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Aneuploidy, polyploidy and ploidy reversal in the liver

https://doi.org/10.1016/j.semcdb.2013.01.003

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.1971.03190210160044openalex-snapshot

Regeneration of Liver and Kidney

inferredcites →https://doi.org/10.1002/cne.21648openalex-snapshot

Aneuploid mosaicism in the developing and adult cerebellar cortex

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Marked aneuploidy and loss of multiple chromosomes are common in autosomal mutants isolated from normal mouse kidney epithelium

inferredcites →https://doi.org/10.1002/hep.1840180424openalex-snapshot

Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide

inferredcites →https://doi.org/10.1002/hep.20600openalex-snapshot

Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury†

inferredcites →https://doi.org/10.1002/hep.22488openalex-snapshot

Cell fusion is a physiological process in mouse liver

inferredcites →https://doi.org/10.1002/hep.22516openalex-snapshot

The stem cell niche of human livers: Symmetry between development and regeneration

inferredcites →https://doi.org/10.1002/hep.24157openalex-snapshot

Human Hepatic Stem Cell and Maturational Liver Lineage Biology Δ

inferredcites →https://doi.org/10.1002/hep.26233openalex-snapshot

p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver

inferredcites →https://doi.org/10.1002/hep.510280409openalex-snapshot

Clonal analysis of macronodules in cirrhosis

inferredcites →https://doi.org/10.1002/hep.510310311openalex-snapshot

Clonal expansion in evolution of chronic hepatitis to hepatocellular carcinoma as seen at an X-chromosome locus

inferredcites →https://doi.org/10.1002/ijc.23901openalex-snapshot

Clinical implication of recurrent copy number alterations in hepatocellular carcinoma and putative oncogenes in recurrent gains on 1q

inferredcites →https://doi.org/10.1002/path.1700130121openalex-snapshot

The histology of liver tissue regeneration

inferredcites →https://doi.org/10.1002/path.3013openalex-snapshot

Cytokinesis, ploidy and aneuploidy

inferredcites →https://doi.org/10.1006/bbrc.1997.6220openalex-snapshot

The Mutagenicity of the Tyrosine Metabolite, Fumarylacetoacetate, Is Enhanced by Glutathione Depletion

inferredcites →https://doi.org/10.1006/excr.1997.3715openalex-snapshot

Overexpression of Antioxidant Enzymes in Transgenic Mice Decreases Cellular Ploidy during Liver Regeneration

inferredcites →https://doi.org/10.1006/scbi.2000.0317openalex-snapshot

Hepatic polyploidy and liver growth control

inferredcites →https://doi.org/10.1007/bf02915139openalex-snapshot

Human hepatocyte polyploidization kinetics in the course of life cycle

inferredcites →https://doi.org/10.1007/s00335-007-9048-yopenalex-snapshot

Microarray analysis of gene expression of mouse hepatocytes of different ploidy

inferredcites →https://doi.org/10.1016/j.bbrc.2006.02.076openalex-snapshot

Multiplicative mononuclear small hepatocytes in adult rat liver: Their isolation as a homogeneous population and localization to periportal zone

inferredcites →https://doi.org/10.1016/j.biocel.2009.09.014openalex-snapshot

Liver regeneration: Alternative epithelial pathways

inferredcites →https://doi.org/10.1016/j.ccr.2008.11.011openalex-snapshot

The Aneuploidy Paradox in Cell Growth and Tumorigenesis

inferredcites →https://doi.org/10.1016/j.cell.2007.10.022openalex-snapshot

The Evolutionary Consequences of Polyploidy

inferredcites →https://doi.org/10.1016/j.cell.2008.09.039openalex-snapshot

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

inferredcites →https://doi.org/10.1016/j.clinre.2011.05.011openalex-snapshot

Polyploidy and liver proliferation

inferredcites →https://doi.org/10.1016/j.cub.2010.01.034openalex-snapshot

Mechanisms of Chromosomal Instability

inferredcites →https://doi.org/10.1016/j.gde.2007.02.011openalex-snapshot

Tetraploidy, aneuploidy and cancer

inferredcites →https://doi.org/10.1016/j.jhep.2005.07.033openalex-snapshot

Iron overload promotes Cyclin D1 expression and alters cell cycle in mouse hepatocytes

inferredcites →https://doi.org/10.1016/j.jhep.2010.06.009openalex-snapshot

Ageing, telomeres, senescence, and liver injury

inferredcites →https://doi.org/10.1016/j.molmed.2011.01.004openalex-snapshot

The magic trick of hepatocytes: uncoupling genomic instability from cancer

inferredcites →https://doi.org/10.1016/j.tcb.2009.07.005openalex-snapshot

Molecular mediators of macrophage fusion

inferredcites →https://doi.org/10.1016/j.ydbio.2004.12.035openalex-snapshot

Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype

inferredcites →https://doi.org/10.1016/j.yjmcc.2006.06.012openalex-snapshot

Anillin localization defect in cardiomyocyte binucleation

inferredcites →https://doi.org/10.1016/s0002-9440(10)64212-5openalex-snapshot

Kinetics of Liver Repopulation after Bone Marrow Transplantation

inferredcites →https://doi.org/10.1016/s0002-9440(10)64835-3openalex-snapshot

Hepatocyte Transplantation into Diseased Mouse Liver

inferredcites →https://doi.org/10.1016/s0002-9440(10)65531-9openalex-snapshot

The Repopulation Potential of Hepatocyte Populations Differing in Size and Prior Mitotic Expansion

inferredcites →https://doi.org/10.1016/s0925-4773(02)00338-6openalex-snapshot

The role of hepatocytes and oval cells in liver regeneration and repopulation

inferredcites →https://doi.org/10.1038/labinvest.3780165openalex-snapshot

Clonal Analysis of Micronodules in Virus C-Induced Liver Cirrhosis Using Laser Capture Microdissection (LCM) and HUMARA Assay

inferredcites →https://doi.org/10.1038/nature01531openalex-snapshot

Cell fusion is the principal source of bone-marrow-derived hepatocytes

inferredcites →https://doi.org/10.1038/nature01539openalex-snapshot

Transplanted bone marrow regenerates liver by cell fusion

inferredcites →https://doi.org/10.1038/nature08136openalex-snapshot

A mechanism linking extra centrosomes to chromosomal instability

inferredcites →https://doi.org/10.1038/nature09414openalex-snapshot

The ploidy conveyor of mature hepatocytes as a source of genetic variation

inferredcites →https://doi.org/10.1038/nature09529openalex-snapshot

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

inferredcites →https://doi.org/10.1038/nature10795openalex-snapshot

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

inferredcites →https://doi.org/10.1038/nature10802openalex-snapshot

DNA breaks and chromosome pulverization from errors in mitosis

inferredcites →https://doi.org/10.1038/nbt1326openalex-snapshot

Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice

inferredcites →https://doi.org/10.1038/nm1062openalex-snapshot

Myelomonocytic cells are sufficient for therapeutic cell fusion in liver

inferredcites →https://doi.org/10.1038/nrc2191openalex-snapshot

Molecular mechanisms of alcohol-mediated carcinogenesis

inferredcites →https://doi.org/10.1053/j.gastro.2009.05.044openalex-snapshot

Stem Cells and Liver Regeneration

inferredcites →https://doi.org/10.1053/j.gastro.2011.10.029openalex-snapshot

Frequent Aneuploidy Among Normal Human Hepatocytes

inferredcites →https://doi.org/10.1073/pnas.96.21.11928openalex-snapshot

In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I

inferredcites →https://doi.org/10.1074/jbc.m300982200openalex-snapshot

Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes

inferredcites →https://doi.org/10.1093/hmg/ddq003openalex-snapshot

Mechanisms of mosaicism, chimerism and uniparental disomy identified by single nucleotide polymorphism array analysis

inferredcites →https://doi.org/10.1101/gad.2027811openalex-snapshot

Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential

inferredcites →https://doi.org/10.1101/gad.2029411openalex-snapshot

Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice

inferredcites →https://doi.org/10.1111/j.1432-2277.2012.01523.xopenalex-snapshot

Telomere shortening and karyotypic alterations in hepatocytes in long-term transplanted human liver allografts

inferredcites →https://doi.org/10.1126/science.1148910openalex-snapshot

Widespread Monoallelic Expression on Human Autosomes

inferredcites →https://doi.org/10.1136/gut.2004.043893openalex-snapshot

Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis

inferredcites →https://doi.org/10.1152/ajpgi.1999.276.5.g1260openalex-snapshot

Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events

inferredcites →https://doi.org/10.1159/000070044openalex-snapshot

Hepatocyte Ploidy in Regenerating Livers after Partial Hepatectomy, Drug-Induced Necrosis, and Cirrhosis

inferredcites →https://doi.org/10.1172/jci38677openalex-snapshot

The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents

inferredcites →https://doi.org/10.1172/jci64026openalex-snapshot

Aneuploidy as a mechanism for stress-induced liver adaptation

inferredcites →https://doi.org/10.1182/blood.v91.10.3711openalex-snapshot

Endomitosis of Human Megakaryocytes Are Due to Abortive Mitosis

inferredcites →https://doi.org/10.1242/dev.068353openalex-snapshot

Myoblast fusion: lessons from flies and mice

inferredcites →https://doi.org/10.1242/jcs.00716openalex-snapshot

Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms

inferredcites →https://doi.org/10.1242/jcs.016907openalex-snapshot

Liver tetraploidization is controlled by a new process of incomplete cytokinesis

inferredcites →https://doi.org/10.1242/jcs.114.16.2943openalex-snapshot

Polyploidy associated with oxidative injury attenuates proliferative potential of cells

inferredcites →https://doi.org/10.1371/journal.pgen.1000385openalex-snapshot

Ploidy Reductions in Murine Fusion-Derived Hepatocytes

inferredcites →https://doi.org/10.1371/journal.pgen.1002719openalex-snapshot

Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast

inferredcites →https://doi.org/10.1371/journal.pone.0026080openalex-snapshot

Single-Cell Analysis of Ploidy and Centrosomes Underscores the Peculiarity of Normal Hepatocytes

inferredcites →https://doi.org/10.1667/rr3240openalex-snapshot

Persistence of Chromatid Aberrations in the Cells of Solid Mouse Tissues Exposed to137Cs Gamma Radiation

inferredcites →https://doi.org/10.3748/wjg.14.6915openalex-snapshot

Mouse models in liver cancer research: A review of current literature

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3897/compcytogen.18.121459zenodo-depositor-declared

The role of cellular polyploidy in the regeneration of the cirrhotic liver in rats and humans

inferred← citeshttps://doi.org/10.1002/9781118647110.ch1openalex-snapshot

Polyploidy in Animal Development and Disease

inferred← citeshttps://doi.org/10.1002/9781118663387.ch1openalex-snapshot

Hepatocytes

inferred← citeshttps://doi.org/10.1002/9781119436812.ch47openalex-snapshot

Polyploidy in Liver Function, Mitochondrial Metabolism, and Cancer

inferred← citeshttps://doi.org/10.1002/advs.202306318openalex-snapshot

Surviving the Storm: The Role of Poly‐ and Depolyploidization in Tissues and Tumors

inferred← citeshttps://doi.org/10.1002/bies.201700058openalex-snapshot

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inferred← citeshttps://doi.org/10.1002/bies.202000105openalex-snapshot

CHRONOCRISIS: When Cell Cycle Asynchrony Generates DNA Damage in Polyploid Cells

inferred← citeshttps://doi.org/10.1002/hep.27908openalex-snapshot

Pathological polyploidy in liver disease

inferred← citeshttps://doi.org/10.1002/hep.28573openalex-snapshot

MicroRNA‐122 regulates polyploidization in the murine liver

inferred← citeshttps://doi.org/10.1002/hep.28661openalex-snapshot

Stem/progenitor cells in liver regeneration

inferred← citeshttps://doi.org/10.1002/hep.30286openalex-snapshot

The Polyploid State Restricts Hepatocyte Proliferation and Liver Regeneration in Mice

inferred← citeshttps://doi.org/10.1002/hep.30425openalex-snapshot

Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes

inferred← citeshttps://doi.org/10.1002/wsbm.1629openalex-snapshot

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inferred← citeshttps://doi.org/10.1007/978-3-319-26221-5_9openalex-snapshot

Heterogeneity Mediated System Complexity: The Ultimate Challenge for Studying Common and Complex Diseases

inferred← citeshttps://doi.org/10.1007/978-3-319-26587-2_170-1openalex-snapshot

Nucleus, Nuclear Structure, and Nuclear Functions: Pathogenesis of Nuclear Abnormalities in Cancer

inferred← citeshttps://doi.org/10.1007/978-3-319-26956-6_170openalex-snapshot

Nucleus, Nuclear Structure, and Nuclear Functions: Pathogenesis of Nuclear Abnormalities in Cancer

inferred← citeshttps://doi.org/10.1007/s00018-015-1970-7openalex-snapshot

Regulation of hepatocyte identity and quiescence

inferred← citeshttps://doi.org/10.1007/s00441-016-2427-5openalex-snapshot

Dynamic zonation of liver polyploidy

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Altered glycogen metabolism causes hepatomegaly following an Atg7 deletion

inferred← citeshttps://doi.org/10.1007/s10577-023-09731-xopenalex-snapshot

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inferred← citeshttps://doi.org/10.1007/s10699-017-9535-xopenalex-snapshot

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inferred← citeshttps://doi.org/10.1007/s12015-025-11001-8openalex-snapshot

Liver Regeneration: Polyploidy and Cellular Senescence as Potential Regulators

inferred← citeshttps://doi.org/10.1007/s40142-013-0029-zopenalex-snapshot

Human Somatic Variation: It’s Not Just for Cancer Anymore

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inferred← citeshttps://doi.org/10.1016/b978-0-12-813635-5.16001-xopenalex-snapshot

Bibliography

inferred← citeshttps://doi.org/10.1016/b978-0-12-822514-1.00004-3openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/b978-0-443-15428-7.16001-5openalex-snapshot

Bibliography

inferred← citeshttps://doi.org/10.1016/bs.ircmb.2014.09.001openalex-snapshot

New Insight into Cancer Aneuploidy in Zebrafish

inferred← citeshttps://doi.org/10.1016/j.ajpath.2013.06.035openalex-snapshot

Polyploidization in Liver Tissue

inferred← citeshttps://doi.org/10.1016/j.ajpath.2013.11.004openalex-snapshot

Hepatic Regenerative Medicine

inferred← citeshttps://doi.org/10.1016/j.ajpath.2019.02.008openalex-snapshot

Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury

inferred← citeshttps://doi.org/10.1016/j.antiviral.2022.105417openalex-snapshot

Chemical-induced degradation of PreS2 mutant surface antigen via the induction of microautophagy

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Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations

inferred← citeshttps://doi.org/10.1016/j.bbcan.2019.05.008openalex-snapshot

Defective mitosis-linked DNA damage response and chromosomal instability in liver cancer

inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188408openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.biopha.2019.109795openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.canlet.2025.217526openalex-snapshot

Temporal myc dynamics permit mitotic bypass, promoting polyploid phenotypes

inferred← citeshttps://doi.org/10.1016/j.ccell.2017.04.004openalex-snapshot

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

inferred← citeshttps://doi.org/10.1016/j.cell.2014.06.029openalex-snapshot

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

inferred← citeshttps://doi.org/10.1016/j.celrep.2014.06.025openalex-snapshot

Organ Size Control Is Dominant over Rb Family Inactivation to Restrict Proliferation In Vivo

inferred← citeshttps://doi.org/10.1016/j.celrep.2018.01.086openalex-snapshot

LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration

inferred← citeshttps://doi.org/10.1016/j.celrep.2018.09.042openalex-snapshot

Polyploid Superficial Cells that Maintain the Urothelial Barrier Are Produced via Incomplete Cytokinesis and Endoreplication

inferred← citeshttps://doi.org/10.1016/j.csbj.2019.07.021openalex-snapshot

Hallmarks of Aging in the Liver

inferred← citeshttps://doi.org/10.1016/j.devcel.2017.08.024openalex-snapshot

Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue

inferred← citeshttps://doi.org/10.1016/j.devcel.2018.01.010openalex-snapshot

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

inferred← citeshttps://doi.org/10.1016/j.devcel.2018.10.026openalex-snapshot

Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.117981openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.exppara.2025.108928openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.jgg.2022.04.008openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.jhep.2020.01.019openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.jhep.2021.06.030openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.jhepr.2021.100416openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.jhepr.2023.100779openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.molcel.2015.01.027openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.omtm.2019.12.004openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.pt.2014.07.002openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.12.027openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.tcb.2013.06.002openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.tcb.2013.10.005openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.tem.2019.05.006openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.tig.2015.03.011openalex-snapshot

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Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus

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Mosaicism in health and disease — clones picking up speed

inferred← citeshttps://doi.org/10.1038/s41419-026-08448-zopenalex-snapshot

Diploid hepatocytes resist acetaminophen-induced liver injury through suppressed JNK signaling

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Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway

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IL6 supports long-term expansion of hepatocytes in vitro

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Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death

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Spatial heterogeneity in the mammalian liver

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Polyploidy in liver development, homeostasis and disease

inferred← citeshttps://doi.org/10.1038/s41598-019-39428-3openalex-snapshot

p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury

inferred← citeshttps://doi.org/10.1038/s41598-019-40210-8openalex-snapshot

Allele-specific expression variation at different ploidy levels in Squalius alburnoides

inferred← citeshttps://doi.org/10.1038/s41598-020-64621-0openalex-snapshot

Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy

inferred← citeshttps://doi.org/10.1038/s41598-022-27173-zopenalex-snapshot

Single-cell resolved ploidy and chromosomal aberrations in nonalcoholic steatohepatitis-(NASH) induced hepatocellular carcinoma and its precursor lesions

inferred← citeshttps://doi.org/10.1038/s42003-019-0453-zopenalex-snapshot

Cardiac interstitial tetraploid cells can escape replicative senescence in rodents but not large mammals

inferred← citeshttps://doi.org/10.1042/cs20180560openalex-snapshot

Advances in heart regeneration based on cardiomyocyte proliferation and regenerative potential of binucleated cardiomyocytes and polyploidization

inferred← citeshttps://doi.org/10.1053/j.gastro.2017.12.013openalex-snapshot

Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration

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Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Genes With Euchromatic Promoters in Mice

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Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury

inferred← citeshttps://doi.org/10.1055/a-2211-2144openalex-snapshot

The Ploidy State as a Determinant of Hepatocyte Proliferation

inferred← citeshttps://doi.org/10.1055/s-0040-1719175openalex-snapshot

Differential Roles for Diploid and Polyploid Hepatocytes in Acute and Chronic Liver Injury

inferred← citeshttps://doi.org/10.1074/jbc.m117.782052openalex-snapshot

Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1074/jbc.ra117.001474openalex-snapshot

Hepatic loss of Lissencephaly 1 (Lis1) induces fatty liver and accelerates liver tumorigenesis in mice

inferred← citeshttps://doi.org/10.1080/15384101.2015.1044175openalex-snapshot

p27Kip1participates in the regulation of endoreplication in differentiating chick retinal ganglion cells

inferred← citeshttps://doi.org/10.1080/15384101.2019.1618123openalex-snapshot

The origins and functions of hepatic polyploidy

inferred← citeshttps://doi.org/10.1089/scd.2014.0137openalex-snapshot

Asymmetric Aneuploidy in Mesenchymal Stromal Cells Detected by In Situ Karyotyping and Fluorescence In Situ Hybridization: Suggestions for Reference Values for Stem Cells

inferred← citeshttps://doi.org/10.1089/scd.2019.0193openalex-snapshot

Residual Diploidy in Polyploid Tissues: A Cellular State with Enhanced Proliferative Capacity for Tissue Regeneration?

inferred← citeshttps://doi.org/10.1091/mbc.e16-03-0159openalex-snapshot

Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability

inferred← citeshttps://doi.org/10.1093/carcin/bgv011openalex-snapshot

Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice

inferred← citeshttps://doi.org/10.1096/fj.202402520ropenalex-snapshot

Ascending E2F7a/b ratio facilitates KLF13 transcription in hepatocellular carcinoma and correlates with the abundance of binuclear hepatocytes ( ABH ) modulation for short‐term recurrence

inferred← citeshttps://doi.org/10.1097/hep.0000000000001422openalex-snapshot

Arid1a deficiency promotes hepatocyte hyperpolyploidy and drives intrahepatic cholangiocarcinoma in mice

inferred← citeshttps://doi.org/10.1101/2021.02.28.433243openalex-snapshot

Tetraploidy accelerates adaption under drug-selection in a fungal pathogen

inferred← citeshttps://doi.org/10.1101/2021.07.10.451875openalex-snapshot

Splicing Factor SRSF1 Deficiency in the Liver Triggers NASH-like Pathology via R-Loop Induced DNA Damage and Cell Death

inferred← citeshttps://doi.org/10.1101/2022.01.24.477454openalex-snapshot

Chemical-induced degradation of PreS2 mutant surface antigen reverses HBV-mediated hepatocarcinogenesis

inferred← citeshttps://doi.org/10.1101/2023.06.26.546280openalex-snapshot

Aneuploidies are an ancestral feature of trypanosomatids, and an ancient chromosome duplication is maintained in extant species

inferred← citeshttps://doi.org/10.1101/2024.07.06.602336openalex-snapshot

ESRP2-microRNA-122 axis directs the postnatal onset of liver polyploidization and maturation

inferred← citeshttps://doi.org/10.1101/521716openalex-snapshot

Cardiac interstitial tetraploid cells that escape replicative senescence are found in rodents but not large mammals

inferred← citeshttps://doi.org/10.1101/cshperspect.a019604openalex-snapshot

Rapid Mechanisms for Generating Genome Diversity: Whole Ploidy Shifts, Aneuploidy, and Loss of Heterozygosity

inferred← citeshttps://doi.org/10.1101/gad.311910.118openalex-snapshot

Endoreduplication of the mouse genome in the absence of ORC1

inferred← citeshttps://doi.org/10.1101/gad.352129.124openalex-snapshot

ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation

inferred← citeshttps://doi.org/10.1111/1574-6976.12048openalex-snapshot

Yeast: a simple model system to study complex phenomena of aneuploidy

inferred← citeshttps://doi.org/10.1111/cmi.12282openalex-snapshot

Susceptibility toPlasmodiumliver stage infection is altered by hepatocyte polyploidy

inferred← citeshttps://doi.org/10.1111/eva.70059openalex-snapshot

Evolutionary View of Liver Pathology

inferred← citeshttps://doi.org/10.1111/exd.12305openalex-snapshot

The functional relevance of polyploidization in the skin

inferred← citeshttps://doi.org/10.1111/joa.12585openalex-snapshot

Stereological analysis of size and density of hepatocytes in the porcine liver

inferred← citeshttps://doi.org/10.1128/9781555819583.ch28openalex-snapshot

Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution

inferred← citeshttps://doi.org/10.1128/microbiolspec.funk-0051-2016openalex-snapshot

Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution

inferred← citeshttps://doi.org/10.1136/gutjnl-2018-318021openalex-snapshot

Polyploidy spectrum: a new marker in HCC classification

inferred← citeshttps://doi.org/10.1146/annurev-genet-120417-031501openalex-snapshot

Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging

inferred← citeshttps://doi.org/10.1146/annurev-physiol-032822-094134openalex-snapshot

Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver

inferred← citeshttps://doi.org/10.1152/ajpheart.00666.2021openalex-snapshot

Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration

inferred← citeshttps://doi.org/10.1155/2016/7276463openalex-snapshot

Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers

inferred← citeshttps://doi.org/10.1158/0008-5472.can-14-0529openalex-snapshot

TALEN-Mediated Somatic Mutagenesis in Murine Models of Cancer

inferred← citeshttps://doi.org/10.1161/circresaha.119.315408openalex-snapshot

Polyploidy in Cardiomyocytes

inferred← citeshttps://doi.org/10.1172/jci73957openalex-snapshot

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

inferred← citeshttps://doi.org/10.1172/jci78585openalex-snapshot

Lineage fate of ductular reactions in liver injury and carcinogenesis

inferred← citeshttps://doi.org/10.1186/s12917-021-02812-1openalex-snapshot

Hepatocyte ploidy in cats with and without hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1186/s12935-018-0683-zopenalex-snapshot

Mifepristone inhibits non-small cell lung carcinoma cellular escape from DNA damaging cisplatin

inferred← citeshttps://doi.org/10.1186/s12964-026-02775-6openalex-snapshot

ICMT deficiency ameliorates weight loss and mortality, but not tumor formation in a mouse model of liver cancer

inferred← citeshttps://doi.org/10.1186/s13287-020-02100-zopenalex-snapshot

Effect of sex-specific differences on function of induced hepatocyte-like cells generated from male and female mouse embryonic fibroblasts

inferred← citeshttps://doi.org/10.1186/s13287-023-03400-wopenalex-snapshot

Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.1242/dev.197343openalex-snapshot

Metabolically active and polyploid renal tissues rely on graded cytoprotection to drive developmental and homeostatic stress resilience

inferred← citeshttps://doi.org/10.1242/dev.201318openalex-snapshot

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

inferred← citeshttps://doi.org/10.1371/journal.pone.0074625openalex-snapshot

Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis

inferred← citeshttps://doi.org/10.1371/journal.pone.0167158openalex-snapshot

TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure

inferred← citeshttps://doi.org/10.1371/journal.pone.0171738openalex-snapshot

p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging

inferred← citeshttps://doi.org/10.1534/genetics.115.178020openalex-snapshot

Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans

inferred← citeshttps://doi.org/10.1534/genetics.119.302289openalex-snapshot

Physiology, Development, and Disease Modeling in the Drosophila Excretory System

inferred← citeshttps://doi.org/10.17235/reed.2019.6270/2019openalex-snapshot

Hepatocyte transplantation

inferred← citeshttps://doi.org/10.18632/oncotarget.12118openalex-snapshot

Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature

inferred← citeshttps://doi.org/10.18632/oncotarget.6432openalex-snapshot

Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition

inferred← citeshttps://doi.org/10.21037/sci.2017.10.02openalex-snapshot

There and back again: amitosis to repopulate a stem cell pool

inferred← citeshttps://doi.org/10.2147/ott.s340435openalex-snapshot

The Controversial Role of Polyploidy in Hepatocellular Carcinoma

inferred← citeshttps://doi.org/10.3109/10715762.2015.1016019openalex-snapshot

Oxidative stress triggers cytokinesis failure in hepatocytes upon isolation

inferred← citeshttps://doi.org/10.32657/10356/155390openalex-snapshot

Age-dependent transcriptional and epigenetic alterations in mouse hepatocytes

inferred← citeshttps://doi.org/10.3389/ffunb.2022.984377openalex-snapshot

Tetraploidy accelerates adaptation under drug selection in a fungal pathogen

inferred← citeshttps://doi.org/10.3389/fimmu.2020.00650openalex-snapshot

Cell-in-Cell Structures in the Liver: A Tale of Four E’s

inferred← citeshttps://doi.org/10.3389/fmed.2022.842024openalex-snapshot

Understanding the Unique Microenvironment in the Aging Liver

inferred← citeshttps://doi.org/10.3389/fmicb.2014.00274openalex-snapshot

Polyploidy in haloarchaea: advantages for growth and survival

inferred← citeshttps://doi.org/10.3390/cancers13205151openalex-snapshot

Hepatocyte Polyploidy: Driver or Gatekeeper of Chronic Liver Diseases

inferred← citeshttps://doi.org/10.3390/cells10092447openalex-snapshot

Circadian Organelles: Rhythms at All Scales

inferred← citeshttps://doi.org/10.3390/cells8020192openalex-snapshot

In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

inferred← citeshttps://doi.org/10.3390/fishes10050227openalex-snapshot

Application of Flow Cytometry to Determine Cell DNA Content in the Genetic Breeding of Fish

inferred← citeshttps://doi.org/10.3390/genes13091626openalex-snapshot

Individual Genetic Heterogeneity

inferred← citeshttps://doi.org/10.3390/genes8020045openalex-snapshot

Links between DNA Replication, Stem Cells and Cancer

inferred← citeshttps://doi.org/10.3390/ijms22073791openalex-snapshot

Ssu72 Dual-Specific Protein Phosphatase: From Gene to Diseases

inferred← citeshttps://doi.org/10.3410/f.737111051.793583029openalex-snapshot

Faculty Opinions recommendation of In Vivo Lineage Tracing of Polyploid Hepatocytes Reveals Extensive Proliferation during Liver Regeneration.

inferred← citeshttps://doi.org/10.36253/caryologia-1122openalex-snapshot

Influence of chronic alcoholic intoxication and lighting regime on karyometric and ploidometric parameters of hepatocytes of rats

inferred← citeshttps://doi.org/10.3724/abbs.2025175openalex-snapshot

The dual role of whole-genome duplication: biological mechanisms, functional consequences, and detection advances

inferred← citeshttps://doi.org/10.4254/wjh.v10.i2.213openalex-snapshot

Cell fusion in the liver, revisited

inferred← citeshttps://doi.org/10.5496/wjmg.v4.i4.77openalex-snapshot

Genome variation in the trophoblast cell lifespan: Diploidy, polyteny, depolytenization, genome segregation

inferred← citeshttps://doi.org/10.5603/fhc.a2015.0001openalex-snapshot

DNA ploidy and morphology of colon tumors in the adenoma–carcinoma sequence

inferred← citeshttps://doi.org/10.5772/intechopen.97247openalex-snapshot

Genome Modifications Involved in Developmental Programs of the Placental Trophoblast

inferred← citeshttps://doi.org/10.6084/m9.figshare.13642402openalex-snapshot

Additional file 1 of Effect of sex-specific differences on function of induced hepatocyte-like cells generated from male and female mouse embryonic fibroblasts

inferred← citeshttps://doi.org/10.6084/m9.figshare.13642405openalex-snapshot

Additional file 2 of Effect of sex-specific differences on function of induced hepatocyte-like cells generated from male and female mouse embryonic fibroblasts

inferred← citeshttps://doi.org/10.6084/m9.figshare.23625476openalex-snapshot

Additional file 1 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.6084/m9.figshare.23625482openalex-snapshot

Additional file 2 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.6084/m9.figshare.23625485openalex-snapshot

Additional file 3 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.6084/m9.figshare.23625491openalex-snapshot

Additional file 4 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.6084/m9.figshare.23625494openalex-snapshot

Additional file 6 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.6084/m9.figshare.23625497openalex-snapshot

Additional file 9 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.6084/m9.figshare.23625500openalex-snapshot

Additional file 10 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.6084/m9.figshare.23625503openalex-snapshot

Additional file 11 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.6084/m9.figshare.23625506openalex-snapshot

Additional file 12 of Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead

inferred← citeshttps://doi.org/10.64898/2026.01.15.699545openalex-snapshot

Distinct p21 dynamics drive alternative routes to whole-genome duplication through a common CDK4/6-dependent polyploid G0 state

inferred← citeshttps://doi.org/10.64898/2026.08.17.745319openalex-snapshot

Spindle scaling promotes adaptation to polyploidy

inferred← citeshttps://doi.org/10.70675/73c5ad47z37c8z4114zaf3ez3ddd10007a35openalex-snapshot

Genome instability : from genome content variations to gene expression plasticity

inferred← citeshttps://doi.org/10.70675/778b2a6bzdcc7z4c5eza6c0z42ce6738d5b0openalex-snapshot

Microencapsulation of hepatic cells for extracorporeal liver supply

inferred← citeshttps://doi.org/10.70675/eb0d4c50z81dez4186zbf94zabbcd74f451fopenalex-snapshot

Altérations de la polyploïdie hépatocytaire au cours du développement des hépatopathies stéatosiques dites non-alcooliques

inferred← citeshttps://doi.org/10.70675/f98c5197z2bf3z42a9z946az3cce0b05462copenalex-snapshot

PhotoFib - Etude par histologie spectrale du développement de la cirrhose dans des modèles murins et chez l’Homme.

inferred← citeshttps://doi.org/10.7554/elife.36204openalex-snapshot

Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity

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