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Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis

https://doi.org/10.1161/jaha.121.022332

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Systematic quantification of histologic ventricular fibrosis in isolated mitral valve prolapse and sudden cardiac death

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Myocardial Fibrosis in Patients With Primary Mitral Regurgitation With and Without Prolapse

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The Mitral Annulus Disjunction Arrhythmic Syndrome

inferredcites →https://doi.org/10.1016/j.jacc.2018.09.048openalex-snapshot

Arrhythmic Mitral Valve Prolapse

inferredcites →https://doi.org/10.1016/j.jacc.2018.11.018openalex-snapshot

Atrial Fibrillation and Mitral Valve Prolapse

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Long-Term Results of Mitral Valve Repair for Regurgitation Due to Leaflet Prolapse

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IFT88 influences chondrocyte actin organization and biomechanics

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Left ventricular dysfunction after mitral valve repair—the fallacy of “normal” preoperative myocardial function

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Burden of valvular heart diseases: a population-based study

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IL-11 is a crucial determinant of cardiovascular fibrosis

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Genetic association analyses highlight biological pathways underlying mitral valve prolapse

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Mitral valve repair based on intraoperative objective measurement

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Connexin-43 reduction prevents muscle defects in a mouse model of manifesting Duchenne muscular dystrophy female carriers

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TGFβ1 – induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner

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Intercellular Calcium Signaling in Astrocytes via ATP Release through Connexin Hemichannels

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Inhibition of Connexin 43 Hemichannel-Mediated ATP Release Attenuates Early Inflammation During the Foreign Body Response

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Mechanobiology of Ciliogenesis

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Mitral chordae tendineae force profile characterization using a posterior ventricular anchoring neochordal repair model for mitral regurgitation in a three-dimensional-printed ex vivo left heart simulator

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2017 ESC/EACTS Guidelines for the management of valvular heart disease

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P3500The primary cilium, a sensory apparatus of cells regulates the profibrotic capacity of fibroblasts in atrial fibrillation

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ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y 2 receptors

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Patched1 Regulates Hedgehog Signaling at the Primary Cilium

inferredcites →https://doi.org/10.1126/scitranslmed.aax0290openalex-snapshot

Primary cilia defects causing mitral valve prolapse

inferredcites →https://doi.org/10.1136/heartjnl-2016-309303openalex-snapshot

Diffuse myocardial fibrosis in patients with mitral valve prolapse and ventricular arrhythmia

inferredcites →https://doi.org/10.1136/heartjnl-2018-314269openalex-snapshot

Left ventricular mechanical dispersion predicts arrhythmic risk in mitral valve prolapse

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Genome-Wide Association Study–Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse

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Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

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Cardiac Fibrosis

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Arrhythmic Mitral Valve Prolapse and Sudden Cardiac Death

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Fibroblast Primary Cilia Are Required for Cardiac Fibrosis

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Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death

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Replacement Myocardial Fibrosis in Patients With Mitral Valve Prolapse

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Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

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Increased Infiltration of Extra-Cardiac Cells in Myxomatous Valve Disease

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Connexin-43-dependent ATP release mediates macrophage activation during sepsis

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Fibroblast mechanotransduction network predicts targets for mechano-adaptive infarct therapies

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Primary Cilia Confer TGFβ1-Dependent Resistance in Rat Cardiac Fibroblasts after X-Ray Injury

inferred← citeshttps://doi.org/10.1002/ccd.31158openalex-snapshot

A modified Carpentier classification in transcatheter edge‐to‐edge repair for mitral regurgitation

inferred← citeshttps://doi.org/10.1002/cpz1.1025openalex-snapshot

In Vitro Assessment of Cardiac Fibroblast Activation at Physiologic Stiffness

inferred← citeshttps://doi.org/10.1007/s00330-023-10413-9openalex-snapshot

Imaging for the assessment of the arrhythmogenic potential of mitral valve prolapse

inferred← citeshttps://doi.org/10.1007/s10554-023-02985-wopenalex-snapshot

Left ventricular fibrosis and CMR tissue characterization of papillary muscles in mitral valve prolapse patients

inferred← citeshttps://doi.org/10.1007/s13258-025-01626-xopenalex-snapshot

Whole exome sequencing of 80 cases of sporadic mitral valve prolapse reveals novel disease-associated genes and variants in a Southern Chinese population

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2025.119919openalex-snapshot

Connexin 43 dephosphorylation mediates the Dchs1/YAP/TEAD signaling pathway to induce cardiac fibrosis

inferred← citeshttps://doi.org/10.1016/j.cjca.2026.07.004openalex-snapshot

Extra-Mitral Abnormalities in Nonsyndromic Mitral Valve Prolapse Assessed By Means of Cardiovascular Magnetic Resonance

inferred← citeshttps://doi.org/10.1016/j.cmpb.2025.109151openalex-snapshot

Magnetic resonance-based computational modelling of healthy and prolapsing mitral valves to quantify the load transfer between the mitral apparatus and the ventricular myocardium

inferred← citeshttps://doi.org/10.1016/j.cpcardiol.2023.101724openalex-snapshot

Arrhythmogenic Mitral Valve Prolapse and Sudden Cardiac Death: An Update and Current Perspectives

inferred← citeshttps://doi.org/10.1016/j.jacc.2022.09.044openalex-snapshot

Research Opportunities in the Treatment of Mitral Valve Prolapse

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Reversed Remodeling Unveils Mitral Annular Disjunction

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Mitral annulus disjunction in consecutive patients undergoing cardiovascular magnetic resonance: Where is the boundary between normality and disease?

inferred← citeshttps://doi.org/10.1016/j.jocmr.2024.101117openalex-snapshot

Interstitial fibrosis and arrhythmic mitral valve prolapse: Unraveling sex-based differences

inferred← citeshttps://doi.org/10.1016/j.jocmr.2024.101137openalex-snapshot

Cardiovascular magnetic resonance in patients with mitral valve prolapse

inferred← citeshttps://doi.org/10.1016/j.jtcvs.2023.04.026openalex-snapshot

Neochordal Goldilocks: Analyzing the biomechanics of neochord length on papillary muscle forces suggests higher tolerance to shorter neochordae

inferred← citeshttps://doi.org/10.1016/j.jvc.2025.10.007openalex-snapshot

Distribution of ionized calcium–binding adaptor molecule 1–positive macrophages and papillary muscle fibrosis in dogs with myxomatous mitral valve disease

inferred← citeshttps://doi.org/10.1038/s41572-023-00478-7openalex-snapshot

Degenerative mitral regurgitation

inferred← citeshttps://doi.org/10.1038/s41598-025-33951-2openalex-snapshot

Left atrioventricular coupling in isolated pediatric mitral valve prolapse with preserved ejection fraction and moderate regurgitation

inferred← citeshttps://doi.org/10.1053/j.semtcvs.2025.03.005openalex-snapshot

Arrhythmic Mitral Valve Prolapse: Pathophysiology, Diagnostics, and Management Strategies

inferred← citeshttps://doi.org/10.1063/5.0248930openalex-snapshot

Modeling the fluid dynamics of mitral valve for clinical applications and surgical mitral valve repair

inferred← citeshttps://doi.org/10.1080/15569527.2026.2715412openalex-snapshot

Evaluation of facial cutaneous aging in individuals with mitral valve prolapse

inferred← citeshttps://doi.org/10.1093/ehjopen/oeae034openalex-snapshot

Gene expression and ultra-structural evidence for metabolic derangement in the primary mitral regurgitation heart

inferred← citeshttps://doi.org/10.1093/ehjqcco/qcaf016openalex-snapshot

Prevalence, progression, and clinical outcomes of mitral valve prolapse: a systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1093/ejcts/ezae312openalex-snapshot

Presentation and outcomes of women and men undergoing surgery for degenerative mitral regurgitation

inferred← citeshttps://doi.org/10.1093/eurheartj/ehag242openalex-snapshot

Is true -MAD what we are truly looking for in arrhythmic risk stratification?

inferred← citeshttps://doi.org/10.1111/ahg.12534openalex-snapshot

Functions of cilia in cardiac development and disease

inferred← citeshttps://doi.org/10.1111/echo.15657openalex-snapshot

Secondary leaflet tethering in patients with severe degenerative mitral regurgitation and its association with the severity of mitral regurgitation

inferred← citeshttps://doi.org/10.1111/echo.15894openalex-snapshot

Cardiac magnetic resonance imaging in the evaluation and management of mitral valve prolapse – a comprehensive review

inferred← citeshttps://doi.org/10.1148/ryct.230247openalex-snapshot

Arrhythmic Mitral Valve Prolapse Phenotype: An Unsupervised Machine Learning Analysis Using a Multicenter Cardiac MRI Registry

inferred← citeshttps://doi.org/10.1161/circimaging.122.014963openalex-snapshot

Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse

inferred← citeshttps://doi.org/10.1161/circimaging.124.017313openalex-snapshot

Multimodality Imaging of Arrhythmic Risk in Mitral Valve Prolapse

inferred← citeshttps://doi.org/10.1161/circinterventions.122.011928openalex-snapshot

Native and Post-Repair Residual Mitral Valve Prolapse Increases Forces Exerted on the Papillary Muscles: A Possible Mechanism for Localized Fibrosis?

inferred← citeshttps://doi.org/10.1161/circinterventions.125.016161openalex-snapshot

Aberrant, Elevated Papillary Muscle and LV Wall Forces Associated With Mitral Valve Prolapse Are Normalized by Surgical Neochordal Repair but Not by Transcatheter Edge-to-Edge Repair

inferred← citeshttps://doi.org/10.1161/jaha.125.045002openalex-snapshot

Sex‐Based Differences in Outcomes Following Mitral Valve Surgery: A Contemporary Analysis From 2 Institutions

inferred← citeshttps://doi.org/10.3389/fcvm.2022.862044openalex-snapshot

Left Ventricular Remodeling in Non-syndromic Mitral Valve Prolapse: Volume Overload or Concomitant Cardiomyopathy?

inferred← citeshttps://doi.org/10.3389/fcvm.2023.1057986openalex-snapshot

Histopathological insights into mitral valve prolapse-induced fibrosis

inferred← citeshttps://doi.org/10.3389/fcvm.2023.1077788openalex-snapshot

Genetics and pathophysiology of mitral valve prolapse

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The evolving role of cardiovascular magnetic resonance in the assessment of mitral valve prolapse

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Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review

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Serum Proteomic Profiles Reflect the Stages of Myxomatous Mitral Valve Disease in Dogs

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Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

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Atrial Fibrillation and Primary Cilia-Associated Genes: The Role of CEP68

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Left Ventricle Segmental Longitudinal Strain and Regional Myocardial Work Index Could Help Determine Mitral Valve Prolapse Patients with Increased Risk of Ventricular Arrhythmias

inferred← citeshttps://doi.org/10.3390/jcdd13090437openalex-snapshot

Arrhythmic Mitral Valve Prolapse as a Regional Stretch-Induced Cardiomyopathy with Fibro-Inflammatory Signature: A Conceptual Review

inferred← citeshttps://doi.org/10.3390/jcm12237441openalex-snapshot

The Potential of Intertwining Gene Diagnostics and Surgery for Mitral Valve Prolapse

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Does Preliminary Chest Shape Assessment Improve the Prognostic Risk Stratification of Individuals with Mitral Annular Disjunction? A Case Report and Narrative Review

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The Arrhythmogenic Spectrum of Mitral Valve Disease: Pathophysiology, Risk Stratification, and Surgical Management

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The Importance of Mitral Valve Prolapse Doming Volume in the Assessment of Left Ventricular Stroke Volume with Cardiac MRI

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Aplastic Posterior Mitral Leaflet with an Unusual Clinical Course

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Genetic Architecture and Myocardial Fibrotic Remodeling in Mitral Valve Prolapse

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