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Chemical screening in zebrafish for novel biological and therapeutic discovery
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/bdrc.20216openalex-snapshot
A high‐content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling
inferredcites →https://doi.org/10.1002/dvdy.21967openalex-snapshot
Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus
inferredcites →https://doi.org/10.1006/dbio.1998.8927openalex-snapshot
Ventral and Lateral Regions of the Zebrafish Gastrula, Including the Neural Crest Progenitors, Are Established by abmp2b/swirlPathway of Genes
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Three Different noggin Genes Antagonize the Activity of Bone Morphogenetic Proteins in the Zebrafish Embryo
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Small Molecule Screen in Zebrafish and HSC Expansion
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Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
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Structural genomics of protein phosphatases
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15 years of zebrafish chemical screening
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Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule
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Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen
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PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation
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An In Vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog Signaling Inhibition
inferredcites →https://doi.org/10.1016/j.chembiol.2004.07.012openalex-snapshot
Modular Synthesis and Preliminary Biological Evaluation of Stereochemically Diverse 1,3-Dioxanes
inferredcites →https://doi.org/10.1016/j.chembiol.2013.05.008openalex-snapshot
Juxtaposition of Chemical and Mutation-Induced Developmental Defects in Zebrafish Reveal a Copper-Chelating Activity for Kalihinol F
inferredcites →https://doi.org/10.1016/j.chembiol.2014.02.013openalex-snapshot
Neural Crest Development and Craniofacial Morphogenesis Is Coordinated by Nitric Oxide and Histone Acetylation
inferredcites →https://doi.org/10.1016/j.chembiol.2014.02.015openalex-snapshot
A Zebrafish Chemical Suppressor Screening Identifies Small Molecule Inhibitors of the Wnt/β-catenin Pathway
inferredcites →https://doi.org/10.1016/j.cub.2006.05.046openalex-snapshot
Artery/Vein Specification Is Governed by Opposing Phosphatidylinositol-3 Kinase and MAP Kinase/ERK Signaling
inferredcites →https://doi.org/10.1016/j.eururo.2010.05.024openalex-snapshot
Rosuvastatin, Identified From a Zebrafish Chemical Genetic Screen for Antiangiogenic Compounds, Suppresses the Growth of Prostate Cancer
inferredcites →https://doi.org/10.1016/j.jmb.2006.05.059openalex-snapshot
Crystal Structure of the Catalytic Domain of Human MAP Kinase Phosphatase 5: Structural Insight into Constitutively Active Phosphatase
inferredcites →https://doi.org/10.1016/j.mod.2009.01.002openalex-snapshot
Small molecule screen for compounds that affect vascular development in the zebrafish retina
inferredcites →https://doi.org/10.1016/j.reprotox.2011.10.018openalex-snapshot
Zebrafish developmental screening of the ToxCast™ Phase I chemical library
inferredcites →https://doi.org/10.1016/j.ydbio.2005.09.011openalex-snapshot
Functions and regulations of fibroblast growth factor signaling during embryonic development
inferredcites →https://doi.org/10.1016/s0169-409x(00)00129-0openalex-snapshot
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
inferredcites →https://doi.org/10.1021/cb3000474openalex-snapshot
A Chemical Screening System for Glucocorticoid Stress Hormone Signaling in an Intact Vertebrate
inferredcites →https://doi.org/10.1021/ja0036108openalex-snapshot
Split−Pool Synthesis of 1,3-Dioxanes Leading to Arrayed Stock Solutions of Single Compounds Sufficient for Multiple Phenotypic and Protein-Binding Assays
inferredcites →https://doi.org/10.1021/ja017248oopenalex-snapshot
Diversity-Oriented Synthesis of Biaryl-Containing Medium Rings Using a One Bead/One Stock Solution Platform
inferredcites →https://doi.org/10.1021/ja026720iopenalex-snapshot
A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening
inferredcites →https://doi.org/10.1021/ja035334dopenalex-snapshot
Facilitated Forward Chemical Genetics Using a Tagged Triazine Library and Zebrafish Embryo Screening
inferredcites →https://doi.org/10.1021/jm1001502openalex-snapshot
Design and Synthesis of Novel Xyloketal Derivatives and Their Vasorelaxing Activities in Rat Thoracic Aorta and Angiogenic Activities in Zebrafish Angiogenesis Screen
inferredcites →https://doi.org/10.1038/5861openalex-snapshot
Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.
inferredcites →https://doi.org/10.1038/nature05883openalex-snapshot
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
inferredcites →https://doi.org/10.1038/nature09882openalex-snapshot
DHODH modulates transcriptional elongation in the neural crest and melanoma
inferredcites →https://doi.org/10.1038/nature14569openalex-snapshot
Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment
inferredcites →https://doi.org/10.1038/nbt963openalex-snapshot
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation
inferredcites →https://doi.org/10.1038/nchembio.1136openalex-snapshot
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism
inferredcites →https://doi.org/10.1038/nchembio.1183openalex-snapshot
Photochemical activation of TRPA1 channels in neurons and animals
inferredcites →https://doi.org/10.1038/nchembio.147openalex-snapshot
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation
inferredcites →https://doi.org/10.1038/nchembio.190openalex-snapshot
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages
inferredcites →https://doi.org/10.1038/nchembio.2007.54openalex-snapshot
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
inferredcites →https://doi.org/10.1038/nchembio.307openalex-snapshot
Rapid behavior-based identification of neuroactive small molecules in the zebrafish
inferredcites →https://doi.org/10.1038/nchembio749openalex-snapshot
Small molecules that delay S phase suppress a zebrafish bmyb mutant
inferredcites →https://doi.org/10.1038/ncomms3410openalex-snapshot
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment
inferredcites →https://doi.org/10.1038/nrd1606openalex-snapshot
In vivo drug discovery in the zebrafish
inferredcites →https://doi.org/10.1038/nrd4627openalex-snapshot
Zebrafish as tools for drug discovery
inferredcites →https://doi.org/10.1039/b417765gopenalex-snapshot
Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish
inferredcites →https://doi.org/10.1073/pnas.0506583102openalex-snapshot
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
inferredcites →https://doi.org/10.1073/pnas.0911987106openalex-snapshot
Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models
inferredcites →https://doi.org/10.1073/pnas.1107156108openalex-snapshot
Chemical modulation of memory formation in larval zebrafish
inferredcites →https://doi.org/10.1073/pnas.1113081108openalex-snapshot
Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation
inferredcites →https://doi.org/10.1073/pnas.97.24.12965openalex-snapshot
Small molecule developmental screens reveal the logic and timing of vertebrate development
inferredcites →https://doi.org/10.1074/jbc.m113.453811openalex-snapshot
Cannabinoid Receptor 2 Suppresses Leukocyte Inflammatory Migration by Modulating the JNK/c-Jun/Alox5 Pathway
inferredcites →https://doi.org/10.1074/jbc.m706640200openalex-snapshot
Unraveling Tissue Regeneration Pathways Using Chemical Genetics
inferredcites →https://doi.org/10.1089/zeb.2009.0633openalex-snapshot
A Chemical Screen to Identify Novel Inhibitors of Fin Regeneration in Zebrafish
inferredcites →https://doi.org/10.1089/zeb.2009.0643openalex-snapshot
A Chemical Genetic Screen in Zebrafish for Pathways Interacting with cdx4 in Primitive Hematopoiesis
inferredcites →https://doi.org/10.1093/cvr/cvr350openalex-snapshot
In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling
inferredcites →https://doi.org/10.1093/toxsci/kft235openalex-snapshot
Multidimensional In Vivo Hazard Assessment Using Zebrafish
inferredcites →https://doi.org/10.1096/fj.12-225037openalex-snapshot
Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure
inferredcites →https://doi.org/10.1111/j.1747-0285.2006.00439.xopenalex-snapshot
A Chemical Genetic Screen for Cell Cycle Inhibitors in Zebrafish Embryos
inferredcites →https://doi.org/10.1111/j.1747-0285.2009.00782.xopenalex-snapshot
A Forward Chemical Screen Using Zebrafish Embryos with Novel 2‐Substituted 2H‐Chromene Derivatives
inferredcites →https://doi.org/10.1111/j.1755-148x.2012.00977.xopenalex-snapshot
Small molecule screening identifies targetable zebrafish pigmentation pathways
inferredcites →https://doi.org/10.1126/science.1183090openalex-snapshot
Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
inferredcites →https://doi.org/10.1126/science.287.5460.1964openalex-snapshot
Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery
inferredcites →https://doi.org/10.1126/scitranslmed.3008008openalex-snapshot
Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy
inferredcites →https://doi.org/10.1126/scitranslmed.3010189openalex-snapshot
Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase
inferredcites →https://doi.org/10.1126/stke.2282004pe17openalex-snapshot
Promotion and Attenuation of FGF Signaling Through the Ras-MAPK Pathway
inferredcites →https://doi.org/10.1158/0008-5472.can-07-3126openalex-snapshot
Automated, Quantitative Screening Assay for Antiangiogenic Compounds Using Transgenic Zebrafish
inferredcites →https://doi.org/10.1161/01.cir.0000061912.88753.87openalex-snapshot
Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish
inferredcites →https://doi.org/10.1161/circulationaha.110.003731openalex-snapshot
Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen
inferredcites →https://doi.org/10.1172/jci65093openalex-snapshot
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia
inferredcites →https://doi.org/10.1177/1087057112458153openalex-snapshot
An In Vivo Zebrafish Screen Identifies Organophosphate Antidotes with Diverse Mechanisms of Action
inferredcites →https://doi.org/10.1182/blood-2011-12-398818openalex-snapshot
Zebrafish screen identifies novel compound with selective toxicity against leukemia
inferredcites →https://doi.org/10.1242/dev.088427openalex-snapshot
A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development
inferredcites →https://doi.org/10.1242/dev.123.1.81openalex-snapshot
Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes
inferredcites →https://doi.org/10.1242/dev.128.6.859openalex-snapshot
lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation
inferredcites →https://doi.org/10.1242/dmm.005769openalex-snapshot
Combined zebrafish-yeast chemical-genetic screens reveal gene–copper-nutrition interactions that modulate melanocyte pigmentation
inferredcites →https://doi.org/10.1242/dmm.018689openalex-snapshot
Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion
inferredcites →https://doi.org/10.1242/dmm.024166openalex-snapshot
Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies
inferredcites →https://doi.org/10.1371/journal.pgen.1000020openalex-snapshot
Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death
inferredcites →https://doi.org/10.1371/journal.pgen.1005305openalex-snapshot
Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish
inferredcites →https://doi.org/10.1371/journal.pone.0001947openalex-snapshot
Identification of a Novel Retinoid by Small Molecule Screening with Zebrafish Embryos
inferredcites →https://doi.org/10.1371/journal.pone.0007867openalex-snapshot
Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase
inferredcites →https://doi.org/10.1371/journal.pone.0010004openalex-snapshot
A Forward Chemical Screen in Zebrafish Identifies a Retinoic Acid Derivative with Receptor Specificity
inferredcites →https://doi.org/10.1371/journal.pone.0012386openalex-snapshot
Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish
inferredcites →https://doi.org/10.1371/journal.pone.0021715openalex-snapshot
A New System for the Rapid Collection of Large Numbers of Developmentally Staged Zebrafish Embryos
inferredcites →https://doi.org/10.1371/journal.pone.0083293openalex-snapshot
A Phenotypic Screen in Zebrafish Identifies a Novel Small-Molecule Inducer of Ectopic Tail Formation Suggestive of Alterations in Non-Canonical Wnt/PCP Signaling
inferredcites →https://doi.org/10.1371/journal.pone.0104112openalex-snapshot
Whole Organism High Content Screening Identifies Stimulators of Pancreatic Beta-Cell Proliferation
inferredcites →https://doi.org/10.1385/1-59259-802-1:085openalex-snapshot
Application of Chemoinformatics to High-Throughput Screening
inferredcites →https://doi.org/10.1523/jneurosci.3905-11.2012openalex-snapshot
Identification of Modulators of Hair Cell Regeneration in the Zebrafish Lateral Line
inferredcites →https://doi.org/10.4155/fmc.11.63openalex-snapshot
Software and Resources for Computational Medicinal Chemistry
inferredcites →https://doi.org/10.7554/elife.08261openalex-snapshot
First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish
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Reduction of oxidative stress suppresses poly-GR-mediated toxicity in zebrafish embryos
inferred← citeshttps://doi.org/10.1242/dmm.052649openalex-snapshot
A small-molecule screen identifies that elafibranor links mechanical cues and Irf6-dependent epithelial differentiation
inferred← citeshttps://doi.org/10.12659/msm.940550openalex-snapshot
A Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identification and Drug Targeting, and Developments in Personalized Medicine in Breast Cancer
inferred← citeshttps://doi.org/10.12997/jla.2021.10.1.42openalex-snapshot
Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases
inferred← citeshttps://doi.org/10.14218/fim.2026.00017openalex-snapshot
Stratified Safety Evaluation Framework for Natural Products Based on New Approach Methodologies in Integrative Medicine: A Narrative Review
inferred← citeshttps://doi.org/10.20517/2572-8180.2017.15openalex-snapshot
Zebrafish as Toxicological model for screening and recapitulate human diseases
inferred← citeshttps://doi.org/10.2174/1570159x17666191001145550openalex-snapshot
Modeling Neuronal Diseases in Zebrafish in the Era of CRISPR
inferred← citeshttps://doi.org/10.3233/jad-230522openalex-snapshot
The Use of Zebrafish in Transcriptome Analysis of the Early Effects of Mutations Causing Early Onset Familial Alzheimer’s Disease and Other Inherited Neurodegenerative Conditions
inferred← citeshttps://doi.org/10.3233/jnd-190389openalex-snapshot
Discovery of Novel Therapeutics for Muscular Dystrophies using Zebrafish Phenotypic Screens
inferred← citeshttps://doi.org/10.3389/fcell.2020.592967openalex-snapshot
Chemical-Induced Cleft Palate Is Caused and Rescued by Pharmacological Modulation of the Canonical Wnt Signaling Pathway in a Zebrafish Model
inferred← citeshttps://doi.org/10.3389/fcell.2023.1112378openalex-snapshot
The current regenerative medicine approaches of craniofacial diseases: A narrative review
inferred← citeshttps://doi.org/10.3389/fendo.2019.00006openalex-snapshot
Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds
inferred← citeshttps://doi.org/10.3389/fendo.2022.1000662openalex-snapshot
Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta
inferred← citeshttps://doi.org/10.3389/fgene.2021.625466openalex-snapshot
Zebrafish Chromosome 14 Gene Differential Expression in the fmr1hu2787 Model of Fragile X Syndrome
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01084openalex-snapshot
A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death
inferred← citeshttps://doi.org/10.3389/fnins.2018.00976openalex-snapshot
The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity
inferred← citeshttps://doi.org/10.3389/fphar.2019.00508openalex-snapshot
Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae
inferred← citeshttps://doi.org/10.3390/antiox10060827openalex-snapshot
A Synthetic SOD/Catalase Mimic Compound for the Treatment of ALS
inferred← citeshttps://doi.org/10.3390/app122110961openalex-snapshot
Rearing Conditions and Automated Feed Distribution Systems for Zebrafish (Danio rerio)
inferred← citeshttps://doi.org/10.3390/app15158156openalex-snapshot
Enhanced Drug Screening Efficacy in Zebrafish Using a Highly Oxygen-Permeable Culture Plate
inferred← citeshttps://doi.org/10.3390/biology12020153openalex-snapshot
Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish
inferred← citeshttps://doi.org/10.3390/books978-3-0365-1805-3openalex-snapshot
Crocus sativus L. Extract and Its Constituents: Chemistry, Pharmacology and Therapeutic Potential
inferred← citeshttps://doi.org/10.3390/cells8101179openalex-snapshot
Special Issue on “Disease and the Hippo Pathway”
inferred← citeshttps://doi.org/10.3390/cells9051285openalex-snapshot
stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae
inferred← citeshttps://doi.org/10.3390/genes8090236openalex-snapshot
Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology
inferred← citeshttps://doi.org/10.3390/ijms23042102openalex-snapshot
Zebrafish as a Model to Study Vascular Elastic Fibers and Associated Pathologies
inferred← citeshttps://doi.org/10.3390/ijms24054747openalex-snapshot
Zebra-Sphinx: Modeling Sphingolipidoses in Zebrafish
inferred← citeshttps://doi.org/10.3390/ijms24065656openalex-snapshot
Zebrafish as a Model of Cardiac Pathology and Toxicity: Spotlight on Uremic Toxins
inferred← citeshttps://doi.org/10.3390/ijms242115511openalex-snapshot
Heterogeneous Cellular Response of Primary and Metastatic Human Gastric Adenocarcinoma Cell Lines to Magnoflorine and Its Additive Interaction with Docetaxel
inferred← citeshttps://doi.org/10.3390/jdb6040029openalex-snapshot
Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model
inferred← citeshttps://doi.org/10.3390/life11101088openalex-snapshot
Molecular and Cellular Mechanisms of Vascular Development in Zebrafish
inferred← citeshttps://doi.org/10.3390/md20030196openalex-snapshot
Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp.
inferred← citeshttps://doi.org/10.3390/molecules24132516openalex-snapshot
Molecular Characterization and Heterologous Production of the Bacteriocin Peocin, a DNA Starvation/Stationary Phase Protection Protein, from Paenibacillus ehimensis NPUST1
inferred← citeshttps://doi.org/10.3390/molecules25061318openalex-snapshot
Cytotoxic Evaluation and Anti-Angiogenic Effects of Two Furano-Sesquiterpenoids from Commiphora myrrh Resin
inferred← citeshttps://doi.org/10.3390/molecules25225223openalex-snapshot
Crocins from Crocus sativus L. in the Management of Hyperglycemia. In Vivo Evidence from Zebrafish
inferred← citeshttps://doi.org/10.3390/nu13030998openalex-snapshot
Nutraceutical Screening in a Zebrafish Model of Muscular Dystrophy: Gingerol as a Possible Food Aid
inferred← citeshttps://doi.org/10.3390/pharmaceutics16070961openalex-snapshot
Upgrading Mitochondria-Targeting Peptide-Based Nanocomplexes for Zebrafish In Vivo Compatibility Assays
inferred← citeshttps://doi.org/10.64898/2026.04.18.719270openalex-snapshot
Zebrafish Functional Screening of FDA-Approved Drugs for Autosomal Dominant Retinitis Pigmentosa Caused by RHODOPSIN Q344X Mutation
inferred← citeshttps://doi.org/10.70675/62e63249z6d6fz47a8z8d72zb57416f816ceopenalex-snapshot
Complications cardiovasculaires des élastinopathies : caractérisation d’un nouveau modèle expérimental et évaluation d’une stratégie thérapeutique innovante
inferred← citeshttps://doi.org/10.7554/elife.44889openalex-snapshot
Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant
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