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Clonal Hematopoiesis Before, During, and After Human Spaceflight
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jamacardio.2019.0302openalex-snapshot
Connections Between Clonal Hematopoiesis, Cardiovascular Disease, and Cancer
inferredcites →https://doi.org/10.1007/978-0-387-98141-3openalex-snapshot
ggplot2: Elegant Graphics for Data Analysis
inferredcites →https://doi.org/10.1016/j.ajhg.2016.02.003openalex-snapshot
Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue
inferredcites →https://doi.org/10.1016/j.cell.2017.07.032openalex-snapshot
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
inferredcites →https://doi.org/10.1016/j.celrep.2020.108429openalex-snapshot
Multi-Omic, Single-Cell, and Biochemical Profiles of Astronauts Guide Pharmacological Strategies for Returning to Gravity
inferredcites →https://doi.org/10.1016/j.celrep.2020.108435openalex-snapshot
Temporal Telomere and DNA Damage Responses in the Space Radiation Environment
inferredcites →https://doi.org/10.1016/j.celrep.2020.108457openalex-snapshot
Telomere Length Dynamics and DNA Damage Responses Associated with Long-Duration Spaceflight
inferredcites →https://doi.org/10.1016/j.jacc.2017.12.037openalex-snapshot
Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome
inferredcites →https://doi.org/10.1016/j.mayocp.2018.04.002openalex-snapshot
Clinical Implications of Clonal Hematopoiesis
inferredcites →https://doi.org/10.1016/j.stem.2017.07.010openalex-snapshot
Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes
inferredcites →https://doi.org/10.1016/j.tig.2011.03.002openalex-snapshot
Somatic mosaicism in healthy human tissues
inferredcites →https://doi.org/10.1038/nature19768openalex-snapshot
Tissue-specific mutation accumulation in human adult stem cells during life
inferredcites →https://doi.org/10.1038/ng.2413openalex-snapshot
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
inferredcites →https://doi.org/10.1038/s41586-018-0317-6openalex-snapshot
Prediction of acute myeloid leukaemia risk in healthy individuals
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The case for biotech on Mars
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Cancer therapy shapes the fitness landscape of clonal hematopoiesis
inferredcites →https://doi.org/10.1038/s41591-018-0081-zopenalex-snapshot
Somatic mutations precede acute myeloid leukemia years before diagnosis
inferredcites →https://doi.org/10.1056/nejmoa1408617openalex-snapshot
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
inferredcites →https://doi.org/10.1056/nejmoa1409405openalex-snapshot
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
inferredcites →https://doi.org/10.1056/nejmoa1701719openalex-snapshot
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
inferredcites →https://doi.org/10.1093/bioinformatics/btr509openalex-snapshot
A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data
inferredcites →https://doi.org/10.1093/bioinformatics/bty560openalex-snapshot
fastp: an ultra-fast all-in-one FASTQ preprocessor
inferredcites →https://doi.org/10.1093/nar/gkw227openalex-snapshot
VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research
inferredcites →https://doi.org/10.1093/pcmedi/pbz022openalex-snapshot
Translating current biomedical therapies for long duration, deep space missions
inferredcites →https://doi.org/10.1101/848739openalex-snapshot
Oncologic therapy shapes the fitness landscape of clonal hematopoiesis
inferredcites →https://doi.org/10.1111/j.1467-985x.2010.00676_9.xopenalex-snapshot
ggplot2: Elegant Graphics for Data Analysis
inferredcites →https://doi.org/10.1126/science.aaa6806openalex-snapshot
High burden and pervasive positive selection of somatic mutations in normal human skin
inferredcites →https://doi.org/10.1126/science.aag1381openalex-snapshot
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
inferredcites →https://doi.org/10.1126/science.aan4673openalex-snapshot
Clonal hematopoiesis in human aging and disease
inferredcites →https://doi.org/10.1126/science.aau8650openalex-snapshot
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
inferredcites →https://doi.org/10.1126/scitranslmed.3004315openalex-snapshot
Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
inferredcites →https://doi.org/10.1172/jci.insight.135204openalex-snapshot
Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction
inferredcites →https://doi.org/10.1172/jci6117openalex-snapshot
Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo
inferredcites →https://doi.org/10.1182/blood-2015-03-631747openalex-snapshot
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
inferredcites →https://doi.org/10.1182/blood-2017-02-769869openalex-snapshot
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
inferredcites →https://doi.org/10.1182/blood.2019001793openalex-snapshot
Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality
inferredcites →https://doi.org/10.1182/blood.v88.1.59.59openalex-snapshot
Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age
inferredcites →https://doi.org/10.1186/s12859-019-3280-9openalex-snapshot
Gencore: an efficient tool to generate consensus reads for error suppressing and duplicate removing of NGS data
inferredcites →https://doi.org/10.1186/s13059-016-0974-4openalex-snapshot
The Ensembl Variant Effect Predictor
inferredcites →https://doi.org/10.1200/jco.18.00331openalex-snapshot
Managing Clonal Hematopoiesis in Patients With Solid Tumors
inferredcites →https://doi.org/10.6084/m9.figshare.963153.v1openalex-snapshot
Aligning sequence reads, clone sequences and assembly con*gs with BWA-MEM
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk
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Causes of Clonal Hematopoiesis: a Review
inferred← citeshttps://doi.org/10.1016/j.arr.2023.101909openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.arr.2026.103191openalex-snapshot
Aging in orbit: The twelve hallmarks as a bidirectional bridge between spaceflight-induced senescence and terrestrial geroscience
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Ph-chromosome-negative myeloproliferative neoplasms: clonal dynamics are the name of the game
inferred← citeshttps://doi.org/10.1016/j.ccell.2022.08.024openalex-snapshot
Clonal hematopoiesis and differential outcomes after immune checkpoint blockade
inferred← citeshttps://doi.org/10.1016/j.cell.2020.10.050openalex-snapshot
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108435openalex-snapshot
Temporal Telomere and DNA Damage Responses in the Space Radiation Environment
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108457openalex-snapshot
Telomere Length Dynamics and DNA Damage Responses Associated with Long-Duration Spaceflight
inferred← citeshttps://doi.org/10.1016/j.ijrobp.2025.10.006openalex-snapshot
Clonal Hematopoiesis of Indeterminate Potential After Radiation Therapy
inferred← citeshttps://doi.org/10.1016/j.lssr.2026.04.008openalex-snapshot
Comparative pharmacogenomic coverage of ISS medications across regulatory, clinical, and research databases in human spaceflight
inferred← citeshttps://doi.org/10.1016/j.omtn.2024.102260openalex-snapshot
Differential network analysis reveals the key role of the ECM-receptor pathway in α-particle-induced malignant transformation
inferred← citeshttps://doi.org/10.1016/j.patter.2022.100550openalex-snapshot
Routine omics collection is a golden opportunity for European human research in space and analog environments
inferred← citeshttps://doi.org/10.1016/j.stem.2022.05.006openalex-snapshot
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
inferred← citeshttps://doi.org/10.1016/j.stem.2025.07.013openalex-snapshot
Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging
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Space-associated stem cell hallmarks of aging and resilience in astronauts
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Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)
inferred← citeshttps://doi.org/10.1038/s41467-024-52302-9openalex-snapshot
Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis
inferred← citeshttps://doi.org/10.1038/s41569-024-01056-4openalex-snapshot
Consequences of ionizing radiation exposure to the cardiovascular system
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A second space age spanning omics, platforms and medicine across orbits
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Aging and putative frailty biomarkers are altered by spaceflight
inferred← citeshttps://doi.org/10.1038/s42003-022-03777-zopenalex-snapshot
Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts
inferred← citeshttps://doi.org/10.1038/s42256-023-00617-5openalex-snapshot
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The case for space as a model of accelerated aging
inferred← citeshttps://doi.org/10.1038/s43856-023-00408-4openalex-snapshot
Considering clonal hematopoiesis of indeterminate potential in space radiation risk analysis for hematologic cancers and cardiovascular disease
inferred← citeshttps://doi.org/10.1053/j.seminhematol.2024.01.006openalex-snapshot
The crossroads of cancer therapies and clonal hematopoiesis
inferred← citeshttps://doi.org/10.1080/09553002.2021.1956010openalex-snapshot
Ad Astra – telomeres in space!
inferred← citeshttps://doi.org/10.1080/09553002.2025.2470947openalex-snapshot
Biological effects of high-LET irradiation on the circulatory system
inferred← citeshttps://doi.org/10.1093/pcmedi/pbae007openalex-snapshot
Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight
inferred← citeshttps://doi.org/10.1101/2022.07.29.22278015openalex-snapshot
Genomic and phenomic landscape of clonal hematopoiesis in over a million ancestrally diverse participants
inferred← citeshttps://doi.org/10.1101/2023.09.05.23295093openalex-snapshot
Long-term longitudinal analysis of 4,187 participants reveals new insights into determinants of incident clonal hematopoiesis
inferred← citeshttps://doi.org/10.1101/2024.09.27.24314321openalex-snapshot
Risk of Clonal Hematopoiesis of Indeterminate Potential after Cancer Radiation Therapy
inferred← citeshttps://doi.org/10.1101/2025.07.21.665900openalex-snapshot
Differential sensitivity to LINE 1-induced damage contributes to the expansion of Tet2-deficient HSCs upon chronic inflammatory stress
inferred← citeshttps://doi.org/10.1140/epjp/s13360-025-07199-8openalex-snapshot
Radiation risk mitigation in human space exploration: a primer, a vision, and the state of the art
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Cigarette smoke stimulates clonal expansion of Jak2V617F and Tet2-/- cells
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Molecular and clinical aspects relevant for counseling individuals with clonal hematopoiesis of indeterminate potential
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