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Trypanosoma cruzi: Activities of lapachol and α- and β-lapachone derivatives against epimastigote and trypomastigote forms
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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In vitro andin vivo Leishmanicidal activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol)
inferredcites →https://doi.org/10.1007/0-306-47931-1_8openalex-snapshot
Induction of Apoptosis by Redox-Cycling Quinones
inferredcites →https://doi.org/10.1007/pl00008532openalex-snapshot
Setting of a colorimetric method to determine the viability of Trypanosoma cruzi epimastigotes
inferredcites →https://doi.org/10.1007/s00436-006-0153-8openalex-snapshot
Oxyrane derivative of α-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms
inferredcites →https://doi.org/10.1016/0006-2952(87)90648-4openalex-snapshot
DNA damage induced by reduced nitroimidazole drugs
inferredcites →https://doi.org/10.1016/0014-4894(77)90071-6openalex-snapshot
Trypanosoma cruzi: Ultrastructural and metabolic alterations of epimastigotes by β-lapachone
inferredcites →https://doi.org/10.1016/0166-6851(85)90073-8openalex-snapshot
In vitro differentiation of Trypanosoma cruzi under chemically defined conditions
inferredcites →https://doi.org/10.1016/0306-4492(78)90063-1openalex-snapshot
Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi
inferredcites →https://doi.org/10.1016/0742-8413(95)02003-9openalex-snapshot
Effects and mode of action of 1,4-naphthoquinones isolated from Calceolaria sessilis on tumoral cells and Trypanosoma parasites
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Synthesis of dihydronaphthofurandiones and dihydrofuroquinolinediones with trypanocidal activity and analysis of their stereoelectronic properties
inferredcites →https://doi.org/10.1016/j.bmc.2006.04.046openalex-snapshot
Trypanocidal agents with low cytotoxicity to mammalian cell line: A comparison of the theoretical and biological features of lapachone derivatives
inferredcites →https://doi.org/10.1016/j.ejmech.2004.02.015openalex-snapshot
Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from β-lapachone
inferredcites →https://doi.org/10.1016/j.pt.2005.08.026openalex-snapshot
Chemotherapy of trypanosomiases and leishmaniasis
inferredcites →https://doi.org/10.1016/s0006-2952(02)01663-5openalex-snapshot
Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives
inferredcites →https://doi.org/10.1016/s0040-4039(98)01880-2openalex-snapshot
A preparative synthesis of lapachol and related naphthoquinones
inferredcites →https://doi.org/10.1016/s0305-0491(99)00155-8openalex-snapshot
The effects of hydrostatic pressure on pertussis toxin-catalyzed ribosylation of G proteins from deep-living macrourid fishes
inferredcites →https://doi.org/10.1016/s0960-894x(97)00354-5openalex-snapshot
Trypanocidal activity and redox potential of heterocyclic- and 2-hydroxy-naphthoquinones
inferredcites →https://doi.org/10.1016/s0968-0896(97)00155-7openalex-snapshot
Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiophen-4,9-quinones
inferredcites →https://doi.org/10.1021/ja01298a033openalex-snapshot
The Constitution of Lapachol and its Derivatives. Part V. The Structure of Paternò's “Isolapachone”1,2
inferredcites →https://doi.org/10.1021/ja01402a030openalex-snapshot
THE ALKYLATION OF HYDROXYNAPHTHOQUINONE. III. A SYNTHESIS OF LAPACHOL
inferredcites →https://doi.org/10.1039/p29950000939openalex-snapshot
Regioselectivity in Diels–Alder reactions of pyranobenzoquinones
inferredcites →https://doi.org/10.1042/bj1750431openalex-snapshot
Effect of β-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi
inferredcites →https://doi.org/10.1071/ch9731121openalex-snapshot
Chemical Studies of the Proteaceae. VI Two Naphthoquinones From Stenocarpus salignus
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In vitroandin vivoevaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives againstTrypanosoma cruzi
inferredcites →https://doi.org/10.1080/00397919008051533openalex-snapshot
Studies on Quinones. XX. synthesis of 2-acetonylpyranonaphthoqoinones
inferredcites →https://doi.org/10.1080/00397919208020860openalex-snapshot
Synthesis of 3,4-Dihydro-4-Hydroxy-2,2-Dimethyl-2H-1-Benzopyran-5 8-Dione. A Potential Key Intermediate for the Preparation of Naphtho[2,3-b]Pyranoquinones
inferredcites →https://doi.org/10.1191/0960327106het653oaopenalex-snapshot
Toxic Side Effects of Drugs Used to Treat Chagas’ Disease (American Trypanosomiasis)
inferredcites →https://doi.org/10.1590/s0074-02762002000100001openalex-snapshot
A Critical Review on Chagas Disease Chemotherapy
inferredcites →https://doi.org/10.1590/s0074-02762003000400026openalex-snapshot
8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase
inferredcites →https://doi.org/10.1590/s0100-879x1999000900001openalex-snapshot
The regulation of apoptotic cell death
inferredcites →https://doi.org/10.2174/1568026023393011openalex-snapshot
Natural Products as Trypanocidal, Antileishmanial and Antimalarial Drugs
inferredcites →https://doi.org/10.3987/com-94-6696openalex-snapshot
Synthesis of Naphtho[2,3-b]pyranoquinones and Its Aza-Analogues from a Useful Benzopyranoquinone Intermediate
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Beta-lapachone: Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis
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Ex vivo Activities of β‐Lapachone and α‐Lapachone on Macrophages: A Quantitative Pharmacological Analysis Based on Amperometric Monitoring of Oxidative Bursts by Single Cells
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Organocatalytic Michael Addition of Naphthoquinone with α,β‐Unsaturated Ketones: Primary Amine Catalyzed Asymmetric Synthesis of Lapachol Analogues
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Synthesis of β‐Lapachone, a Potential Anticancer Agent from the Lapacho Tree
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Redox Center Modification of Lapachones towards the Synthesis of Nitrogen Heterocycles as Selective Fluorescent Mitochondrial Imaging Probes
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Synthesis of a Regioisomer of β‐Lapachone and Analogs as Potent Antitumor Agents
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Advanced Routes in Synthesis and Reactions of Lawsone Molecules (2‐Hydroxynaphthalene‐1,4‐dione)
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Adaptable Access for Naphthaquinone Annulation: Bioactivity and Molecular Modeling Evaluations
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Concise Synthesis and Pharmacological Applications of New α‐Lapachone Analogues
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Selective Electrophile‐Promoted Cyclization Reactions of Lapachol and Evaluation of Bioactive Naphthoquinones Against Cancer Cell Lines
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Photosensitizing Properties of 6H ‐Dibenzo[ b, h ]xanthene Derivatives
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Biological Properties of 1H-1,2,3- and 2H-1,2,3-Triazoles
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Pharmacological Potential of Natural Compounds in the Control of Selected Protozoan Diseases
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Screening of 1,2-furanonaphthoquinones 1,2,3-1H-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity
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In vitro and in silico evaluations of new aryloxy-1,4-naphthoquinones as anti-Trypanosoma cruzi agents
inferred← citeshttps://doi.org/10.1007/s00436-018-6084-3openalex-snapshot
Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi
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The first catalytic application of copper aluminate nanoparticles in C–C and C–O coupling reaction: green synthesis of some new α‐lapachone derivatives
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Comparison of the cytotoxic effect of lapachol, α-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells
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Synthesis and biological evaluation of β-lapachone and nor-β-lapachone complexes with 2-hydroxypropyl-β-cyclodextrin as trypanocidal agents
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Semisynthetic and newly designed derivatives based on natural chemical scaffolds: moving beyond natural products to fight Trypanosoma cruzi
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Natural products for the treatment of Chagas disease: a review of plant-derived compounds and related synthetic derivatives as potential trypanocidal drugs
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Antitrypanosomal activities and cytotoxicity of some novel imidosubstituted 1,4-naphthoquinone derivatives
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In-vivo immunomodulatory activity of standardized Stereospermum suaveolens (Roxb.) DC. root extract
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Insecticidal efficacy and chemical profile of Handroanthus impetiginosus extracts for sustainable management of the coffee leaf miner (Leucoptera coffeella)
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Antitrypanosomal Activity of Hydroquinone and Quinone Derivatives Isolated from Miconia willdenowii
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Epoxy-α-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2′-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites
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New pterocarpanquinones: Synthesis, antineoplasic activity on cultured human malignant cell lines and TNF-α modulation in human PBMC cells
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Pterocarpanquinones, aza-pterocarpanquinone and derivatives: Synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis
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2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities
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Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives
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Design of hybrid molecules as antimycobacterial compounds: Synthesis of isoniazid-naphthoquinone derivatives and their activity against susceptible and resistant strains of Mycobacterium tuberculosis
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Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases
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Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells
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Structural studies of the Trypanosoma cruzi Old Yellow Enzyme: Insights into enzyme dynamics and specificity
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Spectroscopic and in silico evaluation on the interactive behavior between substituted β-2,3-dihydrofuran naphthoquinones and human serum albumin
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β-Lapachone analogs with enhanced antiproliferative activity
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Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones
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Phospholipase C gamma and ERK1/2 Mitogen Activated Kinase Pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta
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An extensive review on genus “Tabebuia”, family bignoniaceae: Phytochemistry and biological activities (1967 to 2018)
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Effects of a novel β–lapachone derivative on Trypanosoma cruzi: Parasite death involving apoptosis, autophagy and necrosis
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The hydroxy-naphthoquinone lapachol arrests mycobacterial growth and immunomodulates host macrophages
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Lewis acid mediated highly regioselective intramolecular cyclization for the synthesis of β-lapachone
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Plasma pharmacokinetics and brain distribution kinetics of lapachol in rats using LC-MS and microdialysis techniques
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Crystal structure and conformational analysis of 2-hydroxy-3-(2-methylprop-1-en-1-yl)naphthalene-1,4-dione
inferred← citeshttps://doi.org/10.1111/cbdd.14122openalex-snapshot
Natural naphthoquinones and their derivatives as potential drug molecules against trypanosome parasites
inferred← citeshttps://doi.org/10.1111/lam.12251openalex-snapshot
Cytotoxicity of lapachol metabolites produced by probiotics
inferred← citeshttps://doi.org/10.11606/d.60.2013.tde-21062013-142531openalex-snapshot
Biotransformação da B-lapachona utilizando culturas microbianas: uma alternativa para estudos de metabolismo in vitro
inferred← citeshttps://doi.org/10.11606/t.76.2014.tde-24032014-151614openalex-snapshot
Estudo estrutural das enzimas Topoisomerase II Mitocondrial e Old Yellow Enzyme de Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1177/1934578x1601100128openalex-snapshot
Antifungal and Cytotoxic Assessment of Lapachol Derivatives Produced by Fungal Biotransformation
inferred← citeshttps://doi.org/10.1590/0001-3765202420230375openalex-snapshot
Design, synthesis and identification of novel molecular hybrids based on naphthoquinone aromatic hydrazides as potential trypanocide and leishmanicidal agents
inferred← citeshttps://doi.org/10.1590/s0074-02762009000400008openalex-snapshot
In vitro synergic effect of ²-lapachone and isoniazid on the growth of Mycobacterium fortuitum and Mycobacterium smegmatis
inferred← citeshttps://doi.org/10.1590/s0100-879x2010007500012openalex-snapshot
Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice
inferred← citeshttps://doi.org/10.2174/092986711793979779openalex-snapshot
Natural and Synthetic Naphthoquinones Active Against Trypanosoma Cruzi: An Initial Step Towards New Drugs for Chagas Disease
inferred← citeshttps://doi.org/10.2174/092986712800229023openalex-snapshot
The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part I
inferred← citeshttps://doi.org/10.2174/1381612826666201109111802openalex-snapshot
Naphthoquinones and Derivatives for Chemotherapy: Perspectives and Limitations of their Anti-trypanosomatids Activities
inferred← citeshttps://doi.org/10.2174/1568026622666220912101332openalex-snapshot
Mechanism of Action and Implication of Naphthoquinone as Potent Anti-trypanosomal Drugs
inferred← citeshttps://doi.org/10.2174/1570179419666220401121714openalex-snapshot
Recent Developments in Multi-component Synthesis of Lawsone Derivatives
inferred← citeshttps://doi.org/10.2174/1874848100902010042openalex-snapshot
Preclinical and Clinical Studies of Lapachol and Beta-Lapachone
inferred← citeshttps://doi.org/10.29328/journal.apps.1001041openalex-snapshot
Identification and Infrared Spectroscopic Study of Lapachol, β-Lapachone and Hydroxy-hydrolapachol
inferred← citeshttps://doi.org/10.3389/fmicb.2019.01995openalex-snapshot
Microtiter Screening Reveals Oxygen-Dependent Antimicrobial Activity of Natural Products Against Mastitis-Causing Bacteria
inferred← citeshttps://doi.org/10.3389/fnut.2023.1258516openalex-snapshot
Unlocking the power of nanomedicine: the future of nutraceuticals in oncology treatment
inferred← citeshttps://doi.org/10.3390/antibiotics12030576openalex-snapshot
Antibacterial and Antibiofilm Activities of β-Lapachone by Modulating the Catalase Enzyme
inferred← citeshttps://doi.org/10.3390/molecules14114570openalex-snapshot
The Trypanocidal Activity of Naphthoquinones: A Review
inferred← citeshttps://doi.org/10.3390/molecules181214797openalex-snapshot
New Short Strategy for the Synthesis of the Dibenz[b,f]oxepin Scaffold
inferred← citeshttps://doi.org/10.3390/molecules25040893openalex-snapshot
Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues
inferred← citeshttps://doi.org/10.3987/rev-18-sr(t)2openalex-snapshot
Construction of Cyclic Ether-Fused Tricyclic Naphthoquinone Derivatives by Intramolecular Cyclization Reaction
inferred← citeshttps://doi.org/10.4049/jimmunol.1500459openalex-snapshot
Inhibitory Receptor Expression on CD8+ T Cells Is Linked to Functional Responses against Trypanosoma cruzi Antigens in Chronic Chagasic Patients
inferred← citeshttps://doi.org/10.4067/s0716-97602010000300007openalex-snapshot
Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal
inferred← citeshttps://doi.org/10.4236/pp.2011.22006openalex-snapshot
Antitrypanosomal Activity of a Semi-Purified Subfraction Rich in Labdane Sesquiterpenes, Obtained from Flowers of Anthemis Tinctoria, Against Trypanosoma Cruzi
inferred← citeshttps://doi.org/10.5935/1984-6835.20100013openalex-snapshot
ß-Lapachone: Medicinal chemistry significance and structural modifications
inferred← citeshttps://doi.org/10.5935/1984-6835.20150020openalex-snapshot
Photochemistry of Naphthoquinones
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