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TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bdra.20794openalex-snapshot
TGFβ signaling and congenital heart disease: Insights from mouse studies
inferredcites →https://doi.org/10.1002/cm.970050302openalex-snapshot
Analysis of the morphology and function of primary cilia in connective tissues:A cellular cybernetic probe?
inferredcites →https://doi.org/10.1002/path.3004openalex-snapshot
Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling
inferredcites →https://doi.org/10.1006/meth.2001.1262openalex-snapshot
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
inferredcites →https://doi.org/10.1007/978-1-60761-369-5_11openalex-snapshot
Immunoflourescence and mRNA Analysis of Human Embryonic Stem Cells (hESCs) Grown Under Feeder-Free Conditions
inferredcites →https://doi.org/10.1007/s00467-010-1731-7openalex-snapshot
Ciliopathies: an expanding disease spectrum
inferredcites →https://doi.org/10.1016/j.cell.2011.05.030openalex-snapshot
A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development
inferredcites →https://doi.org/10.1016/j.cub.2005.09.012openalex-snapshot
PDGFRαα Signaling Is Regulated through the Primary Cilium in Fibroblasts
inferredcites →https://doi.org/10.1016/j.diff.2011.11.012openalex-snapshot
Inversin, Wnt signaling and primary cilia
inferredcites →https://doi.org/10.1016/j.tcb.2011.03.006openalex-snapshot
Rabs and the exocyst in ciliogenesis, tubulogenesis and beyond
inferredcites →https://doi.org/10.1016/s0076-6879(07)38006-3openalex-snapshot
Use of Dynasore, the Small Molecule Inhibitor of Dynamin, in the Regulation of Endocytosis
inferredcites →https://doi.org/10.1016/s0091-679x(08)94009-7openalex-snapshot
Using Nucleofection of siRNA Constructs for Knockdown of Primary Cilia in P19.CL6 Cancer Stem Cell Differentiation into Cardiomyocytes
inferredcites →https://doi.org/10.1016/s1472-6483(10)60697-9openalex-snapshot
Regional differences in expression of specific markers for human embryonic stem cells
inferredcites →https://doi.org/10.1038/cr.2008.302openalex-snapshot
Signaling cross-talk between TGF-β/BMP and other pathways
inferredcites →https://doi.org/10.1038/ncb1670openalex-snapshot
Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms
inferredcites →https://doi.org/10.1038/ncb2117openalex-snapshot
Primary cilia regulate mTORC1 activity and cell size through Lkb1
inferredcites →https://doi.org/10.1038/nrg2774openalex-snapshot
The primary cilium: a signalling centre during vertebrate development
inferredcites →https://doi.org/10.1038/nrm2748openalex-snapshot
Endocytosis and signalling: intertwining molecular networks
inferredcites →https://doi.org/10.1038/nrm3151openalex-snapshot
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
inferredcites →https://doi.org/10.1042/bc20100128openalex-snapshot
The ciliary pocket: a once-forgotten membrane domain at the base of cilia
inferredcites →https://doi.org/10.1056/nejmra1010172openalex-snapshot
Ciliopathies
inferredcites →https://doi.org/10.1074/jbc.m008412200openalex-snapshot
A Regulatory Light Chain of Ciliary Outer Arm Dynein inTetrahymena thermophila
inferredcites →https://doi.org/10.1091/mbc.e04-03-0245openalex-snapshot
Ligand-dependent and -independent Transforming Growth Factor-β Receptor Recycling Regulated by Clathrin-mediated Endocytosis and Rab11
inferredcites →https://doi.org/10.1093/bioinformatics/btn025openalex-snapshot
SOAP: short oligonucleotide alignment program
inferredcites →https://doi.org/10.1093/emboj/19.17.4577openalex-snapshot
Localization of phosphatidylinositol 3‐phosphate in yeast and mammalian cells
inferredcites →https://doi.org/10.1093/nar/gkn705openalex-snapshot
Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms
inferredcites →https://doi.org/10.1111/j.1365-2958.2004.04224.xopenalex-snapshot
Endocytosis, membrane recycling and sorting of GPI‐anchored proteins: Trypanosoma brucei as a model system
inferredcites →https://doi.org/10.1161/circresaha.108.192237openalex-snapshot
Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.1161/circresaha.110.231860openalex-snapshot
Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition
inferredcites →https://doi.org/10.1186/2045-3701-2-9openalex-snapshot
Regulation of TGF-β receptor activity
inferredcites →https://doi.org/10.1186/2046-2530-1-4openalex-snapshot
Trafficking in and to the primary cilium
inferredcites →https://doi.org/10.1242/jcs.035626openalex-snapshot
Flagellum elongation is required for correct structure, orientation and function of the flagellar pocket in Trypanosoma brucei
inferredcites →https://doi.org/10.1242/jcs.049676openalex-snapshot
The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation
inferredcites →https://doi.org/10.1242/jcs.050377openalex-snapshot
The primary cilium at a glance
inferredcites →https://doi.org/10.1242/jcs.059519openalex-snapshot
The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia
inferredcites →https://doi.org/10.1242/jcs.085852openalex-snapshot
EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms
inferredcites →https://doi.org/10.1242/jcs.095299openalex-snapshot
TGF-β-induced activation of mTOR complex 2 drives epithelial–mesenchymal transition and cell invasion
inferredcites →https://doi.org/10.1247/csf.21.101openalex-snapshot
Differentiation of Beating Cardiac Muscle Cells from a Derivative of P19 Embryonal Carcinoma Cells.
inferredcites →https://doi.org/10.1371/journal.pgen.1000315openalex-snapshot
The Golgin GMAP210/TRIP11 Anchors IFT20 to the Golgi Complex
inferredcites →https://doi.org/10.14670/hh-25.865openalex-snapshot
Primary cilia in fibroblast-like type B synoviocytes lie within a cilium pit: a site of endocytosis.
inferredcites →https://doi.org/10.2741/e147openalex-snapshot
Smad anchor for receptor activation SARA in TGF-beta signaling

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4797658openalex-extracted
Primary Cilia Confer TGFβ1-Dependent Resistance in Rat Cardiac Fibroblasts after X-Ray Injury
inferred← citeshttps://doi.org/10.1002/advs.201801138openalex-snapshot
Primary Cilia as Signaling Hubs in Health and Disease
inferred← citeshttps://doi.org/10.1002/alz.71645openalex-snapshot
Primary cilia–extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential
inferred← citeshttps://doi.org/10.1002/bdrc.21063openalex-snapshot
Primary cilia in pancreatic development and disease
inferred← citeshttps://doi.org/10.1002/bdrc.21067openalex-snapshot
Role of cilia in structural birth defects: Insights from ciliopathy mutant mouse models
inferred← citeshttps://doi.org/10.1002/bem.22187openalex-snapshot
The cellular effects of Pulsed Electromagnetic Fields on osteoblasts: A review
inferred← citeshttps://doi.org/10.1002/cbin.10337openalex-snapshot
Evolutionary implications of localization of the signaling scaffold protein Parafusin to both cilia and the nucleus
inferred← citeshttps://doi.org/10.1002/dvdy.24524openalex-snapshot
A role for primary cilia in aortic valve development and disease
inferred← citeshttps://doi.org/10.1002/dvdy.724openalex-snapshot
Actin cytoskeletal regulation of ciliogenesis in development and disease
inferred← citeshttps://doi.org/10.1002/humu.23362openalex-snapshot
Expanding the genetic architecture and phenotypic spectrum in the skeletal ciliopathies
inferred← citeshttps://doi.org/10.1002/jbmr.3902openalex-snapshot
IFT80 Is Required for Fracture Healing Through Controlling the Regulation of TGF-β Signaling in Chondrocyte Differentiation and Function
inferred← citeshttps://doi.org/10.1002/jcp.25005openalex-snapshot
TGF‐β Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells
inferred← citeshttps://doi.org/10.1002/jcp.25839openalex-snapshot
Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria
inferred← citeshttps://doi.org/10.1002/jcp.30787openalex-snapshot
Ciliary membrane, localised lipid modification and cilia function
inferred← citeshttps://doi.org/10.1002/jcp.31163openalex-snapshot
Primary cilium participates in radiation‐induced bystander effects through TGF‐β1 signaling
inferred← citeshttps://doi.org/10.1002/jcp.31292openalex-snapshot
Primary cilia abnormalities participate in the occurrence of spontaneous abortion through TGF‐β/SMAD2/3 signaling pathway
inferred← citeshttps://doi.org/10.1002/jor.23732openalex-snapshot
The primary cilium as a signaling nexus for growth plate function and subsequent skeletal development
inferred← citeshttps://doi.org/10.1002/stem.1975openalex-snapshot
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation
inferred← citeshttps://doi.org/10.1002/stem.2341openalex-snapshot
Concise Review: Primary Cilia: Control Centers for Stem Cell Lineage Specification and Potential Targets for Cell-Based Therapies
inferred← citeshttps://doi.org/10.1007/7651_2014_127openalex-snapshot
Immunofluorescence Microscopy and mRNA Analysis of Human Embryonic Stem Cells (hESCs) Including Primary Cilia Associated Signaling Pathways
inferred← citeshttps://doi.org/10.1007/978-1-0716-0732-9_3openalex-snapshot
Analysis of Caveolin in Primary Cilia
inferred← citeshttps://doi.org/10.1007/978-1-4939-3789-9openalex-snapshot
Cilia
inferred← citeshttps://doi.org/10.1007/978-1-4939-3789-9_3openalex-snapshot
Morphological and Functional Characterization of the Ciliary Pocket by Electron and Fluorescence Microscopy
inferred← citeshttps://doi.org/10.1007/978-3-031-11665-0_9openalex-snapshot
Ciliopathies: Their Role in Pediatric Kidney Disease
inferred← citeshttps://doi.org/10.1007/978-3-031-70835-0_10openalex-snapshot
The Skeletal Ciliopathies
inferred← citeshttps://doi.org/10.1007/978-3-032-19509-8_12openalex-snapshot
Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases
inferred← citeshttps://doi.org/10.1007/978-3-662-52972-0_11openalex-snapshot
Ciliopathies: Their Role in Pediatric Renal Disease
inferred← citeshttps://doi.org/10.1007/s00018-017-2460-xopenalex-snapshot
Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2
inferred← citeshttps://doi.org/10.1007/s00018-017-2570-5openalex-snapshot
Routes and machinery of primary cilium biogenesis
inferred← citeshttps://doi.org/10.1007/s00018-018-2761-8openalex-snapshot
TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
inferred← citeshttps://doi.org/10.1007/s00223-019-00554-9openalex-snapshot
The Response of Osteoblasts and Bone to Sinusoidal Electromagnetic Fields: Insights from the Literature
inferred← citeshttps://doi.org/10.1007/s00424-020-02501-2openalex-snapshot
TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei
inferred← citeshttps://doi.org/10.1007/s00439-024-02703-zopenalex-snapshot
Rare homozygous cilia gene variants identified in consanguineous congenital heart disease patients
inferred← citeshttps://doi.org/10.1007/s00441-020-03343-1openalex-snapshot
A role for primary cilia in coral calcification?
inferred← citeshttps://doi.org/10.1007/s11010-023-04765-5openalex-snapshot
Skeletal ciliopathy: pathogenesis and related signaling pathways
inferred← citeshttps://doi.org/10.1007/s11010-023-04817-wopenalex-snapshot
The implication of ciliary signaling pathways for epithelial–mesenchymal transition
inferred← citeshttps://doi.org/10.1007/s11914-017-0351-6openalex-snapshot
Functional Diversity of Ciliary Proteins in Bone Development and Disease
inferred← citeshttps://doi.org/10.1007/s11926-019-0822-0openalex-snapshot
The Primary Cilium: Emerging Role as a Key Player in Fibrosis
inferred← citeshttps://doi.org/10.1007/s12565-022-00663-wopenalex-snapshot
Depletion of Ift88 in thymic epithelial cells affects thymic synapse and T-cell differentiation in aged mice
inferred← citeshttps://doi.org/10.1007/s12672-026-05763-xopenalex-snapshot
Primary cilia connect epithelial mesenchymal plasticity with anoikis resistance and cancer stemness
inferred← citeshttps://doi.org/10.1007/s42764-022-00068-zopenalex-snapshot
Centrosome, microtubule and DNA damage response
inferred← citeshttps://doi.org/10.1016/b978-0-12-394447-4.20064-3openalex-snapshot
Cilia and Flagella
inferred← citeshttps://doi.org/10.1016/b978-0-12-408077-5.00013-4openalex-snapshot
Hemodynamics in the Developing Cardiovascular System
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11211-5openalex-snapshot
Cilia-Mediated Signaling
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00209-1openalex-snapshot
Cilia and Flagella
inferred← citeshttps://doi.org/10.1016/bs.mcb.2018.11.016openalex-snapshot
Sea urchin embryonic cilia
inferred← citeshttps://doi.org/10.1016/j.actbio.2016.01.037openalex-snapshot
Differentiation of mesenchymal stem cells for cartilage tissue engineering: Individual and synergetic effects of three-dimensional environment and mechanical loading
inferred← citeshttps://doi.org/10.1016/j.actbio.2017.04.004openalex-snapshot
Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis
inferred← citeshttps://doi.org/10.1016/j.ajhg.2021.02.008openalex-snapshot
Mendelian pathway analysis of laboratory traits reveals distinct roles for ciliary subcompartments in common disease pathogenesis
inferred← citeshttps://doi.org/10.1016/j.ajhg.2022.03.015openalex-snapshot
Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.10.037openalex-snapshot
Overexpression of smad7 inhibits the TGF-β/Smad signaling pathway and EMT in NPHP1-defective MDCK cells
inferred← citeshttps://doi.org/10.1016/j.bcp.2020.113906openalex-snapshot
The primary cilium: Its role as a tumor suppressor organelle
inferred← citeshttps://doi.org/10.1016/j.biocel.2020.105718openalex-snapshot
The primary cilia in diabetic kidney disease: A tubulocentric view?
inferred← citeshttps://doi.org/10.1016/j.biocel.2025.106754openalex-snapshot
SIRT2 inhibition attenuates myofibroblast transition through autophagy-mediated ciliogenesis in renal epithelial cells
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.07.178openalex-snapshot
Comparative transcriptomics of shear stress treated Pkd1−/− cells and pre-cystic kidneys reveals pathways involved in early polycystic kidney disease
inferred← citeshttps://doi.org/10.1016/j.bone.2016.09.008openalex-snapshot
Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium
inferred← citeshttps://doi.org/10.1016/j.bone.2020.115738openalex-snapshot
Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice
inferred← citeshttps://doi.org/10.1016/j.ceb.2016.05.004openalex-snapshot
Permeability barriers for generating a unique ciliary protein and lipid composition
inferred← citeshttps://doi.org/10.1016/j.ceb.2017.03.012openalex-snapshot
Gates for soluble and membrane proteins, and two trafficking systems (IFT and LIFT), establish a dynamic ciliary signaling compartment
inferred← citeshttps://doi.org/10.1016/j.ceb.2018.01.008openalex-snapshot
Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides
inferred← citeshttps://doi.org/10.1016/j.ceb.2018.03.004openalex-snapshot
The molecular machines that traffic signaling receptors into and out of cilia
inferred← citeshttps://doi.org/10.1016/j.ceb.2019.04.007openalex-snapshot
Membrane retrieval, recycling and release pathways that organise and sculpt the ciliary membrane
inferred← citeshttps://doi.org/10.1016/j.cellsig.2014.04.004openalex-snapshot
The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity
inferred← citeshttps://doi.org/10.1016/j.celrep.2015.04.025openalex-snapshot
TGF-β Signaling Regulates the Differentiation of Motile Cilia
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.02.043openalex-snapshot
CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117906openalex-snapshot
Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state
inferred← citeshttps://doi.org/10.1016/j.cub.2014.11.066openalex-snapshot
Proteomic Analysis of Isolated Ciliary Transition Zones Reveals the Presence of ESCRT Proteins
inferred← citeshttps://doi.org/10.1016/j.cub.2025.08.022openalex-snapshot
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia
inferred← citeshttps://doi.org/10.1016/j.devcel.2015.07.016openalex-snapshot
Components of Intraflagellar Transport Complex A Function Independently of the Cilium to Regulate Canonical Wnt Signaling in Drosophila
inferred← citeshttps://doi.org/10.1016/j.devcel.2019.05.022openalex-snapshot
Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis
inferred← citeshttps://doi.org/10.1016/j.devcel.2020.09.016openalex-snapshot
Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells
inferred← citeshttps://doi.org/10.1016/j.diff.2024.100782openalex-snapshot
The ciliary protein C2cd3 is required for mandibular musculoskeletal tissue patterning
inferred← citeshttps://doi.org/10.1016/j.diff.2024.100818openalex-snapshot
The primary cilia: Orchestrating cranial neural crest cell development
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.118200openalex-snapshot
Lithium carbonate exposure disrupts neurodevelopment by perturbing primary cilia and ER homeostasis
inferred← citeshttps://doi.org/10.1016/j.gde.2019.05.002openalex-snapshot
Cilia and development
inferred← citeshttps://doi.org/10.1016/j.gendis.2018.12.004openalex-snapshot
Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants
inferred← citeshttps://doi.org/10.1016/j.isci.2024.111123openalex-snapshot
The secretory pathway in Tetrahymena is organized for efficient constitutive secretion at ciliary pockets
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100680openalex-snapshot
Nonredundant roles of DIAPHs in primary ciliogenesis
inferred← citeshttps://doi.org/10.1016/j.jbiomech.2014.04.004openalex-snapshot
Primary cilium mechanotransduction of tensile strain in 3D culture: Finite element analyses of strain amplification caused by tensile strain applied to a primary cilium embedded in a collagen matrix
inferred← citeshttps://doi.org/10.1016/j.jhep.2024.06.002openalex-snapshot
Primary cilia as a targetable node between biliary injury, senescence and regeneration in liver transplantation
inferred← citeshttps://doi.org/10.1016/j.jot.2024.09.004openalex-snapshot
From polarity to pathology: Decoding the role of cell orientation in osteoarthritis
inferred← citeshttps://doi.org/10.1016/j.molimm.2019.04.014openalex-snapshot
The role of microtubules in the immune system and as potential targets for gut-based immunotherapy
inferred← citeshttps://doi.org/10.1016/j.nbd.2026.107418openalex-snapshot
Modulating primary cilia and cilia-dependent Shh signaling increases retinal ganglion cell survival by repressing astrocyte reactivity after optic nerve injury
inferred← citeshttps://doi.org/10.1016/j.ocarto.2023.100357openalex-snapshot
Chondrocyte primary cilia lengthening and shortening in response to mediators of osteoarthritis; a role for integrin α1β1 and focal adhesions
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2018.01.002openalex-snapshot
Cardiac repair by epicardial EMT: Current targets and a potential role for the primary cilium
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107632openalex-snapshot
Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2017.05.001openalex-snapshot
Cilia - The sensory antennae in the eye
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2022.101064openalex-snapshot
The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up
inferred← citeshttps://doi.org/10.1016/j.sbi.2016.06.009openalex-snapshot
The intraflagellar transport machinery in ciliary signaling
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.169702openalex-snapshot
Understanding the effects of per- and polyfluoroalkyl substances on early skin development: Role of ciliogenesis inhibition and altered microtubule dynamics
inferred← citeshttps://doi.org/10.1016/j.semcdb.2020.06.003openalex-snapshot
Right, left and cilia: How asymmetry is established
inferred← citeshttps://doi.org/10.1016/j.tibs.2016.06.002openalex-snapshot
Endocytic Control of Cellular Signaling at the Primary Cilium
inferred← citeshttps://doi.org/10.1016/j.ydbio.2015.05.012openalex-snapshot
Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts
inferred← citeshttps://doi.org/10.1016/j.ygeno.2021.05.015openalex-snapshot
Biallelic variant in DACH1, encoding Dachshund Homolog 1, defines a novel candidate locus for recessive postaxial polydactyly type A
inferred← citeshttps://doi.org/10.1017/s175173111900209xopenalex-snapshot
Review: Enhancing intramuscular fat development via targeting fibro-adipogenic progenitor cells in meat animals
inferred← citeshttps://doi.org/10.1038/cdd.2014.171openalex-snapshot
Autophagy and regulation of cilia function and assembly
inferred← citeshttps://doi.org/10.1038/cdd.2015.80openalex-snapshot
Primary cilia and autophagic dysfunction in Huntington’s disease
inferred← citeshttps://doi.org/10.1038/nature14269openalex-snapshot
Global genetic analysis in mice unveils central role for cilia in congenital heart disease
inferred← citeshttps://doi.org/10.1038/ncb3109openalex-snapshot
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation
inferred← citeshttps://doi.org/10.1038/nri.2016.54openalex-snapshot
Origins of the cytolytic synapse
inferred← citeshttps://doi.org/10.1038/s41388-025-03416-xopenalex-snapshot
Primary cilia and cancer: a tale of many faces
inferred← citeshttps://doi.org/10.1038/s41392-024-02069-8openalex-snapshot
The molecular mechanisms of cardiac development and related diseases
inferred← citeshttps://doi.org/10.1038/s41419-024-06972-4openalex-snapshot
CYLD/HDAC6 signaling regulates the interplay between epithelial-mesenchymal transition and ciliary homeostasis during pulmonary fibrosis
inferred← citeshttps://doi.org/10.1038/s41467-019-08520-7openalex-snapshot
Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
inferred← citeshttps://doi.org/10.1038/s41467-019-09403-7openalex-snapshot
Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish
inferred← citeshttps://doi.org/10.1038/s41467-022-28982-6openalex-snapshot
Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition
inferred← citeshttps://doi.org/10.1038/s41568-018-0023-6openalex-snapshot
Ciliary signalling in cancer
inferred← citeshttps://doi.org/10.1038/s41569-021-00635-zopenalex-snapshot
A change of heart: new roles for cilia in cardiac development and disease
inferred← citeshttps://doi.org/10.1038/s41576-023-00587-9openalex-snapshot
Primary cilia as dynamic and diverse signalling hubs in development and disease
inferred← citeshttps://doi.org/10.1038/s41580-019-0116-4openalex-snapshot
Establishing and regulating the composition of cilia for signal transduction
inferred← citeshttps://doi.org/10.1038/s41581-019-0116-9openalex-snapshot
Cellular signalling by primary cilia in development, organ function and disease
inferred← citeshttps://doi.org/10.1038/s41581-023-00773-2openalex-snapshot
Transport and barrier mechanisms that regulate ciliary compartmentalization and ciliopathies
inferred← citeshttps://doi.org/10.1038/s41581-026-01129-2openalex-snapshot
Primary cilia: master conductors of cellular communication in development and disease
inferred← citeshttps://doi.org/10.1038/s41598-017-01156-xopenalex-snapshot
The centrosomal OFD1 protein interacts with the translation machinery and regulates the synthesis of specific targets
inferred← citeshttps://doi.org/10.1038/s41598-017-10330-0openalex-snapshot
BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1
inferred← citeshttps://doi.org/10.1038/s41598-017-15649-2openalex-snapshot
The primary cilium is necessary for the differentiation and the maintenance of human adipose progenitors into myofibroblasts
inferred← citeshttps://doi.org/10.1038/s41598-018-27854-8openalex-snapshot
The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
inferred← citeshttps://doi.org/10.1038/s41598-018-29502-7openalex-snapshot
Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
inferred← citeshttps://doi.org/10.1038/s41598-019-51381-9openalex-snapshot
Coordination of WNT signaling and ciliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1
inferred← citeshttps://doi.org/10.1038/s41598-024-60164-wopenalex-snapshot
Integrating tumor and healthy epithelium in a micro-physiology multi-compartment approach to study renal cell carcinoma pathophysiology
inferred← citeshttps://doi.org/10.1038/s41598-024-71159-yopenalex-snapshot
Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling
inferred← citeshttps://doi.org/10.1038/s41598-025-22584-0openalex-snapshot
Phosphoproteomic profiling highlights CDC42 and CDK2 as key players in the regulation of the TGF-β pathway in ALMS1 and BBS1 knockout models
inferred← citeshttps://doi.org/10.1038/s44319-023-00019-zopenalex-snapshot
Cep120 is essential for kidney stromal progenitor cell growth and differentiation
inferred← citeshttps://doi.org/10.1038/s44319-024-00170-1openalex-snapshot
DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
inferred← citeshttps://doi.org/10.1038/srep10364openalex-snapshot
Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells
inferred← citeshttps://doi.org/10.1038/srep35542openalex-snapshot
TGFβ1 – induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner
inferred← citeshttps://doi.org/10.1042/bst20253108openalex-snapshot
The primary cilium at the helm: gatekeeper of TGF-β superfamily signaling in development, homeostasis, and disease
inferred← citeshttps://doi.org/10.1042/ebc20180030openalex-snapshot
Trafficking of ciliary membrane proteins by the intraflagellar transport/BBSome machinery
inferred← citeshttps://doi.org/10.1051/medsci/20143011009openalex-snapshot
La poche ciliaire : fruit des liaisons du centrosome avec le trafic vésiculaire
inferred← citeshttps://doi.org/10.1051/medsci/20143011014openalex-snapshot
Cils et morphogenèse cardiaque
inferred← citeshttps://doi.org/10.1055/a-2563-9791openalex-snapshot
Primary Cilia in Hepatic Biliary Hyperplasia: Implications for Liver Diseases
inferred← citeshttps://doi.org/10.1073/pnas.1518079113openalex-snapshot
Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei
inferred← citeshttps://doi.org/10.1073/pnas.2021942118openalex-snapshot
Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells
inferred← citeshttps://doi.org/10.1080/10985549.2023.2198931openalex-snapshot
Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog
inferred← citeshttps://doi.org/10.1080/21541248.2017.1353847openalex-snapshot
Rab GTPases in cilium formation and function
inferred← citeshttps://doi.org/10.1083/jcb.201709041openalex-snapshot
BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone
inferred← citeshttps://doi.org/10.1089/scd.2017.0054openalex-snapshot
Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation
inferred← citeshttps://doi.org/10.1089/scd.2018.0231openalex-snapshot
Comparison of Cultured Human Cardiomyocyte Clusters Obtained from Embryos/Fetuses or Derived from Human Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1091/mbc.e13-07-0429openalex-snapshot
The fate of the primary cilium during myofibroblast transition
inferred← citeshttps://doi.org/10.1091/mbc.e18-06-0399openalex-snapshot
Cutting off ciliary protein import: intraflagellar transport after dendritic femtosecond-laser ablation
inferred← citeshttps://doi.org/10.1091/mbc.e21-05-0226openalex-snapshot
An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field
inferred← citeshttps://doi.org/10.1091/mbc.e22-02-0033openalex-snapshot
Developmental changes in ciliary composition during gametogenesis inChlamydomonas
inferred← citeshttps://doi.org/10.1093/biosci/biu179openalex-snapshot
Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development
inferred← citeshttps://doi.org/10.1093/cid/ciab216openalex-snapshot
Common and Rare Genetic Variants That Could Contribute to Severe Otitis Media in an Australian Aboriginal Population
inferred← citeshttps://doi.org/10.1093/hmg/ddu104openalex-snapshot
Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis
inferred← citeshttps://doi.org/10.1093/hmg/ddx163openalex-snapshot
Photoreceptor outer segment as a sink for membrane proteins: hypothesis and implications in retinal ciliopathies
inferred← citeshttps://doi.org/10.1093/hmg/ddx183openalex-snapshot
Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling
inferred← citeshttps://doi.org/10.1093/nar/gky873openalex-snapshot
Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation
inferred← citeshttps://doi.org/10.1096/fj.201701228ropenalex-snapshot
Primary cilia‐regulated transcriptome in the renal collecting duct
inferred← citeshttps://doi.org/10.1096/fj.201800334openalex-snapshot
Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP‐1–mediated endocytosis
inferred← citeshttps://doi.org/10.1096/fj.202001178ropenalex-snapshot
DIAPH1 regulates ciliogenesis and trafficking in primary cilia
inferred← citeshttps://doi.org/10.1096/fj.202001998ropenalex-snapshot
Fluid shear stress generates a unique signaling response by activating multiple TGFβ family type I receptors in osteocytes
inferred← citeshttps://doi.org/10.1096/fj.202101613ropenalex-snapshot
Midbody plays an active role in fibroblast‐myofibroblast transition by mediating TGF‐β signaling
inferred← citeshttps://doi.org/10.1097/bor.0000000000000841openalex-snapshot
The dynamic organelle primary cilia: emerging roles in organ fibrosis
inferred← citeshttps://doi.org/10.1097/brs.0000000000001927openalex-snapshot
Mutation of the Planar Cell Polarity Gene VANGL1 in Adolescent Idiopathic Scoliosis
inferred← citeshttps://doi.org/10.1097/hep.0000000000001055openalex-snapshot
Cholangiocyte ciliary defects induce sustained epidermal growth factor receptor signaling
inferred← citeshttps://doi.org/10.1097/igc.0000000000001321openalex-snapshot
Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma
inferred← citeshttps://doi.org/10.1098/rsob.220104openalex-snapshot
A transgenic zebrafish for in vivo visualization of cilia
inferred← citeshttps://doi.org/10.1101/2020.12.22.423978openalex-snapshot
A WDR35-dependent coatomer transports ciliary membrane proteins from the Golgi to the cilia
inferred← citeshttps://doi.org/10.1101/2022.11.02.514847openalex-snapshot
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes
inferred← citeshttps://doi.org/10.1101/2022.11.04.514246openalex-snapshot
Phosphoproteomic profiling highlights CDC42 and CDK2 as key players in the regulation of the TGF-β pathway in ALMS1 and BBS1 knockout models
inferred← citeshttps://doi.org/10.1101/2023.04.04.535583openalex-snapshot
Impaired centrosome biogenesis in kidney stromal progenitors reduces abundance of interstitial lineages and accelerates injury-induced fibrosis
inferred← citeshttps://doi.org/10.1101/2024.10.23.619933openalex-snapshot
Depletion of BBSome Subunits Alters Receptor Endocytosis and Promotes EMT via TGF-β Signalling
inferred← citeshttps://doi.org/10.1101/487330openalex-snapshot
Super-resolution Molecular Map of Basal Foot Reveals Novel Cilium in Airway Multiciliated Cells
inferred← citeshttps://doi.org/10.1101/cshperspect.a027904openalex-snapshot
The Biology of Ciliary Dynamics
inferred← citeshttps://doi.org/10.1101/cshperspect.a028167openalex-snapshot
Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling
inferred← citeshttps://doi.org/10.1101/cshperspect.a028266openalex-snapshot
Cilia and Ciliopathies in Congenital Heart Disease
inferred← citeshttps://doi.org/10.1111/ahg.12519openalex-snapshot
Uncovering cilia function in glial development
inferred← citeshttps://doi.org/10.1111/ahg.12534openalex-snapshot
Functions of cilia in cardiac development and disease
inferred← citeshttps://doi.org/10.1111/aogs.14306openalex-snapshot
Cyclic activity of signal transduction pathways in fimbrial epithelium of the human fallopian tube
inferred← citeshttps://doi.org/10.1111/boc.202300026openalex-snapshot
Functions of actin‐binding proteins in cilia structure remodeling and signaling
inferred← citeshttps://doi.org/10.1111/cpr.12765openalex-snapshot
Primary cilia: Versatile regulator in cartilage development
inferred← citeshttps://doi.org/10.1111/febs.14583openalex-snapshot
Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
inferred← citeshttps://doi.org/10.1111/jcmm.12290openalex-snapshot
Comparative proteomic analysis of human lung telocytes with fibroblasts
inferred← citeshttps://doi.org/10.1111/tra.12166openalex-snapshot
New Insights into an Old Organelle: Meeting Report on Biology of Cilia and Flagella
inferred← citeshttps://doi.org/10.1111/tra.12195openalex-snapshot
Ciliopathies: The Trafficking Connection
inferred← citeshttps://doi.org/10.1126/scisignal.aam7464openalex-snapshot
TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis
inferred← citeshttps://doi.org/10.1126/scitranslmed.aax0290openalex-snapshot
Primary cilia defects causing mitral valve prolapse
inferred← citeshttps://doi.org/10.1126/scitranslmed.abn3486openalex-snapshot
Primary cilia mediate skeletogenic BMP and Hedgehog signaling in heterotopic ossification
inferred← citeshttps://doi.org/10.1128/mcb.00765-15openalex-snapshot
Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization
inferred← citeshttps://doi.org/10.1134/s0006297926601590openalex-snapshot
Dysfunction of Primary Cilium in Huntington’s Disease: How Mutant Huntingtin Disrupts This Cellular Signaling Hub
inferred← citeshttps://doi.org/10.1152/ajplung.00017.2025openalex-snapshot
Lung-specific TGFβ overexpression increases airway fibrosis and airway contractility in transgenic mice
inferred← citeshttps://doi.org/10.1152/ajprenal.00366.2020openalex-snapshot
Overexpression of TGF-β1 induces renal fibrosis and accelerates the decline in kidney function in polycystic kidney disease
inferred← citeshttps://doi.org/10.1155/2017/4367019openalex-snapshot
New Roles of the Primary Cilium in Autophagy
inferred← citeshttps://doi.org/10.1159/000493217openalex-snapshot
Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out
inferred← citeshttps://doi.org/10.1161/circulationaha.117.028752openalex-snapshot
Fibroblast Primary Cilia Are Required for Cardiac Fibrosis
inferred← citeshttps://doi.org/10.1161/jaha.121.022332openalex-snapshot
Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis
inferred← citeshttps://doi.org/10.1177/11779322241280431openalex-snapshot
detectCilia: An R Package for Automated Detection and Length Measurement of Primary Cilia
inferred← citeshttps://doi.org/10.1177/1758835918801169openalex-snapshot
Primary cilium and glioblastoma
inferred← citeshttps://doi.org/10.1177/2045894018764629openalex-snapshot
Endothelial dysfunction in pulmonary arterial hypertension: loss of cilia length regulation upon cytokine stimulation
inferred← citeshttps://doi.org/10.1186/2046-2530-2-17openalex-snapshot
Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium
inferred← citeshttps://doi.org/10.1186/2046-2530-3-6openalex-snapshot
Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8
inferred← citeshttps://doi.org/10.1186/2046-2530-4-s1-p17openalex-snapshot
Coordination of TGFβ/BMP signaling is associated with the primary cilium
inferred← citeshttps://doi.org/10.1186/s12964-025-02403-9openalex-snapshot
The primary cilium as a multifunctional organelle: emerging roles and unanswered questions
inferred← citeshttps://doi.org/10.1186/s12964-026-03177-4openalex-snapshot
INPP5E interactome reveals novel connections to growth factor signaling
inferred← citeshttps://doi.org/10.1186/s12987-025-00631-2openalex-snapshot
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia
inferred← citeshttps://doi.org/10.1186/s13041-023-01029-7openalex-snapshot
Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9/mortalin-depleted SH-SY5Y cells
inferred← citeshttps://doi.org/10.1186/s13062-023-00441-2openalex-snapshot
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes
inferred← citeshttps://doi.org/10.1186/s13064-016-0064-zopenalex-snapshot
Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish
inferred← citeshttps://doi.org/10.1186/s13075-026-03826-6openalex-snapshot
Aurora A kinase activation contributes to the fibrotic phenotype in systemic sclerosis through primary cilia shortening
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