On the public citation graph

TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5

https://doi.org/10.1007/s00109-010-0619-0
0 signed · 114 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcp.20099openalex-snapshot
Emerging non‐apoptotic functions of tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)/Apo2L
inferredcites →https://doi.org/10.1007/978-1-4020-6554-5_7openalex-snapshot
Trail Receptors: Targets for Cancer Therapy
inferredcites →https://doi.org/10.1007/s10495-009-0321-2openalex-snapshot
Is TRAIL the holy grail of cancer therapy?
inferredcites →https://doi.org/10.1016/j.biocel.2007.02.007openalex-snapshot
TRAIL signalling: Decisions between life and death
inferredcites →https://doi.org/10.1016/j.ceb.2005.09.010openalex-snapshot
Nonapoptotic functions of FADD-binding death receptors and their signaling molecules
inferredcites →https://doi.org/10.1016/j.cellsig.2006.12.008openalex-snapshot
Role of caspases in CD95L- and TRAIL-induced non-apoptotic signalling in pancreatic tumour cells
inferredcites →https://doi.org/10.1016/j.immuni.2004.08.017openalex-snapshot
Compartmentalization of TNF Receptor 1 Signaling
inferredcites →https://doi.org/10.1016/s0014-5793(97)01231-3openalex-snapshot
Characterization of two receptors for TRAIL1
inferredcites →https://doi.org/10.1016/s0014-5793(98)01109-0openalex-snapshot
The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFκB
inferredcites →https://doi.org/10.1016/s0960-9822(06)00297-1openalex-snapshot
TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL
inferredcites →https://doi.org/10.1038/5517openalex-snapshot
Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo
inferredcites →https://doi.org/10.1038/nm1627openalex-snapshot
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
inferredcites →https://doi.org/10.1038/sj.bjc.6601330openalex-snapshot
Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells
inferredcites →https://doi.org/10.1038/sj.cdd.4400791openalex-snapshot
Activation of protein kinase C inhibits TRAIL-induced caspases activation, mitochondrial events and apoptosis in a human leukemic T cell line
inferredcites →https://doi.org/10.1038/sj.cdd.4401649openalex-snapshot
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1
inferredcites →https://doi.org/10.1038/sj.onc.1203816openalex-snapshot
Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression
inferredcites →https://doi.org/10.1038/sj.onc.1203936openalex-snapshot
Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis
inferredcites →https://doi.org/10.1038/sj.onc.1204558openalex-snapshot
Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative
inferredcites →https://doi.org/10.1038/sj.onc.1204559openalex-snapshot
CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-κB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells
inferredcites →https://doi.org/10.1038/sj.onc.1204750openalex-snapshot
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
inferredcites →https://doi.org/10.1038/sj.onc.1209719openalex-snapshot
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma
inferredcites →https://doi.org/10.1053/gast.2001.28663openalex-snapshot
Inactivating mutations of KILLER/DR5 gene in gastric cancers
inferredcites →https://doi.org/10.1074/jbc.272.43.26953openalex-snapshot
FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b
inferredcites →https://doi.org/10.1074/jbc.m307376200openalex-snapshot
Protein Kinase C Modulates Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Targeting the Apical Events of Death Receptor Signaling
inferredcites →https://doi.org/10.1074/jbc.m410660200openalex-snapshot
Receptor-selective Mutants of Apoptosis-inducing Ligand 2/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Reveal a Greater Contribution of Death Receptor (DR) 5 than DR4 to Apoptosis Signaling
inferredcites →https://doi.org/10.1074/jbc.m704210200openalex-snapshot
Tumor-derived Mutations in the TRAIL Receptor DR5 Inhibit TRAIL Signaling through the DR4 Receptor by Competing for Ligand Binding
inferredcites →https://doi.org/10.1093/emboj/16.17.5386openalex-snapshot
TRAIL‐R2: a novel apoptosis‐mediating receptor for TRAIL
inferredcites →https://doi.org/10.1096/fj.04-2984fjeopenalex-snapshot
CD95 and TRAF2 promote invasiveness of pancreatic cancer cells
inferredcites →https://doi.org/10.1126/science.276.5309.111openalex-snapshot
The Receptor for the Cytotoxic Ligand TRAIL
inferredcites →https://doi.org/10.1126/science.277.5327.815openalex-snapshot
An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL
inferredcites →https://doi.org/10.1128/mcb.00520-06openalex-snapshot
Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2
inferredcites →https://doi.org/10.1158/0008-5472.can-04-2749openalex-snapshot
Overexpression of Soluble TRAIL Induces Apoptosis in Human Lung Adenocarcinoma and Inhibits Growth of Tumor Xenografts in Nude Mice
inferredcites →https://doi.org/10.1158/0008-5472.can-04-3875openalex-snapshot
Protein Kinase C Inhibition and X-Linked Inhibitor of Apoptosis Protein Degradation Contribute to the Sensitization Effect of Luteolin on Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis in Cancer Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-0251openalex-snapshot
Bortezomib Sensitizes Primary Human Astrocytoma Cells of WHO Grades I to IV for Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis
inferredcites →https://doi.org/10.4049/jimmunol.149.10.3166openalex-snapshot
Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4508954openalex-extracted
TRAIL-Dependent Apoptosis of Peritoneal Mesothelial Cells by NK Cells Promotes Ovarian Cancer Invasion
inferred← citeshttps://doi.org/10.1002/cnr2.2048openalex-snapshot
The pivotal role of irradiation‐induced apoptosis in the pathogenesis and therapy of medulloblastoma
inferred← citeshttps://doi.org/10.1002/jcb.25094openalex-snapshot
Notch4 Signaling Confers Susceptibility to TRAIL‐Induced Apoptosis in Breast Cancer Cells
inferred← citeshttps://doi.org/10.1007/s00432-010-0952-2openalex-snapshot
Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines
inferred← citeshttps://doi.org/10.1016/b978-0-12-397925-4.00019-5openalex-snapshot
Separation of Magnetically Isolated TNF Receptosomes from Mitochondria
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2017.12.006openalex-snapshot
TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2021.119191openalex-snapshot
Ars moriendi: Proteases as sculptors of cellular suicide
inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.10.144openalex-snapshot
Chaetospirolactone reverses the apoptotic resistance towards TRAIL in pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.bcp.2014.08.010openalex-snapshot
Two death-inducing human TRAIL receptors to target in cancer: Similar or distinct regulation and function?
inferred← citeshttps://doi.org/10.1016/j.canlet.2010.11.006openalex-snapshot
Antibody-based fusion proteins to target death receptors in cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2011.10.035openalex-snapshot
IFN-γ combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells
inferred← citeshttps://doi.org/10.1016/j.ccell.2015.02.014openalex-snapshot
Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis
inferred← citeshttps://doi.org/10.1016/j.cellsig.2016.07.016openalex-snapshot
Negative control of TRAIL-R1 signaling by transforming growth factor β1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1
inferred← citeshttps://doi.org/10.1016/j.ejcb.2010.10.008openalex-snapshot
Impact of death receptor signaling on the malignancy of pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.1016/j.ejcb.2010.11.002openalex-snapshot
Subcellular compartmentalization of TNF receptor-1 and CD95 signaling pathways
inferred← citeshttps://doi.org/10.1016/j.isci.2023.108401openalex-snapshot
TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101223openalex-snapshot
BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma
inferred← citeshttps://doi.org/10.1016/j.jconrel.2020.07.013openalex-snapshot
TRAIL therapy and prospective developments for cancer treatment
inferred← citeshttps://doi.org/10.1016/j.leukres.2015.03.019openalex-snapshot
Liposome-bound TRAIL induces superior DR5 clustering and enhanced DISC recruitment in histiocytic lymphoma U937 cells
inferred← citeshttps://doi.org/10.1016/j.taap.2011.12.010openalex-snapshot
Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: Involvement of Ca2+ influx
inferred← citeshttps://doi.org/10.1016/j.trecan.2020.06.006openalex-snapshot
TRAIL of Hope Meeting Resistance in Cancer
inferred← citeshttps://doi.org/10.1016/s0580-9517(10)37002-4openalex-snapshot
Immunomagnetic Isolation of Subcellular Compartments
inferred← citeshttps://doi.org/10.1016/s1499-3872(13)60012-0openalex-snapshot
TRAIL-induced expression of uPA and IL-8 strongly enhanced by overexpression of TRAF2 and Bcl-xL in pancreatic ductal adenocarcinoma cells
inferred← citeshttps://doi.org/10.1021/acs.nanolett.1c04365openalex-snapshot
Lipid Phase Separation in Vesicles Enhances TRAIL-Mediated Cytotoxicity
inferred← citeshttps://doi.org/10.1038/cdd.2013.28openalex-snapshot
Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family
inferred← citeshttps://doi.org/10.1038/cdd.2014.81openalex-snapshot
Getting TRAIL back on track for cancer therapy
inferred← citeshttps://doi.org/10.1038/cdd.2015.174openalex-snapshot
Onto better TRAILs for cancer treatment
inferred← citeshttps://doi.org/10.1038/cddis.2013.19openalex-snapshot
Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects
inferred← citeshttps://doi.org/10.1038/cddis.2013.555openalex-snapshot
CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants
inferred← citeshttps://doi.org/10.1038/cddis.2014.417openalex-snapshot
c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells
inferred← citeshttps://doi.org/10.1038/cddis.2017.423openalex-snapshot
Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells
inferred← citeshttps://doi.org/10.1038/cgt.2012.46openalex-snapshot
TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells
inferred← citeshttps://doi.org/10.1038/nrc.2017.28openalex-snapshot
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
inferred← citeshttps://doi.org/10.1038/oncsis.2012.35openalex-snapshot
The ‘N-factors’ in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancer
inferred← citeshttps://doi.org/10.1038/s41418-022-01059-zopenalex-snapshot
Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries
inferred← citeshttps://doi.org/10.1038/s41419-018-0478-0openalex-snapshot
The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells
inferred← citeshttps://doi.org/10.1038/s41598-025-00070-xopenalex-snapshot
Comparative study of the anti-tumour effects of the imipridone, ONC201 and its fluorinated analogues on pancreatic cancer cell line
inferred← citeshttps://doi.org/10.1053/j.gastro.2013.10.009openalex-snapshot
Nuclear Death Receptor TRAIL-R2 Inhibits Maturation of Let-7 and Promotes Proliferation of Pancreatic and Other Tumor Cells
inferred← citeshttps://doi.org/10.1074/jbc.m116.738302openalex-snapshot
Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition
inferred← citeshttps://doi.org/10.1093/carcin/bgs220openalex-snapshot
EMT-associated up-regulation of L1CAM provides insights into L1CAM-mediated integrin signalling and NF-κB activation
inferred← citeshttps://doi.org/10.1101/cshperspect.a008698openalex-snapshot
Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation
inferred← citeshttps://doi.org/10.1111/1756-185x.70065openalex-snapshot
WTAP ‐Mediated m6A Modification of TRAIL ‐ DR4 Suppresses MH7A Cell Apoptosis
inferred← citeshttps://doi.org/10.1111/boc.201300021openalex-snapshot
Role of the eIF4E binding protein 4E‐BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol‐induced apoptosis
inferred← citeshttps://doi.org/10.1111/bph.12238openalex-snapshot
Death receptors as targets in cancer
inferred← citeshttps://doi.org/10.1111/febs.15637openalex-snapshot
The multifaceted role of TRAIL signaling in cancer and immunity
inferred← citeshttps://doi.org/10.1111/j.1582-4934.2010.01211.xopenalex-snapshot
Targeting AML through DR4 with a novel variant of rhTRAIL
inferred← citeshttps://doi.org/10.1126/scisignal.2003624openalex-snapshot
Simultaneous Profiling of 194 Distinct Receptor Transcripts in Human Cells
inferred← citeshttps://doi.org/10.1155/2022/8148119openalex-snapshot
Role of Apoptosis in HIV Pathogenesis
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-15-0448openalex-snapshot
HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells
inferred← citeshttps://doi.org/10.1186/s12885-015-1508-2openalex-snapshot
TRAIL-receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill
inferred← citeshttps://doi.org/10.1186/s12885-018-4688-8openalex-snapshot
Cytoplasmic TRAIL-R1 is a positive prognostic marker in PDAC
inferred← citeshttps://doi.org/10.1371/journal.pone.0039290openalex-snapshot
General Sensitization of Melanoma Cells for TRAIL-Induced Apoptosis by the Potassium Channel Inhibitor TRAM-34 Depends on Release of SMAC
inferred← citeshttps://doi.org/10.1371/journal.pone.0042526openalex-snapshot
The Transmembrane Domains of TNF-Related Apoptosis-Inducing Ligand (TRAIL) Receptors 1 and 2 Co-Regulate Apoptotic Signaling Capacity
inferred← citeshttps://doi.org/10.1371/journal.pone.0049219openalex-snapshot
Evaluating the Effect of Therapeutic Stem Cells on TRAIL Resistant and Sensitive Medulloblastomas
inferred← citeshttps://doi.org/10.1371/journal.pone.0214847openalex-snapshot
Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells
inferred← citeshttps://doi.org/10.18419/opus-2151openalex-snapshot
Analysis of receptor-receptor interactions and their implications on the formation of signaling competent TRAIL receptor clusters
inferred← citeshttps://doi.org/10.18632/oncotarget.7053openalex-snapshot
Inactivation ofBRCA2in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptormediated apoptosis
inferred← citeshttps://doi.org/10.18632/oncotarget.7066openalex-snapshot
JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells
inferred← citeshttps://doi.org/10.31557/apjcp.2023.24.4.1297openalex-snapshot
Anti-tumor Effects of IL-1β Induced TRAIL-Expressing hUCMSCs on Embelin Treated Breast Cancer Cell Lines
inferred← citeshttps://doi.org/10.3389/fcell.2022.768579openalex-snapshot
Impact of Extracellular pH on Apoptotic and Non-Apoptotic TRAIL-Induced Signaling in Pancreatic Ductal Adenocarcinoma Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2014.00073openalex-snapshot
Combinatorial Cytokine Code Generates Anti-Viral State in Dendritic Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2019.02044openalex-snapshot
TRAIL-Receptor 4 Modulates γδ T Cell-Cytotoxicity Toward Cancer Cells
inferred← citeshttps://doi.org/10.3389/fonc.2026.1788447openalex-snapshot
miR-99b-5p inhibition drives apoptosis and tumor shrinkage in triple-negative breast cancer: functional characterization through AGO2-RIP-seq and mechanistic insights
inferred← citeshttps://doi.org/10.3390/biology13070521openalex-snapshot
The Role of TRAIL Signaling in Cancer: Searching for New Therapeutic Strategies
inferred← citeshttps://doi.org/10.3390/cancers10030077openalex-snapshot
Should We Keep Walking along the Trail for Pancreatic Cancer Treatment? Revisiting TNF-Related Apoptosis-Inducing Ligand for Anticancer Therapy
inferred← citeshttps://doi.org/10.3390/cancers11040444openalex-snapshot
Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/cancers11040456openalex-snapshot
TRAILblazing Strategies for Cancer Treatment
inferred← citeshttps://doi.org/10.3390/cancers11060745openalex-snapshot
The Hepatic Microenvironment and TRAIL-R2 Impact Outgrowth of Liver Metastases in Pancreatic Cancer after Surgical Resection
inferred← citeshttps://doi.org/10.3390/cancers11081167openalex-snapshot
TRAIL Induces Nuclear Translocation and Chromatin Localization of TRAIL Death Receptors
inferred← citeshttps://doi.org/10.3390/cancers12051113openalex-snapshot
Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer
inferred← citeshttps://doi.org/10.3390/cancers13184634openalex-snapshot
Divulging the Critical Role of HuR in Pancreatic Cancer as a Therapeutic Target and a Means to Overcome Chemoresistance
inferred← citeshttps://doi.org/10.3892/ijo.2016.3699openalex-snapshot
Involvement of DR4/JNK pathway-mediated autophagy in acquired TRAIL resistance in HepG2 cells
inferred← citeshttps://doi.org/10.3892/or.2012.2183openalex-snapshot
Differential susceptibility of gastric cancer cells to TRAIL-induced apoptosis
inferred← citeshttps://doi.org/10.4161/15384047.2014.972183openalex-snapshot
DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer
inferred← citeshttps://doi.org/10.4161/cbt.11.5.14671openalex-snapshot
Combined modality therapy with TRAIL or agonistic death receptor antibodies
inferred← citeshttps://doi.org/10.4236/ajmb.2019.94015openalex-snapshot
TRAIL and TRAIL Receptors as Prognostic Markers in Breast Cancer Patients
inferred← citeshttps://doi.org/10.70675/8136eca9z2b12z459az8016zafc790325ed5openalex-snapshot
Role of TRAIL-receptors in apoptosis and nonapoptotic signaling in cancer cells populations undergoing fractional killing
inferred← citeshttps://doi.org/10.70675/c49812bdz7b0az4a95zb5f2z15bd5d386997openalex-snapshot
c-FLIP as a potent anticancer target : Enhancement of cancer cell apoptosis by compounds identified through virtual screening
inferred← citeshttps://doi.org/10.7150/thno.54824openalex-snapshot
Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.