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In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity

https://doi.org/10.1016/j.celrep.2023.112216

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

inferredcites →https://doi.org/10.1002/path.1456openalex-snapshot

Tissue‐specific p53 responses to ionizing radiation and their genetic modification: the key to tissue‐specific tumour susceptibility?

inferredcites →https://doi.org/10.1002/path.4368openalex-snapshot

Tissue‐specific and age‐dependent effects of global Mdm2 loss

inferredcites →https://doi.org/10.1006/excr.1997.3604openalex-snapshot

p53 Induces Myocyte Apoptosis via the Activation of the Renin–Angiotensin System

inferredcites →https://doi.org/10.1007/978-1-0716-1217-0_12openalex-snapshot

Using TUNEL Assay to Quantitate p53-Induced Apoptosis in Mouse Tissues

inferredcites →https://doi.org/10.1016/0092-8674(92)90562-qopenalex-snapshot

Regulation of the specific DNA binding function of p53

inferredcites →https://doi.org/10.1016/0092-8674(93)90500-popenalex-snapshot

WAF1, a potential mediator of p53 tumor suppression

inferredcites →https://doi.org/10.1016/0092-8674(95)90039-xopenalex-snapshot

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

inferredcites →https://doi.org/10.1016/0092-8674(95)90412-3openalex-snapshot

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

inferredcites →https://doi.org/10.1016/j.ccell.2017.09.007openalex-snapshot

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

inferredcites →https://doi.org/10.1016/j.ccr.2006.10.010openalex-snapshot

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo

inferredcites →https://doi.org/10.1016/j.ccr.2014.01.021openalex-snapshot

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

inferredcites →https://doi.org/10.1016/j.cell.2004.05.009openalex-snapshot

Ordered Cooperative Functions of PRMT1, p300, and CARM1 in Transcriptional Activation by p53

inferredcites →https://doi.org/10.1016/j.cell.2008.12.002openalex-snapshot

PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

inferredcites →https://doi.org/10.1016/j.cell.2009.04.037openalex-snapshot

Blinded by the Light: The Growing Complexity of p53

inferredcites →https://doi.org/10.1016/j.cell.2009.04.050openalex-snapshot

Modes of p53 Regulation

inferredcites →https://doi.org/10.1016/j.cell.2011.03.035openalex-snapshot

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

inferredcites →https://doi.org/10.1016/j.celrep.2021.110109openalex-snapshot

Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer

inferredcites →https://doi.org/10.1016/j.jmb.2011.12.001openalex-snapshot

p53 Requires an Intact C-Terminal Domain for DNA Binding and Transactivation

inferredcites →https://doi.org/10.1016/j.molcel.2004.09.032openalex-snapshot

p53 Linear Diffusion along DNA Requires Its C Terminus

inferredcites →https://doi.org/10.1016/j.molcel.2015.02.015openalex-snapshot

The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain

inferredcites →https://doi.org/10.1016/j.molcel.2017.11.004openalex-snapshot

Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene

inferredcites →https://doi.org/10.1016/s0014-5793(02)03004-1openalex-snapshot

Identification of functional p53‐binding motifs in the mouse wig‐1 promoter

inferredcites →https://doi.org/10.1016/s0092-8674(05)80007-8openalex-snapshot

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

inferredcites →https://doi.org/10.1016/s0960-9822(00)00195-0openalex-snapshot

Allosteric activation of latent p53 tetramers

inferredcites →https://doi.org/10.1016/s1097-2765(01)00213-1openalex-snapshot

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

inferredcites →https://doi.org/10.1016/s1097-2765(01)00214-3openalex-snapshot

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

inferredcites →https://doi.org/10.1016/s1097-2765(01)00283-0openalex-snapshot

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

inferredcites →https://doi.org/10.1016/s1097-2765(01)00284-2openalex-snapshot

p53DINP1, a p53-Inducible Gene, Regulates p53-Dependent Apoptosis

inferredcites →https://doi.org/10.1016/s1097-2765(01)00414-2openalex-snapshot

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

inferredcites →https://doi.org/10.1016/s1097-2765(03)00528-8openalex-snapshot

Structural Mechanism of the Bromodomain of the Coactivator CBP in p53 Transcriptional Activation

inferredcites →https://doi.org/10.1038/362847a0openalex-snapshot

p53 is required for radiation-induced apoptosis in mouse thymocytes

inferredcites →https://doi.org/10.1038/cdd.2017.174openalex-snapshot

Mechanisms of transcriptional regulation by p53

inferredcites →https://doi.org/10.1038/embor.2013.25openalex-snapshot

Another fork in the road—life or death decisions by the tumour suppressor p53

inferredcites →https://doi.org/10.1038/nature03117openalex-snapshot

Regulation of p53 activity through lysine methylation

inferredcites →https://doi.org/10.1038/nature05077openalex-snapshot

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

inferredcites →https://doi.org/10.1038/nature05529openalex-snapshot

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

inferredcites →https://doi.org/10.1038/nature05541openalex-snapshot

Restoration of p53 function leads to tumour regression in vivo

inferredcites →https://doi.org/10.1038/nature19759openalex-snapshot

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

inferredcites →https://doi.org/10.1038/nbt.1754openalex-snapshot

Integrative genomics viewer

inferredcites →https://doi.org/10.1038/ng0897-397openalex-snapshot

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

inferredcites →https://doi.org/10.1038/ng1180openalex-snapshot

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

inferredcites →https://doi.org/10.1038/nmeth.2089openalex-snapshot

NIH Image to ImageJ: 25 years of image analysis

inferredcites →https://doi.org/10.1038/nprot.2011.409openalex-snapshot

Transcription factor binding predictions using TRAP for the analysis of ChIP-seq data and regulatory SNPs

inferredcites →https://doi.org/10.1038/nrc2693openalex-snapshot

When mutants gain new powers: news from the mutant p53 field

inferredcites →https://doi.org/10.1038/nrc992openalex-snapshot

The role of p53 in determining sensitivity to radiotherapy

inferredcites →https://doi.org/10.1038/nsb0901-730openalex-snapshot

The C-terminus of p53: the more you learn the less you know.

inferredcites →https://doi.org/10.1038/nsb0901-756openalex-snapshot

Latent and active p53 are identical in conformation.

inferredcites →https://doi.org/10.1038/onc.2008.32openalex-snapshot

p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis

inferredcites →https://doi.org/10.1038/onc.2009.154openalex-snapshot

XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway

inferredcites →https://doi.org/10.1038/onc.2016.502openalex-snapshot

Census and evaluation of p53 target genes

inferredcites →https://doi.org/10.1038/sj.onc.1201454openalex-snapshot

Wig-1, a new p53-induced gene encoding a zinc finger protein

inferredcites →https://doi.org/10.1038/sj.onc.1203717openalex-snapshot

Different impact of p53 and p21 on the radiation response of mouse tissues

inferredcites →https://doi.org/10.1038/sj.onc.1204484openalex-snapshot

Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo

inferredcites →https://doi.org/10.1038/sj.onc.1204722openalex-snapshot

Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein

inferredcites →https://doi.org/10.1038/sj.onc.1205069openalex-snapshot

A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

inferredcites →https://doi.org/10.1038/sj.onc.1205877openalex-snapshot

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

inferredcites →https://doi.org/10.1073/pnas.0506580102openalex-snapshot

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

inferredcites →https://doi.org/10.1073/pnas.0700020104openalex-snapshot

The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage

inferredcites →https://doi.org/10.1073/pnas.1016020107openalex-snapshot

A single-molecule characterization of p53 search on DNA

inferredcites →https://doi.org/10.1073/pnas.91.6.2026openalex-snapshot

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

inferredcites →https://doi.org/10.1074/jbc.m111.322875openalex-snapshot

p53-dependent Induction of PVT1 and miR-1204

inferredcites →https://doi.org/10.1074/jbc.m408679200openalex-snapshot

Brn-3a Transcription Factor Blocks p53-mediated Activation of Proapoptotic Target Genes Noxa and Bax in Vitro and in Vivo to Determine Cell Fate

inferredcites →https://doi.org/10.1083/jcb.200105137openalex-snapshot

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

inferredcites →https://doi.org/10.1093/emboj/16.6.1391openalex-snapshot

Transgenic mice with p53‐responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

inferredcites →https://doi.org/10.1093/nar/gkv1191openalex-snapshot

csaw: a Bioconductor package for differential binding analysis of ChIP-seq data using sliding windows

inferredcites →https://doi.org/10.1093/nar/gkz114openalex-snapshot

The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads

inferredcites →https://doi.org/10.1093/nar/gkz635openalex-snapshot

DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation

inferredcites →https://doi.org/10.1101/gad.190678.112openalex-snapshot

Mutant p53: one name, many proteins

inferredcites →https://doi.org/10.1101/gad.224386.113openalex-snapshot

The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo

inferredcites →https://doi.org/10.1101/gad.227249.113openalex-snapshot

The p53–Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity

inferredcites →https://doi.org/10.1101/gad.7.7a.1126openalex-snapshot

The p53-mdm-2 autoregulatory feedback loop.

inferredcites →https://doi.org/10.1101/gr.849004openalex-snapshot

WebLogo: A Sequence Logo Generator: Figure 1

inferredcites →https://doi.org/10.1126/science.7973635openalex-snapshot

p53 Status and the Efficacy of Cancer Therapy in Vivo

inferredcites →https://doi.org/10.1126/scisignal.abd9099openalex-snapshot

A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo

inferredcites →https://doi.org/10.1128/mcb.00551-06openalex-snapshot

noxin, a Novel Stress-Induced Gene Involved in Cell Cycle and Apoptosis

inferredcites →https://doi.org/10.1128/mcb.17.11.6255openalex-snapshot

Reciprocal Interference between the Sequence-Specific Core and Nonspecific C-Terminal DNA Binding Domains of p53: Implications for Regulation

inferredcites →https://doi.org/10.1128/mcb.22.10.3345-3357.2002openalex-snapshot

mRTVP-1, a Novel p53 Target Gene with Proapoptotic Activities

inferredcites →https://doi.org/10.1158/2159-8290.cd-12-0536openalex-snapshot

ZNF365 Promotes Stability of Fragile Sites and Telomeres

inferredcites →https://doi.org/10.1186/1471-2105-11-237openalex-snapshot

ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data

inferredcites →https://doi.org/10.1242/jcs.108.5.1843openalex-snapshot

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

inferredcites →https://doi.org/10.12688/f1000research.9005.1openalex-snapshot

RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR

inferredcites →https://doi.org/10.12688/f1000research.9005.3openalex-snapshot

RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR

inferredcites →https://doi.org/10.2174/138161211795222568openalex-snapshot

Tissue-Specific Therapeutic Targeting of p53 in Cancer: One Size Does Not Fit All

inferredcites →https://doi.org/10.3892/ijo.21.2.261openalex-snapshot

Tissue-specific regulation of Fas/APO-1/CD95 expression by p53

inferredcites →https://doi.org/10.3892/or.10.5.1139openalex-snapshot

Tissue-specific regulation of Apaf-1 expression by p53

inferredcites →https://doi.org/10.4161/15384101.2014.949083openalex-snapshot

The transcription factor p53: Not a repressor, solely an activator

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes

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Resistant dextrin/xanthan gum gels protect probiotics for application to ionizing radiation shielding

inferred← citeshttps://doi.org/10.1016/j.immuni.2025.06.005openalex-snapshot

Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer

inferred← citeshttps://doi.org/10.1038/s41418-024-01326-1openalex-snapshot

Determinants of p53 DNA binding, gene regulation, and cell fate decisions

inferred← citeshttps://doi.org/10.1038/s41418-025-01538-zopenalex-snapshot

p53 prophylactic therapy for cancer prevention

inferred← citeshttps://doi.org/10.1038/s41526-025-00508-6openalex-snapshot

Exploring molecular and modular insights into space ionizing radiation effects through heterogeneous gene regulatory networks

inferred← citeshttps://doi.org/10.1038/s44318-024-00189-zopenalex-snapshot

Mouse models to investigate in situ cell fate decisions induced by p53

inferred← citeshttps://doi.org/10.1051/bioconf/202625001017openalex-snapshot

Dose-Dependent Activation of p53 signaling pathway in Whole Blood and Small Intestine of Mice Exposed to 60 Co Gamma Radiation

inferred← citeshttps://doi.org/10.1073/pnas.2536303123openalex-snapshot

The physiological relevance of downstream effectors of p53 activity

inferred← citeshttps://doi.org/10.1101/2024.09.30.615916openalex-snapshot

Mutant IDH uncouples p53 from target gene regulation to disable tumor suppression

inferred← citeshttps://doi.org/10.1101/2025.06.04.657901openalex-snapshot

A human ex vivo model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic response

inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-23-0295openalex-snapshot

Systematic Characterization of p53-Regulated Long Noncoding RNAs across Human Cancers Reveals Remarkable Heterogeneity among Different Tumor Types

inferred← citeshttps://doi.org/10.1172/jci.insight.198692openalex-snapshot

A human ex vivo model of radiation-induced skin injury recapitulates p53-driven profibrotic response to radiotherapy

inferred← citeshttps://doi.org/10.1186/s12967-024-05623-8openalex-snapshot

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes

inferred← citeshttps://doi.org/10.1242/dmm.050376openalex-snapshot

A systematic approach identifies p53-DREAM pathway target genes associated with blood or brain abnormalities

inferred← citeshttps://doi.org/10.3389/fcell.2023.1268565openalex-snapshot

DNA damage and repair: underlying mechanisms leading to microcephaly

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1642012openalex-snapshot

Limited immune perturbations in mice exposed to sustained low-dose ionizing radiation

inferred← citeshttps://doi.org/10.3390/ijms241914940openalex-snapshot

p53 in the Molecular Circuitry of Bone Marrow Failure Syndromes

inferred← citeshttps://doi.org/10.70675/cc79cc10zbaf8z4e88za003z8a8d37707576openalex-snapshot

Conséquences pathologiques des dérégulations de la voie p53-DREAM : insuffisance médullaire, microcéphalie et cancer

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