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Cutaneous neuropathy in Parkinson’s disease: a window into brain pathology

https://doi.org/10.1007/s00401-014-1284-0

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Accuracy of the Clinical Diagnoses of Lewy Body Disease, Parkinson Disease, and Dementia With Lewy Bodies

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Clinical progression in Parkinson disease and the neurobiology of axons

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Levodopa, methylmalonic acid, and neuropathy in idiopathic Parkinson disease

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Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra

inferredcites →https://doi.org/10.1002/ana.410270405openalex-snapshot

Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease

inferredcites →https://doi.org/10.1002/mds.22137openalex-snapshot

Neuropathy as a potential complication of levodopa use in Parkinson's disease

inferredcites →https://doi.org/10.1002/mds.22340openalex-snapshot

Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results

inferredcites →https://doi.org/10.1002/mds.24921openalex-snapshot

Lewy pathology and neurodegeneration in premotor Parkinson's disease

inferredcites →https://doi.org/10.1002/mds.25020openalex-snapshot

Is alpha‐synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases

inferredcites →https://doi.org/10.1002/mds.25585openalex-snapshot

Neuropathy and levodopa in Parkinson's disease: Evidence from a multicenter study

inferredcites →https://doi.org/10.1007/bf00294234openalex-snapshot

Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system

inferredcites →https://doi.org/10.1007/s00115-010-3010-zopenalex-snapshot

Non-motor Symptoms Questionnaire und Scale für das idiopathische Parkinson-Syndrom

inferredcites →https://doi.org/10.1007/s00401-010-0687-9openalex-snapshot

α-Synucleinopathy in the human olfactory system in Parkinson’s disease: involvement of calcium-binding protein- and substance P-positive cells

inferredcites →https://doi.org/10.1007/s00401-010-0739-1openalex-snapshot

Cell type specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies

inferredcites →https://doi.org/10.1007/s00401-012-1028-yopenalex-snapshot

Spinal cord lesions in sporadic Parkinson’s disease

inferredcites →https://doi.org/10.1007/s00401-013-1214-6openalex-snapshot

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

inferredcites →https://doi.org/10.1007/s00415-011-6396-zopenalex-snapshot

Polyneuropathy while on duodenal levodopa infusion in Parkinson’s disease patients: we must be alert

inferredcites →https://doi.org/10.1007/s00415-012-6432-7openalex-snapshot

Analysis of myelinated fibers in human skin biopsies of patients with neuropathies

inferredcites →https://doi.org/10.1007/s00702-002-0808-2openalex-snapshot

Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

inferredcites →https://doi.org/10.1007/s00702-005-0431-0openalex-snapshot

Skin biopsy for assessment of autonomic denervation in Parkinson’s disease

inferredcites →https://doi.org/10.1016/0006-8993(84)90217-8openalex-snapshot

Substance P immunoreactivity in the post-mortem parkinsonian brain

inferredcites →https://doi.org/10.1016/0304-3940(89)90200-0openalex-snapshot

Lewy bodies in tyrosine hydroxylase-synthesizing neurons of the human cerebral cortex

inferredcites →https://doi.org/10.1016/j.neulet.2005.11.012openalex-snapshot

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

inferredcites →https://doi.org/10.1016/j.neulet.2009.12.027openalex-snapshot

Clinical availability of skin biopsy in the diagnosis of Parkinson's disease

inferredcites →https://doi.org/10.1016/j.neulet.2013.07.016openalex-snapshot

Diagnostic value of minor salivary glands biopsy for the detection of Lewy pathology

inferredcites →https://doi.org/10.1016/j.pain.2006.01.041openalex-snapshot

Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values

inferredcites →https://doi.org/10.1016/j.pain.2010.07.026openalex-snapshot

Reference data for quantitative sensory testing (QST): Refined stratification for age and a novel method for statistical comparison of group data

inferredcites →https://doi.org/10.1016/j.parkreldis.2013.09.007openalex-snapshot

Prevalence and features of peripheral neuropathy in Parkinson's disease patients under different therapeutic regimens

inferredcites →https://doi.org/10.1016/s0197-4580(02)00065-9openalex-snapshot

Staging of brain pathology related to sporadic Parkinson’s disease

inferredcites →https://doi.org/10.1074/jbc.m113.451815openalex-snapshot

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

inferredcites →https://doi.org/10.1093/brain/114.5.2253openalex-snapshot

SUBSTANCE P-CONTAINING NEURONS IN THE MESOPONTINE TEGMENTUM ARE SEVERELY AFFECTED IN PARKINSON'S DISEASE

inferredcites →https://doi.org/10.1093/brain/114.5.2283openalex-snapshot

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

inferredcites →https://doi.org/10.1093/brain/119.3.823openalex-snapshot

Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease

inferredcites →https://doi.org/10.1093/brain/awf080openalex-snapshot

The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service

inferredcites →https://doi.org/10.1093/brain/awh483openalex-snapshot

Skin biopsies in myelin-related neuropathies: bringing molecular pathology to the bedside

inferredcites →https://doi.org/10.1093/brain/awm302openalex-snapshot

Axonal -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

inferredcites →https://doi.org/10.1093/brain/awn102openalex-snapshot

Sensory deficit in Parkinson's disease: evidence of a cutaneous denervation

inferredcites →https://doi.org/10.1093/brain/awp274openalex-snapshot

Shortened internodal length of dermal myelinated nerve fibres in Charcot-Marie-Tooth disease type 1A

inferredcites →https://doi.org/10.1093/brain/aws133openalex-snapshot

Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease

inferredcites →https://doi.org/10.1093/brain/awt192openalex-snapshot

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

inferredcites →https://doi.org/10.1097/nen.0b013e318186de48openalex-snapshot

Lewy Body Pathology Involves Cutaneous Nerves

inferredcites →https://doi.org/10.1097/nen.0b013e3182805c72openalex-snapshot

Submandibular Gland Biopsy for the Diagnosis of Parkinson Disease

inferredcites →https://doi.org/10.1097/nen.0b013e3182965886openalex-snapshot

Parkinson Disease Affects Peripheral Sensory Nerves in the Pharynx

inferredcites →https://doi.org/10.1111/j.1460-9568.2006.05210.xopenalex-snapshot

Impairment of microtubule‐dependent trafficking by overexpression of α‐synuclein

inferredcites →https://doi.org/10.1111/j.1468-1331.2005.01260.xopenalex-snapshot

EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy

inferredcites →https://doi.org/10.1111/j.1471-4159.2010.06832.xopenalex-snapshot

Over‐expression of alpha‐synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain

inferredcites →https://doi.org/10.1111/j.1529-8027.2010.00271.xopenalex-snapshot

Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study

inferredcites →https://doi.org/10.1136/jnnp.2007.128801openalex-snapshot

Non-length dependent small fibre neuropathy/ganglionopathy

inferredcites →https://doi.org/10.1136/jnnp.55.3.181openalex-snapshot

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

inferredcites →https://doi.org/10.1136/jnnp.73.5.529openalex-snapshot

How valid is the clinical diagnosis of Parkinson's disease in the community?

inferredcites →https://doi.org/10.1212/wnl.0b013e3181e0f7b3openalex-snapshot

Elevated proinflammatory cytokine expression in affected skin in small fiber neuropathy

inferredcites →https://doi.org/10.1212/wnl.0b013e31823a0ee4openalex-snapshot

Neuropathy in Parkinson disease

inferredcites →https://doi.org/10.1212/wnl.0b013e3182a9f449openalex-snapshot

α-Synuclein in cutaneous autonomic nerves

inferredcites →https://doi.org/10.1212/wnl.17.5.427openalex-snapshot

Parkinsonism

inferredcites →https://doi.org/10.1371/journal.pgen.1002537openalex-snapshot

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

inferredcites →https://doi.org/10.1371/journal.pone.0012728openalex-snapshot

Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms

inferredcites →https://doi.org/10.1371/journal.pone.0066639openalex-snapshot

Neuropathy in Parkinson’s Disease Patients with Intestinal Levodopa Infusion versus Oral Drugs

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Comparison of Different Biospecimens for α-Synuclein Seed Amplification Assays in Parkinson's Disease: A Systematic Review and Network Meta-Analysis

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inferred← citeshttps://doi.org/10.1001/jamaneurol.2020.3311openalex-snapshot

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

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Parkinson disease and progressive supranuclear palsy: protein expression in skin

inferred← citeshttps://doi.org/10.1002/acn3.51301openalex-snapshot

Peripheral synucleinopathy in Parkinson disease with LRRK2 G2385R variants

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Phosphorylated alpha‐synuclein in Iba1‐positive macrophages in the skin of patients with Parkinson's disease

inferred← citeshttps://doi.org/10.1002/acn3.669openalex-snapshot

Cervical skin denervation associates with alpha‐synuclein aggregates in Parkinson disease

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Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

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Identification of small fiber neuropathy in neuronal intranuclear inclusion disease: A clinicopathological study

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Skin nerve misfolded α‐synuclein in pure autonomic failure and P arkinson disease

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Reduced central sympathetic activity in Parkinson's disease

inferred← citeshttps://doi.org/10.1002/mdc3.12425openalex-snapshot

The Skin and Parkinson's Disease: Review of Clinical, Diagnostic, and Therapeutic Issues

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Levodopa‐Induced Neuropathy: A Systematic Review

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Unraveling Peripheral Neuropathy in Parkinsonism from Acquired to Genetic Forms: A Review with Diagnostic Framework for Clinicians

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Distinctive distribution of phospho‐alpha‐synuclein in dermal nerves in multiple system atrophy

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Prodromal Parkinson's Disease: The Decade Past, the Decade to Come

inferred← citeshttps://doi.org/10.1002/mds.27794openalex-snapshot

Value of in vivo α‐synuclein deposits in Parkinson's disease: A systematic review and meta‐analysis

inferred← citeshttps://doi.org/10.1002/mds.28126openalex-snapshot

Skin Biopsy May Help to Distinguish Multiple System Atrophy–Parkinsonism from Parkinson's Disease With Orthostatic Hypotension

inferred← citeshttps://doi.org/10.1002/mds.28399openalex-snapshot

Immunohistochemical Detection of Synuclein Pathology in Skin in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinsonism

inferred← citeshttps://doi.org/10.1002/mds.28602openalex-snapshot

Corneal Confocal Microscopy Identifies Parkinson's Disease with More Rapid Motor Progression

inferred← citeshttps://doi.org/10.1002/mds.28655openalex-snapshot

Linking Parkinson's Disease and Melanoma: Interplay Between α‐Synuclein and Pmel17 Amyloid Formation

inferred← citeshttps://doi.org/10.1002/mds.29340openalex-snapshot

Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy

inferred← citeshttps://doi.org/10.1002/med.22091openalex-snapshot

α‐Synuclein in Parkinson's Disease: From Bench to Bedside

inferred← citeshttps://doi.org/10.1002/mus.70235openalex-snapshot

Synuclein Deposition in Idiopathic Small‐Fiber Neuropathy: A Pilot Study

inferred← citeshttps://doi.org/10.1007/978-3-030-62263-3_22openalex-snapshot

Autonomic Dysfunction in Parasomnias of REM Sleep

inferred← citeshttps://doi.org/10.1007/978-3-031-20565-1_32openalex-snapshot

Seeding Activity of Skin Misfolded Proteins as a Biomarker in Prion and Prion-Like Diseases

inferred← citeshttps://doi.org/10.1007/978-3-031-66513-4_6openalex-snapshot

Skin Biomarkers of Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1007/978-3-031-66513-4_8openalex-snapshot

Skin Biomarker in Parkinson Disease

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Neuropathology of Parkinson’s Disease

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Overview of Small Fiber Neuropathy

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Small Fiber Pathology in Neurodegenerative Disorders

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A review of the current research on in vivo and in vitro detection for alpha-synuclein: a biomarker of Parkinson’s disease

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Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

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Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson’s disease

inferred← citeshttps://doi.org/10.1007/s00401-018-1876-1openalex-snapshot

Small fiber pathology parallels disease progression in Parkinson disease: a longitudinal study

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Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases

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Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study

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Heterogeneous pattern of autonomic dysfunction in Parkinson’s disease

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Somatosensory symptoms in unmedicated de novo patients with idiopathic Parkinson’s disease

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Assessment of cutaneous axon-reflex responses to evaluate functional integrity of autonomic small nerve fibers

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Peripheral neuropathy in Parkinson’s disease

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A comprehensive study of clinicopathological and genetic features of neuronal intranuclear inclusion disease

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Hearing dysfunction heralds an increase in non-motor burden and a worse quality of life in Parkinson’s disease: new insights from non-motor spectrum

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Autonomic dysfunction in Parkinson disease and animal models

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Skin nerve α-synuclein deposits in Parkinson’s disease and other synucleinopathies: a review

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Cutaneous α-Synuclein Pathology as a Differential Marker: A Histological and Statistical Comparison across Neurodegenerative Disease Groups

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Fluid and Biopsy Based Biomarkers in Parkinson's Disease

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Alpha-Synuclein-Ablagerungen in peripheren Nervenfasern der Haut: ein diagnostischer Marker bei Parkinson-Syndromen?

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Neue Therapien am Horizont?

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Dopaminergic neurotransmission

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Thermoregulation in Parkinson disease

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Neuropathology of Nonmotor Symptoms of Parkinson's Disease

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Neuropathological substrates of cognition in Parkinson's disease

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Prevalence and factors associated with polyneuropathy in Parkinson’s disease

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Tissue expansion for challenging DBS hardware erosions in patients with Parkinson's disease

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Contribution of functional dopamine D2 and D3 receptor variants to motor and non-motor symptoms of early onset Parkinson’s disease

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Polyneuropathy in Parkinson's Disease is Highly Prevalent and Not Related to Treatment

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Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes

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Climate change and neurodegenerative diseases

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Polyneuropathy in levodopa-treated Parkinson's patients

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Peripheral neuropathy in idiopathic Parkinson's disease: A systematic review

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A systematic review of the potential consequences of abnormal serum levels of vitamin B6 in people living with Parkinson's disease

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Prospective cohort study of patients with early gastric cancer to detect prodromal Parkinson disease (EGC-PPD): A study protocol and baseline characteristics

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Non-length-dependent somatosensory small fiber pathology presenting with restless legs syndrome in pre-motor Parkinson’s disease. Evidence from skin biopsy in four patients

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Parkinson's Disease-related Pains are Not Equal: Clinical, Somatosensory and Cortical Excitability Findings in Individuals With Nociceptive Pain

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Dermal and cardiac autonomic fiber involvement in Parkinson's disease and multiple system atrophy

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Biomarkers in Parkinson’s Disease

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Clinical correlates of sural neurography impairment within normal limits in patients with Parkinsons disease

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Plantar cutaneous function in Parkinson’s disease patients ON and OFF L-dopa

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Generation of monoclonal antibodies against phosphorylated α-Synuclein at serine 129: Research tools for synucleinopathies

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La transconformation protéique, nouveau paradigme en neurologie

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Microorganismos relacionados con un mayor riesgo de presentar la enfermedad de Parkinson

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Microorganisms associated with increased risk of Parkinson’s disease

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Peripheral nervous system involvement in Parkinson's disease: Evidence and controversies

inferred← citeshttps://doi.org/10.1016/j.parkreldis.2015.10.019openalex-snapshot

Small fiber neuropathy in Parkinson's disease: A clinical, pathological and corneal confocal microscopy study

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The peripheral nerve involvement in Parkinson Disease: A multifaceted phenomenon

inferred← citeshttps://doi.org/10.1016/j.parkreldis.2016.06.003openalex-snapshot

Reduced intraepidermal nerve fiber density in patients with REM sleep behavior disorder

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Phosphorylated α-synuclein deposits in sural nerve deriving from Schwann cells: A biomarker for Parkinson's disease

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The aggregation state of α-synuclein deposits in dermal nerve fibers of patients with Parkinson's disease resembles that in the brain

inferred← citeshttps://doi.org/10.1016/j.parkreldis.2019.03.007openalex-snapshot

Clinical utility of SUDOSCAN in predicting autonomic neuropathy in patients with Parkinson's disease

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Small fiber neuropathy and phosphorylated alpha-synuclein in the skin of E46K-SNCA mutation carriers

inferred← citeshttps://doi.org/10.1016/j.parkreldis.2020.11.017openalex-snapshot

Parkinson's disease and skin

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Skin conditions in early Parkinson's disease

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Consistent skin α-synuclein positivity in REM sleep behavior disorder – A two center two-to-four-year follow-up study

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Skin biopSYN or how to predict Parkinson's disease

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Sudomotor deficits in Parkinson's disease with special reference to motor subtypes

inferred← citeshttps://doi.org/10.1016/j.parkreldis.2023.105899openalex-snapshot

Corneal confocal microscopy demonstrates varying degrees of neurodegeneration in atypical parkinsonian disorders

inferred← citeshttps://doi.org/10.1016/j.parkreldis.2024.107178openalex-snapshot

Association between sebum secretion and cardiac sympathetic dysfunction in Parkinson's disease

inferred← citeshttps://doi.org/10.1016/j.physbeh.2014.09.015openalex-snapshot

Point pressure sensitivity in early stage Parkinson's disease

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2024.102673openalex-snapshot

Neuronal threshold functions: Determining symptom onset in neurological disorders

inferred← citeshttps://doi.org/10.1016/j.sleep.2017.09.035openalex-snapshot

Somatosensory function is impaired in patients with idiopathic REM sleep behaviour disorder

inferred← citeshttps://doi.org/10.1016/j.sleepe.2024.100100openalex-snapshot

Association between skin temperature and actigraphic sleep metrics in patients with Parkinson's disease: The PHASE study

inferred← citeshttps://doi.org/10.1016/j.smrv.2020.101283openalex-snapshot

The role of tissue biopsy as a biomarker in REM sleep behavior disorder

inferred← citeshttps://doi.org/10.1016/j.stemcr.2015.11.004openalex-snapshot

Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson’s Disease-Related LRRK2 G2019S Mutation

inferred← citeshttps://doi.org/10.1016/j.ynpai.2025.100207openalex-snapshot

Peripheral immune response and axonal degeneration in the hind paw skin of mice with experimental autoimmune encephalomyelitis

inferred← citeshttps://doi.org/10.1016/s1474-4422(25)00194-2openalex-snapshot

α-synuclein biomarker assays: bridging research and patient care

inferred← citeshttps://doi.org/10.1016/s1474-4422(26)00033-5openalex-snapshot

Detection of phosphorylated α-synuclein in skin

inferred← citeshttps://doi.org/10.1021/acschemneuro.8b00383openalex-snapshot

Alpha-Synuclein in Peripheral Tissues in Parkinson’s Disease

inferred← citeshttps://doi.org/10.1038/nrdp.2017.13openalex-snapshot

Parkinson disease

inferred← citeshttps://doi.org/10.1038/nrneurol.2017.31openalex-snapshot

New technologies for the assessment of neuropathies

inferred← citeshttps://doi.org/10.1038/s41467-018-08130-9openalex-snapshot

Early preclinical detection of prions in the skin of prion-infected animals

inferred← citeshttps://doi.org/10.1038/s41531-020-00148-5openalex-snapshot

Parkinson’s disease with restless legs syndrome—an in vivo corneal confocal microscopy study

inferred← citeshttps://doi.org/10.1038/s41531-021-00242-2openalex-snapshot

Diagnostic value of skin RT-QuIC in Parkinson’s disease: a two-laboratory study

inferred← citeshttps://doi.org/10.1038/s41531-022-00357-0openalex-snapshot

Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies

inferred← citeshttps://doi.org/10.1038/s41531-022-00379-8openalex-snapshot

Linking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding

inferred← citeshttps://doi.org/10.1038/s41531-022-00388-7openalex-snapshot

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

inferred← citeshttps://doi.org/10.1038/s41531-023-00519-8openalex-snapshot

Combining skin and olfactory α-synuclein seed amplification assays (SAA)—towards biomarker-driven phenotyping in synucleinopathies

inferred← citeshttps://doi.org/10.1038/s41531-024-00728-9openalex-snapshot

Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies

inferred← citeshttps://doi.org/10.1038/s41531-025-01030-yopenalex-snapshot

Cutaneous nerve fiber pathology and function in Parkinson’s disease and atypical parkinsonism – a cohort study

inferred← citeshttps://doi.org/10.1038/s41597-021-01087-3openalex-snapshot

Wide-field mosaics of the corneal subbasal nerve plexus in Parkinson’s disease using in vivo confocal microscopy

inferred← citeshttps://doi.org/10.1038/s41598-018-32588-8openalex-snapshot

Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study

inferred← citeshttps://doi.org/10.1038/s41598-019-53684-3openalex-snapshot

The autonomic innervation of hairy skin in humans: an in vivo confocal study

inferred← citeshttps://doi.org/10.1038/s41598-021-98423-9openalex-snapshot

Non-invasive diagnostic tool for Parkinson’s disease by sebum RNA profile with machine learning

inferred← citeshttps://doi.org/10.1038/s44328-026-00094-xopenalex-snapshot

Detection of α-synuclein aggregates in synucleinopathies: current approaches, biomarkers and challenges

inferred← citeshttps://doi.org/10.1055/a-0590-4464openalex-snapshot

Das idiopathische Parkinsonsyndrom und Schmerz – diagnostische und therapeutische Ansätze für ein herausforderndes nicht-motorisches Symptom

inferred← citeshttps://doi.org/10.1080/10408363.2019.1711359openalex-snapshot

Methods for detecting toxic α-synuclein species as a biomarker for Parkinson’s disease

inferred← citeshttps://doi.org/10.1093/brain/awab431openalex-snapshot

Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies

inferred← citeshttps://doi.org/10.1093/brain/awac026openalex-snapshot

Peripheral neuropathy in Parkinson’s disease: prevalence and functional impact on gait and balance

inferred← citeshttps://doi.org/10.1093/brain/awaf395openalex-snapshot

Distinct cutaneous α-synuclein signatures in body-first and brain-first Parkinson’s disease subtypes

inferred← citeshttps://doi.org/10.1093/brain/awv138openalex-snapshot

Phosphorylated α-synuclein in skin nerve fibres differentiates Parkinson’s disease from multiple system atrophy

inferred← citeshttps://doi.org/10.1093/brain/awv251openalex-snapshot

Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?

inferred← citeshttps://doi.org/10.1093/jnen/nlaa048openalex-snapshot

A Longitudinal Skin Biopsy Study of Phosphorylated Alpha-Synuclein in a Patient With Parkinson Disease and Orthostatic Hypotension

inferred← citeshttps://doi.org/10.1093/jnen/nlac034openalex-snapshot

The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study

inferred← citeshttps://doi.org/10.1093/jnen/nlae015openalex-snapshot

Skin nerve phosphorylated α-synuclein in the elderly

inferred← citeshttps://doi.org/10.1093/jnen/nlaf036openalex-snapshot

Evaluation of 6 monoclonal antibodies against Ser129-phosphorylated α-synuclein: Critical role of proteinase K antigen retrieval and superior sensitivity of the D1R1R clone in human skin biopsies

inferred← citeshttps://doi.org/10.1093/jnen/nlw103openalex-snapshot

The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease

inferred← citeshttps://doi.org/10.1093/jnen/nlx021openalex-snapshot

Spine Topographical Distribution of Skin α-Synuclein Deposits in Idiopathic Parkinson Disease

inferred← citeshttps://doi.org/10.1093/jnen/nly074openalex-snapshot

Skin Nerve Phosphorylated α-Synuclein Deposits in Parkinson Disease With Orthostatic Hypotension

inferred← citeshttps://doi.org/10.1093/oxfordhb/9780190860509.013.22openalex-snapshot

The Diversity of Neuropathic Pain

inferred← citeshttps://doi.org/10.1097/j.pain.0000000000002968openalex-snapshot

Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them

inferred← citeshttps://doi.org/10.1097/md.0000000000003058openalex-snapshot

Pathophysiology of Small-Fiber Sensory System in Parkinson's Disease

inferred← citeshttps://doi.org/10.1097/wco.0000000000000948openalex-snapshot

Update on alpha-synuclein-based biomarker approaches in the skin, submandibular gland, gastrointestinal tract, and biofluids

inferred← citeshttps://doi.org/10.1101/2022.03.30.486322openalex-snapshot

Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies

inferred← citeshttps://doi.org/10.1111/ene.12753openalex-snapshot

Can we use peripheral tissue biopsies to diagnose Parkinson's disease? A review of the literature

inferred← citeshttps://doi.org/10.1111/ene.12846openalex-snapshot

Peripheral neuropathy associated with levodopa–carbidopa intestinal infusion: a long‐term prospective assessment

inferred← citeshttps://doi.org/10.1111/ene.13939openalex-snapshot

Abnormal α‐synuclein deposits in skin nerves: intra‐ and inter‐laboratory reproducibility

inferred← citeshttps://doi.org/10.1111/ene.15733openalex-snapshot

Two‐Year observational study of autonomic skin function in patients with Parkinson's disease compared to healthy individuals

inferred← citeshttps://doi.org/10.1111/ene.16041openalex-snapshot

Comparison of biospecimens for α‐synuclein seed amplification assays in Parkinson's disease: A systematic review and network meta‐analysis

inferred← citeshttps://doi.org/10.1111/ene.16167openalex-snapshot

A fast and non‐invasive artificial intelligence olfactory‐like system that aids diagnosis of Parkinson's disease

inferred← citeshttps://doi.org/10.1111/jnc.13750openalex-snapshot

Current and experimental treatments of Parkinson disease: A guide for neuroscientists

inferred← citeshttps://doi.org/10.1111/jnc.14809openalex-snapshot

Parkinson’s disease biomarkers based on α‐synuclein

inferred← citeshttps://doi.org/10.1111/nan.12298openalex-snapshot

Review: Sporadic Parkinson's disease: development and distribution ofα‐synuclein pathology

inferred← citeshttps://doi.org/10.1111/nan.12692openalex-snapshot

Cutaneous sensory and autonomic denervation in progressive supranuclear palsy

inferred← citeshttps://doi.org/10.1111/neup.12691openalex-snapshot

Where and how alpha‐synuclein pathology spreads in Parkinson’s disease:

inferred← citeshttps://doi.org/10.1111/neup.12772openalex-snapshot

Lewy pathology of the submandibular gland in Lewy body disease: A report of autopsy cases

inferred← citeshttps://doi.org/10.1155/2015/167038openalex-snapshot

Clinical Utility of Skin Biopsy in Differentiating between Parkinson’s Disease and Multiple System Atrophy

inferred← citeshttps://doi.org/10.1155/2016/4958068openalex-snapshot

Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry

inferred← citeshttps://doi.org/10.1155/2017/5012129openalex-snapshot

The Contribution of α -Synuclein Spreading to Parkinson’s Disease Synaptopathy

inferred← citeshttps://doi.org/10.1155/2017/6064974openalex-snapshot

Should Skin Biopsies Be Performed in Patients Suspected of Having Parkinson’s Disease?

inferred← citeshttps://doi.org/10.1177/0891988716656083openalex-snapshot

Revisiting DLB Diagnosis

inferred← citeshttps://doi.org/10.1177/1877718x261420669openalex-snapshot

Quantitative measures of total and phosphorylated alpha-synuclein in skin tissue as potential biomarkers for synucleinopathies

inferred← citeshttps://doi.org/10.1186/s12883-016-0784-zopenalex-snapshot

Looking beyond the brain to improve the pathogenic understanding of Parkinson’s disease: implications of whole transcriptome profiling of Patients’ skin

inferred← citeshttps://doi.org/10.1186/s13024-026-00966-wopenalex-snapshot

Standardized protocol to detect phosphorylated α-synuclein in skin biopsies: recommendations from an expert panel

inferred← citeshttps://doi.org/10.1186/s13195-020-00611-8openalex-snapshot

An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s40001-024-01705-xopenalex-snapshot

Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson’s disease in the Chinese population

inferred← citeshttps://doi.org/10.1186/s40478-015-0236-9openalex-snapshot

Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons

inferred← citeshttps://doi.org/10.1186/s40478-021-01175-wopenalex-snapshot

Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies

inferred← citeshttps://doi.org/10.1186/s42466-024-00354-zopenalex-snapshot

Large-fiber neuropathy in Parkinson’s disease: a narrative review

inferred← citeshttps://doi.org/10.1212/wnl.0000000000002126openalex-snapshot

Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder

inferred← citeshttps://doi.org/10.1212/wnl.0000000000002919openalex-snapshot

The diagnostic discrimination of cutaneous α-synuclein deposition in Parkinson disease

inferred← citeshttps://doi.org/10.1212/wnl.0000000000004146openalex-snapshot

A new potential biomarker for dementia with Lewy bodies

inferred← citeshttps://doi.org/10.1212/wnl.0000000000004274openalex-snapshot

Loss of cutaneous large and small fibers in naive and l -dopa–treated PD patients

inferred← citeshttps://doi.org/10.1212/wnl.0000000000005104openalex-snapshot

Reader response: A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits

inferred← citeshttps://doi.org/10.1212/wnl.0000000000011935openalex-snapshot

In Vivo Diagnosis of Synucleinopathies

inferred← citeshttps://doi.org/10.1212/wnl.0000000000011941openalex-snapshot

Reader Response: In Vivo Distribution of α-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease

inferred← citeshttps://doi.org/10.1212/wnl.0000000000206772openalex-snapshot

Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease

inferred← citeshttps://doi.org/10.1212/wnl.0000000000218583openalex-snapshot

Association of Skin Denervation With Brain Atrophy and Cognitive Impairment in Patients With Parkinson Disease

inferred← citeshttps://doi.org/10.12688/f1000research.10100.1openalex-snapshot

Recent advances in treating Parkinson’s disease

inferred← citeshttps://doi.org/10.1369/0022155420960250openalex-snapshot

Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson’s Disease: The Implications of Sample Thickness on Results

inferred← citeshttps://doi.org/10.1371/journal.pone.0276564openalex-snapshot

Proinflammatory profile in the skin of Parkinson’s disease patients with and without pain

inferred← citeshttps://doi.org/10.1586/14737175.2015.1095093openalex-snapshot

Recognition and treatment of autonomic disturbances in Parkinson’s disease

inferred← citeshttps://doi.org/10.20453/rnp.v83i4.3892openalex-snapshot

Neuropatía Periférica en la enfermedad de Parkinson

inferred← citeshttps://doi.org/10.21203/rs.3.rs-10953905/v1openalex-snapshot

α-Synuclein Seeding Activity in Fixed Antemortem Skin Biopsies From Patients With Synucleinopathies

inferred← citeshttps://doi.org/10.2147/ndt.s117423openalex-snapshot

Alpha-synuclein in cutaneous small nerve fibers

inferred← citeshttps://doi.org/10.2147/ndt.s166322openalex-snapshot

The direct and indirect effects of α-synuclein on microtubule stability in the pathogenesis of Parkinson’s disease

inferred← citeshttps://doi.org/10.2217/bmm-2016-0366openalex-snapshot

The Systemic Synuclein Sampling Study: Toward a Biomarker for Parkinson’s Disease

inferred← citeshttps://doi.org/10.2298/vsp240528061popenalex-snapshot

Clinical and laboratory status in Parkinson’s disease patients with and without polyneuropathy

inferred← citeshttps://doi.org/10.2340/actadv.v105.43908openalex-snapshot

Prevalence and Characteristics of Itch in Patients with Parkinson’s Disease

inferred← citeshttps://doi.org/10.3233/jpd-150685openalex-snapshot

The Concept of Prodromal Parkinson’s Disease

inferred← citeshttps://doi.org/10.3233/jpd-160779openalex-snapshot

Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?

inferred← citeshttps://doi.org/10.3233/jpd-171088openalex-snapshot

Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson’s Disease

inferred← citeshttps://doi.org/10.3233/jpd-181357openalex-snapshot

Autonomic Sweat Responses in REM Sleep Behavior Disorder and Parkinsonism

inferred← citeshttps://doi.org/10.3233/jpd-191697openalex-snapshot

Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides

inferred← citeshttps://doi.org/10.3233/jpd-202489openalex-snapshot

Detection of Dermal Alpha-Synuclein Deposits as a Biomarker for Parkinson’s Disease

inferred← citeshttps://doi.org/10.3233/jpd-212904openalex-snapshot

Presence of Skin α-Synuclein Deposits Discriminates Parkinson’s Disease from Progressive Supranuclear Palsy and Corticobasal Syndrome

inferred← citeshttps://doi.org/10.3233/jpd-223421openalex-snapshot

Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism

inferred← citeshttps://doi.org/10.3233/jpd-230256openalex-snapshot

Chronotropic Incompetence in Parkinson’s Disease: A Possible Marker of Severe Disease Phenotype?

inferred← citeshttps://doi.org/10.3238/persneuro.2017.09.15.05openalex-snapshot

Forschung: Parkinson-Krankheit – Hautbiopsie unterstützt Diagnose in Prodromalphase

inferred← citeshttps://doi.org/10.33448/rsd-v10i7.16813openalex-snapshot

Estudo da neuropatia periférica em pacientes com doença de Parkinson: Revisão de literatura

inferred← citeshttps://doi.org/10.3389/fnagi.2021.690293openalex-snapshot

Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders

inferred← citeshttps://doi.org/10.3389/fnagi.2021.702639openalex-snapshot

Alpha-Synuclein as a Biomarker of Parkinson’s Disease: Good, but Not Good Enough

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