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Polymer–Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/adma.201204346openalex-snapshot
Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability
inferredcites →https://doi.org/10.1002/adma.201505822openalex-snapshot
Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
inferredcites →https://doi.org/10.1002/ange.201603648openalex-snapshot
A Single Methylene Group in Oligoalkylamine‐Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery
inferredcites →https://doi.org/10.1002/anie.201603648openalex-snapshot
A Single Methylene Group in Oligoalkylamine‐Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery
inferredcites →https://doi.org/10.1016/0730-725x(95)00024-bopenalex-snapshot
Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: Ferumoxides, ferumoxtran, ferumoxsil
inferredcites →https://doi.org/10.1016/j.biomaterials.2012.01.046openalex-snapshot
Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity
inferredcites →https://doi.org/10.1016/j.ejpb.2008.09.016openalex-snapshot
Current prospects for mRNA gene delivery
inferredcites →https://doi.org/10.1016/j.ijpharm.2013.11.041openalex-snapshot
Gene therapy and DNA delivery systems
inferredcites →https://doi.org/10.1016/j.jconrel.2015.12.032openalex-snapshot
Materials for non-viral intracellular delivery of messenger RNA therapeutics
inferredcites →https://doi.org/10.1016/j.ymthe.2005.02.010openalex-snapshot
A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy
inferredcites →https://doi.org/10.1016/s0005-2736(98)00102-3openalex-snapshot
Aggregation of dimyristoylphosphatidylglycerol liposomes by human plasma low density lipoprotein
inferredcites →https://doi.org/10.1016/s0026-895x(25)09229-6openalex-snapshot
Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides.
inferredcites →https://doi.org/10.1021/acs.biomac.5b00966openalex-snapshot
Highly Branched Poly(β-Amino Esters): Synthesis and Application in Gene Delivery
inferredcites →https://doi.org/10.1021/acs.nanolett.5b02497openalex-snapshot
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
inferredcites →https://doi.org/10.1021/bc0600968openalex-snapshot
Biodegradable Polymeric Vectors for Gene Delivery to Human Endothelial Cells
inferredcites →https://doi.org/10.1021/ja0015388openalex-snapshot
Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA
inferredcites →https://doi.org/10.1021/jm500330kopenalex-snapshot
Synthetic Nucleic Acid Delivery Systems: Present and Perspectives
inferredcites →https://doi.org/10.1021/nn501197vopenalex-snapshot
Biodegradable Polymeric Nanoparticles Show High Efficacy and Specificity at DNA Delivery to Human Glioblastoma in Vitro and in Vivo
inferredcites →https://doi.org/10.1038/mt.2010.85openalex-snapshot
Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
inferredcites →https://doi.org/10.1038/mt.sj.6300132openalex-snapshot
Rapid Optimization of Gene Delivery by Parallel End-modification of Poly(β-amino ester)s
inferredcites →https://doi.org/10.1038/nmat3765openalex-snapshot
Delivery materials for siRNA therapeutics
inferredcites →https://doi.org/10.1038/nnano.2014.84openalex-snapshot
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
inferredcites →https://doi.org/10.1073/pnas.1502281112openalex-snapshot
Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy
inferredcites →https://doi.org/10.1073/pnas.92.16.7297openalex-snapshot
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
inferredcites →https://doi.org/10.1078/0171-9335-00363openalex-snapshot
PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles
inferredcites →https://doi.org/10.1126/science.2660259openalex-snapshot
Progress Toward Human Gene Therapy
inferredcites →https://doi.org/10.1161/01.cir.0000102381.57477.50openalex-snapshot
Endothelial Dysfunction in Pulmonary Hypertension
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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High-throughput evaluation of polymeric nanoparticles for tissue-targeted gene expression using barcoded plasmid DNA
inferred← citeshttps://doi.org/10.1016/j.jconrel.2021.09.016openalex-snapshot
Dynamic mRNA polyplexes benefit from bioreducible cleavage sites for in vitro and in vivo transfer
inferred← citeshttps://doi.org/10.1016/j.jconrel.2021.11.022openalex-snapshot
Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery
inferred← citeshttps://doi.org/10.1016/j.jconrel.2022.03.032openalex-snapshot
mRNA vaccines for COVID-19 and diverse diseases
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.02.002openalex-snapshot
Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.04.030openalex-snapshot
Superior COL7A1 and TGM1 gene expression in difficult-to-transfect skin cell mediated by highly branched poly(β-amino esters) through stepwise fractionation
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.12.038openalex-snapshot
Hyaluronic acid coating of poly(β-amino ester)/mRNA polyplexes enables ultra-high transfection efficiency
inferred← citeshttps://doi.org/10.1016/j.jconrel.2026.115170openalex-snapshot
Advances in RNA delivery to extrahepatic tissues and cells
inferred← citeshttps://doi.org/10.1016/j.jconrel.2026.115337openalex-snapshot
mRNA vaccines for glioblastoma: integrating multiomics and nanomedicine to overcome spatiotemporal heterogeneity
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119289openalex-snapshot
The significance of bioengineered nanoplatforms against SARS-CoV-2: From detection to genome editing
inferred← citeshttps://doi.org/10.1016/j.matdes.2022.110758openalex-snapshot
Amphiphilic cationic triblock polymers for p53-mediated triple-negative breast cancer gene therapy
inferred← citeshttps://doi.org/10.1016/j.matdes.2025.114181openalex-snapshot
Cancer-specific targeting core–shell nanoparticles with magnetic resonance imaging function: Realizing efficient chemo-photothermal synergistic therapy triggered by near-infrared light
inferred← citeshttps://doi.org/10.1016/j.matt.2020.09.020openalex-snapshot
Nanomaterials for Therapeutic RNA Delivery
inferred← citeshttps://doi.org/10.1016/j.matt.2021.12.022openalex-snapshot
Oral mRNA delivery using capsule-mediated gastrointestinal tissue injections
inferred← citeshttps://doi.org/10.1016/j.matt.2022.03.006openalex-snapshot
The roles of polymers in mRNA delivery
inferred← citeshttps://doi.org/10.1016/j.medj.2022.02.001openalex-snapshot
Nanoscale delivery platforms for RNA therapeutics: Challenges and the current state of the art
inferred← citeshttps://doi.org/10.1016/j.mtadv.2022.100240openalex-snapshot
Targeting strategies for mRNA delivery
inferred← citeshttps://doi.org/10.1016/j.mtbio.2025.102584openalex-snapshot
mRNA delivery systems 2.0: Engineering extrahepatic delivery for non-vaccine therapeutics
inferred← citeshttps://doi.org/10.1016/j.nantod.2018.10.005openalex-snapshot
mRNA therapeutics deliver a hopeful message
inferred← citeshttps://doi.org/10.1016/j.omtn.2017.04.006openalex-snapshot
Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA
inferred← citeshttps://doi.org/10.1016/j.omtn.2017.11.005openalex-snapshot
Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse
inferred← citeshttps://doi.org/10.1016/j.omtn.2023.04.019openalex-snapshot
Poly(β-amino ester)s-based nanovehicles: Structural regulation and gene delivery
inferred← citeshttps://doi.org/10.1016/j.ymthe.2018.05.014openalex-snapshot
Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis
inferred← citeshttps://doi.org/10.1016/j.ymthe.2019.02.012openalex-snapshot
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
inferred← citeshttps://doi.org/10.1016/j.ymthe.2019.02.019openalex-snapshot
Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases
inferred← citeshttps://doi.org/10.1016/j.ymthe.2019.03.003openalex-snapshot
Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets
inferred← citeshttps://doi.org/10.1016/j.ymthe.2025.01.037openalex-snapshot
PBAE-PEG-based lipid nanoparticles for lung cell-specific gene delivery
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c00008openalex-snapshot
Visualization of Endogenous Hypochlorite in Drug-Induced Liver Injury Mice via a Bioluminescent Probe Combined with Firefly Luciferase mRNA-Loaded Lipid Nanoparticles
inferred← citeshttps://doi.org/10.1021/acs.biomac.2c00137openalex-snapshot
Poly(beta-amino ester)-Based Nanoparticles Enable Nonviral Delivery of Base Editors for Targeted Tumor Gene Editing
inferred← citeshttps://doi.org/10.1021/acs.biomac.3c00858openalex-snapshot
Amphiphilic Block Copolymer Nanostructures as a Tunable Delivery Platform: Perspective and Framework for the Future Drug Product Development
inferred← citeshttps://doi.org/10.1021/acs.biomac.4c01445openalex-snapshot
Enhanced Pulmonary and Splenic mRNA Delivery Using DOTAP-Incorporated Poly(β-Amino Ester)-Lipid Nanoparticles
inferred← citeshttps://doi.org/10.1021/acs.biomac.5c00802openalex-snapshot
Polyamine-Modified Poly(aspartic acid) for mRNA Delivery with In Vivo Lung-Targeted Ability
inferred← citeshttps://doi.org/10.1021/acs.biomac.7b00666openalex-snapshot
Lipo-Oligomer Nanoformulations for Targeted Intracellular Protein Delivery
inferred← citeshttps://doi.org/10.1021/acs.biomac.7b01356openalex-snapshot
Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers
inferred← citeshttps://doi.org/10.1021/acs.biomac.9b00999openalex-snapshot
Polymeric Carriers for Nucleic Acid Delivery: Current Designs and Future Directions
inferred← citeshttps://doi.org/10.1021/acs.chemrev.3c00611openalex-snapshot
Chemically Modified Platforms for Better RNA Therapeutics
inferred← citeshttps://doi.org/10.1021/acs.langmuir.2c00913openalex-snapshot
Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells
inferred← citeshttps://doi.org/10.1021/acs.langmuir.4c05176openalex-snapshot
The Interplay of Endosomal Escape and RNA Release from Polymeric Nanoparticles
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.0c00618openalex-snapshot
Nanomedicine-Based Approaches for mRNA Delivery
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.1c00916openalex-snapshot
Lipid-Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Components
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.2c00738openalex-snapshot
Poly(aspartic acid)-Based Polymeric Nanoparticle for Local and Systemic mRNA Delivery
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.4c00871openalex-snapshot
Non-Viral RNA Therapies for Non-Small Cell Lung Cancer and Their Corresponding Clinical Trials
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.6c00483openalex-snapshot
mRNA Delivery with Lipopolymers to Rejuvenate TRAIL Therapy for Lung Cancer Treatment
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.7b00356openalex-snapshot
Site-Specific Covalent Conjugation of Modified mRNA by tRNA Guanine Transglycosylase
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.8b00134openalex-snapshot
Serum Nuclease Susceptibility of mRNA Cargo in Condensed Polyplexes
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.9b00180openalex-snapshot
Lung Tissue Delivery of Virus-Like Particles Mediated by Macrolide Antibiotics
inferred← citeshttps://doi.org/10.1021/acs.nanolett.0c00596openalex-snapshot
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo
inferred← citeshttps://doi.org/10.1021/acs.nanolett.2c01784openalex-snapshot
Helper-Polymer Based Five-Element Nanoparticles (FNPs) for Lung-Specific mRNA Delivery with Long-Term Stability after Lyophilization
inferred← citeshttps://doi.org/10.1021/acs.nanolett.4c01854openalex-snapshot
Lung-Specific mRNA Delivery Enabled by Sulfonium Lipid Nanoparticles
inferred← citeshttps://doi.org/10.1021/acs.nanolett.4c02440openalex-snapshot
Tailoring Highly Branched Poly(β-amino ester)s for Efficient and Organ-Selective mRNA Delivery
inferred← citeshttps://doi.org/10.1021/acs.nanolett.5c03826openalex-snapshot
Advancing Lung Cancer Treatment: mRNA Therapeutics and Delivery Strategies
inferred← citeshttps://doi.org/10.1021/acs.nanolett.8b02917openalex-snapshot
Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells
inferred← citeshttps://doi.org/10.1021/acsabm.5c00116openalex-snapshot
Tailoring Alkyl Side Chains of Ionizable Amino-Polyesters for Enhanced In Vivo mRNA Delivery
inferred← citeshttps://doi.org/10.1021/acsami.0c08268openalex-snapshot
Surface-Functionalized PEGylated Nanoparticles Deliver Messenger RNA to Pulmonary Immune Cells
inferred← citeshttps://doi.org/10.1021/acsami.1c20053openalex-snapshot
Dual-Regulated Functionalized Liposome–Nanoparticle Hybrids Loaded with Dexamethasone/TGFβ1-siRNA for Targeted Therapy of Glomerulonephritis
inferred← citeshttps://doi.org/10.1021/acsami.3c03802openalex-snapshot
Enhancing the Gene Transfection of Poly(β-amino ester)/DNA Polyplexes by Modular Manipulation of Amphiphilicity
inferred← citeshttps://doi.org/10.1021/acsami.8b21398openalex-snapshot
Lipid-mRNA Nanoparticle Designed to Enhance Intracellular Delivery Mediated by Shock Waves
inferred← citeshttps://doi.org/10.1021/acsami.9b04051openalex-snapshot
pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.5c00631openalex-snapshot
Reducing Complexity in Lipid Nanoparticles: Three-Component Zwitterionic Amino Lipids for Targeted Extrahepatic mRNA Delivery
inferred← citeshttps://doi.org/10.1021/acschembio.0c00003openalex-snapshot
Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs
inferred← citeshttps://doi.org/10.1021/acsnano.0c00326openalex-snapshot
Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer
inferred← citeshttps://doi.org/10.1021/acsnano.0c04006openalex-snapshot
Nanotechnology for COVID-19: Therapeutics and Vaccine Research
inferred← citeshttps://doi.org/10.1021/acsnano.0c04707openalex-snapshot
Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing
inferred← citeshttps://doi.org/10.1021/acsnano.3c05635openalex-snapshot
mRNA Cancer Vaccines: Construction and Boosting Strategies
inferred← citeshttps://doi.org/10.1021/acsnano.3c07204openalex-snapshot
Stability Criterion for the Assembly of Core–Shell Lipid–Polymer–Nucleic Acid Nanoparticles
inferred← citeshttps://doi.org/10.1021/acsnano.3c13039openalex-snapshot
Antiangiogenic Therapeutic mRNA Delivery Using Lung-Selective Polymeric Nanomedicine for Lung Cancer Treatment
inferred← citeshttps://doi.org/10.1021/acsnano.4c14041openalex-snapshot
Targeted Delivery of mRNA with Polymer–Lipid Nanoparticles for In Vivo Base Editing
inferred← citeshttps://doi.org/10.1021/acsnano.5c07147openalex-snapshot
The Structure and Morphology of Single-Component Oligomeric RNA Delivery Vectors Derived from Amphiphilic Charge-Altering Releasable Transporters
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