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Human hepatocyte polyploidization kinetics in the course of life cycle
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Physiological and Pathological Ageing
inferredcites →https://doi.org/10.1002/ar.1091420402openalex-snapshot
The counting of mono‐ and binucleated cells in tissue sections
inferredcites →https://doi.org/10.1007/978-3-642-48263-2_4openalex-snapshot
Cellular Proliferation in the Liver
inferredcites →https://doi.org/10.1007/bf00493368openalex-snapshot
Studies on DNA content of hepatocytes in cirrhosis and hepatoma by means of microspectrophotometry and radioautography
inferredcites →https://doi.org/10.1007/bf00958971openalex-snapshot
�ber das Karyogramm der menschlichen Leber unter normalen und pathologischen Bedingungen
inferredcites →https://doi.org/10.1007/bf01259493openalex-snapshot
The development in the human liver of multiple desoxyribose nucleic acid (DNA) classes and their relationship to the age of the individual
inferredcites →https://doi.org/10.1007/bf02109231openalex-snapshot
Über die Zweikernigkeit der Leberzellen
inferredcites →https://doi.org/10.1007/bf02889003openalex-snapshot
Human hepatocytes and aging: A cytophotometrical analysis in 35 sudden-death cases
inferredcites →https://doi.org/10.1007/bf02889344openalex-snapshot
Number of nuclei in isolated myocardial cells of pigs
inferredcites →https://doi.org/10.1016/0014-4827(66)90324-7openalex-snapshot
Polyploïdie somatique dans le foie de rat
inferredcites →https://doi.org/10.1016/0014-4827(71)90330-2openalex-snapshot
Zellklassen und Ploidiestufen in isolierten Leberzellen der Maus
inferredcites →https://doi.org/10.1016/0014-4827(72)90401-6openalex-snapshot
Binucleation in mammalian liver
inferredcites →https://doi.org/10.1016/0531-5565(84)90044-5openalex-snapshot
Euploidization of human hepatocytes from donors of different ages and both sexes compared with those from cases of werner's syndrome and progeria
inferredcites →https://doi.org/10.1016/s0022-5193(05)80680-0openalex-snapshot
A method for investigating hepatocyte polyploidization kinetics during postnatal development in mammals
inferredcites →https://doi.org/10.1016/s0074-7696(08)60100-xopenalex-snapshot
Cell Polyploidy: Its Relation to Tissue Growth and Function
inferredcites →https://doi.org/10.1016/s0091-679x(08)61797-5openalex-snapshot
Chapter 4 Preparation of Isolated Rat Liver Cells
inferredcites →https://doi.org/10.1016/s0344-0338(81)80120-3openalex-snapshot
DNS-Gehalt and Zellzahl in Herz and Leber von Kindern
inferredcites →https://doi.org/10.1073/pnas.57.2.327openalex-snapshot
CELL SIZE, NUCLEAR CONTENT, AND THE DEVELOPMENT OF POLYPLOIDY IN THE MAMMALIAN LIVER
inferredcites →https://doi.org/10.1111/j.1365-2184.1978.tb00892.xopenalex-snapshot
Growth Fraction and Cycle Duration of Hepatocytes In the Three‐Week‐Old Rat
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A MORPHOMETRIC STUDY OF NORMAL HUMAN LIVER CELL NUCLEI
inferredcites →https://doi.org/10.18999/nagjms.24.2.97openalex-snapshot
On the fundamental morphology of the senile changes.
inferredcites →https://doi.org/10.18999/nagjms.33.1.1openalex-snapshot
DNA synthesis in polyploid and binucleate hepatic cells in the regenerating rat liver of different ages.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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The role of cellular polyploidy in the regeneration of the cirrhotic liver in rats and humans
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Cardiomyocyte ploidy levels in birds with different growth rates
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Genomic Instability and DNA Repair
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Physiological Relevance and Molecular Control of the Endocycle in Plants
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Polyploidy in Liver Function, Mitochondrial Metabolism, and Cancer
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Rat Left Ventricular Cardiomyocytes Characterization in the Process of Postinfarction Myocardial Remodeling
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Stereological measurement of porto-central gradients in gene expression in mouse liver
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Large Cell Change in a Small Liver: A Histological Clue to Short Telomere Syndromes?
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Roads to polyploidy: The megakaryocyte example
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Functional analysis of mouse hepatocytes differing in DNA content: Volume, receptor expression, and effect of IFNγ
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Mapping hepatocyte size in vivo using temporal diffusion spectroscopy MRI
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Hepatic polyploidy and liver growth control
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Polyploidization and Cancer
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Understanding Cytokinesis Failure
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Polyploidization of liver cells
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Mechanisms of Cell Cycle Blocks at the G2/M Transition and Their Role in Differentiation and Development
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Cell–Cell Fusions and Human Endogenous Retroviruses in Cancer
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Cdc2-kinases, cyclins, and the switch from proliferation to polyploidization
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Microarray analysis of gene expression of mouse hepatocytes of different ploidy
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Donor-derived hepatocytes in human hematopoietic cell transplant recipients: evidence of fusion
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Communal living: the role of polyploidy and syncytia in tissue biology
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Liver Regeneration and Tissue Repair
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Changes in Hepatocyte Ploidy During Liver Regeneration
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Hepatic Defenses Against Toxicity: Liver Regeneration and Tissue Repair
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Hepatic Defenses Against Toxicity: Liver Regeneration and Tissue Repair
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Liver Cell Culture and Lineage Biology
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Hepatic regeneration in aging: Cell type plasticity and redundancies
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Incomplete cytokinesis/binucleation in mammals
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Polyploidization in Liver Tissue
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Anatomy of rodent and human livers: What are the differences?
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Cancer regeneration: Polyploid cells are the key drivers of tumor progression
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Chromosome instability in neoplasia: chaotic roots to continuous growth
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Temporal myc dynamics permit mitotic bypass, promoting polyploid phenotypes
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Diploid hepatocytes drive physiological liver renewal in adult humans
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Polyploidy and liver proliferation
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Liver physiological polyploidization: MicroRNA-122 a key regulator
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Efficiency evaluation of a DNA extraction and purification protocol on archival formalin-fixed and paraffin-embedded tissue
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Transcriptomic Dissection of Hepatocyte Heterogeneity: Linking Ploidy, Zonation, and Stem/Progenitor Cell Characteristics
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The Significance of Polyploid Hepatocytes During Aging Process
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PRMT5 determines the pattern of polyploidization and prevents liver from cirrhosis and carcinogenesis
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Ageing, telomeres, senescence, and liver injury
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Polyploidy control in hepatic health and disease
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Autologous bone marrow stem cells — properties and advantages
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Epithelial proliferation and cell cycle dysregulation in kidney injury and disease
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Surviving Acute Organ Failure: Cell Polyploidization and Progenitor Proliferation
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Fluorescent in situ hybridization in liver cell touch preparations from autopsy
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Targeting tumor cell senescence and polyploidy as potential therapeutic strategies
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Aneuploidy, polyploidy and ploidy reversal in the liver
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Physiological significance of polyploidization in mammalian cells
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Compensatory cellular hypertrophy: the other strategy for tissue homeostasis
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E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models
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Hepatic Stem Cells and Hepatoblasts: Identification, Isolation, and Ex Vivo Maintenance
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Adult stem cells—reprogramming neurological repair?
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Multi-nucleate retinal pigment epithelium cells of the human macula exhibit a characteristic and highly specific distribution
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Disorders of the liver, gall bladder and pancreas
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Influence of Age, Sex, and Degree of Liver Fibrosis on the Association Between Serum Alanine Aminotransferase Levels and Liver Inflammation in Patients with Chronic Hepatitis C
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Hepatocyte polyploidization and its association with pathophysiological processes
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The ploidy conveyor of mature hepatocytes as a source of genetic variation
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E2F8 is essential for polyploidization in mammalian cells
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From polyploidy to aneuploidy, genome instability and cancer
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Hepatocyte organoids and cell transplantation: What the future holds
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Hepatitis B virus X protein promotes DNA damage propagation through disruption of liver polyploidization and enhances hepatocellular carcinoma initiation
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Diploid hepatocytes resist acetaminophen-induced liver injury through suppressed JNK signaling
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Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy
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Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease
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Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution
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Cytokinesis defects and cancer
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Polyploidy in liver development, homeostasis and disease
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Towards a reference cell atlas of liver diversity over the human lifespan
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Biomarkers of ageing of humans and non-human primates
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Establishment of Feeder-Independent Cloned Caprine Trophoblast Cell Line Which Expresses Placental Lactogen and Interferon Tau
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Aging and Chronic Liver Disease
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Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data
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Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes
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Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase
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Reprogramming Factors Involved in Hybrids and Cybrids of Human Embryonic Stem Cells Fused with Hepatocytes
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Aging and the Liver: An Update
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Cellular polyploidy in organ homeostasis and regeneration
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Decreased apoptosis as a mechanism for hepatomegaly in streptozotocin- induced diabetic rats
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Diploid hepatocytes drive physiological liver renewal in adult humans
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Binucleated human hepatocytes arise through loss of membrane anchorage to the midbody during endomitosis
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Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.
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Nuclear size measurement is a simple method for the assessment of hepatocellular aging in non-alcoholic fatty liver disease: Comparison with telomere-specific quantitative FISH and p21 immunohistochemistry
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Hepatic Progenitors and Strategies for Liver Cell Therapies
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Identification of multinucleated cells in human kidney cortex: A way for tissue repairing?
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Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution
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Stem cells do not play a significant role in repopulation of adult human cardiomyocytes
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Cell Polyploidy. Cardiac Muscle. Liver. Ontogenesis and Regeneration
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Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis
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Polyploidy spectrum: a new marker in HCC classification
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Animal Cell Cytokinesis
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Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events
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Hepatocytes Polyploidization and Cell Cycle Control in Liver Physiopathology
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Vascular Aging: from Smooth Muscle Cell Differentiation to Polyploidization
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TALEN-Mediated Somatic Mutagenesis in Murine Models of Cancer
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Circulating Tumor Cells as a Biomarker in Pancreatic Ductal Adenocarcinoma
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Determinação de um protocolo de investigação de anomalias congênitas através de Hibridação >i /i< Fluorescente (FISH) em imprints celulares de fígado
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Aneuploidy as a mechanism for stress-induced liver adaptation
inferred← citeshttps://doi.org/10.1172/jci73957openalex-snapshot
Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1177/10668969211054102openalex-snapshot
Liver Histology in Short Telomere Syndrome: A Case Report and Review of the Literature
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Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells
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Mast cells and the liver aging process
inferred← citeshttps://doi.org/10.1186/s13287-023-03400-wopenalex-snapshot
Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
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Developmental Exposure to 2,2′,4,4′–Tetrabromodiphenyl Ether Induces Long-Lasting Changes in Liver Metabolism in Male Mice
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Liver tetraploidization is controlled by a new process of incomplete cytokinesis
inferred← citeshttps://doi.org/10.1371/journal.pone.0026080openalex-snapshot
Single-Cell Analysis of Ploidy and Centrosomes Underscores the Peculiarity of Normal Hepatocytes
inferred← citeshttps://doi.org/10.1371/journal.pone.0026381openalex-snapshot
Targeted Cell Fusion Facilitates Stable Heterokaryon Generation In Vitro and In Vivo
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Aged-related Function Disorder of Liver is Reversed after Exposing to Young Milieu via Conversion of Hepatocyte Ploidy
inferred← citeshttps://doi.org/10.1631/jzus.b2400127openalex-snapshot
Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes
inferred← citeshttps://doi.org/10.17615/qe8d-f168openalex-snapshot
Hyaluronan hydrogels, 3-dimensional scaffolds for ex vivo maintenance of human hepatic stem cells and hepatoblasts
inferred← citeshttps://doi.org/10.18632/oncotarget.22648openalex-snapshot
Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis
inferred← citeshttps://doi.org/10.21037/tlcr-22-516openalex-snapshot
False positivity in break apart fluorescence in-situ hybridization due to polyploidy
inferred← citeshttps://doi.org/10.2165/00002512-200118110-00005openalex-snapshot
Liver Function and Phase I Drug Metabolism in the Elderly
inferred← citeshttps://doi.org/10.2217/epi-2017-0111openalex-snapshot
Epigenome Mapping of Human Normal Purified Hepatocytes: Personal Epigenome Variation and Genome–Epigenome Correlation
inferred← citeshttps://doi.org/10.2217/epi-2019-0315openalex-snapshot
Rat Liver Epigenome Programing by Perinatal Exposure to 2,2′,4′4′-Tetrabromodiphenyl Ether
inferred← citeshttps://doi.org/10.2492/inflammregen.33.003openalex-snapshot
Primary evaluation of induced pluripotent stem cells using flow cytometry
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Regulation of cytokinesis and its clinical significance
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Oxidative stress triggers cytokinesis failure in hepatocytes upon isolation
inferred← citeshttps://doi.org/10.31857/s0044459624010047openalex-snapshot
Cell polyploidy. Cardiac muscle. Liver. Ontogenesis and regeneration
inferred← citeshttps://doi.org/10.32657/10356/155390openalex-snapshot
Age-dependent transcriptional and epigenetic alterations in mouse hepatocytes
inferred← citeshttps://doi.org/10.3390/cells12060860openalex-snapshot
Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases
inferred← citeshttps://doi.org/10.3390/genes14040921openalex-snapshot
Deep-Learning-Based Hepatic Ploidy Quantification Using H&E Histopathology Images
inferred← citeshttps://doi.org/10.3390/ijms21051836openalex-snapshot
Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress
inferred← citeshttps://doi.org/10.3390/ijms23169409openalex-snapshot
Implications of Polyploidy and Ploidy Alterations in Hepatocytes in Liver Injuries and Cancers
inferred← citeshttps://doi.org/10.3390/ijms232113085openalex-snapshot
Aging of Liver in Its Different Diseases
inferred← citeshttps://doi.org/10.3390/ijms24076546openalex-snapshot
Electrophysiological Properties of Tetraploid Cardiomyocytes Derived from Murine Pluripotent Stem Cells Generated by Fusion of Adult Somatic Cells with Embryonic Stem Cells
inferred← citeshttps://doi.org/10.3390/ijms26167729openalex-snapshot
Histological and Molecular Evaluation of Liver Biopsies: A Practical and Updated Review
inferred← citeshttps://doi.org/10.3748/wjg.v12.i28.4546openalex-snapshot
Conserved balance of hepatocyte nuclear DNA content in mononuclear and binuclear hepatocyte populations during the course of chronic viral hepatitis
inferred← citeshttps://doi.org/10.3791/64792openalex-snapshot
Isolation of Nuclei from Flash-frozen Liver Tissue for Single-cell Multiomics
inferred← citeshttps://doi.org/10.3791/64792-vopenalex-snapshot
Isolation of Nuclei from Flash-frozen Liver Tissue for Single-cell Multiomics
inferred← citeshttps://doi.org/10.4062/biomolther.2022.070openalex-snapshot
Polyploidization of Hepatocytes: Insights into the Pathogenesis of Liver Diseases
inferred← citeshttps://doi.org/10.5496/wjmg.v4.i4.77openalex-snapshot
Genome variation in the trophoblast cell lifespan: Diploidy, polyteny, depolytenization, genome segregation
inferred← citeshttps://doi.org/10.5772/19364openalex-snapshot
Cell Cycle Modification in Trophoblast Cell Populations in the Course of Placenta Formation
inferred← citeshttps://doi.org/10.5772/intechopen.97247openalex-snapshot
Genome Modifications Involved in Developmental Programs of the Placental Trophoblast
inferred← citeshttps://doi.org/10.6084/m9.figshare.23625476openalex-snapshot
Additional file 1 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
inferred← citeshttps://doi.org/10.6084/m9.figshare.23625482openalex-snapshot
Additional file 2 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
inferred← citeshttps://doi.org/10.6084/m9.figshare.23625485openalex-snapshot
Additional file 3 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
inferred← citeshttps://doi.org/10.6084/m9.figshare.23625491openalex-snapshot
Additional file 4 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
inferred← citeshttps://doi.org/10.6084/m9.figshare.23625494openalex-snapshot
Additional file 6 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
inferred← citeshttps://doi.org/10.6084/m9.figshare.23625497openalex-snapshot
Additional file 9 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
inferred← citeshttps://doi.org/10.6084/m9.figshare.23625500openalex-snapshot
Additional file 10 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
inferred← citeshttps://doi.org/10.6084/m9.figshare.23625503openalex-snapshot
Additional file 11 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
inferred← citeshttps://doi.org/10.6084/m9.figshare.23625506openalex-snapshot
Additional file 12 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead
inferred← citeshttps://doi.org/10.70675/1fc5906az1637z451czab81z7529e034be63openalex-snapshot
Rôle de la kinase ATR dans la progression de la stéatose hépatique non alcoolique
inferred← citeshttps://doi.org/10.70675/73c5ad47z37c8z4114zaf3ez3ddd10007a35openalex-snapshot
Genome instability : from genome content variations to gene expression plasticity
inferred← citeshttps://doi.org/10.70675/eb0d4c50z81dez4186zbf94zabbcd74f451fopenalex-snapshot
Altérations de la polyploïdie hépatocytaire au cours du développement des hépatopathies stéatosiques dites non-alcooliques
inferred← citeshttps://doi.org/10.7287/peerj.6949v0.1/reviews/1openalex-snapshot
Peer Review #1 of "Comprehensive transcriptional profiling of aging porcine liver (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.6949v0.1/reviews/2openalex-snapshot
Peer Review #2 of "Comprehensive transcriptional profiling of aging porcine liver (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.6949v0.1/reviews/3openalex-snapshot
Peer Review #3 of "Comprehensive transcriptional profiling of aging porcine liver (v0.1)"
inferred← citeshttps://doi.org/10.7717/peerj.6949openalex-snapshot
Comprehensive transcriptional profiling of aging porcine liver
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.