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Safety and Efficacy of CMX001 as Salvage Therapy for Severe Adenovirus Infections in Immunocompromised Patients

https://doi.org/10.1016/j.bbmt.2011.09.007
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/rmv.386openalex-snapshot
The impact of adenovirus infection on the immunocompromised host
inferredcites →https://doi.org/10.1002/sim.1149openalex-snapshot
Intention‐to‐treat: methods for dealing with missing values in clinical trials of progressively deteriorating diseases
inferredcites →https://doi.org/10.1006/viro.1997.8482openalex-snapshot
Spontaneous Occurrence of Early Region 1A Reiteration Mutants of Type 5 Adenovirus in Persistently Infected Human T-Lymphocytes
inferredcites →https://doi.org/10.1007/s10096-004-1165-xopenalex-snapshot
Treatment of adenovirus infections in the immunocompromised host
inferredcites →https://doi.org/10.1016/j.antiviral.2009.01.005openalex-snapshot
Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art
inferredcites →https://doi.org/10.1016/j.jcv.2007.01.001openalex-snapshot
Sequential emergence of multiple adenovirus serotypes after pediatric stem cell transplantation
inferredcites →https://doi.org/10.1016/j.tibtech.2004.06.008openalex-snapshot
Design and development of oral drugs for the prophylaxis and treatment of smallpox infection
inferredcites →https://doi.org/10.1016/s0002-9343(99)80169-7openalex-snapshot
Evolving pathogens in allogeneic bone marrow transplantation: Increased fatal adenoviral infections
inferredcites →https://doi.org/10.1016/s0002-9394(14)70925-0openalex-snapshot
Treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome
inferredcites →https://doi.org/10.1016/s0140-6736(01)05580-5openalex-snapshot
Prediction of severe disseminated adenovirus infection by serum PCR
inferredcites →https://doi.org/10.1016/s0166-3542(03)00110-4openalex-snapshot
Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney
inferredcites →https://doi.org/10.1034/j.1600-6143.2003.00007.xopenalex-snapshot
Adenovirus Infection in Pediatric Liver and Intestinal Transplant Recipients: Utility of DNA Detection by PCR
inferredcites →https://doi.org/10.1038/sj.bmt.1701563openalex-snapshot
Adenovirus infection after pediatric bone marrow transplantation
inferredcites →https://doi.org/10.1038/sj.bmt.1702716openalex-snapshot
Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation
inferredcites →https://doi.org/10.1038/sj.bmt.1703798openalex-snapshot
Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation
inferredcites →https://doi.org/10.1038/sj.bmt.1704682openalex-snapshot
Cidofovir for treating adenoviral hemorrhagic cystitis in hematopoietic stem cell transplant recipients
inferredcites →https://doi.org/10.1038/sj.bmt.1704852openalex-snapshot
Adenovirus infection in children after allogeneic stem cell transplantation: diagnosis, treatment and immunity
inferredcites →https://doi.org/10.1053/bbmt.2001.v7.pm11529489openalex-snapshot
Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation
inferredcites →https://doi.org/10.1053/jhin.1999.0656openalex-snapshot
Genotyping of adenoviruses isolated in an outbreak in a bone marrow transplant unit shows that diverse strains are involved
inferredcites →https://doi.org/10.1055/s-2005-872530openalex-snapshot
Adenoviral Infections after Transplantation of Positive Selected Stem Cells from Haploidentical Donors in Children: An Update
inferredcites →https://doi.org/10.1056/nejm198502283120901openalex-snapshot
Adenovirus Infections in Patients Undergoing Bone-Marrow Transplantation
inferredcites →https://doi.org/10.1056/nejm199707103370207openalex-snapshot
Treatment of Cytomegalovirus Retinitis in Patients with the Acquired Immunodeficiency Syndrome
inferredcites →https://doi.org/10.1086/313514openalex-snapshot
Adenovirus Infections in Hematopoietic Stem Cell Transplant Recipients
inferredcites →https://doi.org/10.1086/319352openalex-snapshot
Adenovirus Infections in Adult Recipients of Blood and Marrow Transplants
inferredcites →https://doi.org/10.1086/319984openalex-snapshot
Treatment of Adenovirus Infections in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
inferredcites →https://doi.org/10.1086/380450openalex-snapshot
Real‐Time Blood Plasma Polymerase Chain Reaction for Management of Disseminated Adenovirus Infection
inferredcites →https://doi.org/10.1093/infdis/169.4.775openalex-snapshot
Increasing Incidence of Adenovirus Disease in Bone Marrow Transplant Recipients
inferredcites →https://doi.org/10.1097/00006454-198802000-00009openalex-snapshot
Viral infections in pediatric bone marrow transplant patients
inferredcites →https://doi.org/10.1097/01.tp.0000072808.93060.0fopenalex-snapshot
ADENOVIRUS INFECTION IN PEDIATRIC SMALL BOWEL TRANSPLANTATION RECIPIENTS
inferredcites →https://doi.org/10.1097/01.tp.0000209195.95115.8eopenalex-snapshot
Cidofovir for the Treatment of Adenoviral Infection in Pediatric Hematopoietic Stem Cell Transplant Patients
inferredcites →https://doi.org/10.1097/01.tp.0000230432.39447.8bopenalex-snapshot
Reactivation of Viruses in Solid Organ Transplant Patients Receiving Cytomegalovirus Prophylaxis
inferredcites →https://doi.org/10.1097/tp.0b013e3181e0de97openalex-snapshot
Adenovirus Infections in Pediatric Small Bowel Transplant Recipients
inferredcites →https://doi.org/10.1111/j.1365-2141.2004.05331.xopenalex-snapshot
Detection of adenovirus‐specific T cells in children with adenovirus infection after allogeneic stem cell transplantation
inferredcites →https://doi.org/10.1111/j.1365-2141.2005.05649.xopenalex-snapshot
Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation
inferredcites →https://doi.org/10.1111/j.1399-3062.2006.00184.xopenalex-snapshot
Invasive adenoviral infections in T‐cell‐depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir
inferredcites →https://doi.org/10.1111/j.1600-0609.2007.00821.xopenalex-snapshot
Assessment of disseminated adenovirus infections using quantitative plasma PCR in adult allogeneic stem cell transplant recipients receiving reduced intensity or myeloablative conditioning
inferredcites →https://doi.org/10.1124/mol.63.3.678openalex-snapshot
Increased Antiviral Activity of 1-O-Hexadecyloxypropyl-[2-14C]cidofovir in MRC-5 Human Lung Fibroblasts Is Explained by Unique Cellular Uptake and Metabolism
inferredcites →https://doi.org/10.1128/cmr.00052-07openalex-snapshot
Adenoviruses in Immunocompromised Hosts
inferredcites →https://doi.org/10.1128/jvi.76.21.10608-10616.2002openalex-snapshot
Prevalence and Quantitation of Species C Adenovirus DNA in Human Mucosal Lymphocytes
inferredcites →https://doi.org/10.1182/blood-2002-02-0377openalex-snapshot
Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery
inferredcites →https://doi.org/10.1182/blood-2002-07-2152openalex-snapshot
Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Adenoviruses
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Adenovirus Vaccines
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Adenoviruses
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Adenoviruses
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Adenoviruses
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Human Adenovirus Vaccines
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Infections in Pediatric Lung Transplantation
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Human Polyomaviruses
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Adenoviruses
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Noninfluenza Respiratory Viruses
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Cidofovir and brincidofovir reduce the pathology caused by systemic infection with human type 5 adenovirus in immunosuppressed Syrian hamsters, while ribavirin is largely ineffective in this model
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Short-term clinical safety profile of brincidofovir: A favorable benefit–risk proposition in the treatment of smallpox
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Combination therapy with brincidofovir and valganciclovir against species C adenovirus infection in the immunosuppressed Syrian hamster model allows for substantial reduction of dose for both compounds
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Oral USC-093, a novel homoserinamide analogue of the tyrosinamide (S)-HPMPA prodrug USC-087 has decreased nephrotoxicity while maintaining antiviral efficacy against human adenovirus infection of Syrian hamsters
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Anti-adenoviral Artificial MicroRNAs Expressed from AAV9 Vectors Inhibit Human Adenovirus Infection in Immunosuppressed Syrian Hamsters
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Lipid nanoparticle-encapsulated, chemically modified anti-adenoviral siRNAs inhibit hepatic adenovirus infection in immunosuppressed Syrian hamsters
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Conduite à tenir devant une réactivation ou une infection à virus respiratoire syncytial, herpèsvirus 6 et adénovirus après allogreffe de cellules souches hématopoïétiques
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Case 1-2018: A 39-Year-Old Woman with Rapidly Progressive Respiratory Failure
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Brincidofovir is a robust replication inhibitor against African swine fever virus in vivo and in vitro
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Editorial Commentary: Adenovirus Viremia and Infection After Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplant: Should We Institute a Routine Screening Program?
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Drug development against human adenoviruses and its advancement by Syrian hamster models
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Renal Toxicity in Pediatric Patients Receiving Cidofovir for the Treatment of Adenovirus Infection
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What do we know about adenovirus in renal transplantation?
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Prodrug strategies for improved efficacy of nucleoside antiviral inhibitors
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Adenovirus Infections in Heart Transplantation
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Impact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients
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Diagnosis and Management of Pediatric Transplant-associated Viral Infections
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Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient
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Adenovirus
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Adenovirus infection in pediatric transplant recipients: are effective antiviral agents coming our way?
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Successful Treatment of Disseminated Adenovirus Infection in an Infant With Acute Lymphoblastic Leukemia
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Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD
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Histologic Manifestations of Gastrointestinal Adenovirus Infection After Stem Cell Transplant
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Approach to adenovirus infections in the setting of hematopoietic cell transplantation
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Antiviral treatment of severe non-influenza respiratory virus infection
inferred← citeshttps://doi.org/10.1097/qco.0000000000000558openalex-snapshot
Approach to infection and disease due to adenoviruses in solid organ transplantation
inferred← citeshttps://doi.org/10.1097/qco.0000000000000605openalex-snapshot
Adenovirus infection and disease in recipients of hematopoietic cell transplantation
inferred← citeshttps://doi.org/10.1097/qco.0b013e3283630e85openalex-snapshot
Community-acquired respiratory viral infections in lung transplant recipients
inferred← citeshttps://doi.org/10.1097/tp.0000000000003988openalex-snapshot
Adenovirus Infection and Transplantation
inferred← citeshttps://doi.org/10.1101/2024.11.01.621456openalex-snapshot
Synthesis of USC-093 and comparison with its promoiety enantiomer USC-093D against adenovirus in vitro and in a Syrian hamster model
inferred← citeshttps://doi.org/10.1111/ajt.12112openalex-snapshot
Adenovirus in Solid Organ Transplantation
inferred← citeshttps://doi.org/10.1111/ctr.13527openalex-snapshot
Adenovirus in solid organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice
inferred← citeshttps://doi.org/10.1111/ctr.14481openalex-snapshot
Viral kinetics and outcomes of adenovirus viremia following allogeneic hematopoietic cell transplantation
inferred← citeshttps://doi.org/10.1111/irv.12173openalex-snapshot
Advances in antivirals for non‐influenza respiratory virus infections
inferred← citeshttps://doi.org/10.1111/irv.12293openalex-snapshot
Overview of the 3rd isirv‐Antiviral Group Conference – advances in clinical management
inferred← citeshttps://doi.org/10.1111/jpc.13303openalex-snapshot
Seasonal variability of respiratory syncytial virus infection in the Top End of the Northern Territory (2012–2014)
inferred← citeshttps://doi.org/10.1111/tid.12022openalex-snapshot
European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL ‐4 (2011)
inferred← citeshttps://doi.org/10.1111/tid.12248openalex-snapshot
Adenovirus causing fever, upper respiratory infection, and allograft nephritis complicated by persistent asymptomatic viremia
inferred← citeshttps://doi.org/10.1111/tid.12519openalex-snapshot
Clinical characteristics and outcomes of adenovirus infection of the urinary tract after renal transplantation
inferred← citeshttps://doi.org/10.1111/tid.12582openalex-snapshot
Brincidofovir clearance of acyclovir‐resistant herpes simplex virus‐1 and adenovirus infection after stem cell transplantation
inferred← citeshttps://doi.org/10.1111/tid.12716openalex-snapshot
Adenoviral nephritis in a renal transplant recipient: Case report and literature review
inferred← citeshttps://doi.org/10.1128/9781555817381.ch103openalex-snapshot
Adenoviruses
inferred← citeshttps://doi.org/10.1128/9781555819040.ch10openalex-snapshot
Adenovirus
inferred← citeshttps://doi.org/10.1128/9781555819439.ch14openalex-snapshot
Antirespiratory Virus Agents
inferred← citeshttps://doi.org/10.1128/9781555819439.ch19openalex-snapshot
Poxviruses
inferred← citeshttps://doi.org/10.1128/9781555819439.ch2openalex-snapshot
Respiratory Infections
inferred← citeshttps://doi.org/10.1128/aac.00489-24openalex-snapshot
NPP-669, a prodrug of cidofovir, is highly efficacious against human adenovirus infection in the permissive Syrian hamster model
inferred← citeshttps://doi.org/10.1128/aac.01925-18openalex-snapshot
Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus
inferred← citeshttps://doi.org/10.1128/aac.03860-14openalex-snapshot
Ganciclovir Inhibits Human Adenovirus Replication and Pathogenicity in Permissive Immunosuppressed Syrian Hamsters
inferred← citeshttps://doi.org/10.1128/aac.04348-14openalex-snapshot
Pharmacokinetics and Safety of Intravenous Cidofovir for Life-Threatening Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients
inferred← citeshttps://doi.org/10.1128/cmr.00116-13openalex-snapshot
Adenovirus Infections in Immunocompetent and Immunocompromised Patients
inferred← citeshttps://doi.org/10.1128/jcm.01893-13openalex-snapshot
Disseminated Adenovirus Infection in Cancer Patients Presenting with Focal Pulmonary Consolidation
inferred← citeshttps://doi.org/10.1128/microbiolspec.dmih2-0020-2015openalex-snapshot
Adenovirus
inferred← citeshttps://doi.org/10.1155/2013/176418openalex-snapshot
Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation
inferred← citeshttps://doi.org/10.1155/2013/969186openalex-snapshot
Severe Necrotizing Adenovirus Tubulointerstitial Nephritis in a Kidney Transplant Recipient
inferred← citeshttps://doi.org/10.1177/20499361211018027openalex-snapshot
Post-allogeneic hematopoietic stem cell transplantation viral reactivations and viremias: a focused review on human herpesvirus-6, BK virus and adenovirus
inferred← citeshttps://doi.org/10.1182/blood-2017-02-767582openalex-snapshot
Guarded promise for adenovirus therapy
inferred← citeshttps://doi.org/10.1186/s13045-017-0469-0openalex-snapshot
Curative or pre-emptive adenovirus-specific T cell transfer from matched unrelated or third party haploidentical donors after HSCT, including UCB transplantations: a successful phase I/II multicenter clinical trial
inferred← citeshttps://doi.org/10.1212/wnl.0b013e3182904f96openalex-snapshot
Fatal adenovirus encephalomyeloradiculitis in an umbilical cord stem cell transplant recipient
inferred← citeshttps://doi.org/10.1371/journal.pone.0162199openalex-snapshot
Experimental Treatment of Ebola Virus Disease with Brincidofovir
inferred← citeshttps://doi.org/10.1517/14656566.2015.1083975openalex-snapshot
New drug on the horizon for treating adenovirus
inferred← citeshttps://doi.org/10.1556/oh.2012.29496openalex-snapshot
Adenovirus infections in immuncompromised patients
inferred← citeshttps://doi.org/10.1586/14787210.2013.836964openalex-snapshot
Diagnosis and treatment of adenovirus infection in immunocompromised patients
inferred← citeshttps://doi.org/10.1586/14787210.2014.948847openalex-snapshot
Development of CMX001 (Brincidofovir) for the treatment of serious diseases or conditions caused by dsDNA viruses
inferred← citeshttps://doi.org/10.1586/eri.13.25openalex-snapshot
Opportunistic viral infections in intestinal transplantation
inferred← citeshttps://doi.org/10.21037/jtd-2021-24openalex-snapshot
Viral infections in lung transplantation
inferred← citeshttps://doi.org/10.21767/2573-0282.100046openalex-snapshot
Respiratory Viral Detection in the Pediatric Hematopoietic Stem Cell Transplant Population
inferred← citeshttps://doi.org/10.2217/fmb-2019-0288openalex-snapshot
Brincidofovir: Understanding its Unique Profile and Potential Role Against Adenovirus and Other Viral Infections
inferred← citeshttps://doi.org/10.2217/fvl.13.85openalex-snapshot
Addressing the Public Health Burden of Respiratory Viruses: The Battle Against Respiratory Viruses (BRaVe) Initiative
inferred← citeshttps://doi.org/10.2958/suizo.29.828openalex-snapshot
A case of acute pancreatitis after an adenoviral infection in a kidney transplantation patient receiving mycophenolate mofetil
inferred← citeshttps://doi.org/10.3389/fmicb.2019.00414openalex-snapshot
Diagnostic Parameters of Adenoviremia in Pediatric Stem Cell Transplant Recipients
inferred← citeshttps://doi.org/10.3389/fped.2025.1552958openalex-snapshot
Research progress on human adenovirus sepsis
inferred← citeshttps://doi.org/10.3389/fpubh.2022.878161openalex-snapshot
Human Adenovirus Associated Hepatic Injury
inferred← citeshttps://doi.org/10.3390/jcm9030865openalex-snapshot
Make Sure You Have a Safety Net: Updates in the Prevention and Management of Infectious Complications in Stem Cell Transplant Recipients
inferred← citeshttps://doi.org/10.3390/v13102019openalex-snapshot
Viral Enteritis in Solid-Organ Transplantation
inferred← citeshttps://doi.org/10.3390/v14071459openalex-snapshot
Fulminant Adenoviral-Induced Hepatitis in Immunosuppressed Patients
inferred← citeshttps://doi.org/10.3390/v16081200openalex-snapshot
Longitudinal Monitoring of the Effects of Anti-Adenoviral Treatment Regimens in a Permissive In Vivo Model
inferred← citeshttps://doi.org/10.3390/v17050599openalex-snapshot
Treating Adenovirus Infection in Transplant Populations: Therapeutic Options Beyond Cidofovir?
inferred← citeshttps://doi.org/10.3390/v7031409openalex-snapshot
Valganciclovir Inhibits Human Adenovirus Replication and Pathology in Permissive Immunosuppressed Female and Male Syrian Hamsters
inferred← citeshttps://doi.org/10.3390/v9060147openalex-snapshot
HAdV-C6 Is a More Relevant Challenge Virus than HAdV-C5 for Testing Antiviral Drugs with the Immunosuppressed Syrian Hamster Model
inferred← citeshttps://doi.org/10.3748/wjg.v20.i31.10658openalex-snapshot
Cytomegalovirus infection in liver transplant recipients: Updates on clinical management
inferred← citeshttps://doi.org/10.3851/imp3047openalex-snapshot
Biological Antivirals for Treatment of Adenovirus Infections
inferred← citeshttps://doi.org/10.3851/imp3230openalex-snapshot
Broad-Spectrum Antiviral Activity of the Deubiquitinase Inhibitor HBX against Human Adenoviruses
inferred← citeshttps://doi.org/10.4084/mjhid.2016.031openalex-snapshot
CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION
inferred← citeshttps://doi.org/10.47102/annals-acadmedsg.v44n2p50openalex-snapshot
Risk Factors for Severe Adenovirus Infection in Children during an Outbreak in Singapore
inferred← citeshttps://doi.org/10.70675/9297b9f7z64fdz45e2z9d6fzd046830c540copenalex-snapshot
Cibles thérapeutiques des infections à adénovirus humains
inferred← citeshttps://doi.org/10.7759/cureus.5296openalex-snapshot
Brincidofovir (CMX001) for the Treatment of Severe Adenoviral Pneumonia in Kidney Transplant Recipient
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