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Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies

https://doi.org/10.1101/2022.03.30.486322

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Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult

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Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice

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α-synuclein phosphorylation and truncation are normal events in the adult human brain

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Mass Spectrometric Analysis of Lewy Body-Enriched α-Synuclein in Parkinson’s Disease

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Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions

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The Antibody Society’s antibody validation webinar series

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Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein

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Morphogenesis of Lewy Bodies: Dissimilar Incorporation of α-Synuclein, Ubiquitin, and p62

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Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity

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Detection and Purification of Lewy Pathology from Formalin Fixed Primary Human Tissue Using Biotinylation by Antigen Recognition

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Specific Detection of Endogenous S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay

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Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies

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A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity

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The making of a Lewy body: the role of alpha-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions.

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Biochemical Increase in Phosphorylated Alpha‐Synuclein Precedes Histopathology of Lewy‐Type Synucleinopathies

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A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research

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A novel SNCA E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration

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Comparison of commercially available antibodies for the detection of phosphorylated alpha‐synuclein in primary culture of ENS

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Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

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The vermiform appendix impacts the risk of developing Parkinson’s disease

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Can we clinically diagnose dementia with Lewy bodies yet?

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Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes

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Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease

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LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

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Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2

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The challenges with the validation of research antibodies

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Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein

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Subcellular Fractionation of Cultured Human Cell Lines

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Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System

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Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms

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The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases

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Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay

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Plasma pS129-α-Synuclein Is a Surrogate Biofluid Marker of Motor Severity and Progression in Parkinson’s Disease

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies

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Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases

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