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High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
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Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon
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Chromogranin A and Derived Peptides in Health and Disease
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Fast and Accurate Protein False Discovery Rates on Large-Scale Proteomics Data Sets with Percolator 3.0
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Neuropeptide Y Receptors
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Neuropeptide Y receptors; antisecretory control of intestinal epithelial function
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Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function
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Nesfatin-1 stimulates glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide secretion from STC-1 cells in vitro
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Recent updates on GLP-1 agonists: Current advancements & challenges
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Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate
inferredcites →https://doi.org/10.1016/j.cell.2018.12.029openalex-snapshot
Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping
inferredcites →https://doi.org/10.1016/j.cell.2019.10.010openalex-snapshot
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors
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Quantification of Protein Levels in Single Living Cells
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A Single-Cell Transcriptome Atlas of the Human Pancreas
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Glucose Sensing in L Cells: A Primary Cell Study
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The Melanocortin-4 Receptor Is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 In Vivo
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Enteroendocrine cell types revisited
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A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development
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Irx3, a new leader on obesity genetics
inferredcites →https://doi.org/10.1016/j.gene.2016.01.044openalex-snapshot
mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts
inferredcites →https://doi.org/10.1016/j.jcmgh.2019.04.010openalex-snapshot
Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion
inferredcites →https://doi.org/10.1016/j.jmoldx.2011.08.002openalex-snapshot
RNAscope
inferredcites →https://doi.org/10.1016/j.mce.2018.04.002openalex-snapshot
Intestinal CART is a regulator of GIP and GLP-1 secretion and expression
inferredcites →https://doi.org/10.1016/j.molmet.2013.08.006openalex-snapshot
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells
inferredcites →https://doi.org/10.1016/j.molmet.2019.08.007openalex-snapshot
Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production
inferredcites →https://doi.org/10.1016/j.physbeh.2017.02.039openalex-snapshot
Signalling in the gut endocrine axis
inferredcites →https://doi.org/10.1016/j.tcb.2019.08.004openalex-snapshot
Endogenous Fluorescence Tagging by CRISPR
inferredcites →https://doi.org/10.1038/386852a0openalex-snapshot
An achaete-scute homologue essential for neuroendocrine differentiation in the lung
inferredcites →https://doi.org/10.1038/emboj.2012.166openalex-snapshot
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
inferredcites →https://doi.org/10.1038/mi.2017.73openalex-snapshot
Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity
inferredcites →https://doi.org/10.1038/nature02033openalex-snapshot
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
inferredcites →https://doi.org/10.1038/nature06196openalex-snapshot
Identification of stem cells in small intestine and colon by marker gene Lgr5
inferredcites →https://doi.org/10.1038/nature07935openalex-snapshot
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
inferredcites →https://doi.org/10.1038/nature13863openalex-snapshot
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
inferredcites →https://doi.org/10.1038/nature14966openalex-snapshot
Single-cell messenger RNA sequencing reveals rare intestinal cell types
inferredcites →https://doi.org/10.1038/nature24489openalex-snapshot
A single-cell survey of the small intestinal epithelium
inferredcites →https://doi.org/10.1038/ncomms12338openalex-snapshot
CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism
inferredcites →https://doi.org/10.1038/nmeth.1802openalex-snapshot
Controlled gene expression in primary Lgr5 organoid cultures
inferredcites →https://doi.org/10.1038/nmeth.3901openalex-snapshot
The Perseus computational platform for comprehensive analysis of (prote)omics data
inferredcites →https://doi.org/10.1038/nmeth.4662openalex-snapshot
FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data
inferredcites →https://doi.org/10.1038/nprot.2008.211openalex-snapshot
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
inferredcites →https://doi.org/10.1038/nprot.2013.143openalex-snapshot
Genome engineering using the CRISPR-Cas9 system
inferredcites →https://doi.org/10.1038/nprot.2015.088openalex-snapshot
Efficient genetic engineering of human intestinal organoids using electroporation
inferredcites →https://doi.org/10.1038/nrgastro.2013.180openalex-snapshot
The gut as a sensory organ
inferredcites →https://doi.org/10.1038/s41556-018-0143-yopenalex-snapshot
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient
inferredcites →https://doi.org/10.1038/s41556-020-0472-5openalex-snapshot
Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing
inferredcites →https://doi.org/10.1038/s41581-018-0078-3openalex-snapshot
The Klotho proteins in health and disease
inferredcites →https://doi.org/10.1038/s41586-019-0992-yopenalex-snapshot
Colonic epithelial cell diversity in health and inflammatory bowel disease
inferredcites →https://doi.org/10.1038/s41588-018-0173-1openalex-snapshot
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells
inferredcites →https://doi.org/10.1038/sj.bjp.0705742openalex-snapshot
Neurokinin NK1 and NK3 receptors as targets for drugs to treat gastrointestinal motility disorders and pain
inferredcites →https://doi.org/10.1038/sj.npp.1301196openalex-snapshot
Variations in the Vesicular Monoamine Transporter 1 Gene (VMAT1/SLC18A1) are Associated with Bipolar I Disorder
inferredcites →https://doi.org/10.1053/j.gastro.2011.07.050openalex-snapshot
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
inferredcites →https://doi.org/10.1073/pnas.1610158114openalex-snapshot
FGF14 is a regulator of KCNQ2/3 channels
inferredcites →https://doi.org/10.1074/jbc.m111.289215openalex-snapshot
Neuronostatin, a Novel Peptide Encoded by Somatostatin Gene, Regulates Cardiac Contractile Function and Cardiomyocyte Survival
inferredcites →https://doi.org/10.1093/nar/gkw064openalex-snapshot
Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair
inferredcites →https://doi.org/10.1096/fj.201800357ropenalex-snapshot
DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS‐induced FGF21
inferredcites →https://doi.org/10.1097/md.0b013e31802b518copenalex-snapshot
Serum Gastrin in Zollinger-Ellison Syndrome
inferredcites →https://doi.org/10.1101/771261openalex-snapshot
Seeing cells smell: Dynamic optical measurements of Ca 2+ and cAMP signaling from Olfactory Receptors transiently expressed in HEK293TN cells
inferredcites →https://doi.org/10.1101/gad.235499.113openalex-snapshot
The diabetes gene Hhex maintains δ-cell differentiation and islet function
inferredcites →https://doi.org/10.1111/j.1463-1326.2010.01247.xopenalex-snapshot
Cerebellin1 is a novel orexigenic peptide
inferredcites →https://doi.org/10.1111/j.1748-1716.2006.01600.xopenalex-snapshot
Angiotensin II induced contraction of rat and human small intestinal wall musculaturein vitro
inferredcites →https://doi.org/10.1126/science.1142382openalex-snapshot
A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
inferredcites →https://doi.org/10.1136/bmj.332.7542.665openalex-snapshot
One-time general consent for research on biological samples: Opt out system for patients is optimal and endorsed in many countries
inferredcites →https://doi.org/10.1152/ajpendo.00434.2001openalex-snapshot
Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures
inferredcites →https://doi.org/10.1152/ajpregu.00638.2003openalex-snapshot
Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake
inferredcites →https://doi.org/10.1159/000452891openalex-snapshot
DcR3, TFF3, and Midkine Are Novel Serum Biomarkers in Small Intestinal Neuroendocrine Tumors
inferredcites →https://doi.org/10.1186/s12263-018-0602-xopenalex-snapshot
Investigation of the influence of high glucose on molecular and genetic responses: an in vitro study using a human intestine model
inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
inferredcites →https://doi.org/10.1186/s13059-016-0938-8openalex-snapshot
CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq
inferredcites →https://doi.org/10.1186/s13059-017-1382-0openalex-snapshot
SCANPY: large-scale single-cell gene expression data analysis
inferredcites →https://doi.org/10.1210/en.2018-00672openalex-snapshot
Models and Tools for Studying Enteroendocrine Cells
inferredcites →https://doi.org/10.1210/me.2014-1194openalex-snapshot
RNA-Seq Analysis of Enteroendocrine Cells Reveals a Role for FABP5 in the Control of GIP Secretion
inferredcites →https://doi.org/10.1210/me.2015-1106openalex-snapshot
Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells
inferredcites →https://doi.org/10.1242/dev.126011openalex-snapshot
Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells
inferredcites →https://doi.org/10.1242/dev.130682openalex-snapshot
Lmx1a functions in intestinal serotonin-producing enterochromaffin cells downstream of Nkx2.2
inferredcites →https://doi.org/10.1242/dev.165795openalex-snapshot
Deriving functional human enteroendocrine cells from pluripotent stem cells
inferredcites →https://doi.org/10.1242/dmm.017400openalex-snapshot
How informative is the mouse for human gut microbiota research?
inferredcites →https://doi.org/10.1371/journal.pone.0019462openalex-snapshot
ENPP1 Affects Insulin Action and Secretion: Evidences from In Vitro Studies
inferredcites →https://doi.org/10.1371/journal.pone.0036449openalex-snapshot
The Homeodomain-Containing Transcription Factors Arx and Pax4 Control Enteroendocrine Subtype Specification in Mice
inferredcites →https://doi.org/10.1371/journal.pone.0088299openalex-snapshot
Midkine, a Potential Link between Obesity and Insulin Resistance
inferredcites →https://doi.org/10.15252/embj.2018100300openalex-snapshot
Long‐term expanding human airway organoids for disease modeling
inferredcites →https://doi.org/10.1530/eje-12-0814openalex-snapshot
Olfactory receptor 51E1 protein as a potential novel tissue biomarker for small intestine neuroendocrine carcinomas
inferredcites →https://doi.org/10.1677/jme-09-0095openalex-snapshot
Stepwise loss of motilin and its specific receptor genes in rodents
inferredcites →https://doi.org/10.21105/joss.00861openalex-snapshot
UMAP: Uniform Manifold Approximation and Projection
inferredcites →https://doi.org/10.2337/db18-0883openalex-snapshot
Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling
inferredcites →https://doi.org/10.3389/fphar.2010.00124openalex-snapshot
A Gut Feeling about GABA: Focus on GABAB Receptors
inferredcites →https://doi.org/10.3389/fphys.2017.00888openalex-snapshot
Odorant Receptor 51E2 Agonist β-ionone Regulates RPE Cell Migration and Proliferation
inferredcites →https://doi.org/10.3892/ijmm.2017.3141openalex-snapshot
Phosphorylation of carboxypeptidase B1 protein regulates β-cell proliferation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Dual States of Bmi1-Expressing Intestinal Stem Cells Drive Epithelial Development
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The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues
inferred← citeshttps://doi.org/10.1002/ange.5498199openalex-snapshot
Spatiotemporally Resolved Protein Tagging for Dynamic and Tissue‐Specific Secretome Profiling In Vivo
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Spatiotemporally Resolved Protein Tagging for Dynamic and Tissue‐Specific Secretome Profiling In Vivo
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Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells
inferred← citeshttps://doi.org/10.1002/cpim.113openalex-snapshot
Co‐Culture System of Human Enteroids/Colonoids with Innate Immune Cells
inferred← citeshttps://doi.org/10.1002/ctm2.1526openalex-snapshot
Decoding endocrine cell differentiation: insights from high‐throughput CRISPR screening in human gut organoids
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Artificial Intelligence for Organoids Multidimensional Assessment
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Targeting the Enteroendocrine System for Treatment of Obesity
inferred← citeshttps://doi.org/10.1007/7651_2024_542openalex-snapshot
Organoid Culture of Different Intestinal Segments from Human and Mouse
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Differentiated Epithelial Cells of the Gut
inferred← citeshttps://doi.org/10.1007/978-1-0716-3076-1_16openalex-snapshot
Co-culturing Human Intestinal Enteroid Monolayers with Innate Immune Cells
inferred← citeshttps://doi.org/10.1007/s00125-024-06293-3openalex-snapshot
Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids
inferred← citeshttps://doi.org/10.1007/s00428-023-03490-0openalex-snapshot
Phox2B is a sensitive and reliable marker of paraganglioma—Phox2B immunohistochemistry in diagnosis of neuroendocrine neoplasms
inferred← citeshttps://doi.org/10.1007/s11428-022-00924-2openalex-snapshot
Diabetes mellitus 2022 – Was ist neu?
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Cholecystokinin in intestinal and extraintestinal endocrine cells
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Enhanced secretion of satiety-promoting gut hormones in healthy humans after consumption of white bread enriched with cellular chickpea flour: A randomized crossover study
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Nicotinic acetylcholine receptors and their role in ghrelin-producing cells
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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping
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inferred← citeshttps://doi.org/10.1016/j.cell.2022.06.051openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.cell.2024.10.044openalex-snapshot
Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.108819openalex-snapshot
Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109484openalex-snapshot
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An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116500openalex-snapshot
Single-cell RNA-seq of small-intestinal neuroendocrine tumors reveals the cell of origin and gene expression of early tumor development
inferred← citeshttps://doi.org/10.1016/j.chembiol.2022.08.001openalex-snapshot
In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system
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Urinary acid-base excretion deciphers high acid load from colonic bicarbonate loss in intestinal failure patients with ileocolonic anastomosis – Guidance for composition of parenteral support
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3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk
inferred← citeshttps://doi.org/10.1016/j.coemr.2022.100318openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.csbj.2020.10.007openalex-snapshot
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Dual states of murine Bmi1-expressing intestinal stem cells drive epithelial development utilizing non-canonical Wnt signaling
inferred← citeshttps://doi.org/10.1016/j.devcel.2025.06.036openalex-snapshot
Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila
inferred← citeshttps://doi.org/10.1016/j.dmpk.2022.100476openalex-snapshot
Establishment of MDR1-knockout human enteroids for pharmaceutical application
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Colonic L-cell impairment in aged subjects with type 2 diabetes leads to diminished GLP-1 production
inferred← citeshttps://doi.org/10.1016/j.envint.2022.107287openalex-snapshot
Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response
inferred← citeshttps://doi.org/10.1016/j.gastha.2024.07.007openalex-snapshot
Human Milk Supports Robust Intestinal Organoid Growth, Differentiation, and Homeostatic Cytokine Production
inferred← citeshttps://doi.org/10.1016/j.gde.2022.101977openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.gde.2025.102398openalex-snapshot
Human gut evolution: insights from stem cell models and single-cell genomics
inferred← citeshttps://doi.org/10.1016/j.immuni.2023.01.002openalex-snapshot
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon
inferred← citeshttps://doi.org/10.1016/j.isci.2023.108517openalex-snapshot
SCFAs switch stem cell fate through HDAC inhibition to improve barrier integrity in 3D intestinal organoids from patients with obesity
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Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2022.02.007openalex-snapshot
A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics
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Gut Microbiota Remodeling and Intestinal Adaptation to Lipid Malabsorption After Enteroendocrine Cell Loss in Adult Mice
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A Single-Cell Atlas of Transcriptome Changes in the Intestinal Epithelium at the Suckling-to-Weaning Transition in Male Rabbits
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Current Practices and Considerations for Benchmarking Human Gastrointestinal Organoids
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Mechanics of serotonin-producing human entero-endocrine cells
inferred← citeshttps://doi.org/10.1016/j.mce.2024.112339openalex-snapshot
Enteroendocrine cells regulate intestinal homeostasis and epithelial function
inferred← citeshttps://doi.org/10.1016/j.mce.2025.112607openalex-snapshot
Enteroendocrine cell differentiation: Implications for human disease
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Secretome Analysis: Reading Cellular Sign Language to Understand Intercellular Communication
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Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease
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The gut–brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders
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L-cell Arntl is required for rhythmic glucagon-like peptide-1 secretion and maintenance of intestinal homeostasis
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101356openalex-snapshot
Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids
inferred← citeshttps://doi.org/10.1016/j.molmet.2025.102118openalex-snapshot
Glucose-dependent insulinotropic polypeptide (GIP)
inferred← citeshttps://doi.org/10.1016/j.neuron.2023.12.012openalex-snapshot
Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function
inferred← citeshttps://doi.org/10.1016/j.peptides.2021.170532openalex-snapshot
Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice
inferred← citeshttps://doi.org/10.1016/j.peptides.2023.171050openalex-snapshot
Desacyl-ghrelin, not just an inactive form of ghrelin? A review of current knowledge on the biological actions of desacyl-ghrelin
inferred← citeshttps://doi.org/10.1016/j.stem.2020.10.014openalex-snapshot
CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids
inferred← citeshttps://doi.org/10.1016/j.stem.2022.08.002openalex-snapshot
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
inferred← citeshttps://doi.org/10.1016/j.stem.2024.04.015openalex-snapshot
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
inferred← citeshttps://doi.org/10.1016/j.stem.2024.06.008openalex-snapshot
Oscillation steers differentiation
inferred← citeshttps://doi.org/10.1016/j.stem.2025.02.003openalex-snapshot
Interferon-responsive intestinal BEST4/CA7+ cells are targets of bacterial diarrheal toxins
inferred← citeshttps://doi.org/10.1016/j.stemcr.2020.11.009openalex-snapshot
The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19
inferred← citeshttps://doi.org/10.1016/j.tcb.2023.03.007openalex-snapshot
The diverse nature of intestinal fibroblasts in development, homeostasis, and disease
inferred← citeshttps://doi.org/10.1016/j.tem.2025.07.009openalex-snapshot
Spatiotemporal coordination between local flux and systemic homeostasis in the small intestine
inferred← citeshttps://doi.org/10.1016/j.tig.2020.06.016openalex-snapshot
Genetics and Epigenetics of Sex Bias: Insights from Human Cancer and Autoimmunity
inferred← citeshttps://doi.org/10.1016/j.xpro.2020.100164openalex-snapshot
Organoid Sample Preparation and Extraction for LC-MS Peptidomics
inferred← citeshttps://doi.org/10.1016/j.xpro.2022.101639openalex-snapshot
Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c00912openalex-snapshot
Development of a Primary Human Intestinal Epithelium Enriched in L-Cells for Assay of GLP-1 Secretion
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c06033openalex-snapshot
Measurement of Real-Time Serotonin Dynamics from Human-Derived Gut Organoids
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c07672openalex-snapshot
Protein-Corona-Based Nanomagnetic Enrichment Strategy for In-Depth Secretome Profiling of Lung Adenocarcinoma Organoids
inferred← citeshttps://doi.org/10.1038/s41366-026-02024-3openalex-snapshot
Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells
inferred← citeshttps://doi.org/10.1038/s41392-022-01194-6openalex-snapshot
Applications of human organoids in the personalized treatment for digestive diseases
inferred← citeshttps://doi.org/10.1038/s41420-026-03204-wopenalex-snapshot
Glucocorticoid-induced Leucine Zipper (GILZ) is a novel secreted protein by intestinal L-cells and is dysregulated during active ulcerative colitis
inferred← citeshttps://doi.org/10.1038/s41467-021-27249-wopenalex-snapshot
A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium
inferred← citeshttps://doi.org/10.1038/s41467-021-27901-5openalex-snapshot
Robust differentiation of human enteroendocrine cells from intestinal stem cells
inferred← citeshttps://doi.org/10.1038/s41467-022-29279-4openalex-snapshot
Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids
inferred← citeshttps://doi.org/10.1038/s41467-022-34270-0openalex-snapshot
A hierarchical transcription factor cascade regulates enteroendocrine cell diversity and plasticity in Drosophila
inferred← citeshttps://doi.org/10.1038/s41467-023-42502-0openalex-snapshot
Organoids transplantation attenuates intestinal ischemia/reperfusion injury in mice through L-Malic acid-mediated M2 macrophage polarization
inferred← citeshttps://doi.org/10.1038/s41467-024-55567-2openalex-snapshot
A tunable human intestinal organoid system achieves controlled balance between self-renewal and differentiation
inferred← citeshttps://doi.org/10.1038/s41467-025-57305-8openalex-snapshot
Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumors
inferred← citeshttps://doi.org/10.1038/s41575-023-00784-1openalex-snapshot
A Roadmap for the Human Gut Cell Atlas
inferred← citeshttps://doi.org/10.1038/s41575-023-00830-yopenalex-snapshot
The intestine as an endocrine organ and the role of gut hormones in metabolic regulation
inferred← citeshttps://doi.org/10.1038/s41575-024-00962-9openalex-snapshot
Cellular and molecular basis of proximal small intestine disorders
inferred← citeshttps://doi.org/10.1038/s41575-026-01225-5openalex-snapshot
Regional organization of nutrient absorption across the small intestine
inferred← citeshttps://doi.org/10.1038/s41580-026-00974-0openalex-snapshot
New developments and applications of human organoids
inferred← citeshttps://doi.org/10.1038/s41586-021-03852-1openalex-snapshot
Cells of the human intestinal tract mapped across space and time
inferred← citeshttps://doi.org/10.1038/s41586-024-07952-6openalex-snapshot
Tuft cells act as regenerative stem cells in the human intestine
inferred← citeshttps://doi.org/10.1038/s41586-025-09508-8openalex-snapshot
Human gastroids to model regional patterning in early stomach development
inferred← citeshttps://doi.org/10.1038/s41586-025-09829-8openalex-snapshot
Human gut M cells resemble dendritic cells and present gluten antigen
inferred← citeshttps://doi.org/10.1038/s41586-026-10343-8openalex-snapshot
Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis
inferred← citeshttps://doi.org/10.1038/s41590-025-02097-8openalex-snapshot
An SSTR2–somatostatin chemotactic axis drives T cell progenitor homing to the intestines
inferred← citeshttps://doi.org/10.1038/s41590-025-02155-1openalex-snapshot
Bat organoids reveal antiviral responses at epithelial surfaces
inferred← citeshttps://doi.org/10.1038/s41590-026-02665-6openalex-snapshot
Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial–immune cell interactions
inferred← citeshttps://doi.org/10.1038/s41591-022-02104-7openalex-snapshot
Impact of the Human Cell Atlas on medicine
inferred← citeshttps://doi.org/10.1038/s41596-021-00589-zopenalex-snapshot
Intestinal organoid cocultures with microbes
inferred← citeshttps://doi.org/10.1038/s41596-026-01447-6openalex-snapshot
Tutorial: interrogating biology using organoid technologies
inferred← citeshttps://doi.org/10.1038/s41598-024-63699-0openalex-snapshot
Single-cell transcriptome analysis reveals secretin as a hallmark of human enteroendocrine cell maturation
inferred← citeshttps://doi.org/10.1038/s41598-025-07219-8openalex-snapshot
Comprehensive characterization of human alveolar epithelial cells cultured for 28 days at the air-liquid interface
inferred← citeshttps://doi.org/10.1038/s41598-025-95721-4openalex-snapshot
Cellular landscape of avian intestinal organoids revealed by single cell transcriptomics
inferred← citeshttps://doi.org/10.1038/s42003-025-08340-0openalex-snapshot
Metabolic acclimation to warming links unexpected immune activation and sexual dimorphism attenuation in Xenopus tropicalis
inferred← citeshttps://doi.org/10.1038/s42255-025-01309-7openalex-snapshot
Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study
inferred← citeshttps://doi.org/10.1038/s44222-025-00384-5openalex-snapshot
Organoid analytical toolkits
inferred← citeshttps://doi.org/10.1042/bcj20200883openalex-snapshot
Phasing the intranuclear organization of steroid hormone receptors
inferred← citeshttps://doi.org/10.1042/bsr20221956openalex-snapshot
Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin
inferred← citeshttps://doi.org/10.1042/cs20240787openalex-snapshot
Cross-talk between microbiota–gut–brain axis and blood pressure regulation
inferred← citeshttps://doi.org/10.1042/cs20250793openalex-snapshot
How lipid ingestion is sensed: the mechanisms underlying intestinal hormone secretion
inferred← citeshttps://doi.org/10.1073/pnas.2212057119openalex-snapshot
Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models
inferred← citeshttps://doi.org/10.1073/pnas.2405463121openalex-snapshot
Single-cell resolution of intestinal regeneration in pythons without crypts illuminates conserved vertebrate regenerative mechanisms
inferred← citeshttps://doi.org/10.1073/pnas.2411189121openalex-snapshot
A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine
inferred← citeshttps://doi.org/10.1073/pnas.2501525122openalex-snapshot
Population imaging of enterochromaffin cell activity reveals regulation by somatostatin
inferred← citeshttps://doi.org/10.1080/19490976.2023.2256043openalex-snapshot
Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling
inferred← citeshttps://doi.org/10.1080/19490976.2025.2456592openalex-snapshot
Interkingdom signaling between gastrointestinal hormones and the gut microbiome
inferred← citeshttps://doi.org/10.1085/jgp.202213324openalex-snapshot
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors
inferred← citeshttps://doi.org/10.1093/bbb/zbaf121openalex-snapshot
Mucin-dependent transcriptional dynamics of Akkermansia muciniphila in co-culture with human colonic organoids
inferred← citeshttps://doi.org/10.1093/chemse/bjad027openalex-snapshot
Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease
inferred← citeshttps://doi.org/10.1093/ibd/izad044openalex-snapshot
Therapeutic Potential of Human Intestinal Organoids in Tissue Repair Approaches in Inflammatory Bowel Diseases
inferred← citeshttps://doi.org/10.1093/toxsci/kfae158openalex-snapshot
Development of the serotonin release assay with enterochromaffin cell-rich human intestinal organoids for the risk evaluation of drug-induced emesis
inferred← citeshttps://doi.org/10.1097/med.0000000000000610openalex-snapshot
Ghrelin-cell physiology and role in the gastrointestinal tract
inferred← citeshttps://doi.org/10.1097/med.0000000000000613openalex-snapshot
Editorial: Gastrointestinal regulatory peptides
inferred← citeshttps://doi.org/10.1097/med.0000000000000614openalex-snapshot
Chemosensing in enteroendocrine cells: mechanisms and therapeutic opportunities
inferred← citeshttps://doi.org/10.1097/med.0000000000000709openalex-snapshot
Enteroendocrine cell differentiation and function in the intestine
inferred← citeshttps://doi.org/10.1097/med.0000000000000719openalex-snapshot
Gastrointestinal regulatory peptides
inferred← citeshttps://doi.org/10.1101/2021.05.28.446100openalex-snapshot
Dissecting Functional, Structural, and Molecular Requirements for Serotonin Release from Mouse Enterochromaffin Cells
inferred← citeshttps://doi.org/10.1101/2021.09.17.21263540openalex-snapshot
Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade
inferred← citeshttps://doi.org/10.1101/2021.09.24.460132openalex-snapshot
Maturation of human intestinal epithelium from pluripotency in vitro
inferred← citeshttps://doi.org/10.1101/2021.11.30.470653openalex-snapshot
The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D risk
inferred← citeshttps://doi.org/10.1101/2022.09.25.509333openalex-snapshot
Separation of the effects of small intestinal microbiome-diet interactions on human gut hormone secretion
inferred← citeshttps://doi.org/10.1101/2022.09.30.509798openalex-snapshot
Dual states of Bmi1-expressing intestinal stem cells drive epithelial development and tissue regeneration
inferred← citeshttps://doi.org/10.1101/2023.08.10.552796openalex-snapshot
Uranium-bearing dust induces differentiation and expansion of enteroendocrine cells in human colonoids
inferred← citeshttps://doi.org/10.1101/2023.12.18.572103openalex-snapshot
Dynamics and plasticity of stem cells in the regenerating human colonic epithelium
inferred← citeshttps://doi.org/10.1101/2024.01.01.573838openalex-snapshot
A high-fidelity in vitro model of the human intestinal epithelium
inferred← citeshttps://doi.org/10.1101/2024.06.26.600832openalex-snapshot
Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin and juvenile hormone
inferred← citeshttps://doi.org/10.1101/2024.09.10.612352openalex-snapshot
Neuroendocrine Control of Intestinal Regeneration Through the Vascular Niche in Drosophila
inferred← citeshttps://doi.org/10.1101/2024.10.29.620704openalex-snapshot
Mapping the druggable targets displayed by human colonic enteroendocrine cells
inferred← citeshttps://doi.org/10.1101/2024.12.02.626361openalex-snapshot
A single-cell atlas of transcriptome changes in the intestinal epithelium at the suckling-to-weaning transition
inferred← citeshttps://doi.org/10.1101/2025.02.10.637596openalex-snapshot
A single-cell transcriptomic comparison between small intestinal neuroendocrine tumors and their progenitor
inferred← citeshttps://doi.org/10.1101/2025.05.02.651468openalex-snapshot
Modeling host-microbe interactions in immunocompetent engineered human gut tissues
inferred← citeshttps://doi.org/10.1101/2025.07.21.665913openalex-snapshot
Single cell transcriptomics reveals that air-liquid interface culture promotes goblet cell differentiation and inhibits glycolysis in cell monolayers derived from rabbit caecum organoids
inferred← citeshttps://doi.org/10.1101/2025.08.27.672561openalex-snapshot
Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut
inferred← citeshttps://doi.org/10.1111/bph.70010openalex-snapshot
Opportunities of patient‐derived organoids in drug development
inferred← citeshttps://doi.org/10.1111/dme.15212openalex-snapshot
Dorothy Hodgkin lecture 2023: The enteroendocrine system—Sensors in your guts
inferred← citeshttps://doi.org/10.1111/febs.16067openalex-snapshot
The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review
inferred← citeshttps://doi.org/10.1111/his.14789openalex-snapshot
Pitx2 is a useful marker of midgut‐derived neuroendocrine tumours – an immunohistochemical study of 224 cases
inferred← citeshttps://doi.org/10.1111/jne.70249openalex-snapshot
Comparative analysis of SCGN expression patterns in the anterior pituitary gland of mouse, pig, and human by single‐cell transcriptomics
inferred← citeshttps://doi.org/10.1113/jp287463openalex-snapshot
Single‐cell transcriptomics of human organoid‐derived enteroendocrine cell populations from the small intestine
inferred← citeshttps://doi.org/10.1124/pharmrev.121.000423openalex-snapshot
Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics
inferred← citeshttps://doi.org/10.1126/science.add5787openalex-snapshot
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target
inferred← citeshttps://doi.org/10.1126/science.adi2246openalex-snapshot
Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation
inferred← citeshttps://doi.org/10.1126/science.adl1460openalex-snapshot
Description and functional validation of human enteroendocrine cell sensors
inferred← citeshttps://doi.org/10.1126/science.adr8753openalex-snapshot
Epithelial tension controls intestinal cell extrusion
inferred← citeshttps://doi.org/10.1126/sciimmunol.adr4057openalex-snapshot
Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages
inferred← citeshttps://doi.org/10.1126/scitranslmed.ado5177openalex-snapshot
Intestinal TGR5-targeted carrier-drug conjugate improves glycemic control in mice and pigs
inferred← citeshttps://doi.org/10.1128/msphere.00820-24openalex-snapshot
Intestinal organoid models as tools to interrogate the physiology of human mucosal tissues and host-microbe interactions
inferred← citeshttps://doi.org/10.1136/gutjnl-2021-326560openalex-snapshot
Organoids in gastrointestinal diseases: from experimental models to clinical translation
inferred← citeshttps://doi.org/10.1146/annurev-genom-120324-024252openalex-snapshot
Organoid Perturbations as Tools to Explore Cellular Function and Plasticity
inferred← citeshttps://doi.org/10.1146/annurev-physiol-042222-023455openalex-snapshot
The Coding Logic of Interoception
inferred← citeshttps://doi.org/10.1152/ajpgi.00147.2023openalex-snapshot
Transcriptional regulation of metabolism in the intestinal epithelium
inferred← citeshttps://doi.org/10.1152/ajpgi.00222.2021openalex-snapshot
Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types
inferred← citeshttps://doi.org/10.1152/ajpgi.00251.2025openalex-snapshot
Single-cell transcriptomics reveals that air-liquid interface culture promotes goblet cell differentiation and inhibits glycolysis in organoid cell monolayers
inferred← citeshttps://doi.org/10.1152/physiolgenomics.00094.2026openalex-snapshot
Bacterial serine protease EspP induces differentiation and expansion of enteroendocrine cells in human colonoids
inferred← citeshttps://doi.org/10.1152/physrev.00018.2022openalex-snapshot
The enteric nervous system
inferred← citeshttps://doi.org/10.1152/physrev.00057.2024openalex-snapshot
Proglucagon-derived peptides: human physiology and therapeutic potential
inferred← citeshttps://doi.org/10.11569/wcjd.v32.i7.468openalex-snapshot
Recent studies on gut-brain axis and irritable bowel syndrome
inferred← citeshttps://doi.org/10.1158/0008-5472.can-21-0933openalex-snapshot
Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage
inferred← citeshttps://doi.org/10.1172/jci.insight.153045openalex-snapshot
MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors
inferred← citeshttps://doi.org/10.1172/jci197772openalex-snapshot
Multiomic analyses delineate human neuroendocrine tumor cell states in relation to normal enteroendocrine cell ontogeny
inferred← citeshttps://doi.org/10.1186/s12885-023-10722-8openalex-snapshot
Exposure to nonanoic acid alters small intestinal neuroendocrine tumor phenotype
inferred← citeshttps://doi.org/10.1186/s13024-025-00804-5openalex-snapshot
Lewy body diseases and the gut
inferred← citeshttps://doi.org/10.1186/s13578-024-01257-xopenalex-snapshot
Protein arginine methyltransferase 1 regulates mouse enteroendocrine cell development and homeostasis
inferred← citeshttps://doi.org/10.1186/s13619-020-00059-zopenalex-snapshot
Organoid based personalized medicine: from bench to bedside
inferred← citeshttps://doi.org/10.1186/s13619-022-00127-6openalex-snapshot
Intestinal cellular heterogeneity and disease development revealed by single-cell technology
inferred← citeshttps://doi.org/10.1186/s41232-024-00355-0openalex-snapshot
Regulation of intestinal epithelial homeostasis by mesenchymal cells
inferred← citeshttps://doi.org/10.1186/s43556-025-00364-6openalex-snapshot
Single-cell sequencing and organoids: applications in organ development and disease
inferred← citeshttps://doi.org/10.1186/s43556-026-00467-8openalex-snapshot
Glioblastoma: epidemiology, molecular pathogenesis, diagnosis, management, and therapeutic resistance
inferred← citeshttps://doi.org/10.1210/endocr/bqac118openalex-snapshot
Disrupted and Elevated Circadian Secretion of Glucagon-Like Peptide-1 in a Murine Model of Type 2 Diabetes
inferred← citeshttps://doi.org/10.1210/endocr/bqac159openalex-snapshot
The Molecular Determinants of Glucagon-like Peptide Secretion by the Intestinal L cell
inferred← citeshttps://doi.org/10.1210/endrev/bnaa032openalex-snapshot
Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation
inferred← citeshttps://doi.org/10.1242/bio.062083openalex-snapshot
Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development
inferred← citeshttps://doi.org/10.1289/ehp13855openalex-snapshot
Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust
inferred← citeshttps://doi.org/10.1360/ssv-2024-0025openalex-snapshot
Research progress and perspectives on the evolution of mammal diet
inferred← citeshttps://doi.org/10.1371/journal.pone.0308942openalex-snapshot
Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract
inferred← citeshttps://doi.org/10.1530/jme-23-0112openalex-snapshot
Cellular mechanisms of incretin hormone secretion
inferred← citeshttps://doi.org/10.18632/oncotarget.27935openalex-snapshot
Controlling for cellular heterogeneity using single-cell deconvolution of gene expression reveals novel markers of colorectal tumors exhibiting microsatellite instability
inferred← citeshttps://doi.org/10.21203/rs.3.rs-10374273/v1openalex-snapshot
Proteomic analysis reveals WNT3a, TGFβ, and cAMP-dependent cell type differentiation in gastric antral mucosoids
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5411079/v1openalex-snapshot
Mapping the druggable targets displayed by human colonic enteroendocrine cells
inferred← citeshttps://doi.org/10.2147/jir.s448819openalex-snapshot
Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis
inferred← citeshttps://doi.org/10.33540/1556openalex-snapshot
Cellular Heterogeneity during Metastatic Colonization of Colorectal Cancer
inferred← citeshttps://doi.org/10.33540/930openalex-snapshot
Modelling of a wide variety of disease using adult stem cell-derived organoids
inferred← citeshttps://doi.org/10.3389/fcell.2022.841090openalex-snapshot
Digital Spatial Profiling Reveals Functional Shift of Enterochromaffin Cell in Patients With Ulcerative Colitis
inferred← citeshttps://doi.org/10.3389/fcell.2022.915654openalex-snapshot
Single-Cell RNA Sequencing for Analyzing the Intestinal Tract in Healthy and Diseased Individuals
inferred← citeshttps://doi.org/10.3389/fendo.2021.694284openalex-snapshot
What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?
inferred← citeshttps://doi.org/10.3389/fendo.2023.1206063openalex-snapshot
GPCR-mediated effects of fatty acids and bile acids on glucose homeostasis
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