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Inhibition of lysyl oxidase-like 1 (LOXL1) expression arrests liver fibrosis progression in cirrhosis by reducing elastin crosslinking
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hep.20425openalex-snapshot
Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats
inferredcites →https://doi.org/10.1002/hep.21868openalex-snapshot
ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride–induced hepatic fibrosis in mice
inferredcites →https://doi.org/10.1002/hep.25567openalex-snapshot
Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis
inferredcites →https://doi.org/10.1002/hep.26326openalex-snapshot
Elastin-based molecular MRI of liver fibrosis
inferredcites →https://doi.org/10.1002/hep.27320openalex-snapshot
Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma
inferredcites →https://doi.org/10.1002/jcb.10413openalex-snapshot
Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell
inferredcites →https://doi.org/10.1016/j.ajpath.2013.01.036openalex-snapshot
Antifibrotic Effects of a Recombinant Adeno-Associated Virus Carrying Small Interfering RNA Targeting TIMP-1 in Rat Liver Fibrosis
inferredcites →https://doi.org/10.1016/j.bbadis.2012.11.002openalex-snapshot
Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation
inferredcites →https://doi.org/10.1016/j.biomaterials.2004.04.016openalex-snapshot
Evaluation of the matrix-synthesis potential of crosslinked hyaluronan gels for tissue engineering of aortic heart valves
inferredcites →https://doi.org/10.1016/j.biomaterials.2008.07.022openalex-snapshot
The expression of cross-linked elastin by rabbit blood vessel smooth muscle cells cultured in polyhydroxyalkanoate scaffolds
inferredcites →https://doi.org/10.1016/j.bpg.2017.04.005openalex-snapshot
Reversal of liver fibrosis: From fiction to reality
inferredcites →https://doi.org/10.1016/j.jbiomech.2014.12.005openalex-snapshot
Collagen crosslinking does not dictate stiffness in a transgenic mouse model of skeletal muscle fibrosis
inferredcites →https://doi.org/10.1016/j.jchromb.2015.03.004openalex-snapshot
A sensitive and rapid HPLC–MS/MS method for the quantitative determination of trace amount of bromocriptine in small clinical prolactinoma tissue
inferredcites →https://doi.org/10.1016/j.jhep.2005.02.052openalex-snapshot
Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2
inferredcites →https://doi.org/10.1016/s0021-9258(19)86269-5openalex-snapshot
Evidence that tropoelastin is the primary precursor in elastin biosynthesis.
inferredcites →https://doi.org/10.1016/s0079-6603(01)70012-8openalex-snapshot
Lysyl oxidases: A novel multifunctional amine oxidase family
inferredcites →https://doi.org/10.1016/s0945-053x(03)00017-9openalex-snapshot
Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells
inferredcites →https://doi.org/10.1038/ng1297openalex-snapshot
Elastic fiber homeostasis requires lysyl oxidase–like 1 protein
inferredcites →https://doi.org/10.1038/srep27398openalex-snapshot
The alterations in the extracellular matrix composition guide the repair of damaged liver tissue
inferredcites →https://doi.org/10.1053/j.gastro.2004.03.009openalex-snapshot
Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking☆
inferredcites →https://doi.org/10.1053/j.gastro.2011.01.040openalex-snapshot
Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice
inferredcites →https://doi.org/10.1073/pnas.1017834108openalex-snapshot
Substantial expression of mature elastin in arterial constructs
inferredcites →https://doi.org/10.1074/jbc.m506832200openalex-snapshot
The Pro-regions of Lysyl Oxidase and Lysyl Oxidase-like 1 Are Required for Deposition onto Elastic Fibers
inferredcites →https://doi.org/10.1096/fj.14-268425openalex-snapshot
Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice
inferredcites →https://doi.org/10.1111/j.1440-1827.2008.02274.xopenalex-snapshot
Newly proposed fibrosis staging criterion for assessing carbon tetrachloride‐ and albumin complex‐induced liver fibrosis in rodents
inferredcites →https://doi.org/10.1111/liv.12247openalex-snapshot
Relaxin decreases the severity of established hepatic fibrosis in mice
inferredcites →https://doi.org/10.1136/gut.2004.042127openalex-snapshot
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
inferredcites →https://doi.org/10.1136/gutjnl-2016-312473openalex-snapshot
Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
inferredcites →https://doi.org/10.1152/ajpgi.00032.2007openalex-snapshot
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
inferredcites →https://doi.org/10.1152/ajpgi.00447.2014openalex-snapshot
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis
inferredcites →https://doi.org/10.1152/physrev.00013.2007openalex-snapshot
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
inferredcites →https://doi.org/10.1155/2016/1492694openalex-snapshot
TGF‐β1 Induces the Dual Regulation of Hepatic Progenitor Cells with Both Anti‐ and Proliver Fibrosis
inferredcites →https://doi.org/10.1167/iovs.14-14214openalex-snapshot
Elastin Development-Associated Extracellular Matrix Constituents of Subepithelial Connective Tissue in Human Pterygium
inferredcites →https://doi.org/10.1172/jci30542openalex-snapshot
Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
inferredcites →https://doi.org/10.1371/journal.pone.0154558openalex-snapshot
Elastin Fiber Accumulation in Liver Correlates with the Development of Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1517/13543784.2015.1057568openalex-snapshot
Current drugs in early development for treating hepatitis C virus-related hepatic fibrosis
inferredcites →https://doi.org/10.1517/14728222.2016.1151003openalex-snapshot
Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer
inferredcites →https://doi.org/10.3389/fphys.2016.00047openalex-snapshot
Promising Therapy Candidates for Liver Fibrosis
inferredcites →https://doi.org/10.3892/mmr.2016.5474openalex-snapshot
The effect of LOXL2 in hepatocellular carcinoma
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4654347openalex-extracted
Inhibition of Lysyl Oxidase Family of Enzymes Has No Effect on Healthy Fibroblast – Extracellular Matrix Cross-Talk in vitro
inferred← citeshttps://doi.org/10.1002/adts.202300859openalex-snapshot
Conformation Changes Associated with the Formation and Activation of Lysine Tyrosylquinone of LOXL2 Studied by Metadynamics Simulation
inferred← citeshttps://doi.org/10.1002/advs.202401254openalex-snapshot
Reactive Oxygen Species‐Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression
inferred← citeshttps://doi.org/10.1002/hep.31236openalex-snapshot
Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis
inferred← citeshttps://doi.org/10.1002/jcp.28827openalex-snapshot
Dynamics of elastin in liver fibrosis: Accumulates late during progression and degrades slowly in regression
inferred← citeshttps://doi.org/10.1002/jcp.30915openalex-snapshot
Intercellular communication among liver cells in the perisinusoidal space of the injured liver: Pathophysiology and therapeutic directions
inferred← citeshttps://doi.org/10.1002/osi2.1182openalex-snapshot
Collagen cross‐linking in oral cancer
inferred← citeshttps://doi.org/10.1007/978-1-4939-9133-4_21openalex-snapshot
Novel Approaches for Extracellular Matrix Targeting in Disease Treatment
inferred← citeshttps://doi.org/10.1007/978-3-032-05273-5_11openalex-snapshot
Collagen in Fibrotic Diseases
inferred← citeshttps://doi.org/10.1007/s00018-025-05647-3openalex-snapshot
Fibulin-1 deficiency alleviates liver fibrosis by inhibiting hepatic stellate cell activation via the p38 MAPK pathway
inferred← citeshttps://doi.org/10.1007/s00109-024-02448-2openalex-snapshot
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review
inferred← citeshttps://doi.org/10.1007/s12026-022-09267-yopenalex-snapshot
Research progress on drugs targeting the TGF-β signaling pathway in fibrotic diseases
inferred← citeshttps://doi.org/10.1007/s12072-021-10210-wopenalex-snapshot
Hepatic stellate cells-specific LOXL1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice
inferred← citeshttps://doi.org/10.1007/s12291-019-00845-wopenalex-snapshot
Carvacrol Downregulates Lysyl Oxidase Expression and Ameliorates Oxidative Stress in the Liver of Rats with Carbon Tetrachloride‐Induced Liver Fibrosis
inferred← citeshttps://doi.org/10.1007/s13577-023-00889-4openalex-snapshot
Identification of LBH and SPP1 involved in hepatic stellate cell activation during liver fibrogenesis
inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115740openalex-snapshot
Targeting collagen homeostasis for the treatment of liver fibrosis: Opportunities and challenges
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.08.156openalex-snapshot
Knockdown of LOXL1 inhibits TGF-β1-induced proliferation and fibrogenesis of hepatic stellate cells by inhibition of Smad2/3 phosphorylation
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110791openalex-snapshot
Lysyl oxidases: Emerging biomarkers and therapeutic targets for various diseases
inferred← citeshttps://doi.org/10.1016/j.ejcb.2025.151527openalex-snapshot
The role of the LOX family in cancer
inferred← citeshttps://doi.org/10.1016/j.exer.2019.107818openalex-snapshot
The role of lysyl oxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma
inferred← citeshttps://doi.org/10.1016/j.exer.2020.107975openalex-snapshot
Lysyl Oxidase Like 1: Biological roles and regulation
inferred← citeshttps://doi.org/10.1016/j.fct.2020.111556openalex-snapshot
The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix
inferred← citeshttps://doi.org/10.1016/j.isci.2024.110426openalex-snapshot
A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2025.101637openalex-snapshot
Targeting LOXL1-expressing Hepatic Stellate Cell Inhibits Fibrogenesis and Sinusoid Angiogenesis via LOXL1/RUNX1/VEGFA Axis During Progression of Liver Fibrosis
inferred← citeshttps://doi.org/10.1016/j.jconrel.2026.115080openalex-snapshot
Harnessing extracellular niche for liver regeneration: Mechanobiological and immunological unmet needs in decellularised hydrogel-based strategies
inferred← citeshttps://doi.org/10.1016/j.jhepr.2024.101195openalex-snapshot
Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo
inferred← citeshttps://doi.org/10.1016/j.jtcme.2023.12.002openalex-snapshot
The chemical composition of Diwu YangGan capsule and its potential inhibitory roles on hepatocellular carcinoma by microarray-based transcriptomics
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119144openalex-snapshot
MiR-15b and miR-16 suppress TGF-β1-induced proliferation and fibrogenesis by regulating LOXL1 in hepatic stellate cells
inferred← citeshttps://doi.org/10.1016/j.matbio.2022.06.006openalex-snapshot
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues
inferred← citeshttps://doi.org/10.1016/j.mbplus.2022.100120openalex-snapshot
Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice
inferred← citeshttps://doi.org/10.1016/j.mbplus.2022.100127openalex-snapshot
Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2
inferred← citeshttps://doi.org/10.1016/j.tice.2024.102559openalex-snapshot
Impact of heterogeneity in liver matrix and intrahepatic cells on the progression of hepatic fibrosis
inferred← citeshttps://doi.org/10.1016/j.xcrm.2023.101170openalex-snapshot
The extracellular matrix in hepatocellular carcinoma: Mechanisms and therapeutic vulnerability
inferred← citeshttps://doi.org/10.1016/j.ymeth.2018.12.009openalex-snapshot
Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure
inferred← citeshttps://doi.org/10.1051/fopen/2018009openalex-snapshot
Precancerous niche (PCN), a product of fibrosis with remodeling by incessant chronic inflammation
inferred← citeshttps://doi.org/10.1080/15569543.2020.1813779openalex-snapshot
Human umbilical cord-derived mesenchymal stem cells conditioned medium ameliorates CCl4-induced liver fibrosis through regulation of expression and activity of liver lysyl oxidase
inferred← citeshttps://doi.org/10.1096/fj.202100374ropenalex-snapshot
Selective depletion of hepatic stellate cells‐specific LOXL1 alleviates liver fibrosis
inferred← citeshttps://doi.org/10.1097/hc9.0000000000000391openalex-snapshot
Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal
inferred← citeshttps://doi.org/10.1097/md.0000000000038470openalex-snapshot
Identification of hub genes related to metastasis and prognosis of osteosarcoma and establishment of a prognostic model with bioinformatic methods
inferred← citeshttps://doi.org/10.1101/2022.07.08.499292openalex-snapshot
Collagen content and cross-links scale with passive stiffness in dystrophic mouse muscles, but are not altered with administration of collagen cross-linking inhibitor beta-aminopropionitrile
inferred← citeshttps://doi.org/10.1101/2025.04.22.649109openalex-snapshot
CREB5 promotes immunotherapy resistance via tumor-intrinsic collagen matrix deposition
inferred← citeshttps://doi.org/10.1111/apt.15773openalex-snapshot
Review article: the signalling and functional role of the extracellular matrix in the development of liver fibrosis
inferred← citeshttps://doi.org/10.1111/bph.70139openalex-snapshot
Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol‐related liver fibrosis
inferred← citeshttps://doi.org/10.1111/febs.70418openalex-snapshot
Decoding ECM remodeling: proteases as gatekeepers of Lysyl oxidase family‐mediated crosslinking
inferred← citeshttps://doi.org/10.1126/sciadv.adf0133openalex-snapshot
LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung
inferred← citeshttps://doi.org/10.1136/egastro-2023-100040openalex-snapshot
Extracellular vesicles targeting non-parenchymal cells: the therapeutical effect on liver fibrosis
inferred← citeshttps://doi.org/10.1152/ajpcell.00060.2023openalex-snapshot
Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity
inferred← citeshttps://doi.org/10.1152/ajpgi.00004.2023openalex-snapshot
Selective inhibition of hepatic stellate cell and fibroblast-derived LOXL1 attenuates BDL- and Mdr2 −/− -induced cholestatic liver fibrosis
inferred← citeshttps://doi.org/10.1167/iovs.65.13.33openalex-snapshot
Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts
inferred← citeshttps://doi.org/10.1186/s12864-023-09179-7openalex-snapshot
Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome
inferred← citeshttps://doi.org/10.1186/s12885-024-12973-5openalex-snapshot
Matrix stiffness-related extracellular matrix signatures and the DYNLL1 protein promote hepatocellular carcinoma progression through the Wnt/β-catenin pathway
inferred← citeshttps://doi.org/10.1186/s12964-020-00639-1openalex-snapshot
LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP
inferred← citeshttps://doi.org/10.1371/journal.pone.0271776openalex-snapshot
Collagen cross-links scale with passive stiffness in dystrophic mouse muscles, but are not altered with administration of a lysyl oxidase inhibitor
inferred← citeshttps://doi.org/10.14218/jcth.2021.00289openalex-snapshot
Overexpression of Hepcidin Alleviates Steatohepatitis and Fibrosis in a Diet-induced Nonalcoholic Steatohepatitis
inferred← citeshttps://doi.org/10.14218/jcth.2022.00005openalex-snapshot
Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway In Vivo and In vitro
inferred← citeshttps://doi.org/10.18632/aging.203777openalex-snapshot
Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient mice
inferred← citeshttps://doi.org/10.21203/rs.3.rs-53203/v1openalex-snapshot
Analysis of Genetically Determined Gene Expression Suggests Role of Inflammatory Processes in Etiology of Exfoliation Syndrome
inferred← citeshttps://doi.org/10.21608/ejh.2022.133870.1674openalex-snapshot
The ameliorative potential of Alda-1 on experimentally induced liver fibrosis in adult male mice. A histological, immunohistochemical and biochemical study.
inferred← citeshttps://doi.org/10.2217/epi-2019-0104openalex-snapshot
miRNA-150-5p Promotes Hepatic Stellate Cell Proliferation and Sensitizes Hepatocyte Apoptosis During Liver Fibrosis
inferred← citeshttps://doi.org/10.26508/lsa.202302517openalex-snapshot
Comprehensive meta-analysis reveals distinct gene expression signatures of MASLD progression
inferred← citeshttps://doi.org/10.32604/biocell.2025.062325openalex-snapshot
Integrin Alpha8 Beta1 (81): An In-Depth Review of an Overlooked RGD-Binding Receptor
inferred← citeshttps://doi.org/10.3389/fcell.2026.1712643openalex-snapshot
Comparing the expression patterns and differences of LOX and LOXL1 during the development of myodural bridge and ligamentum flavum
inferred← citeshttps://doi.org/10.3389/fgene.2021.706341openalex-snapshot
Integrated Analysis of Hepatic miRNA and mRNA Expression Profiles in the Spontaneous Reversal Process of Liver Fibrosis
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1773909openalex-snapshot
Extracellular matrix stiffness in hepatocellular carcinoma: mechanisms and targeted therapeutic strategies
inferred← citeshttps://doi.org/10.3389/fmolb.2022.778857openalex-snapshot
Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification
inferred← citeshttps://doi.org/10.3389/fmolb.2023.1183808openalex-snapshot
Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis
inferred← citeshttps://doi.org/10.3389/fonc.2022.843880openalex-snapshot
Diagnostic Value, Prognostic Value, and Immune Infiltration of LOX Family Members in Liver Cancer: Bioinformatic Analysis
inferred← citeshttps://doi.org/10.3389/fphys.2023.1098129openalex-snapshot
Regulators, functions, and mechanotransduction pathways of matrix stiffness in hepatic disease
inferred← citeshttps://doi.org/10.3390/biom16060884openalex-snapshot
The Matrix Reloaded: The Hepatic Matrisome as a Therapeutic Opportunity to Fight Liver Fibrosis
inferred← citeshttps://doi.org/10.3390/biomedicines11041090openalex-snapshot
Activated Natural Killer Cell Inoculation Alleviates Fibrotic Liver Pathology in a Carbon Tetrachloride-Induced Liver Cirrhosis Mouse Model
inferred← citeshttps://doi.org/10.3390/cancers14040981openalex-snapshot
Fibrosis in Mesothelioma: Potential Role of Lysyl Oxidases
inferred← citeshttps://doi.org/10.3390/cancers16234107openalex-snapshot
Tumor Biomechanics-Inspired Future Medicine
inferred← citeshttps://doi.org/10.3390/cells13050438openalex-snapshot
Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis
inferred← citeshttps://doi.org/10.3390/cells15040354openalex-snapshot
Adventitial Fibrosis and Fibroblast Mechanosensitivity Are Shaped by Sex and Hormonal Status in Pulmonary Arterial Hypertension
inferred← citeshttps://doi.org/10.3390/ijms21249751openalex-snapshot
Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer
inferred← citeshttps://doi.org/10.3390/ijms22030984openalex-snapshot
TGFβ-1 Induced Cross-Linking of the Extracellular Matrix of Primary Human Dermal Fibroblasts
inferred← citeshttps://doi.org/10.3390/ijms23031636openalex-snapshot
MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of HIF-1α and ANGPT2
inferred← citeshttps://doi.org/10.3390/ijms241411745openalex-snapshot
Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting
inferred← citeshttps://doi.org/10.3390/v14092072openalex-snapshot
Lysyl Oxidase-like Protein Recognizes Viral Envelope Proteins and Bacterial Polysaccharides against Pathogen Infection via Induction of Expression of Antimicrobial Peptides
inferred← citeshttps://doi.org/10.4103/jcar.jcar_24_20openalex-snapshot
Understanding the molecular mechanism associated with reversal of oral submucous fibrosis targeting hydroxylysine aldehyde-derived collagen cross-links
inferred← citeshttps://doi.org/10.70675/3f63c15ezc769z48acz89d2z46ba95102826openalex-snapshot
Identification of portal mesenchymal stem cells and derived myofibroblasts in liver fibrosis
inferred← citeshttps://doi.org/10.7150/ijbs.37500openalex-snapshot
Matrix Mechanics as Regulatory Factors and Therapeutic Targets in Hepatic Fibrosis
inferred← citeshttps://doi.org/10.7717/peerj.20274openalex-snapshot
The function and mechanisms of action of lysyl oxidase-like 3 (LOXL3) in cancers
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