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The Inflammatory Cytokines TWEAK and TNFα Reduce Renal Klotho Expression through NFκB
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1 of the 61 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1074/jbc.m109.061903 (notice 2010-07-09).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1006/bbrc.1998.9246openalex-snapshot
Downregulation of theKlothoGene in the Kidney under Sustained Circulatory Stress in Rats
inferredcites →https://doi.org/10.1006/bbrc.1998.9576openalex-snapshot
Molecular Cloning of RatklothocDNA: Markedly Decreased Expression ofklothoby Acute Inflammatory Stress
inferredcites →https://doi.org/10.1006/bbrc.1999.2009openalex-snapshot
Establishment of the Anti-Klotho Monoclonal Antibodies and Detection of Klotho Protein in Kidneys
inferredcites →https://doi.org/10.1006/bbrc.2000.4226openalex-snapshot
Severely Reduced Production of Klotho in Human Chronic Renal Failure Kidney
inferredcites →https://doi.org/10.1007/s00198-010-1319-xopenalex-snapshot
Osteoporosis in inflammatory joint diseases
inferredcites →https://doi.org/10.1007/s00401-010-0722-xopenalex-snapshot
Contribution of systemic inflammation to chronic neurodegeneration
inferredcites →https://doi.org/10.1007/s00467-008-0933-8openalex-snapshot
Simvastatin ameliorates glomerulosclerosis in Adriamycin-induced-nephropathy rats
inferredcites →https://doi.org/10.1016/j.cardiores.2004.07.011openalex-snapshot
HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells
inferredcites →https://doi.org/10.1016/j.cyto.2007.09.007openalex-snapshot
TWEAKing tissue remodeling by a multifunctional cytokine: Role of TWEAK/Fn14 pathway in health and disease
inferredcites →https://doi.org/10.1016/j.gene.2007.01.016openalex-snapshot
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
inferredcites →https://doi.org/10.1016/s0014-5793(03)00894-9openalex-snapshot
Iron chelation and a free radical scavenger suppress angiotensin II‐induced downregulation of klotho, an anti‐aging gene, in rat
inferredcites →https://doi.org/10.1016/s0092-8674(01)00237-9openalex-snapshot
The TNF and TNF Receptor Superfamilies
inferredcites →https://doi.org/10.1016/s1097-2765(04)00131-5openalex-snapshot
Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB
inferredcites →https://doi.org/10.1038/36285openalex-snapshot
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
inferredcites →https://doi.org/10.1038/ki.1997.2openalex-snapshot
Understanding the nature of renal disease progression
inferredcites →https://doi.org/10.1038/ki.2010.328openalex-snapshot
Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective
inferredcites →https://doi.org/10.1038/nature05315openalex-snapshot
Klotho converts canonical FGF receptor into a specific receptor for FGF23
inferredcites →https://doi.org/10.1038/ni1196openalex-snapshot
Interactions of NF-κB with chromatin: the art of being at the right place at the right time
inferredcites →https://doi.org/10.1038/sj.jid.5701146openalex-snapshot
HDAC Activity Is Required for p65/RelA-Dependent Repression of PPARδ-Mediated Transactivation in Human Keratinocytes
inferredcites →https://doi.org/10.1038/sj.ki.5001866openalex-snapshot
Cytokine cooperation in renal tubular cell injury: The role of TWEAK
inferredcites →https://doi.org/10.1046/j.1523-1755.2000.00925.xopenalex-snapshot
Expression of apoptosis regulatory proteins in tubular epithelium stressed in culture or following acute renal failure
inferredcites →https://doi.org/10.1046/j.1523-1755.64.s86.10.xopenalex-snapshot
Expression of Smac/Diablo in tubular epithelial cells and during acute renal failure
inferredcites →https://doi.org/10.1053/j.ackd.2010.03.010openalex-snapshot
Chronic Kidney Disease and End-Stage Renal Disease in the Elderly Population: Current Prevalence, Future Projections, and Clinical Significance
inferredcites →https://doi.org/10.1073/pnas.0611079104openalex-snapshot
Amelioration of progressive renal injury by genetic manipulation of Klotho gene
inferredcites →https://doi.org/10.1074/jbc.m109.061903openalex-snapshot
Histone Deacetylase-1 Is Enriched at the Platelet-derived Growth Factor-D Promoter in Response to Interleukin-1β and Forms a Cytokine-inducible Gene-silencing Complex with NF-κB p65 and Interferon Regulatory Factor-1
inferredcites →https://doi.org/10.1074/jbc.m304266200openalex-snapshot
TWEAK Induces NF-κB2 p100 Processing and Long Lasting NF-κB Activation
inferredcites →https://doi.org/10.1074/jbc.m309552200openalex-snapshot
Tumor Necrosis Factor-α Inhibits Endothelial Nitric-oxide Synthase Gene Promoter Activity in Bovine Aortic Endothelial Cells
inferredcites →https://doi.org/10.1074/jbc.m509039200openalex-snapshot
Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦
inferredcites →https://doi.org/10.1093/ndt/gfi165openalex-snapshot
Klotho reduces apoptosis in experimental ischaemic acute renal failure
inferredcites →https://doi.org/10.1097/01.mnh.0000172716.41853.1eopenalex-snapshot
Recent findings in phosphate homeostasis
inferredcites →https://doi.org/10.1111/j.1582-4934.2009.00766.xopenalex-snapshot
Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia
inferredcites →https://doi.org/10.1111/j.1600-6143.2008.02536.xopenalex-snapshot
Upregulation of TNF Receptor Type 2 in Human and Experimental Renal Allograft Rejection
inferredcites →https://doi.org/10.1126/science.1112766openalex-snapshot
Suppression of Aging in Mice by the Hormone Klotho
inferredcites →https://doi.org/10.1126/science.1143578openalex-snapshot
Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging
inferredcites →https://doi.org/10.1128/mcb.21.20.7065-7077.2001openalex-snapshot
The p65 (RelA) Subunit of NF-κB Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression
inferredcites →https://doi.org/10.1152/ajpheart.01100.2006openalex-snapshot
Tumor necrosis factor-α reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells
inferredcites →https://doi.org/10.1152/ajprenal.90746.2008openalex-snapshot
Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-κB p65 signaling
inferredcites →https://doi.org/10.1159/000086500openalex-snapshot
Oxidative Stress Decreases Klotho Expression in a Mouse Kidney Cell Line
inferredcites →https://doi.org/10.1159/000368472openalex-snapshot
Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein
inferredcites →https://doi.org/10.1161/01.hyp.0000013734.33441.eaopenalex-snapshot
In Vivo klotho Gene Transfer Ameliorates Angiotensin II-Induced Renal Damage
inferredcites →https://doi.org/10.1161/01.res.86.12.1266openalex-snapshot
Angiotensin II Activates Nuclear Transcription Factor κB Through AT1and AT2in Vascular Smooth Muscle Cells
inferredcites →https://doi.org/10.1161/01.str.0000230648.00027.00openalex-snapshot
Fn14 Is Upregulated in Cytokine-Stimulated Vascular Smooth Muscle Cells and Is Expressed in Human Carotid Atherosclerotic Plaques
inferredcites →https://doi.org/10.1161/atvbaha.109.194852openalex-snapshot
Tumor Necrosis Factor–Like Weak Inducer of Apoptosis (TWEAK) Enhances Vascular and Renal Damage Induced by Hyperlipidemic Diet in ApoE-Knockout Mice
inferredcites →https://doi.org/10.1186/1476-9255-7-19openalex-snapshot
Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy
inferredcites →https://doi.org/10.1371/journal.pone.0008955openalex-snapshot
TWEAK Activates the Non-Canonical NFκB Pathway in Murine Renal Tubular Cells: Modulation of CCL21
inferredcites →https://doi.org/10.1371/journal.pone.0010192openalex-snapshot
Epigenetic Mechanisms Regulate MHC and Antigen Processing Molecules in Human Embryonic and Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.1681/01.asn.0000926868.48235.3dopenalex-snapshot
The Antisenescence Protein Klotho Is Necessary for FGF23-Induced Phosphaturia
inferredcites →https://doi.org/10.1681/asn.2004121089openalex-snapshot
Proliferation of Bone Marrow-Derived Cells Contributes to Regeneration after Folic Acid-Induced Acute Tubular Injury
inferredcites →https://doi.org/10.1681/asn.2005070690openalex-snapshot
Role of Parathyroid Hormone–Related Protein in Tubulointerstitial Apoptosis and Fibrosis after Folic Acid–Induced Nephrotoxicity
inferredcites →https://doi.org/10.1681/asn.2007050577openalex-snapshot
The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation
inferredcites →https://doi.org/10.1681/asn.2007121336openalex-snapshot
Mechanisms of Renal Apoptosis in Health and Disease
inferredcites →https://doi.org/10.1681/asn.2009020227openalex-snapshot
BASP1 Promotes Apoptosis in Diabetic Nephropathy
inferredcites →https://doi.org/10.1681/asn.2009040427openalex-snapshot
FGF23 Fails to Inhibit Uremic Parathyroid Glands
inferredcites →https://doi.org/10.2215/cjn.02790608openalex-snapshot
Additive Effects of Soluble TWEAK and Inflammation on Mortality in Hemodialysis Patients
inferredcites →https://doi.org/10.2215/cjn.03670807openalex-snapshot
Emerging Biomarkers for Evaluating Cardiovascular Risk in the Chronic Kidney Disease Patient
inferredcites →https://doi.org/10.2353/ajpath.2006.050634openalex-snapshot
Attenuation of Folic Acid-Induced Renal Inflammatory Injury in Platelet-Activating Factor Receptor-Deficient Mice
inferredcites →https://doi.org/10.2353/ajpath.2009.080884openalex-snapshot
Decrease in Tumor Necrosis Factor-α Receptor-Associated Death Domain Results from Ubiquitin-Dependent Degradation in Obstructive Renal Injury in Rats
inferredcites →https://doi.org/10.2741/1395openalex-snapshot
The role of TWEAK/Fn14 IN the pathogenesis of inflammation and systemic autoimmunity
inferredcites →https://doi.org/10.4049/jimmunol.163.10.5617openalex-snapshot
The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex
inferredcites →https://doi.org/10.4049/jimmunol.178.2.771openalex-snapshot
Klotho—a Common Link in Physiological and Rheumatoid Arthritis-Related Aging of Human CD4+ Lymphocytes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/iub.2667openalex-snapshot
Stem cell genes in atheromatosis: The role of Klotho, HIF1α, OCT4, and BMP4
inferred← citeshttps://doi.org/10.1002/jbmr.2585openalex-snapshot
Disturbances in Bone Largely Predict Aortic Calcification in an Alternative Rat Model Developed to Study Both Vascular and Bone Pathology in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1002/jbt.23483openalex-snapshot
TWEAK promotes inflammatory response in liver fibrosis
inferred← citeshttps://doi.org/10.1002/jcb.26511openalex-snapshot
Upregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF‐κB in glomerular mesangial cells
inferred← citeshttps://doi.org/10.1002/jcp.27797openalex-snapshot
The role of nitric oxide signaling in renoprotective effects of hydrogen sulfide against chronic kidney disease in rats: Involvement of oxidative stress, autophagy and apoptosis
inferred← citeshttps://doi.org/10.1002/path.5011openalex-snapshot
Podocytes are new cellular targets of haemoglobin‐mediated renal damage
inferred← citeshttps://doi.org/10.1002/path.5282openalex-snapshot
PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI
inferred← citeshttps://doi.org/10.1002/path.5631openalex-snapshot
TWEAK–Fn14 as a common pathway in the heart and the kidneys in cardiorenal syndrome
inferred← citeshttps://doi.org/10.1007/978-3-030-91623-7_7openalex-snapshot
Phosphate and Cellular Senescence
inferred← citeshttps://doi.org/10.1007/978-3-642-30018-9_198openalex-snapshot
Reactive Oxygen Species as Potential Mediators of Obesity-Related Cardiovascular Complications
inferred← citeshttps://doi.org/10.1007/978-94-007-7696-8_44openalex-snapshot
Soluble Klotho as Biomarker of Vascular Dysfunction in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1007/978-94-007-7740-8_44-1openalex-snapshot
Soluble Klotho as a Biomarker of Vascular Dysfunction in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1007/s00018-019-03241-yopenalex-snapshot
αKlotho–FGF23 interactions and their role in kidney disease: a molecular insight
inferred← citeshttps://doi.org/10.1007/s00109-018-1644-7openalex-snapshot
Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury
inferred← citeshttps://doi.org/10.1007/s00109-021-02044-8openalex-snapshot
Epigenetic modifications of Klotho expression in kidney diseases
inferred← citeshttps://doi.org/10.1007/s00134-025-08035-4openalex-snapshot
State of the art: Renal recovery after AKI - from basic science to clinical practice
inferred← citeshttps://doi.org/10.1007/s00204-014-1282-yopenalex-snapshot
Role of Klotho, an antiaging protein, in pulmonary fibrosis
inferred← citeshttps://doi.org/10.1007/s00223-019-00525-0openalex-snapshot
Regulation of α-Klotho Expression by Dietary Phosphate During Growth Periods
inferred← citeshttps://doi.org/10.1007/s00393-019-00718-wopenalex-snapshot
The anti-aging protein alpha-Klotho in systemic sclerosis patients: does a relationship to telangiectasia exist?
inferred← citeshttps://doi.org/10.1007/s00424-019-02255-6openalex-snapshot
Renal ischemia-reperfusion injury impairs renal calcium, magnesium, and phosphate handling in mice
inferred← citeshttps://doi.org/10.1007/s00774-015-0706-yopenalex-snapshot
Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate
inferred← citeshttps://doi.org/10.1007/s11033-020-05591-4openalex-snapshot
Parthenolide ameliorates tweak-induced podocytes injury
inferred← citeshttps://doi.org/10.1007/s11255-012-0271-4openalex-snapshot
Cardiovascular risk biomarkers in CKD: the inflammation link and the road less traveled
inferred← citeshttps://doi.org/10.1007/s11255-013-0520-1openalex-snapshot
Unilateral ureteral obstruction: beyond obstruction
inferred← citeshttps://doi.org/10.1007/s11255-016-1325-9openalex-snapshot
Klotho, the Holy Grail of the kidney: from salt sensitivity to chronic kidney disease
inferred← citeshttps://doi.org/10.1007/s11255-016-1474-xopenalex-snapshot
The metabolic hormone FGF21 is associated with endothelial dysfunction in hemodialysis patients
inferred← citeshttps://doi.org/10.1007/s11255-017-1646-3openalex-snapshot
Klotho levels: association with insulin resistance and albumin-to-creatinine ratio in type 2 diabetic patients
inferred← citeshttps://doi.org/10.1007/s12031-018-1058-6openalex-snapshot
Differential Expression of Klotho in the Brain and Spinal Cord is Associated with Total Antioxidant Capacity in Mice with Experimental Autoimmune Encephalomyelitis
inferred← citeshttps://doi.org/10.1007/s12035-021-02313-0openalex-snapshot
Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies
inferred← citeshttps://doi.org/10.1007/s12291-022-01078-0openalex-snapshot
Role of Klotho Protein in Neuropsychiatric Disorders: A Narrative Review
inferred← citeshttps://doi.org/10.1007/s12325-019-01180-5openalex-snapshot
Albuminuria Downregulation of the Anti-Aging Factor Klotho: The Missing Link Potentially Explaining the Association of Pathological Albuminuria with Premature Death
inferred← citeshttps://doi.org/10.1007/s40265-014-0224-6openalex-snapshot
Next-Generation Phosphate Binders: Focus on Iron-Based Binders
inferred← citeshttps://doi.org/10.1007/s40265-018-0942-2openalex-snapshot
The Future of IL-1 Targeting in Kidney Disease
inferred← citeshttps://doi.org/10.1007/s42000-024-00586-3openalex-snapshot
Fibroblast growth-factor 23-Klotho axis is associated with systemic inflammation and myokine profile in children with chronic kidney disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-805376-8.00021-6openalex-snapshot
Anti-inflammatory Dietary Ingredients, Medicinal Plants, and Herbs Exert Beneficial Health Effects in Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-812504-5.00007-6openalex-snapshot
Kidney Damage in Obese Subjects
inferred← citeshttps://doi.org/10.1016/b978-0-12-818036-5.00011-2openalex-snapshot
α-Klotho gene and protein measurements in humans and their role as a clinical biomarker of disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-823318-4.00005-6openalex-snapshot
Therapeutic cell reconditioning
inferred← citeshttps://doi.org/10.1016/b978-0-12-823931-5.00016-5openalex-snapshot
Role of histone modifications in the development of acute kidney injury
inferred← citeshttps://doi.org/10.1016/b978-0-12-824069-4.00004-5openalex-snapshot
Biomarkers for ischemia reperfusion injury and delayed graft function
inferred← citeshttps://doi.org/10.1016/b978-0-323-44942-7.00029-7openalex-snapshot
Maladaptive Repair and Progression to CKD
inferred← citeshttps://doi.org/10.1016/bs.acc.2020.09.005openalex-snapshot
Epigenetics in kidney diseases
inferred← citeshttps://doi.org/10.1016/bs.vh.2016.02.004openalex-snapshot
Klotho Is a Neuroprotective and Cognition-Enhancing Protein
inferred← citeshttps://doi.org/10.1016/bs.vh.2016.02.005openalex-snapshot
Klotho Prevents Translocation of NFκB
inferred← citeshttps://doi.org/10.1016/bs.vh.2016.02.007openalex-snapshot
αKlotho and Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1016/j.abb.2025.110480openalex-snapshot
High-intensity interval training elicits superior effects than continuous training to improve renal redox status via klotho and Nrf2 signaling in female rats with cisplatin nephrotoxicity
inferred← citeshttps://doi.org/10.1016/j.arr.2017.03.003openalex-snapshot
The relevance of α-KLOTHO to the central nervous system: Some key questions
inferred← citeshttps://doi.org/10.1016/j.bbadis.2016.01.006openalex-snapshot
NFκBiz protein downregulation in acute kidney injury: Modulation of inflammation and survival in tubular cells
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.09.029openalex-snapshot
Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.149357openalex-snapshot
The current and emerging Klotho-enhancement strategies
inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114426openalex-snapshot
Inactivation of Wnt/β-catenin/renin angiotensin axis by tumor necrosis factor-alpha inhibitor, infliximab, ameliorates CKD induced in rats
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116203openalex-snapshot
Butyrate promotes kidney resilience through a coordinated kidney protective response in tubular cells
inferred← citeshttps://doi.org/10.1016/j.biocel.2014.06.002openalex-snapshot
Resveratrol increases anti-aging Klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signaling pathway
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113677openalex-snapshot
Sodium-glucose co-transporter-2 inhibitors increase Klotho in patients with diabetic kidney disease: A clinical and experimental study
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114901openalex-snapshot
Renal fibrosis in type 2 cardiorenal syndrome: An update on mechanisms and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115925openalex-snapshot
Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury
inferred← citeshttps://doi.org/10.1016/j.bone.2017.01.017openalex-snapshot
Potential application of klotho in human chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.clim.2012.08.008openalex-snapshot
Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis
inferred← citeshttps://doi.org/10.1016/j.clinbiochem.2018.03.022openalex-snapshot
Ischemic acute kidney injury and klotho in renal transplantation
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2012.01.004openalex-snapshot
FGF23/Klotho axis: Phosphorus, mineral metabolism and beyond
inferred← citeshttps://doi.org/10.1016/j.ejim.2023.09.010openalex-snapshot
A novel risk factor for malignancy: Albuminuria
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176703openalex-snapshot
The PP2A inhibitor LB-100 mitigates lupus nephritis by suppressing tertiary lymphoid structure formation
inferred← citeshttps://doi.org/10.1016/j.euroneuro.2017.12.012openalex-snapshot
Electroconvulsive therapy enhances the anti-ageing hormone Klotho in the cerebrospinal fluid of geriatric patients with major depression
inferred← citeshttps://doi.org/10.1016/j.ijcard.2017.01.005openalex-snapshot
Activated p300 acetyltransferase activity modulates aortic valvular calcification with osteogenic transdifferentiation and downregulation of Klotho
inferred← citeshttps://doi.org/10.1016/j.intimp.2019.106042openalex-snapshot
The kidney injury caused by the onset of acute graft-versus-host disease is associated with down-regulation of αKlotho
inferred← citeshttps://doi.org/10.1016/j.jdiacomp.2019.107476openalex-snapshot
FGF23-klotho axis as predictive factors of fractures in type 2 diabetics with early chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.jss.2025.02.042openalex-snapshot
Aging Impairs the Capacity of Cardiac Functional Recovery Following Endotoxemia: Modulation of Myocardial Klotho Level for Remedy
inferred← citeshttps://doi.org/10.1016/j.kint.2016.07.040openalex-snapshot
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.kint.2016.10.021openalex-snapshot
Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.kint.2017.02.023openalex-snapshot
Klotho restoration via acetylation of Peroxisome Proliferation–Activated Receptor γ reduces the progression of chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.kint.2017.06.030openalex-snapshot
AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms
inferred← citeshttps://doi.org/10.1016/j.kint.2018.11.021openalex-snapshot
Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome
inferred← citeshttps://doi.org/10.1016/j.kint.2022.02.028openalex-snapshot
Growth differentiation factor-15 preserves Klotho expression in acute kidney injury and kidney fibrosis
inferred← citeshttps://doi.org/10.1016/j.kint.2022.10.030openalex-snapshot
Targeting inflammation to treat diabetic kidney disease: the road to 2030
inferred← citeshttps://doi.org/10.1016/j.kint.2022.11.023openalex-snapshot
The transcription factor Fosl1 preserves Klotho expression and protects from acute kidney injury
inferred← citeshttps://doi.org/10.1016/j.kint.2024.10.031openalex-snapshot
Epigenetic alterations and memory: key players in the development/progression of chronic kidney disease promoted by acute kidney injury and diabetes
inferred← citeshttps://doi.org/10.1016/j.lfs.2018.02.039openalex-snapshot
Lipoxin A4 may attenuate the progression of obesity-related glomerulopathy by inhibiting NF-κB and ERK/p38 MAPK-dependent inflammation
inferred← citeshttps://doi.org/10.1016/j.lfs.2023.121528openalex-snapshot
Lactoferrin alleviates cyclophosphamide induced-nephropathy through suppressing the orchestration between Wnt4/β-catenin and ERK1/2/NF-κB signaling and modulating klotho and Nrf2/HO-1 pathway
inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122866openalex-snapshot
The role of perirenal adipose tissue deposition in chronic kidney disease progression: Mechanisms and therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.mad.2012.09.002openalex-snapshot
Klotho modulates the stress response in human senescent endothelial cells
inferred← citeshttps://doi.org/10.1016/j.mad.2018.07.006openalex-snapshot
Proinflammatory cytokines and ageing of the cardiovascular-renal system
inferred← citeshttps://doi.org/10.1016/j.mce.2021.111254openalex-snapshot
Renin-angiotensin system and inflammation update
inferred← citeshttps://doi.org/10.1016/j.medcli.2012.11.010openalex-snapshot
El sistema del factor de crecimiento fibroblástico 23/Klotho en el contexto del daño cardiovascular
inferred← citeshttps://doi.org/10.1016/j.metabol.2020.154435openalex-snapshot
Roles for fibroblast growth factor-23 and α-Klotho in acute kidney injury
inferred← citeshttps://doi.org/10.1016/j.metabol.2023.155530openalex-snapshot
Upstream and downstream regulators of Klotho expression in chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.molmed.2019.02.005openalex-snapshot
NIK as a Druggable Mediator of Tissue Injury
inferred← citeshttps://doi.org/10.1016/j.nefro.2014.12.003openalex-snapshot
Klotho urinario determinado por ELISA como biomarcador precoz de fracaso renal agudo en pacientes sometidos a cirugía cardiaca o angiografía coronaria
inferred← citeshttps://doi.org/10.1016/j.nefro.2019.03.004openalex-snapshot
MAP3K kinases and kidney injury
inferred← citeshttps://doi.org/10.1016/j.nefro.2019.08.001openalex-snapshot
Efecto regulador de paricalcitol sobre parámetros inflamatorios, fibróticos y anticalcificantes en el paciente con enfermedad renal crónica. Más allá de la regulación de la enfermedad óseo-mineral
inferred← citeshttps://doi.org/10.1016/j.nefro.2020.09.008openalex-snapshot
FGF23: de la nefrología de salón a la cabecera del paciente
inferred← citeshttps://doi.org/10.1016/j.nefro.2021.09.004openalex-snapshot
CKD: The burden of disease invisible to research funders
inferred← citeshttps://doi.org/10.1016/j.nefroe.2014.12.001openalex-snapshot
Urinary Klotho measured by ELISA as an early biomarker of acute kidney injury in patients after cardiac surgery or coronary angiography
inferred← citeshttps://doi.org/10.1016/j.nefroe.2019.12.004openalex-snapshot
MAP3K kinases and kidney injury
inferred← citeshttps://doi.org/10.1016/j.nefroe.2020.03.012openalex-snapshot
Paricalcitol regulatory effect on inflammatory, fibrotic and anticalcificating parameters in renal patient. Far beyond mineral bone disease regulation
inferred← citeshttps://doi.org/10.1016/j.nefroe.2021.08.004openalex-snapshot
FGF23: From academic nephrology to personalized patients’ care
inferred← citeshttps://doi.org/10.1016/j.nefroe.2021.09.005openalex-snapshot
CKD: The burden of disease invisible to research funders
inferred← citeshttps://doi.org/10.1016/j.nephro.2018.09.003openalex-snapshot
Toxines urémiques de moyen poids moléculaire : un véritable regain d’intérêt
inferred← citeshttps://doi.org/10.1016/j.nephro.2019.05.003openalex-snapshot
Potentielle application de l’axe fibroblast growth factor 23-Klotho dans la maladie rénale chronique
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2013.07.019openalex-snapshot
Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2026.03.005openalex-snapshot
The antiaging protein Klotho is a key factor in susceptibility to cerebral ischemia
inferred← citeshttps://doi.org/10.1016/j.numecd.2014.06.006openalex-snapshot
Fish and omega-3 fatty acid intake in relation to circulating fibroblast growth factor 23 levels in renal transplant recipients
inferred← citeshttps://doi.org/10.1016/j.nut.2021.111376openalex-snapshot
Nicotinamide retains Klotho expression and ameliorates rhabdomyolysis-induced acute kidney injury
inferred← citeshttps://doi.org/10.1016/j.nut.2025.112809openalex-snapshot
Association of serum Klotho concentrations with abdominal obesity among middle-aged adults in the US: Evidence from NHANES 2011–2016
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105531openalex-snapshot
αKlotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy
inferred← citeshttps://doi.org/10.1016/j.pmedr.2024.102877openalex-snapshot
Correlation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with serum α-klotho levels in US middle-aged and older individuals: Results from NHANES 2007–2016
inferred← citeshttps://doi.org/10.1016/j.pop.2014.08.008openalex-snapshot
Obesity-related Kidney Disease
inferred← citeshttps://doi.org/10.1016/j.reth.2021.07.003openalex-snapshot
The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis
inferred← citeshttps://doi.org/10.1016/j.semnephrol.2014.09.005openalex-snapshot
New Insights Into the FGF23-Klotho Axis
inferred← citeshttps://doi.org/10.1016/j.semnephrol.2016.03.006openalex-snapshot
Out of the TWEAKlight: Elucidating the Role of Fn14 and TWEAK in Acute Kidney Injury
inferred← citeshttps://doi.org/10.1016/j.semnephrol.2018.02.004openalex-snapshot
Updates on the Mechanisms and the Care of Cardiovascular Calcification in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1016/j.semnephrol.2018.10.005openalex-snapshot
Fibroblast Growth Factor 23 and Klotho in AKI
inferred← citeshttps://doi.org/10.1016/j.semnephrol.2024.151515openalex-snapshot
Acute Kidney Injury and Subsequent Cardiovascular Disease: Epidemiology, Pathophysiology, and Treatment
inferred← citeshttps://doi.org/10.1016/j.tice.2017.06.005openalex-snapshot
SOCS-1 is involved in TNF-α-induced mitochondrial dysfunction and apoptosis in renal tubular epithelial cells
inferred← citeshttps://doi.org/10.1016/j.tox.2023.153657openalex-snapshot
Recombinant Klotho alleviates vancomycin-induced acute kidney injury by upregulating anti-oxidative capacity via JAK2/STAT3/GPx3 axis
inferred← citeshttps://doi.org/10.1016/j.trsl.2022.01.002openalex-snapshot
Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human
inferred← citeshttps://doi.org/10.1016/j.yexcr.2016.03.002openalex-snapshot
Short-term preconditioning enhances the therapeutic potential of adipose-derived stromal/stem cell-conditioned medium in cisplatin-induced acute kidney injury
inferred← citeshttps://doi.org/10.1016/s0140-6736(13)61165-4openalex-snapshot
The demise of calcium-based phosphate binders
inferred← citeshttps://doi.org/10.1016/s0140-6736(14)60384-6openalex-snapshot
Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure
inferred← citeshttps://doi.org/10.1016/s2213-8587(15)00092-3openalex-snapshot
Humble kidneys predict mighty heart troubles
inferred← citeshttps://doi.org/10.1017/s000711452000358xopenalex-snapshot
The effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence
inferred← citeshttps://doi.org/10.1038/cddis.2016.220openalex-snapshot
TWEAK favors phosphate-induced calcification of vascular smooth muscle cells through canonical and non-canonical activation of NFκB
inferred← citeshttps://doi.org/10.1038/emm.2017.89openalex-snapshot
Bcl3: a regulator of NF-κB inducible by TWEAK in acute kidney injury with anti-inflammatory and antiapoptotic properties in tubular cells
inferred← citeshttps://doi.org/10.1038/ki.2013.489openalex-snapshot
Klotho has dual protective effects on cisplatin-induced acute kidney injury
inferred← citeshttps://doi.org/10.1038/ki.2015.332openalex-snapshot
The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury
inferred← citeshttps://doi.org/10.1038/nrneph.2012.92openalex-snapshot
Klotho as a potential biomarker and therapy for acute kidney injury
inferred← citeshttps://doi.org/10.1038/s41371-022-00751-4openalex-snapshot
Hypertension and cardiomyopathy associated with chronic kidney disease: epidemiology, pathogenesis and treatment considerations
inferred← citeshttps://doi.org/10.1038/s41418-020-00631-9openalex-snapshot
Histone deacetylase 3 aberration inhibits Klotho transcription and promotes renal fibrosis
inferred← citeshttps://doi.org/10.1038/s41581-018-0101-8openalex-snapshot
Evolving concepts in the pathogenesis of uraemic cardiomyopathy
inferred← citeshttps://doi.org/10.1038/s41581-018-0103-6openalex-snapshot
Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications
inferred← citeshttps://doi.org/10.1038/s41581-019-0248-yopenalex-snapshot
Targeting the progression of chronic kidney disease
inferred← citeshttps://doi.org/10.1038/s41581-024-00837-xopenalex-snapshot
Post-translational modifications in kidney diseases and associated cardiovascular risk
inferred← citeshttps://doi.org/10.1038/s41598-022-12548-zopenalex-snapshot
Klotho expression in peripheral blood circulating cells is associated with vascular and systemic inflammation in atherosclerotic vascular disease
inferred← citeshttps://doi.org/10.1038/s41598-024-64050-3openalex-snapshot
L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database
inferred← citeshttps://doi.org/10.1038/s41598-024-85018-3openalex-snapshot
Sex differences in the association between serum α-Klotho levels and hyperlipidemia: a cross-sectional study from NHANES 2013–2016
inferred← citeshttps://doi.org/10.1038/s41598-025-88015-2openalex-snapshot
Systemic immune-inflammation index mediates the association between abdominal obesity and serum klotho levels
inferred← citeshttps://doi.org/10.1038/srep46195openalex-snapshot
Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice
inferred← citeshttps://doi.org/10.1038/tp.2015.81openalex-snapshot
Longevity factor klotho and chronic psychological stress
inferred← citeshttps://doi.org/10.1039/c9fo01821bopenalex-snapshot
Identifying mechanisms underlying the amelioration effect of Chrysanthemum morifolium Ramat. ‘ Boju ’ extract on hyperuricemia using biochemical characterization and UPLC-ESI-QTOF/MS-based metabolomics
inferred← citeshttps://doi.org/10.1042/cs20150273openalex-snapshot
Klotho expression is reduced in COPD airway epithelial cells: effects on inflammation and oxidant injury
inferred← citeshttps://doi.org/10.1042/cs20160395openalex-snapshot
Translational science in chronic kidney disease
inferred← citeshttps://doi.org/10.1042/cs20171242openalex-snapshot
Soluble levels and endogenous vascular gene expression of KLOTHO are related to inflammation in human atherosclerotic disease
inferred← citeshttps://doi.org/10.1042/cs20181116openalex-snapshot
TRAIL, OPG, and TWEAK in kidney disease: biomarkers or therapeutic targets?
inferred← citeshttps://doi.org/10.1042/cs20190779openalex-snapshot
Inflammation both increases and causes resistance to FGF23 in normal and uremic rats
inferred← citeshttps://doi.org/10.1053/j.ajkd.2012.11.051openalex-snapshot
Chronic Kidney Disease: A Clinical Model of Premature Aging
inferred← citeshttps://doi.org/10.1053/j.ajkd.2013.02.379openalex-snapshot
Blood Pressure, Proteinuria, and Phosphate as Risk Factors for Progressive Kidney Disease: A Hypothesis
inferred← citeshttps://doi.org/10.1053/j.jrn.2014.06.009openalex-snapshot
In Chronic Kidney Disease, Serum α-Klotho is Related to Serum Bicarbonate and Proteinuria
inferred← citeshttps://doi.org/10.1074/jbc.m112.410357openalex-snapshot
Nuclear Factor κB Mediates Suppression of Canonical Transient Receptor Potential 6 Expression by Reactive Oxygen Species and Protein Kinase C in Kidney Cells
inferred← citeshttps://doi.org/10.1074/jbc.m115.655431openalex-snapshot
Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease
inferred← citeshttps://doi.org/10.1080/0886022x.2024.2385059openalex-snapshot
Systemic immunoinflammatory indexes in albuminuric adults are negatively associated with α-klotho: evidence from NHANES 2007–2016
inferred← citeshttps://doi.org/10.1080/13543784.2016.1196184openalex-snapshot
Targeting inflammation in diabetic kidney disease: early clinical trials
inferred← citeshttps://doi.org/10.1080/15548627.2024.2323785openalex-snapshot
Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex
inferred← citeshttps://doi.org/10.1080/17460441.2020.1690450openalex-snapshot
Design and optimization strategies for the development of new drugs that treat chronic kidney disease
inferred← citeshttps://doi.org/10.1089/rej.2019.2183openalex-snapshot
Decreased Levels of Anti-Aging Klotho in Obstructive Sleep Apnea
inferred← citeshttps://doi.org/10.1093/ckj/sfaa071openalex-snapshot
Bisphenol S is a haemodialysis-associated xenobiotic that is less toxic than bisphenol A
inferred← citeshttps://doi.org/10.1093/ckj/sfaa100openalex-snapshot
Klotho: a link between cardiovascular and non-cardiovascular mortality
inferred← citeshttps://doi.org/10.1093/ckj/sfab170openalex-snapshot
RICORS2040: the need for collaborative research in chronic kidney disease
inferred← citeshttps://doi.org/10.1093/ckj/sfac113openalex-snapshot
From cardiorenal syndromes to cardionephrology: a reflection by nephrologists on renocardiac syndromes
inferred← citeshttps://doi.org/10.1093/ckj/sfac143openalex-snapshot
Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease
inferred← citeshttps://doi.org/10.1093/ckj/sfad093openalex-snapshot
Is there a role in acute kidney injury for FGF23 and Klotho?
inferred← citeshttps://doi.org/10.1093/ckj/sfad259openalex-snapshot
Tubulo-interstitial inflammation increases the risk of graft loss after the recurrence of IgA nephropathy
inferred← citeshttps://doi.org/10.1093/ckj/sfad276openalex-snapshot
Klotho: a potential therapeutic target in aging and neurodegeneration beyond chronic kidney disease—a comprehensive review from the ERA CKD-MBD working group
inferred← citeshttps://doi.org/10.1093/ckj/sfz106openalex-snapshot
A journey from microenvironment to macroenvironment: the role of metaflammation and epigenetic changes in cardiorenal disease
inferred← citeshttps://doi.org/10.1093/ckj/sfz125openalex-snapshot
Klotho, the elusive kidney-derived anti-ageing factor
inferred← citeshttps://doi.org/10.1093/ckj/sfz161openalex-snapshot
Diabetes mellitus: a single cardiorenal syndrome umbrella
inferred← citeshttps://doi.org/10.1093/gerona/glu170openalex-snapshot
Klotho Prevents NFκB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia
inferred← citeshttps://doi.org/10.1093/hmg/ddab263openalex-snapshot
GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels
inferred← citeshttps://doi.org/10.1093/hmg/ddx380openalex-snapshot
Macrophages escape Klotho gene silencing in the mdx mouse model of Duchenne muscular dystrophy and promote muscle growth and increase satellite cell numbers through a Klotho-mediated pathway
inferred← citeshttps://doi.org/10.1093/jpp/rgab129openalex-snapshot
Retracted: Potential therapeutic efficacy of pachymic acid in chronic kidney disease induced in rats: role of Wnt/β-catenin/renin–angiotensin axis
inferred← citeshttps://doi.org/10.1093/ndt/gfae253openalex-snapshot
The role of the intestinal microbiome in cognitive decline in patients with kidney disease
inferred← citeshttps://doi.org/10.1093/ndt/gfaf272openalex-snapshot
Nephrotic syndrome in mice elevates FGF23 levels and leads to cardiac hypertrophy in the absence of hyperphosphatemia
inferred← citeshttps://doi.org/10.1093/ndt/gfs160openalex-snapshot
The emerging role of Klotho in clinical nephrology
inferred← citeshttps://doi.org/10.1093/ndt/gfs426openalex-snapshot
Klotho, phosphate and inflammation/ageing in chronic kidney disease
inferred← citeshttps://doi.org/10.1093/ndt/gft342openalex-snapshot
TWEAK and the progression of renal disease: clinical translation
inferred← citeshttps://doi.org/10.1093/ndt/gft367openalex-snapshot
p-Cresyl sulphate has pro-inflammatory and cytotoxic actions on human proximal tubular epithelial cells
inferred← citeshttps://doi.org/10.1093/ndt/gft368openalex-snapshot
Vascular calcification in chronic kidney disease: are biomarkers useful for probing the pathobiology and the health risks of this process in the clinical scenario?
inferred← citeshttps://doi.org/10.1093/ndt/gfu291openalex-snapshot
The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody
inferred← citeshttps://doi.org/10.1093/ndt/gfx376openalex-snapshot
Albumin downregulates Klotho in tubular cells
inferred← citeshttps://doi.org/10.1093/ndt/gfx379openalex-snapshot
New insights into the key role of interleukin 6 in vascular calcification of chronic kidney disease
inferred← citeshttps://doi.org/10.1093/ndt/gfy009openalex-snapshot
Targeting epigenetic DNA and histone modifications to treat kidney disease
inferred← citeshttps://doi.org/10.1093/ndt/gfy367openalex-snapshot
MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells
inferred← citeshttps://doi.org/10.1093/ndt/gfz169openalex-snapshot
Loss of NLRP6 expression increases the severity of acute kidney injury
inferred← citeshttps://doi.org/10.1096/fj.12-211631openalex-snapshot
Promoter methylation confers kidney‐specific expression of the Klotho gene
inferred← citeshttps://doi.org/10.1096/fj.201700006ropenalex-snapshot
Differential regulation of renal Klotho and FGFR1 in normal and uremic rats
inferred← citeshttps://doi.org/10.1096/fj.201900077ropenalex-snapshot
Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis‐mediated cell death
inferred← citeshttps://doi.org/10.1096/fj.201902446ropenalex-snapshot
IRF‐1 promotes renal fibrosis by downregulation of Klotho
inferred← citeshttps://doi.org/10.1097/01.mnh.0000437331.23794.81openalex-snapshot
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and kidney disease
inferred← citeshttps://doi.org/10.1097/imna-d-24-00021openalex-snapshot
The Protective Function of αKlotho in Chronic Kidney Disease: Evidence and Therapeutic Implications
inferred← citeshttps://doi.org/10.1097/mnh.0000000000000231openalex-snapshot
The role of fibroblast growth factor 23 and Klotho in uremic cardiomyopathy
inferred← citeshttps://doi.org/10.1097/mnh.0b013e32836213eeopenalex-snapshot
FGF23 and Klotho in chronic kidney disease
inferred← citeshttps://doi.org/10.1097/tp.0000000000004331openalex-snapshot
The Value of Klotho in Kidney Transplantation
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