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Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach

https://doi.org/10.1016/j.addr.2020.03.005

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Polycation-based DNA complexes for tumor-targeted gene delivery in vivo

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Advances in Stimulus‐Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids

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In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers

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Melittin-grafted HPMA-oligolysine based copolymers for gene delivery

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Stabilizing effect of tyrosine trimers on pDNA and siRNA polyplexes

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The effect of molar mass and degree of hydroxyethylation on the controlled shielding and deshielding of hydroxyethyl starch-coated polyplexes

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pH-sensitive polymer micelles provide selective and potentiated lytic capacity to venom peptides for effective intracellular delivery

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Testing thousands of nanoparticles in vivo using DNA barcodes

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Gene delivery by peptide-assisted transport

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Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo

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Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding

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A novel environment-sensitive biodegradable polydisulfide with protonatable pendants for nucleic acid delivery

inferredcites →https://doi.org/10.1016/j.jconrel.2008.05.014openalex-snapshot

Delivery of siRNA mediated by histidine-containing reducible polycations

inferredcites →https://doi.org/10.1016/j.jconrel.2008.11.010openalex-snapshot

A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery

inferredcites →https://doi.org/10.1016/j.jconrel.2009.05.016openalex-snapshot

Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging

inferredcites →https://doi.org/10.1016/j.jconrel.2009.08.028openalex-snapshot

Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy

inferredcites →https://doi.org/10.1016/j.jconrel.2010.03.019openalex-snapshot

Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown

inferredcites →https://doi.org/10.1016/j.jconrel.2011.07.009openalex-snapshot

HPMA-oligolysine copolymers for gene delivery: Optimization of peptide length and polymer molecular weight

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Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers

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Polymer coatings for delivery of nucleic acid therapeutics

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Structure–activity relationships of siRNA carriers based on sequence-defined oligo (ethane amino) amides

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Sequence-defined four-arm oligo(ethanamino)amides for pDNA and siRNA delivery: Impact of building blocks on efficacy

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Decationized crosslinked polyplexes for redox-triggered gene delivery

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Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery

inferredcites →https://doi.org/10.1016/j.jconrel.2014.08.028openalex-snapshot

Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy

inferredcites →https://doi.org/10.1016/j.jconrel.2015.04.012openalex-snapshot

Protease-triggered siRNA delivery vehicles

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pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery

inferredcites →https://doi.org/10.1016/j.jconrel.2016.06.011openalex-snapshot

Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes

inferredcites →https://doi.org/10.1016/j.jconrel.2017.05.012openalex-snapshot

Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines

inferredcites →https://doi.org/10.1016/j.jconrel.2018.02.017openalex-snapshot

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells

inferredcites →https://doi.org/10.1016/j.jconrel.2018.02.043openalex-snapshot

Cationic polymers for non-viral gene delivery to human T cells

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Neutralization of negative charges of siRNA results in improved safety and efficient gene silencing activity of lipid nanoparticles loaded with high levels of siRNA

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Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo

inferredcites →https://doi.org/10.1016/j.nano.2010.07.005openalex-snapshot

Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery

inferredcites →https://doi.org/10.1016/j.nano.2013.07.008openalex-snapshot

Fine-tuning of proton sponges by precise diaminoethanes and histidines in pDNA polyplexes

inferredcites →https://doi.org/10.1016/j.nano.2017.09.001openalex-snapshot

Efficient gene editing via non-viral delivery of CRISPR–Cas9 system using polymeric and hybrid microcarriers

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Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber’s Congenital Amaurosis

inferredcites →https://doi.org/10.1016/j.omtn.2019.10.009openalex-snapshot

Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung

inferredcites →https://doi.org/10.1016/j.omto.2018.10.004openalex-snapshot

Effective Therapy Using a Liposomal siRNA that Targets the Tumor Vasculature in a Model Murine Breast Cancer with Lung Metastasis

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Toward Synthetic Viruses: Endosomal pH-Triggered Deshielding of Targeted Polyplexes Greatly Enhances Gene Transfer in vitro and in vivo

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Structure/property studies of polymeric gene delivery using a library of poly(β-amino esters)

inferredcites →https://doi.org/10.1016/j.ymthe.2006.02.003openalex-snapshot

Eradication of p53-Mutated Head and Neck Squamous Cell Carcinoma Xenografts Using Nonviral p53 Gene Therapy and Photochemical Internalization

inferredcites →https://doi.org/10.1016/j.ymthe.2016.10.006openalex-snapshot

A Targeted and Stable Polymeric Nanoformulation Enhances Systemic Delivery of mRNA to Tumors

inferredcites →https://doi.org/10.1016/j.ymthe.2017.03.013openalex-snapshot

Lipid Nanoparticle Systems for Enabling Gene Therapies

inferredcites →https://doi.org/10.1016/j.ymthe.2017.03.023openalex-snapshot

FDA-Approved Oligonucleotide Therapies in 2017

inferredcites →https://doi.org/10.1016/j.ymthe.2017.04.023openalex-snapshot

Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma

inferredcites →https://doi.org/10.1016/j.ymthe.2017.12.021openalex-snapshot

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

inferredcites →https://doi.org/10.1016/j.ymthe.2019.01.014openalex-snapshot

Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9

inferredcites →https://doi.org/10.1016/j.ymthe.2019.03.003openalex-snapshot

Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets

inferredcites →https://doi.org/10.1016/j.ymthe.2019.07.018openalex-snapshot

Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression

inferredcites →https://doi.org/10.1016/j.ymthe.2019.09.010openalex-snapshot

Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles

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Receptor-mediated gene delivery and expression in vivo.

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The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting

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Galactosylated chitosan-graft-poly(ethylene glycol) as hepatocyte-targeting DNA carrier

inferredcites →https://doi.org/10.1016/s0168-3659(03)00230-xopenalex-snapshot

Tumor-targeted gene therapy: strategies for the preparation of ligand–polyethylene glycol–polyethylenimine/DNA complexes

inferredcites →https://doi.org/10.1016/s0168-3659(97)00248-4openalex-snapshot

2-(dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents

inferredcites →https://doi.org/10.1016/s0169-409x(97)00110-5openalex-snapshot

Polylysine-based transfection systems utilizing receptor-mediated delivery

inferredcites →https://doi.org/10.1016/s0304-4165(00)00076-3openalex-snapshot

Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA

inferredcites →https://doi.org/10.1021/acs.accounts.8b00650openalex-snapshot

Re-Engineering RNA Molecules into Therapeutic Agents

inferredcites →https://doi.org/10.1021/acs.bioconjchem.5b00649openalex-snapshot

Combinatorial Optimization of Sequence-Defined Oligo(ethanamino)amides for Folate Receptor-Targeted pDNA and siRNA Delivery

inferredcites →https://doi.org/10.1021/acs.bioconjchem.6b00676openalex-snapshot

Nonviral Genome Editing Based on a Polymer-Derivatized CRISPR Nanocomplex for Targeting Bacterial Pathogens and Antibiotic Resistance

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Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability forIn VivoGene Silencing in Leukemia

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Beyond Gene Transfection with Methacrylate-Based Polyplexes—The Influence of the Amino Substitution Pattern

inferredcites →https://doi.org/10.1021/acs.bioconjchem.8b00585openalex-snapshot

Precise Enzymatic Cleavage Sites for Improved Bioactivity of siRNA Lipo-Polyplexes

inferredcites →https://doi.org/10.1021/acs.bioconjchem.8b00688openalex-snapshot

Polycations for Gene Delivery: Dilemmas and Solutions

inferredcites →https://doi.org/10.1021/acs.bioconjchem.8b00691openalex-snapshot

Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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