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Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo
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1 of the 65 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1186/1741-7015-10-40 (notice 2022-07-08).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/dmrr.2295openalex-snapshot
Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin‐induced diabetes
inferredcites →https://doi.org/10.1007/s00424-009-0735-2openalex-snapshot
Evidence against a direct role of klotho in insulin resistance
inferredcites →https://doi.org/10.1007/s10741-012-9313-3openalex-snapshot
Diabetic cardiomyopathy: pathophysiology and clinical features
inferredcites →https://doi.org/10.1007/s12020-009-9181-3openalex-snapshot
Klotho suppresses TNF-α-induced expression of adhesion molecules in the endothelium and attenuates NF-κB activation
inferredcites →https://doi.org/10.1016/j.bbadis.2014.06.030openalex-snapshot
Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy
inferredcites →https://doi.org/10.1016/j.bbadis.2015.02.011openalex-snapshot
Blockage of ROS and NF-κB-mediated inflammation by a new chalcone L6H9 protects cardiomyocytes from hyperglycemia-induced injuries
inferredcites →https://doi.org/10.1016/j.bbadis.2016.08.005openalex-snapshot
Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress
inferredcites →https://doi.org/10.1016/j.bbadis.2017.03.006openalex-snapshot
Astragaloside IV attenuates lead acetate-induced inhibition of neurite outgrowth through activation of Akt-dependent Nrf2 pathway in vitro
inferredcites →https://doi.org/10.1016/j.bbagen.2012.02.010openalex-snapshot
High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2009.05.028openalex-snapshot
Cardiotoxicity of calmidazolium chloride is attributed to calcium aggravation, oxidative and nitrosative stress, and apoptosis
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2015.04.028openalex-snapshot
Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling
inferredcites →https://doi.org/10.1016/j.ijcard.2012.09.080openalex-snapshot
Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation
inferredcites →https://doi.org/10.1016/j.jacc.2010.07.033openalex-snapshot
Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy
inferredcites →https://doi.org/10.1016/j.neuint.2013.01.030openalex-snapshot
Neuroprotective mechanisms of the standardized extract of Bacopa monniera in a paraquat/diquat-mediated acute toxicity
inferredcites →https://doi.org/10.1016/j.pharmthera.2014.01.003openalex-snapshot
Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways
inferredcites →https://doi.org/10.1016/j.yjmcc.2011.06.012openalex-snapshot
Methods in cardiomyocyte isolation, culture, and gene transfer
inferredcites →https://doi.org/10.1016/j.yjmcc.2014.10.002openalex-snapshot
Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.yjmcc.2015.02.029openalex-snapshot
EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model
inferredcites →https://doi.org/10.1016/j.yjmcc.2015.12.011openalex-snapshot
Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities
inferredcites →https://doi.org/10.1016/j.yjmcc.2015.12.025openalex-snapshot
Mitochondrial quality control in the diabetic heart
inferredcites →https://doi.org/10.1038/36285openalex-snapshot
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
inferredcites →https://doi.org/10.1038/cddis.2017.106openalex-snapshot
Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy
inferredcites →https://doi.org/10.1038/nature05315openalex-snapshot
Klotho converts canonical FGF receptor into a specific receptor for FGF23
inferredcites →https://doi.org/10.1038/ncb2167openalex-snapshot
Klotho suppresses RIG-I-mediated senescence-associated inflammation
inferredcites →https://doi.org/10.1038/ncomms2240openalex-snapshot
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
inferredcites →https://doi.org/10.1038/nrendo.2012.75openalex-snapshot
The role of Klotho in energy metabolism
inferredcites →https://doi.org/10.1038/srep05029openalex-snapshot
No evident dose-response relationship between cellular ROS level and its cytotoxicity – a paradoxical issue in ROS-based cancer therapy
inferredcites →https://doi.org/10.1038/srep44239openalex-snapshot
Myricitrin Alleviates Oxidative Stress-induced Inflammation and Apoptosis and Protects Mice against Diabetic Cardiomyopathy
inferredcites →https://doi.org/10.1042/cs20150273openalex-snapshot
Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury
inferredcites →https://doi.org/10.1073/pnas.1116584109openalex-snapshot
Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure
inferredcites →https://doi.org/10.1074/jbc.m115.655431openalex-snapshot
Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease
inferredcites →https://doi.org/10.1074/jbc.m509039200openalex-snapshot
Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦
inferredcites →https://doi.org/10.1093/cvr/cvx011openalex-snapshot
An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy
inferredcites →https://doi.org/10.1093/gerona/glu170openalex-snapshot
Klotho Prevents NFκB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia
inferredcites →https://doi.org/10.1096/fj.10-154765openalex-snapshot
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
inferredcites →https://doi.org/10.1111/j.1474-9726.2012.00796.xopenalex-snapshot
Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP‐PKA pathway
inferredcites →https://doi.org/10.1111/jcmm.12996openalex-snapshot
The anti‐ageing hormone klotho induces Nrf2‐mediated antioxidant defences in human aortic smooth muscle cells
inferredcites →https://doi.org/10.1126/science.1112766openalex-snapshot
Suppression of Aging in Mice by the Hormone Klotho
inferredcites →https://doi.org/10.1126/science.1135901openalex-snapshot
α-Klotho as a Regulator of Calcium Homeostasis
inferredcites →https://doi.org/10.1152/ajpheart.00230.2009openalex-snapshot
eNOS uncoupling and endothelial dysfunction in aged vessels
inferredcites →https://doi.org/10.1152/ajpheart.00340.2014openalex-snapshot
Cardiac-specific suppression of NF-κB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system
inferredcites →https://doi.org/10.1152/ajplung.00306.2013openalex-snapshot
α-Klotho protects against oxidative damage in pulmonary epithelia
inferredcites →https://doi.org/10.1155/2011/652097openalex-snapshot
Potential Role of Nuclear Factor κ B in Diabetic Cardiomyopathy
inferredcites →https://doi.org/10.1155/2012/216512openalex-snapshot
Prevention of Diabetic Complications by Activation of Nrf2: Diabetic Cardiomyopathy and Nephropathy
inferredcites →https://doi.org/10.1155/2016/2193210openalex-snapshot
Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells
inferredcites →https://doi.org/10.1159/000453208openalex-snapshot
Exogenous Hydrogen Sulfide Attenuates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation by Suppressing TLR4/NF-κB Pathway in H9c2 Cells
inferredcites →https://doi.org/10.1161/01.cir.0000124224.48962.32openalex-snapshot
Sinoatrial Node Dysfunction and Early Unexpected Death of Mice With a Defect of klotho Gene Expression
inferredcites →https://doi.org/10.1161/01.cir.55.6.853openalex-snapshot
Detection of remote myocardial infarction in patients with positron emission transaxial tomography and intravenous 11C-palmitate.
inferredcites →https://doi.org/10.1161/circresaha.110.223545openalex-snapshot
Oxidative Stress and Diabetic Complications
inferredcites →https://doi.org/10.1161/circulationaha.108.802918openalex-snapshot
Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure
inferredcites →https://doi.org/10.1161/circulationaha.111.053405openalex-snapshot
Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23
inferredcites →https://doi.org/10.1161/hypertensionaha.115.06825openalex-snapshot
Antiaging Gene Klotho Deficiency Promoted High-Fat Diet–Induced Arterial Stiffening via Inactivation of AMP-Activated Protein Kinase
inferredcites →https://doi.org/10.1172/jci46122openalex-snapshot
FGF23 induces left ventricular hypertrophy
inferredcites →https://doi.org/10.1186/1475-2840-12-158openalex-snapshot
Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy
inferredcites →https://doi.org/10.1186/1741-7015-10-40openalex-snapshot
RETRACTED ARTICLE: Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function
inferredcites →https://doi.org/10.1210/er.2013-1079openalex-snapshot
Molecular Basis of Klotho: From Gene to Function in Aging
inferredcites →https://doi.org/10.1681/asn.2010101073openalex-snapshot
The Inflammatory Cytokines TWEAK and TNFα Reduce Renal Klotho Expression through NFκB
inferredcites →https://doi.org/10.1681/asn.2014060543openalex-snapshot
Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy
inferredcites →https://doi.org/10.18632/aging.100194openalex-snapshot
The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging
inferredcites →https://doi.org/10.18632/oncotarget.14933openalex-snapshot
Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice
inferredcites →https://doi.org/10.2337/db10-1262openalex-snapshot
Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation
inferredcites →https://doi.org/10.2337/db11-0477openalex-snapshot
Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy
inferredcites →https://doi.org/10.2337/db13-1577openalex-snapshot
Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy
inferredcites →https://doi.org/10.2337/db15-0568openalex-snapshot
Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy
inferredcites →https://doi.org/10.4093/dmj.2014.38.5.337openalex-snapshot
Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4673402openalex-extracted
Shengxian Decoction Protects Against Obesity-Induced Cardiac Injuryin Rats by Regulating the Hk1/Nlrp3 Signalling Pathway
inferred← citeshttps://doi.org/10.1002/1878-0261.12577openalex-snapshot
Klotho‐mediated targeting of CCL 2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments
inferred← citeshttps://doi.org/10.1002/path.5631openalex-snapshot
TWEAK–Fn14 as a common pathway in the heart and the kidneys in cardiorenal syndrome
inferred← citeshttps://doi.org/10.1002/ptr.70109openalex-snapshot
Pinoresinol Diglucoside Alleviates Cardiac Fibrosis Through Inhibiting Endothelial–Mesenchymal Transition via the Transforming Growth Factor‐ β1 /Smads Pathway in db/db Mice
inferred← citeshttps://doi.org/10.1002/tox.23043openalex-snapshot
Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats
inferred← citeshttps://doi.org/10.1007/s00345-024-04837-1openalex-snapshot
Association of serum soluble α‑klotho with risk of kidney stone disease: a population-based cross-sectional study
inferred← citeshttps://doi.org/10.1007/s00424-023-02863-3openalex-snapshot
PKC regulates αKlotho gene expression in MDCK and NRK-52E cells
inferred← citeshttps://doi.org/10.1007/s10719-022-10081-9openalex-snapshot
6-O-desulfated heparin attenuates myocardial ischemia/reperfusion injury in mice through the regulation of miR-199a-5p/klotho axis
inferred← citeshttps://doi.org/10.1007/s10735-020-09930-4openalex-snapshot
RETRACTED ARTICLE: Polydatin and polydatin-loaded chitosan nanoparticles attenuate diabetic cardiomyopathy in rats
inferred← citeshttps://doi.org/10.1007/s12020-018-1688-zopenalex-snapshot
LncRNAs and miRs as epigenetic signatures in diabetic cardiac fibrosis: new advances and perspectives
inferred← citeshttps://doi.org/10.1007/s12031-019-01356-2openalex-snapshot
Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS
inferred← citeshttps://doi.org/10.1007/s12035-024-04211-7openalex-snapshot
Enhanced Therapeutic Effects of Human Mesenchymal stem Cells Transduced with Secreted Klotho in a Murine Experimental Autoimmune Encephalomyelitis Model
inferred← citeshttps://doi.org/10.1007/s12035-025-04849-xopenalex-snapshot
Reversing Neuronal Klotho Dysfunction–Mediated Diabetic Neuropathy Through 16:8 Intermittent Fasting
inferred← citeshttps://doi.org/10.1007/s12038-020-00096-5openalex-snapshot
High-glucose-induced apoptosis, ROS production and pro-inflammatory response in cardiomyocytes is attenuated by metformin treatment via PP2A activation
inferred← citeshttps://doi.org/10.1007/s13105-023-00945-5openalex-snapshot
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction
inferred← citeshttps://doi.org/10.1007/s13300-024-01683-7openalex-snapshot
Association Between Serum α-Klotho Levels and Diabetic Kidney Disease Prevalence in Middle-Aged and Elderly US Patients with Diabetes: A Cross-Sectional Study Using NHANES 2007–2016 Data
inferred← citeshttps://doi.org/10.1007/s13410-025-01526-6openalex-snapshot
Klotho: A possible diagnostic biomarker and therapeutic target in diabetes complications
inferred← citeshttps://doi.org/10.1007/s40200-024-01387-6openalex-snapshot
The interaction between klotho protein and epigenetic alteration in diabetes and treatment options
inferred← citeshttps://doi.org/10.1016/b978-0-12-818036-5.00011-2openalex-snapshot
α-Klotho gene and protein measurements in humans and their role as a clinical biomarker of disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-818036-5.00016-1openalex-snapshot
Klotho—open questions, controversies, and future perspectives
inferred← citeshttps://doi.org/10.1016/bs.acc.2020.02.004openalex-snapshot
Biomarkers of vascular calcification in serum
inferred← citeshttps://doi.org/10.1016/j.amjms.2024.12.005openalex-snapshot
Klotho plays a crucial role in the renal-protective effect of allopurinol on renal ischemia-reperfusion injury
inferred← citeshttps://doi.org/10.1016/j.archger.2020.104225openalex-snapshot
The relationship between frailty and serum alpha klotho levels in geriatric patients
inferred← citeshttps://doi.org/10.1016/j.arr.2018.07.004openalex-snapshot
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
inferred← citeshttps://doi.org/10.1016/j.bbadis.2018.08.015openalex-snapshot
Vascular smooth muscle cell senescence and age-related diseases: State of the art
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.04.110openalex-snapshot
Vaspin prevents myocardial injury in rats model of diabetic cardiomyopathy by enhancing autophagy and inhibiting inflammation
inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.11.061openalex-snapshot
Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111312openalex-snapshot
Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways
inferred← citeshttps://doi.org/10.1016/j.cca.2018.05.033openalex-snapshot
Association between klotho expression and malignancies risk and progression: A meta-analysis
inferred← citeshttps://doi.org/10.1016/j.cej.2026.176543openalex-snapshot
Bioactive electrospun membrane with DHBA/Zn-MOF for enhancing neurovascular coupling in diabetic wound healing
inferred← citeshttps://doi.org/10.1016/j.drudis.2021.04.007openalex-snapshot
Klotho: A possible mechanism of action of SGLT2 inhibitors preventing episodes of acute kidney injury and cardiorenal complications of diabetes
inferred← citeshttps://doi.org/10.1016/j.ejphar.2018.10.023openalex-snapshot
Calcitonin gene-related peptide inhibits the cardiac fibroblasts senescence in cardiac fibrosis via up-regulating klotho expression
inferred← citeshttps://doi.org/10.1016/j.fct.2024.115179openalex-snapshot
Renoprotective effect of berberine in cisplatin-induced acute kidney injury: Role of Klotho and the AMPK/mtor/ULK1/Beclin-1 pathway
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e29871openalex-snapshot
RETRACTED: NF-ĸB axis in diabetic neuropathy, cardiomyopathy and nephropathy: A roadmap from molecular intervention to therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.intimp.2019.01.047openalex-snapshot
Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through attenuation of apoptosis, oxidative stress, and inflammation
inferred← citeshttps://doi.org/10.1016/j.intimp.2020.106582openalex-snapshot
Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110105openalex-snapshot
Klotho alleviates contrast-induced acute kidney injury by suppressing oxidative stress, inflammation, and NF-KappaB/NLRP3-mediated pyroptosis
inferred← citeshttps://doi.org/10.1016/j.jrras.2026.102721openalex-snapshot
Exosomal lncRNA PVT1 from adipose-derived stem cell aggravates myocardial injury through CDC25A/PI3Kγ/NF-κB pathway under high glucose condition
inferred← citeshttps://doi.org/10.1016/j.kisu.2021.11.008openalex-snapshot
Considerations for the future: current and future treatment paradigms with mineralocorticoid receptor antagonists—unmet needs and underserved patient cohorts
inferred← citeshttps://doi.org/10.1016/j.lfs.2018.08.074openalex-snapshot
Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.116773openalex-snapshot
Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway
inferred← citeshttps://doi.org/10.1016/j.mad.2021.111442openalex-snapshot
Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1016/j.nut.2021.111376openalex-snapshot
Nicotinamide retains Klotho expression and ameliorates rhabdomyolysis-induced acute kidney injury
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.104926openalex-snapshot
Intermedin alleviates pathological cardiac remodeling by upregulating klotho
inferred← citeshttps://doi.org/10.1016/j.placenta.2025.04.024openalex-snapshot
Hyperglycemia-induced α-Klotho downregulation impairs mitophagy and promotes placental dysfunction in T2DM pregnancies
inferred← citeshttps://doi.org/10.1016/j.psyneuen.2020.104656openalex-snapshot
PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2025.09.004openalex-snapshot
Klotho attenuates D-galactose-induced cardiac aging through the ROS/NLRP3/pyroptosis pathway
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2025.11.003openalex-snapshot
Novel angiotensin receptor target as therapy for the diabetic heart: the AT2R
inferred← citeshttps://doi.org/10.1017/cts.2021.790openalex-snapshot
Biomimetics provides lessons from nature for contemporary ways to improve human health
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00402openalex-snapshot
Recent Progress of Surface Modified Nanomaterials for Scavenging Reactive Oxygen Species in Organism
inferred← citeshttps://doi.org/10.1021/acs.jafc.0c04358openalex-snapshot
Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d -Galactose
inferred← citeshttps://doi.org/10.1038/s41371-022-00751-4openalex-snapshot
Hypertension and cardiomyopathy associated with chronic kidney disease: epidemiology, pathogenesis and treatment considerations
inferred← citeshttps://doi.org/10.1038/s41388-022-02440-5openalex-snapshot
The role of α-klotho in human cancer: molecular and clinical aspects
inferred← citeshttps://doi.org/10.1038/s41569-023-00903-0openalex-snapshot
FGF23 and klotho at the intersection of kidney and cardiovascular disease
inferred← citeshttps://doi.org/10.1038/s41598-019-47199-0openalex-snapshot
Lower levels of α-Klotho in serum are associated with decreased lung function in individuals with interstitial lung abnormalities
inferred← citeshttps://doi.org/10.1038/s41598-022-21132-4openalex-snapshot
Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture
inferred← citeshttps://doi.org/10.1038/s41598-022-22123-1openalex-snapshot
A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine
inferred← citeshttps://doi.org/10.1038/s41598-023-41061-0openalex-snapshot
Expression of TNFR1, VEGFA, CD147 and MCT1 as early biomarkers of diabetes complications and the impact of aging on this profile
inferred← citeshttps://doi.org/10.1038/s41598-024-64050-3openalex-snapshot
L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database
inferred← citeshttps://doi.org/10.1080/07853890.2022.2077428openalex-snapshot
Soluble klotho as an effective biomarker to characterize inflammatory states
inferred← citeshttps://doi.org/10.1080/09273948.2020.1828488openalex-snapshot
Klotho Levels are Decreased and Associated with Enhanced Oxidative Stress and Inflammation in the Aqueous Humor in Patients with Exudative Age-related Macular Degeneration
inferred← citeshttps://doi.org/10.1080/13510002.2023.2246720openalex-snapshot
Oxidative stress signaling in the pathogenesis of diabetic cardiomyopathy and the potential therapeutic role of antioxidant naringenin
inferred← citeshttps://doi.org/10.1080/21655979.2022.2033411openalex-snapshot
Metformin attenuates high glucose-induced injury in islet microvascular endothelial cells
inferred← citeshttps://doi.org/10.1080/21655979.2022.2071023openalex-snapshot
RETRACTED ARTICLE: Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway
inferred← citeshttps://doi.org/10.1080/26895293.2024.2397402openalex-snapshot
The role of NF-κB in diabetic cardiomyopathy
inferred← citeshttps://doi.org/10.1089/ars.2019.7723openalex-snapshot
Salusin-β Promotes Vascular Calcification via Nicotinamide Adenine Dinucleotide Phosphate/Reactive Oxygen Species-Mediated Klotho Downregulation
inferred← citeshttps://doi.org/10.1093/abbs/gmaa162openalex-snapshot
RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy
inferred← citeshttps://doi.org/10.1093/abbs/gmy051openalex-snapshot
SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells
inferred← citeshttps://doi.org/10.1093/ndt/gfz120openalex-snapshot
Understanding the role of the cytoprotective transcription factor nuclear factor erythroid 2-related factor 2—lessons from evolution, the animal kingdom and rare progeroid syndromes
inferred← citeshttps://doi.org/10.1093/toxres/tfac023openalex-snapshot
Synergistic impacts of Montelukast and Klotho against doxorubicin-induced cardiac toxicity in Rats
inferred← citeshttps://doi.org/10.1096/fj.202100952ropenalex-snapshot
Soluble Klotho‐integrin β1/ERK1/2 pathway ameliorates myocardial fibrosis in diabetic cardiomyopathy
inferred← citeshttps://doi.org/10.1097/fjc.0000000000000935openalex-snapshot
Improvement of Cardiac Function in Rats With Myocardial Infarction by Low-Intensity to Moderate-Intensity Endurance Exercise Is Associated With Normalization of Klotho and SIRT1
inferred← citeshttps://doi.org/10.1097/fjc.0000000000001721openalex-snapshot
Cardiac-specific Overexpression of Klotho Attenuates Paraquat-Induced Myocardial Injury by Enhancing the Nrf2/ARE Signaling Pathway
inferred← citeshttps://doi.org/10.1097/md.0000000000049927openalex-snapshot
Relationship between klotho and psoriasis: A cross-sectional analysis of NHANES 2009–2010 and Mendelian randomization study
inferred← citeshttps://doi.org/10.1111/1440-1681.13598openalex-snapshot
Astaxanthin extenuates the inhibition of aldehyde dehydrogenase and Klotho protein expression in cyclophosphamide‐induced acute cardiomyopathic rat model
inferred← citeshttps://doi.org/10.1111/jcmm.14466openalex-snapshot
Yellow Wine Polyphenolic Compounds prevents Doxorubicin‐induced cardiotoxicity through activation of the Nrf2 signalling pathway
inferred← citeshttps://doi.org/10.1111/jcmm.15293openalex-snapshot
Klotho protein contributes to cardioprotection during ischaemia/reperfusion injury
inferred← citeshttps://doi.org/10.1111/jcmm.15699openalex-snapshot
Empagliflozin reduces the senescence of cardiac stromal cells and improves cardiac function in a murine model of diabetes
inferred← citeshttps://doi.org/10.1111/jcmm.17686openalex-snapshot
Costunolide alleviates hyperglycaemia‐induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress
inferred← citeshttps://doi.org/10.1155/2018/5171945openalex-snapshot
The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases
inferred← citeshttps://doi.org/10.1155/2019/8151836openalex-snapshot
Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes
inferred← citeshttps://doi.org/10.1155/2019/9261565openalex-snapshot
Recombinant Klotho Protects Human Periodontal Ligament Stem Cells by Regulating Mitochondrial Function and the Antioxidant System during H2O2-Induced Oxidative Stress
inferred← citeshttps://doi.org/10.1155/2020/1854206openalex-snapshot
Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis
inferred← citeshttps://doi.org/10.1155/2020/6427284openalex-snapshot
Ameliorating Effect of Klotho Protein on Rat Heart during I/R Injury
inferred← citeshttps://doi.org/10.1155/2021/7536614openalex-snapshot
Understanding the Stony Bridge between Osteoporosis and Vascular Calcification: Impact of the FGF23/Klotho axis
inferred← citeshttps://doi.org/10.1155/2022/7382130openalex-snapshot
[Retracted] Investigating Celastrol’s Anti‐DCM Targets and Mechanisms via Network Pharmacology and Experimental Validation
inferred← citeshttps://doi.org/10.1159/000509369openalex-snapshot
The Protective Role of Klotho in CKD-Associated Cardiovascular Disease
inferred← citeshttps://doi.org/10.1159/000541014openalex-snapshot
Early Serum Biomarkers of Cardiovascular Disease in Elderly Patients with Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1177/15353702231191178openalex-snapshot
Metformin inhibits mitochondrial dysfunction and apoptosis in cardiomyocytes induced by high glucose via upregulating AMPK activity
inferred← citeshttps://doi.org/10.1177/1559325819897180openalex-snapshot
Cardiotoxicity and Cardioprotection by Artesunate in Larval Zebrafish
inferred← citeshttps://doi.org/10.1177/2040622320940176openalex-snapshot
The prognostic value of soluble Klotho in patients with haemodialysis: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1186/s12872-024-04375-zopenalex-snapshot
Inverse association between serum klotho levels and C-reactive protein levels in the US population: a cross-sectional study
inferred← citeshttps://doi.org/10.1186/s13098-025-01711-xopenalex-snapshot
Association between serum α-klotho levels and the incidence of diabetic kidney disease and mortality in type 2 diabetes: evidence from a Chinese cohort and the NHANES database
inferred← citeshttps://doi.org/10.1186/s13098-026-02098-zopenalex-snapshot
Myocardial ischemia reperfusion in diabetes: mechanism of injury and its drug treatment
inferred← citeshttps://doi.org/10.12659/msm.907449openalex-snapshot
Klotho Improves Cardiac Function by Suppressing Reactive Oxygen Species (ROS) Mediated Apoptosis by Modulating Mapks/Nrf2 Signaling in Doxorubicin-Induced Cardiotoxicity
inferred← citeshttps://doi.org/10.12659/msm.913244openalex-snapshot
Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-κB (NF-κB)
inferred← citeshttps://doi.org/10.1371/journal.pone.0263285openalex-snapshot
SGLT2 inhibitor dapagliflozin prevents atherosclerotic and cardiac complications in experimental type 1 diabetes
inferred← citeshttps://doi.org/10.14336/ad.2024.0058openalex-snapshot
Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging
inferred← citeshttps://doi.org/10.1515/jpem-2019-0591openalex-snapshot
Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children
inferred← citeshttps://doi.org/10.1590/0001-3765202120201925openalex-snapshot
Free Radicals and Actinobacteria as a Misexplored Goldmine of Antioxidant Compounds
inferred← citeshttps://doi.org/10.18499/2225-7357-2023-12-4-38-46openalex-snapshot
Features of Klotho Protein Expression in Rat Kidneys in Experimental Hyperglycemia Against the Background of Pharmacological Correction with GABA Derivatives
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1323978/v1openalex-snapshot
Klotho, much more than an anti-aging protein, an emerging exerkine: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.22038/ijbms.2022.60579.13428openalex-snapshot
Guanosine protects against glycerol-induced acute kidney injury via up-regulation of the klotho gene.
inferred← citeshttps://doi.org/10.24884/1682-6655-2024-23-3-12-18openalex-snapshot
Role of phosphorus-calcium metabolism regulators in cardiorenal syndrome development
inferred← citeshttps://doi.org/10.3389/fcell.2021.701788openalex-snapshot
Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?
inferred← citeshttps://doi.org/10.3389/fcvm.2022.1013747openalex-snapshot
Association between serum Klotho concentration and all-cause and cardiovascular mortality among American individuals with hypertension
inferred← citeshttps://doi.org/10.3389/fcvm.2022.802287openalex-snapshot
Renal Function Mediates the Association Between Klotho and Congestive Heart Failure Among Middle-Aged and Older Individuals
inferred← citeshttps://doi.org/10.3389/fcvm.2022.897815openalex-snapshot
Pyroptosis: Role and Mechanisms in Cardiovascular Disease
inferred← citeshttps://doi.org/10.3389/fendo.2018.00774openalex-snapshot
Phloretin Prevents Diabetic Cardiomyopathy by Dissociating Keap1/Nrf2 Complex and Inhibiting Oxidative Stress
inferred← citeshttps://doi.org/10.3389/fendo.2021.709564openalex-snapshot
Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control
inferred← citeshttps://doi.org/10.3389/fendo.2024.1471548openalex-snapshot
Association between serum Klotho levels and estimated pulse wave velocity in postmenopausal women: a cross-sectional study of NHANES 2007–2016
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1683116openalex-snapshot
GSDME in cardiovascular diseases: research system and contemporary progress
inferred← citeshttps://doi.org/10.3389/fncel.2019.00012openalex-snapshot
MicroRNA-155 Promotes Heat Stress-Induced Inflammation via Targeting Liver X Receptor α in Microglia
inferred← citeshttps://doi.org/10.3389/fncel.2019.00133openalex-snapshot
Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice
inferred← citeshttps://doi.org/10.3389/fphar.2019.01219openalex-snapshot
Sophocarpine Suppresses NF-κB-Mediated Inflammation Both In Vitro and In Vivo and Inhibits Diabetic Cardiomyopathy
inferred← citeshttps://doi.org/10.3389/fphar.2020.01150openalex-snapshot
Exogenous Hydrogen Sulfide Ameliorates Diabetic Myocardial Fibrosis by Inhibiting Cell Aging Through SIRT6/AMPK Autophagy
inferred← citeshttps://doi.org/10.3389/fphar.2021.719268openalex-snapshot
Effects of Naringin on Cardiomyocytes From a Rodent Model of Type 2 Diabetes
inferred← citeshttps://doi.org/10.3389/fphar.2025.1580943openalex-snapshot
In vitro and in-vivo exploration of physostigmine analogues to understand the mechanistic crosstalk between Klotho and targets for epilepsy
inferred← citeshttps://doi.org/10.3389/fphys.2019.01498openalex-snapshot
α-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise
inferred← citeshttps://doi.org/10.3389/fphys.2021.775029openalex-snapshot
Fibroblast Growth Factor-23-Klotho Axis in Cardiorenal Syndrome: Mediators and Potential Therapeutic Targets
inferred← citeshttps://doi.org/10.3389/fragi.2022.931331openalex-snapshot
Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations
inferred← citeshttps://doi.org/10.3390/antiox11040664openalex-snapshot
Synergistic Effect of L-Carnosine and Hyaluronic Acid in Their Covalent Conjugates on the Antioxidant Abilities and the Mutual Defense against Enzymatic Degradation
inferred← citeshttps://doi.org/10.3390/antiox11112242openalex-snapshot
Resistance Training Modulates Reticulum Endoplasmic Stress, Independent of Oxidative and Inflammatory Responses, in Elderly People
inferred← citeshttps://doi.org/10.3390/antiox12020239openalex-snapshot
Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease
inferred← citeshttps://doi.org/10.3390/biomedicines12040759openalex-snapshot
Interplay between Senescence and Macrophages in Diabetic Cardiomyopathy: A Review of the Potential Role of GDF-15 and Klotho
inferred← citeshttps://doi.org/10.3390/cells13171413openalex-snapshot
Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging
inferred← citeshttps://doi.org/10.3390/genes11091048openalex-snapshot
Klotho Exerts an Emerging Role in Cytokinesis
inferred← citeshttps://doi.org/10.3390/ijms22105327openalex-snapshot
Constitutive Expression of TERT Enhances β-Klotho Expression and Improves Age-Related Deterioration in Early Bovine Embryos
inferred← citeshttps://doi.org/10.3390/ijms22157867openalex-snapshot
Role of Klotho in Hyperglycemia: Its Levels and Effects on Fibroblast Growth Factor Receptors, Glycolysis, and Glomerular Filtration
inferred← citeshttps://doi.org/10.3390/ijms242015268openalex-snapshot
The Importance of α-Klotho in Depression and Cognitive Impairment and Its Connection to Glutamate Neurotransmission—An Up-to-Date Review
inferred← citeshttps://doi.org/10.3390/ijms242317043openalex-snapshot
Cardioprotective and Antifibrotic Effects of Low-Dose Renin–Angiotensin–Aldosterone System Inhibitors in Type 1 Diabetic Rat Model
inferred← citeshttps://doi.org/10.3390/ijms26020731openalex-snapshot
Involvement of ADAM17-Klotho Crosstalk in High Glucose-Induced Alterations of Podocyte Function
inferred← citeshttps://doi.org/10.3390/ijms26093990openalex-snapshot
Macrophage Depletion Alleviates Immunosenescence in Diabetic Kidney by Modulating GDF-15 and Klotho
inferred← citeshttps://doi.org/10.3390/jcm9082522openalex-snapshot
Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control
inferred← citeshttps://doi.org/10.3390/nu15102287openalex-snapshot
Essential Amino Acids-Rich Diet Increases Cardiomyocytes Protection in Doxorubicin-Treated Mice
inferred← citeshttps://doi.org/10.3390/oxygen2030018openalex-snapshot
Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food
inferred← citeshttps://doi.org/10.35206/jan.1087260openalex-snapshot
Klotho Protein and Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.3892/etm.2018.6597openalex-snapshot
Aerobic exercise‑stimulated Klotho upregulation extends life span by attenuating the excess production of reactive oxygen species in the brain and kidney
inferred← citeshttps://doi.org/10.3892/etm.2019.7612openalex-snapshot
Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain‑1 expression and inhibits NF‑κB activation in streptozotocin‑induced diabetic rats
inferred← citeshttps://doi.org/10.3892/etm.2019.8312openalex-snapshot
Metoprolol and bisoprolol ameliorate hypertrophy of neonatal rat cardiomyocytes induced by high glucose via the PKC/NF‑κB/c‑fos signaling pathway
inferred← citeshttps://doi.org/10.3892/mmr.2019.10473openalex-snapshot
Current advances in the study of diabetic cardiomyopathy: From clinicopathological features to molecular therapeutics (Review)
inferred← citeshttps://doi.org/10.3892/mmr.2020.11178openalex-snapshot
Klotho downregulation contributes to myocardial damage of cardiorenal syndrome in sepsis
inferred← citeshttps://doi.org/10.3892/mmr.2021.11854openalex-snapshot
Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats
inferred← citeshttps://doi.org/10.4162/nrp.2023.17.1.164openalex-snapshot
Sodium butyrate inhibits high glucose-induced inflammation by controlling the acetylation of NF-κB p65 in human monocytes
inferred← citeshttps://doi.org/10.4239/wjd.v12.i12.1979openalex-snapshot
Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response
inferred← citeshttps://doi.org/10.5603/ep.a2018.0070openalex-snapshot
Klotho protein function among patients with type 1 diabetes
inferred← citeshttps://doi.org/10.70675/fd0fd36cz6f19z4ce1z9dfbz0c56bbad58e9openalex-snapshot
Homéostasie du cartilage articulaire lors de l'arthrose liée au vieillissement : étude des rôles de la protéine Klotho et d'un cocktail de molécules anti-oxydantes
inferred← citeshttps://doi.org/10.7150/ijms.49690openalex-snapshot
Klotho deficiency aggravates diabetes-induced podocyte injury due to DNA damage caused by mitochondrial dysfunction
inferred← citeshttps://doi.org/10.7717/peerj.19040openalex-snapshot
Effect of high glucose on the gene expression profiling in cardiac fibroblasts from rats at different ages
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