doi.org/10.1016/j.chembiol.2022.11.007openalex-snapshot
A photocaged orexin-B for spatiotemporally precise control of orexin signaling
inferred← citeshttps://doi.org/10.1016/j.clinthera.2024.07.010openalex-snapshot
Weight Loss With Once-nightly Sodium Oxybate for the Treatment of Narcolepsy: Analysis From the Phase III Randomized study Evaluating the efficacy and SafeTy of a ONce nightly formulation of sodium oxybate (REST-ON) Trial
inferred← citeshttps://doi.org/10.1016/j.cobeha.2024.101456openalex-snapshot
Nonsynaptic encoding of behavior by neuropeptides
inferred← citeshttps://doi.org/10.1016/j.cophys.2020.04.001openalex-snapshot
Diet and sleep: is hypothalamus the link?
inferred← citeshttps://doi.org/10.1016/j.cub.2019.07.069openalex-snapshot
Orexin in the Posterior Paraventricular Thalamus Mediates Hunger-Related Signals in the Nucleus Accumbens Core
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114505openalex-snapshot
Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library
inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.176190openalex-snapshot
Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.127229openalex-snapshot
Unseen threats: How nanoplastics trigger anxiety and depression-like behaviors in zebrafish (Danio rerio)
inferred← citeshttps://doi.org/10.1016/j.expneurol.2022.114250openalex-snapshot
T-type Ca2+ channels and inward rectifier K+ channels contribute to the orexin-induced facilitation of GABAergic transmission onto pyramidal neurons in the prefrontal cortex of juvenile mice
inferred← citeshttps://doi.org/10.1016/j.gendis.2020.11.013openalex-snapshot
Depression and stress levels increase risk of liver cancer through epigenetic downregulation of hypocretin
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e36402openalex-snapshot
Sex-dimorphic functions of orexin in neuropsychiatric disorders
inferred← citeshttps://doi.org/10.1016/j.ibneur.2023.11.006openalex-snapshot
Enhanced low-gamma band power in the hippocampus and prefrontal cortex in a rat model of depression is reversed by orexin-1 receptor antagonism
inferred← citeshttps://doi.org/10.1016/j.inpsyc.2025.100122openalex-snapshot
Silent nights: Adjunctive lemborexant for managing nighttime agitation and sleep disturbances in Alzheimer's dementia
inferred← citeshttps://doi.org/10.1016/j.isci.2019.09.003openalex-snapshot
Differential Roles of Each Orexin Receptor Signaling in Obesity
inferred← citeshttps://doi.org/10.1016/j.isci.2026.114833openalex-snapshot
Social stress and affiliative touch: A tale of two affective states
inferred← citeshttps://doi.org/10.1016/j.jad.2018.07.040openalex-snapshot
Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study
inferred← citeshttps://doi.org/10.1016/j.jad.2025.04.015openalex-snapshot
Evaluation of leptin, insulin, orexin, neuropeptide y (NPY) levels in postmortem CSF samples in suicide deaths
inferred← citeshttps://doi.org/10.1016/j.jcte.2018.12.006openalex-snapshot
Improvement of glycemic control by treatment for insomnia with suvorexant in type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.jtauto.2020.100055openalex-snapshot
No evidence of autoimmunity to human OX1 or OX2 orexin receptors in Pandemrix-vaccinated narcoleptic children
inferred← citeshttps://doi.org/10.1016/j.mce.2015.07.022openalex-snapshot
Orexins (hypocretins) and energy balance: More than feeding
inferred← citeshttps://doi.org/10.1016/j.mce.2024.112162openalex-snapshot
Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans
inferred← citeshttps://doi.org/10.1016/j.mehy.2026.112059openalex-snapshot
Nutritional ketosis as a nonpharmacologic approach to executive dysfunction in ADHD and related conditions: a neurometabolic framework
inferred← citeshttps://doi.org/10.1016/j.nbd.2015.04.004openalex-snapshot
Antidepressant effects of exercise are produced via suppression of hypocretin/orexin and melanin-concentrating hormone in the basolateral amygdala
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2014.11.021openalex-snapshot
Limbic thalamus and state-dependent behavior: The paraventricular nucleus of the thalamic midline as a node in circadian timing and sleep/wake-regulatory networks
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2014.12.005openalex-snapshot
Roles of the orexin system in central motor control
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2015.08.005openalex-snapshot
Placing the paraventricular nucleus of the thalamus within the brain circuits that control behavior
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2016.06.044openalex-snapshot
Orexin, Stress and Central Cardiovascular Control. A Link with Hypertension?
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2018.07.003openalex-snapshot
Food intake and addictive-like eating behaviors: Time to think about the circadian clock(s)
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2021.01.012openalex-snapshot
Cardinal role of the environment in stress induced changes across life stages and generations
inferred← citeshttps://doi.org/10.1016/j.neuint.2020.104882openalex-snapshot
Bidirectional gut-brain communication: A role for orexin-A
inferred← citeshttps://doi.org/10.1016/j.neulet.2016.04.002openalex-snapshot
Orexin neurons in the lateral hypothalamus project to the medial prefrontal cortex with a rostro-caudal gradient
inferred← citeshttps://doi.org/10.1016/j.neulet.2017.05.048openalex-snapshot
Orexin exerts excitatory effects on reticulospinal neurons in the rat gigantocellular reticular nucleus through the activation of postsynaptic orexin-1 and orexin-2 receptors
inferred← citeshttps://doi.org/10.1016/j.neures.2017.03.015openalex-snapshot
The roles of orexins in sleep/wake regulation
inferred← citeshttps://doi.org/10.1016/j.neures.2025.104952openalex-snapshot
Role of orexin receptors in histamine- and chloroquine-induced pruriceptive processing
inferred← citeshttps://doi.org/10.1016/j.neuro.2018.04.010openalex-snapshot
Orexin receptor expression is increased during mancozeb-induced feeding impairments and neurodegenerative events in a marine fish
inferred← citeshttps://doi.org/10.1016/j.neuron.2023.10.012openalex-snapshot
Spatial memory requires hypocretins to elevate medial entorhinal gamma oscillations
inferred← citeshttps://doi.org/10.1016/j.neuron.2024.01.007openalex-snapshot
A role for the cerebellum in motor-triggered alleviation of anxiety
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2015.08.014openalex-snapshot
Excitatory orexinergic innervation of rat nucleus incertus – Implications for ascending arousal, motivation and feeding control
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2017.07.008openalex-snapshot
Inhibition of TrkB at the nucleus accumbens, using ANA-12, regulates basal and stress-induced orexin A expression within the mesolimbic system and affects anxiety, sociability and motivation
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.05.008openalex-snapshot
Self-administration of the synthetic cathinone MDPV enhances reward function via a nicotinic receptor dependent mechanism
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.07.004openalex-snapshot
Melanin-concentrating hormone and orexin systems in rat nucleus incertus: Dual innervation, bidirectional effects on neuron activity, and differential influences on arousal and feeding
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.09.033openalex-snapshot
Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.09.034openalex-snapshot
The role of the orexin system in stress response
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.10.024openalex-snapshot
Reactive and predictive homeostasis: Roles of orexin/hypocretin neurons
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.11.017openalex-snapshot
To eat or to sleep: That is a lateral hypothalamic question
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2023.109815openalex-snapshot
Clinical usefulness of dual orexin receptor antagonism beyond insomnia: Neurological and psychiatric comorbidities
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2025.110513openalex-snapshot
How may the hypothalamus control distinct types and stages of memory?
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2026.111127openalex-snapshot
Lemborexant produces antidepressant- and anxiolytic-like effects with sleep-wake regulation compared with fluoxetine in male mice with comorbid depression and insomnia
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2016.07.041openalex-snapshot
The integrated ultradian organization of behavior and physiology in mice and the contribution of orexin to the ultradian patterning
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2016.10.043openalex-snapshot
A food-predictive cue attributed with incentive salience engages subcortical afferents and efferents of the paraventricular nucleus of the thalamus
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2017.02.038openalex-snapshot
Orexin 2 receptor regulation of the hypothalamic–pituitary–adrenal (HPA) response to acute and repeated stress
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2017.11.044openalex-snapshot
Effects on Hedonic Feeding, Energy Expenditure and Balance of the Non-opioid Peptide DYN-A2-17
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2021.06.006openalex-snapshot
Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2021.11.032openalex-snapshot
Appetitive Behavior in the Social Transmission of Food Preference Paradigm Predicts Activation of Orexin-A producing Neurons in a Sex-Dependent Manner
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2025.12.057openalex-snapshot
Acute administration of a dual orexin receptor antagonist attenuates sleep fragmentation in a mouse model of traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.nlm.2016.07.016openalex-snapshot
Consolidation of altered associability information by amygdala central nucleus
inferred← citeshttps://doi.org/10.1016/j.npep.2023.102353openalex-snapshot
Restraint stress potentiates sensitivity to the antinociceptive effect of morphine through orexin receptors in the ventral tegmental area
inferred← citeshttps://doi.org/10.1016/j.pbb.2015.04.003openalex-snapshot
Fasting activated histaminergic neurons and enhanced arousal effect of caffeine in mice
inferred← citeshttps://doi.org/10.1016/j.pbb.2015.04.012openalex-snapshot
Do Orexins contribute to impulsivity-driven binge consumption of rewarding stimulus and transition to drug/food dependence?
inferred← citeshttps://doi.org/10.1016/j.pbb.2016.06.005openalex-snapshot
Etiological theories of addiction: A comprehensive update on neurobiological, genetic and behavioural vulnerability
inferred← citeshttps://doi.org/10.1016/j.pbb.2017.06.013openalex-snapshot
Circadian neurons in the lateral habenula: Clocking motivated behaviors
inferred← citeshttps://doi.org/10.1016/j.pbb.2023.173690openalex-snapshot
The orexin receptor 2 (OX2R)-selective agonist TAK-994 increases wakefulness without affecting cerebrospinal fluid orexin levels in cynomolgus monkeys
inferred← citeshttps://doi.org/10.1016/j.pbb.2025.173997openalex-snapshot
Divergent effects of noradrenergic activation and orexin receptor 1 blockade on hippocampal structure, anxiety-like behavior, and social interaction following chronic stress
inferred← citeshttps://doi.org/10.1016/j.peptides.2017.12.017openalex-snapshot
Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats
inferred← citeshttps://doi.org/10.1016/j.peptides.2021.170530openalex-snapshot
Orexin (hypocretin) participates in central autonomic regulation during fight-or-flight response
inferred← citeshttps://doi.org/10.1016/j.peptides.2023.171009openalex-snapshot
Internal and external modulation factors of the orexin system (REVIEW)
inferred← citeshttps://doi.org/10.1016/j.peptides.2023.171051openalex-snapshot
The present and future of synthetic orexin receptor agonists
inferred← citeshttps://doi.org/10.1016/j.peptides.2023.171080openalex-snapshot
The role of orexinergic system in the regulation of cataplexy
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2017.12.010openalex-snapshot
Chronopathophysiological implications of orexin in sleep disturbances and lifestyle-related disorders
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107693openalex-snapshot
Nicotine’ actions on energy balance: Friend or foe?
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.08.020openalex-snapshot
The hypophagic factor oleoylethanolamide differentially increases c-fos expression in appetite regulating centres in the brain of wild type and histamine deficient mice
inferred← citeshttps://doi.org/10.1016/j.physbeh.2016.02.042openalex-snapshot
Orexin/hypocretin receptor 1 signaling mediates Pavlovian cue-food conditioning and extinction
inferred← citeshttps://doi.org/10.1016/j.physbeh.2016.03.039openalex-snapshot
Ghrelin: A link between memory and ingestive behavior
inferred← citeshttps://doi.org/10.1016/j.physbeh.2020.112952openalex-snapshot
Fast sensory representations in the lateral hypothalamus and their roles in brain function
inferred← citeshttps://doi.org/10.1016/j.physbeh.2020.112988openalex-snapshot
The hypothalamus as a primary coordinator of memory updating
inferred← citeshttps://doi.org/10.1016/j.physbeh.2022.114069openalex-snapshot
Sex-dependent role of orexin deficiency in feeding behavior and affective state of mice following intermittent access to a Western diet – Implications for binge-like eating behavior
inferred← citeshttps://doi.org/10.1016/j.physbeh.2023.114183openalex-snapshot
CO2 reactivity is associated with individual differences in appetitive extinction memory
inferred← citeshttps://doi.org/10.1016/j.physbeh.2025.115009openalex-snapshot
Orexin-A and BDNF in the hippocampus of middle-aged rats: beneficial effects of integrating voluntary physical activity with intermittent fasting
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2015.12.002openalex-snapshot
Challenges in the development of therapeutics for narcolepsy
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2020.101771openalex-snapshot
Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2026.102920openalex-snapshot
Evolution of neuropeptides: From diffusing molecules to modulators of synaptic transmission
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2018.09.006openalex-snapshot
Orexin 1 receptors in the anterior cingulate and orbitofrontal cortex regulate cost and benefit decision-making
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2022.110517openalex-snapshot
Orexin deficiency affects sensorimotor gating and its amphetamine-induced impairment
inferred← citeshttps://doi.org/10.1016/j.psc.2015.08.001openalex-snapshot
New Developments in Insomnia Medications of Relevance to Mental Health Disorders
inferred← citeshttps://doi.org/10.1016/j.psychres.2018.04.010openalex-snapshot
Orexin A in men with heroin use disorder undergoing methadone maintenance treatment
inferred← citeshttps://doi.org/10.1016/j.psychres.2023.115412openalex-snapshot
High-fat diet-induced dopaminergic dysregulation induces REM sleep fragmentation and ADHD-like behaviors
inferred← citeshttps://doi.org/10.1016/j.resp.2018.07.003openalex-snapshot
The role of the hypothalamus in modulation of respiration
inferred← citeshttps://doi.org/10.1016/j.sleep.2020.10.014openalex-snapshot
Quality of life and procrastination in post-H1N1 narcolepsy, sporadic narcolepsy and idiopathic hypersomnia, a Swedish cross-sectional study
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