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Multidimensional In Vivo Hazard Assessment Using Zebrafish

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/aja.1002030302openalex-snapshot

Stages of embryonic development of the zebrafish

inferredcites →https://doi.org/10.1002/bdra.20281openalex-snapshot

Zebrafish as a model for developmental neurotoxicity testing

inferredcites →https://doi.org/10.1007/978-1-60761-849-2_16openalex-snapshot

Evaluation of Embryotoxicity Using the Zebrafish Model

inferredcites →https://doi.org/10.1007/s00204-013-1044-2openalex-snapshot

Zebrafish embryos as an alternative model for screening of drug-induced organ toxicity

inferredcites →https://doi.org/10.1016/j.aquatox.2009.10.008openalex-snapshot

Endosulfan I and endosulfan sulfate disrupts zebrafish embryonic development

inferredcites →https://doi.org/10.1016/j.aquatox.2010.02.003openalex-snapshot

Toxicity, uptake kinetics and behavior assessment in zebrafish embryos following exposure to perfluorooctanesulphonicacid (PFOS)

inferredcites →https://doi.org/10.1016/j.cbpc.2011.09.006openalex-snapshot

Persistent adult zebrafish behavioral deficits results from acute embryonic exposure to gold nanoparticles

inferredcites →https://doi.org/10.1016/j.ntt.2004.06.014openalex-snapshot

Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease

inferredcites →https://doi.org/10.1016/j.ntt.2010.03.002openalex-snapshot

Locomotor activity in zebrafish embryos: A new method to assess developmental neurotoxicity

inferredcites →https://doi.org/10.1016/j.reprotox.2011.10.018openalex-snapshot

Zebrafish developmental screening of the ToxCast™ Phase I chemical library

inferredcites →https://doi.org/10.1016/j.reprotox.2011.11.111openalex-snapshot

Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos

inferredcites →https://doi.org/10.1016/j.taap.2005.06.016openalex-snapshot

Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions

inferredcites →https://doi.org/10.1016/j.taap.2006.04.014openalex-snapshot

Dithiocarbamates have a common toxic effect on zebrafish body axis formation

inferredcites →https://doi.org/10.1016/j.tox.2011.11.001openalex-snapshot

Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish

inferredcites →https://doi.org/10.1016/j.vascn.2006.04.004openalex-snapshot

Neurotoxicity assessment using zebrafish

inferredcites →https://doi.org/10.1038/nature12111openalex-snapshot

The zebrafish reference genome sequence and its relationship to the human genome

inferredcites →https://doi.org/10.1038/nchembio.307openalex-snapshot

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

inferredcites →https://doi.org/10.1038/nmeth.1481openalex-snapshot

High-throughput in vivo vertebrate screening

inferredcites →https://doi.org/10.1038/nrg2091openalex-snapshot

Animal models of human disease: zebrafish swim into view

inferredcites →https://doi.org/10.1093/toxsci/kfj185openalex-snapshot

The Developmental Neurotoxicity of Fipronil: Notochord Degeneration and Locomotor Defects in Zebrafish Embryos and Larvae

inferredcites →https://doi.org/10.1093/toxsci/kfn145openalex-snapshot

Exposure to Sodium Metam during Zebrafish Somitogenesis Results in Early Transcriptional Indicators of the Ensuing Neuronal and Muscular Dysfunction

inferredcites →https://doi.org/10.1093/toxsci/kfp258openalex-snapshot

Developmental Neurotoxicity of Pyrethroid Insecticides in Zebrafish Embryos

inferredcites →https://doi.org/10.1126/science.1183090openalex-snapshot

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

inferredcites →https://doi.org/10.1172/jci60434openalex-snapshot

Hooked! Modeling human disease in zebrafish

inferredcites →https://doi.org/10.1177/001316446002000104openalex-snapshot

A Coefficient of Agreement for Nominal Scales

inferredcites →https://doi.org/10.1177/2211068211432197openalex-snapshot

Automated Zebrafish Chorion Removal and Single Embryo Placement: Optimizing Throughput of Zebrafish Developmental Toxicity Screens

inferredcites →https://doi.org/10.1186/1471-2164-11-643openalex-snapshot

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

inferredcites →https://doi.org/10.1201/9781315117867openalex-snapshot

Introduction to Environmental Toxicology

inferredcites →https://doi.org/10.1201/9781420026283.ch9openalex-snapshot

Bioconcentration and Biomagnification in the Aquatic Environment

inferredcites →https://doi.org/10.1289/ehp.0901392openalex-snapshot

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

inferredcites →https://doi.org/10.1517/17460440902988464openalex-snapshot

Using zebrafish to assess the impact of drugs on neural development and function

inferredcites →https://doi.org/10.32614/r.manualsopenalex-snapshot

R: A Language and Environment for Statistical Computing

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Evaluation of Embryotoxicity Using the Zebrafish Model

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Zebrafish Models of Nanotoxicity: A Comprehensive Account

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Automated Detection of Abnormalities in Zebrafish Development

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Integrating Morphological and Behavioral Phenotypes in Developing Zebrafish

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Generation of Tg(cyp1a:gfp) Transgenic Zebrafish for Development of a Convenient and Sensitive In Vivo Assay for Aryl Hydrocarbon Receptor Activity

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inferred← citeshttps://doi.org/10.1007/s40572-014-0029-5openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/b978-0-12-813602-7.00037-5openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/b978-0-12-813697-3.00016-0openalex-snapshot

US Vision for Toxicity Testing in the 21st Century

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Modulation of the epigenome by xenobiotics in cancer

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Advances in the Use of Zebrafish in Developmental Toxicology: Linking Genetics, Behavior, and High-Throughput Testing Strategies

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PAH bioremediation with Rhodococcus rhodochrous ATCC 21198: Impact of cell immobilization and surfactant use on PAH treatment and post-remediation toxicity

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Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model

inferred← citeshttps://doi.org/10.1016/j.microc.2019.104035openalex-snapshot

Promoting zebrafish embryo tool to identify the effects of chemicals in the context of Water Framework Directive monitoring and assessment

inferred← citeshttps://doi.org/10.1016/j.neuro.2015.11.012openalex-snapshot

Delayed effects of developmental exposure to low levels of the aryl hydrocarbon receptor agonist 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) on adult zebrafish behavior

inferred← citeshttps://doi.org/10.1016/j.neuro.2018.04.016openalex-snapshot

Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity

inferred← citeshttps://doi.org/10.1016/j.neuro.2025.103328openalex-snapshot

Development of a network formation assay for developmental neurotoxicity hazard screening using 3D human iPSC derived BrainSpheres

inferred← citeshttps://doi.org/10.1016/j.neuro.2026.103504openalex-snapshot

Zebrafish behavioral assessment as a first-tier whole-organism NAM for developmental neurotoxicity: A multi-laboratory evaluation

inferred← citeshttps://doi.org/10.1016/j.ntt.2015.05.006openalex-snapshot

Effects of metal exposure on motor neuron development, neuromasts and the escape response of zebrafish embryos

inferred← citeshttps://doi.org/10.1016/j.ntt.2016.05.001openalex-snapshot

Quantitation and prediction of sorptive losses during toxicity testing of polycyclic aromatic hydrocarbon (PAH) and nitrated PAH (NPAH) using polystyrene 96-well plates

inferred← citeshttps://doi.org/10.1016/j.ntt.2019.03.003openalex-snapshot

Screening for neurotoxic potential of 15 flame retardants using freshwater planarians

inferred← citeshttps://doi.org/10.1016/j.pestbp.2025.106506openalex-snapshot

Differential ecotoxicity of nanoencapsulated metamifop and its active ingredient in zebrafish (Danio rerio): Insights from transcriptome and metabolome analysis

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2016.03.009openalex-snapshot

Advancements in zebrafish applications for 21st century toxicology

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.107837openalex-snapshot

The chemistry and toxicology of vaping

inferred← citeshttps://doi.org/10.1016/j.phymed.2019.152959openalex-snapshot

Hepatotoxicity evaluation of Euphorbia kansui on zebrafish larvae in vivo

inferred← citeshttps://doi.org/10.1016/j.redox.2016.01.004openalex-snapshot

Lipidomics and H218O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

inferred← citeshttps://doi.org/10.1016/j.reprotox.2016.04.012openalex-snapshot

Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure

inferred← citeshttps://doi.org/10.1016/j.reprotox.2016.05.015openalex-snapshot

Optimizing multi-dimensional high throughput screening using zebrafish

inferred← citeshttps://doi.org/10.1016/j.reprotox.2016.06.004openalex-snapshot

Gambogic acid causes fin developmental defect in zebrafish embryo partially via retinoic acid signaling

inferred← citeshttps://doi.org/10.1016/j.reprotox.2016.12.004openalex-snapshot

Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity

inferred← citeshttps://doi.org/10.1016/j.reprotox.2017.04.003openalex-snapshot

Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signatures with functional consequences

inferred← citeshttps://doi.org/10.1016/j.reprotox.2017.05.005openalex-snapshot

Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signatures with functional consequences

inferred← citeshttps://doi.org/10.1016/j.reprotox.2018.02.006openalex-snapshot

Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists

inferred← citeshttps://doi.org/10.1016/j.reprotox.2019.02.004openalex-snapshot

A multi-institutional study benchmarking the zebrafish developmental assay for prediction of embryotoxic plasma concentrations from rat embryo–fetal development studies

inferred← citeshttps://doi.org/10.1016/j.reprotox.2020.03.010openalex-snapshot

Computational approach for collection and prediction of molecular initiating events in developmental toxicity

inferred← citeshttps://doi.org/10.1016/j.reprotox.2023.108513openalex-snapshot

Validation of a zebrafish developmental defects assay as a qualified alternative test for its regulatory use following the ICH S5(R3) guideline

inferred← citeshttps://doi.org/10.1016/j.reprotox.2025.109035openalex-snapshot

New approach methodologies for assessing developmental toxicity of pharmaceuticals: Case examples and future directions

inferred← citeshttps://doi.org/10.1016/j.reprotox.2026.109224openalex-snapshot

Zebrafish embryotoxicity test (ZET) as an alternative method for screening the developmental toxicity of difficult-to-test substances

inferred← citeshttps://doi.org/10.1016/j.sciaf.2026.e03527openalex-snapshot

A review on biosurfactants: structure, production, bioremediation application and cytotoxicity

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2015.11.102openalex-snapshot

Effect-directed analysis supporting monitoring of aquatic environments — An in-depth overview

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2017.03.024openalex-snapshot

Elucidating environmental dimensions of neurological disorders and disease: Understanding new tools from federal chemical testing programs

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2018.05.402openalex-snapshot

Comparative behavioral toxicology with two common larval fish models: Exploring relationships among modes of action and locomotor responses

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2018.11.186openalex-snapshot

Mixed-chemical exposure and predicted effects potential in wadeable southeastern USA streams

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2019.06.028openalex-snapshot

Fish behavior: A promising model for aquatic toxicology research

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2019.134210openalex-snapshot

Combined Danio rerio embryo morbidity, mortality and photomotor response assay: A tool for developmental risk assessment from chronic cyanoHAB exposure

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2019.135740openalex-snapshot

Embryo bioassays with aquatic animals for toxicity testing and hazard assessment of emerging pollutants: A review

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2020.136944openalex-snapshot

Mutagenicity assessment downstream of oil and gas produced water discharges intended for agricultural beneficial reuse

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2020.143273openalex-snapshot

Developmental toxicity and transcriptome analysis of zebrafish (Danio rerio) embryos following exposure to chiral herbicide safener benoxacor

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2021.145062openalex-snapshot

Multi-region assessment of chemical mixture exposures and predicted cumulative effects in USA wadeable urban/agriculture-gradient streams

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2021.145577openalex-snapshot

Applications of advanced neuro-behavioral analysis strategies in aquatic ecotoxicology

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2021.147721openalex-snapshot

Pilot-scale expanded assessment of inorganic and organic tapwater exposures and predicted effects in Puerto Rico, USA

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2021.148820openalex-snapshot

Predicting zebrafish (Danio rerio) embryo developmental toxicity through a non-conformational QSAR approach

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2021.149125openalex-snapshot

Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.164394openalex-snapshot

Intergenerational effects of parental [Cnmim]BF4 (n = 4, 6, 8) ionic liquids exposure on zebrafish development based on transcriptomic analysis

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2025.178953openalex-snapshot

Incorporating benchmark dose into sediment toxicity testing using zebrafish (Danio rerio)

inferred← citeshttps://doi.org/10.1016/j.taap.2016.02.001openalex-snapshot

Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders

inferred← citeshttps://doi.org/10.1016/j.taap.2016.02.013openalex-snapshot

Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium

inferred← citeshttps://doi.org/10.1016/j.taap.2016.08.013openalex-snapshot

Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish

inferred← citeshttps://doi.org/10.1016/j.taap.2016.11.010openalex-snapshot

A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades

inferred← citeshttps://doi.org/10.1016/j.taap.2018.03.029openalex-snapshot

Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish

inferred← citeshttps://doi.org/10.1016/j.taap.2022.116141openalex-snapshot

Advances in computational methods along the exposure to toxicological response paradigm

inferred← citeshttps://doi.org/10.1016/j.taap.2023.116659openalex-snapshot

Comparative analysis between zebrafish and an automated live-cell assay to classify developmental neurotoxicant chemicals

inferred← citeshttps://doi.org/10.1016/j.tiv.2019.104638openalex-snapshot

Implementation of a functional endpoint to the zebrafish embryotoxicity test to evaluate craniofacial abnormalities

inferred← citeshttps://doi.org/10.1016/j.tox.2015.06.009openalex-snapshot

Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute

inferred← citeshttps://doi.org/10.1016/j.toxlet.2025.06.011openalex-snapshot

Sublethal effects of diphenyl ether on zebrafish embryo: Developmental, morphological, cardiac and neurotoxic implications

inferred← citeshttps://doi.org/10.1016/j.toxrep.2017.04.005openalex-snapshot

Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing

inferred← citeshttps://doi.org/10.1016/j.toxrep.2024.04.002openalex-snapshot

The addition of mammalian cell culture medium impacts nanoparticle toxicity in zebrafish

inferred← citeshttps://doi.org/10.1016/j.watres.2018.03.062openalex-snapshot

Trade-offs in ecosystem impacts from nanomaterial versus organic chemical ultraviolet filters in sunscreens

inferred← citeshttps://doi.org/10.1016/j.ygcen.2018.11.003openalex-snapshot

The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio)

inferred← citeshttps://doi.org/10.1016/j.yrtph.2014.09.009openalex-snapshot

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

inferred← citeshttps://doi.org/10.1016/j.yrtph.2020.104724openalex-snapshot

Use of computational toxicology (CompTox) tools to predict in vivo toxicity for risk assessment

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.0c00264openalex-snapshot

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.1c00205openalex-snapshot

Using High-Throughput Screening to Evaluate Perturbations Potentially Linked to Neurobehavioral Outcomes: A Case Study Using Publicly Available Tools on FDA Batch-Certified Synthetic Food Dyes

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.9b00290openalex-snapshot

Toward Less Hazardous Industrial Compounds: Coupling Quantum Mechanical Computations, Biomarker Responses, and Behavioral Profiles To Identify Bioactivity of SN2 Electrophiles in Alternative Vertebrate Models

inferred← citeshttps://doi.org/10.1021/acs.chemrestox.9b00484openalex-snapshot

A Case Study with Triazole Fungicides to Explore Practical Application of Next-Generation Hazard Assessment Methods for Human Health

inferred← citeshttps://doi.org/10.1021/acs.est.3c00593openalex-snapshot

Deep Learning-Enabled Morphometric Analysis for Toxicity Screening Using Zebrafish Larvae

inferred← citeshttps://doi.org/10.1021/acs.est.4c10012openalex-snapshot

Critical Structures of Bisphenol Analogues on Embryonic Toxicity Identified by a Computational Approach

inferred← citeshttps://doi.org/10.1021/acs.est.4c11757openalex-snapshot

Leveraging Zebrafish Embryo Phenotypic Observations to Advance Data-Driven Analyses in Toxicology

inferred← citeshttps://doi.org/10.1021/acs.est.5b00499openalex-snapshot

Aerobic Bioremediation of PAH Contaminated Soil Results in Increased Genotoxicity and Developmental Toxicity

inferred← citeshttps://doi.org/10.1021/acs.est.5c12562openalex-snapshot

High-Throughput Toxicity Screening with C. elegans : Current Platforms, Key Advantages, and Future Directions

inferred← citeshttps://doi.org/10.1021/acs.est.6c01661openalex-snapshot

Integrated Chemical and Toxicity Screening of Tap Drinking Water across Western Oregon Using Suspect and Nontarget Screening

inferred← citeshttps://doi.org/10.1021/acs.est.7b01613openalex-snapshot

An “EAR” on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure–Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters

inferred← citeshttps://doi.org/10.1021/acs.est.8b04587openalex-snapshot

Evidence for Cross Species Extrapolation of Mammalian-Based High-Throughput Screening Assay Results

inferred← citeshttps://doi.org/10.1021/acs.est.9b04879openalex-snapshot

Early Life Stage Bioactivity Assessment of Short-Chain Chlorinated Paraffins at Environmentally Relevant Concentrations by Concentration-Dependent Transcriptomic Analysis of Zebrafish Embryos

inferred← citeshttps://doi.org/10.1021/acs.estlett.5b00123openalex-snapshot

Leveraging Embryonic Zebrafish To Prioritize ToxCast Testing

inferred← citeshttps://doi.org/10.1021/acs.estlett.6b00116openalex-snapshot

Identification and Toxicological Evaluation of Unsubstituted PAHs and Novel PAH Derivatives in Pavement Sealcoat Products

inferred← citeshttps://doi.org/10.1021/acs.estlett.6b00400openalex-snapshot

Response to Correspondence on Identification and Toxicological Evaluation of Unsubstituted PAHs and Novel PAH Derivatives in Pavement Sealcoat Products

inferred← citeshttps://doi.org/10.1021/acsnano.8b00036openalex-snapshot

Synergistic Toxicity Produced by Mixtures of Biocompatible Gold Nanoparticles and Widely Used Surfactants

inferred← citeshttps://doi.org/10.1021/acsomega.6c04972openalex-snapshot

Sucralose Induces Neurobehavioral Alterations and Exacerbates Alzheimer’s Disease-Like Phenotypes in Zebrafish Models

inferred← citeshttps://doi.org/10.1021/bk-2016-1241.ch009openalex-snapshot

Identifying Toxic Biotransformation Products of the Insensitive Munitions Compound, 2,4-Dinitroanisole (DNAN), Using Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry (LC-QToF-MS)

inferred← citeshttps://doi.org/10.1021/bk-2019-1308.ch010openalex-snapshot

Eyes to the Future: Approaches To Assess Pesticide Impact on Surface Waters in a Changing Climate

inferred← citeshttps://doi.org/10.1038/nnano.2017.56openalex-snapshot

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

inferred← citeshttps://doi.org/10.1038/s41467-017-01469-5openalex-snapshot

Small molecule screen in embryonic zebrafish using modular variations to target segmentation

inferred← citeshttps://doi.org/10.1038/s41597-023-02021-5openalex-snapshot

The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes

inferred← citeshttps://doi.org/10.1038/s41598-020-71760-xopenalex-snapshot

Vitamin E is necessary for zebrafish nervous system development

inferred← citeshttps://doi.org/10.1038/s41598-024-65610-3openalex-snapshot

The zebrafish gut microbiome influences benzo[a]pyrene developmental neurobehavioral toxicity

inferred← citeshttps://doi.org/10.1038/s41684-020-0573-6openalex-snapshot

Zebrafish microbiome studies make waves

inferred← citeshttps://doi.org/10.1038/s41684-021-00908-7openalex-snapshot

Impact of test chamber design on spontaneous behavioral responses of model crustacean zooplankton Artemia franciscana

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