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Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress

https://doi.org/10.1007/s12640-017-9838-2

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What this work says

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Sigma‐1 receptor activation‐induced glycolytic ATP production and endothelial barrier enhancement

inferred← citeshttps://doi.org/10.1155/2018/8026496openalex-snapshot

Weanling Offspring of Dams Maintained on Serine‐Deficient Diet Are Vulnerable to Oxidative Stress

inferred← citeshttps://doi.org/10.1155/2019/3809308openalex-snapshot

Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress

inferred← citeshttps://doi.org/10.1155/2021/6622232openalex-snapshot

Inhibiting Cardiac Mitochondrial Fatty Acid Oxidation Attenuates Myocardial Injury in a Rat Model of Cardiac Arrest

inferred← citeshttps://doi.org/10.1161/jaha.118.009775openalex-snapshot

Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics

inferred← citeshttps://doi.org/10.1177/1535370221997780openalex-snapshot

Sigma receptor knockdown augments dysfunction and apoptosis of beta cells induced by palmitate

inferred← citeshttps://doi.org/10.1371/journal.pone.0265854openalex-snapshot

Effects of sub-chronic, in vivo administration of sigma-1 receptor ligands on platelet and aortic arachidonate cascade in streptozotocin-induced diabetic rats

inferred← citeshttps://doi.org/10.1371/journal.pone.0352906openalex-snapshot

Bis-hydrophobic 5-(1,2-dithiolan-3-yl)pentanamide budding leads targeting brain sigma-1 receptors

inferred← citeshttps://doi.org/10.14232/phd.11052openalex-snapshot

Sigma-1 receptor mediálta protektív mechanizmus vizsgálata TNBS-indukálta patkány colitis modellben

inferred← citeshttps://doi.org/10.1515/biol-2021-0124openalex-snapshot

Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers

inferred← citeshttps://doi.org/10.20944/preprints202011.0333.v1openalex-snapshot

Dual Aquaporin and Sigma1 Receptor (DAS) Modulators: New Tools for Counteracting Oxidative Stress

inferred← citeshttps://doi.org/10.3389/fncel.2021.685201openalex-snapshot

Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury

inferred← citeshttps://doi.org/10.3389/fnins.2019.00862openalex-snapshot

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.3389/fnins.2019.01012openalex-snapshot

Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

inferred← citeshttps://doi.org/10.3389/fnmol.2024.1513084openalex-snapshot

Chaperones vs. oxidative stress in the pathobiology of ischemic stroke

inferred← citeshttps://doi.org/10.3389/fphar.2020.582310openalex-snapshot

Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?

inferred← citeshttps://doi.org/10.3389/fphar.2021.614949openalex-snapshot

Negative Impact of Sigma-1 Receptor Agonist Treatment on Tissue Integrity and Motor Function Following Spinal Cord Injury

inferred← citeshttps://doi.org/10.3389/fphar.2024.1423356openalex-snapshot

Shaping cardiac destiny: the role of post-translational modifications on endoplasmic reticulum – mitochondria crosstalk in cardiac remodeling

inferred← citeshttps://doi.org/10.3389/fphar.2026.1829506openalex-snapshot

A neuroprotective target in the shadows: a scoping review of pharmacological gaps in σ1R agonists for glutamate-induced neurotoxicity

inferred← citeshttps://doi.org/10.3389/fphys.2021.705575openalex-snapshot

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

inferred← citeshttps://doi.org/10.3390/antiox10121867openalex-snapshot

Effects of Melatonin Supplementation during Pregnancy on Reproductive Performance, Maternal–Placental–Fetal Redox Status, and Placental Mitochondrial Function in a Sow Model

inferred← citeshttps://doi.org/10.3390/antiox11010165openalex-snapshot

Therapeutic Strategies Targeting Mitochondrial Calcium Signaling: A New Hope for Neurological Diseases?

inferred← citeshttps://doi.org/10.3390/antiox12061282openalex-snapshot

Therapeutic Potential of Heterocyclic Compounds Targeting Mitochondrial Calcium Homeostasis and Signaling in Alzheimer’s Disease and Parkinson’s Disease

inferred← citeshttps://doi.org/10.3390/antiox9111081openalex-snapshot

Sigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis

inferred← citeshttps://doi.org/10.3390/biology14081072openalex-snapshot

Paternal Cocaine Exposure and Its Testicular Legacy: Epigenetic, Physiological, and Intergenerational Consequences

inferred← citeshttps://doi.org/10.3390/biomedicines13020432openalex-snapshot

Neuroprotective Effects of Dehydroepiandrosterone Sulphate Against Aβ Toxicity and Accumulation in Cellular and Animal Model of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/cells8030211openalex-snapshot

Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

inferred← citeshttps://doi.org/10.3390/cells8091071openalex-snapshot

Mechanistic Connections between Endoplasmic Reticulum (ER) Redox Control and Mitochondrial Metabolism

inferred← citeshttps://doi.org/10.3390/ijms21134812openalex-snapshot

Steroids and Alzheimer’s Disease: Changes Associated with Pathology and Therapeutic Potential

inferred← citeshttps://doi.org/10.3390/ijms21197088openalex-snapshot

Chaperone Sigma1R and Antidepressant Effect

inferred← citeshttps://doi.org/10.3390/ijms21207620openalex-snapshot

Deferred Administration of Afobazole Induces Sigma1R-Dependent Restoration of Striatal Dopamine Content in a Mouse Model of Parkinson’s Disease

inferred← citeshttps://doi.org/10.3390/ijms22115455openalex-snapshot

Involvement of Chaperone Sigma1R in the Anxiolytic Effect of Fabomotizole

inferred← citeshttps://doi.org/10.3390/ijms22168416openalex-snapshot

An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies

inferred← citeshttps://doi.org/10.3390/ijms22189790openalex-snapshot

Sigma-1 Receptor Agonists Acting on Aquaporin-Mediated H2O2 Permeability: New Tools for Counteracting Oxidative Stress

inferred← citeshttps://doi.org/10.3390/ijms222011049openalex-snapshot

Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish

inferred← citeshttps://doi.org/10.3390/ijms24010823openalex-snapshot

Chaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection

inferred← citeshttps://doi.org/10.3390/ijms24097767openalex-snapshot

SIGMAR1 Confers Innate Resilience against Neurodegeneration

inferred← citeshttps://doi.org/10.3390/ijms25105147openalex-snapshot

Modulation of the Blood–Brain Barrier by Sigma-1R Activation

inferred← citeshttps://doi.org/10.3390/life12081209openalex-snapshot

Tunicamycin-Induced Endoplasmic Reticulum Stress Damages Complex I in Cardiac Mitochondria

inferred← citeshttps://doi.org/10.3390/ph18050700openalex-snapshot

Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders

inferred← citeshttps://doi.org/10.3410/f.734163848.793552073openalex-snapshot

Faculty Opinions recommendation of Structural basis for σ1 receptor ligand recognition.

inferred← citeshttps://doi.org/10.35376/10324/66283openalex-snapshot

Lipid Rafts in brain cells: From enzymatic activity to lipidomic assays in a novel printed Rafts platform

inferred← citeshttps://doi.org/10.4103/1673-5374.265544openalex-snapshot

Current status and future prospects of stem cell therapy in Alzheimer’s disease

inferred← citeshttps://doi.org/10.5114/fpn.2023.131979openalex-snapshot

Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders

inferred← citeshttps://doi.org/10.57098/scirevs.biology.2.2openalex-snapshot

inferred← citeshttps://doi.org/10.57098/scirevs.biology.2.2.1openalex-snapshot

All-natural 5-MeO-DMT sigma receptor 1 agonist and its therapeutic impact in mental and neurodegener-ative diseases through mitochondrial activation

inferred← citeshttps://doi.org/10.70675/f492678cz7ab3z4622z8441z4a845bce0ae2openalex-snapshot

Effets d'une déplétion microgliale transitoire sur la récupération fonctionnelle et l'intégrité tissulaire après une lésion de la moelle épinière : analyse translationnelle des murins aux primates non-humains

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