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NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Regulation of NF-κB induction by TCR/CD28
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STIM- and Orai-mediated calcium entry controls NF-κB activity and function in lymphocytes
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An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man
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Encoding and Decoding Cellular Information through Signaling Dynamics
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Dynamic Ligand Discrimination in the Notch Signaling Pathway
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Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation
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Iterative Modeling Reveals Evidence of Sequential Transcriptional Control Mechanisms
inferredcites →https://doi.org/10.1016/j.cels.2017.09.016openalex-snapshot
Design of Tunable Oscillatory Dynamics in a Synthetic NF-κB Signaling Circuit
inferredcites →https://doi.org/10.1016/j.cels.2017.10.011openalex-snapshot
NF-κB Dynamics Discriminate between TNF Doses in Single Cells
inferredcites →https://doi.org/10.1016/j.immuni.2012.09.012openalex-snapshot
The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells
inferredcites →https://doi.org/10.1016/j.immuni.2016.01.021openalex-snapshot
Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
inferredcites →https://doi.org/10.1016/j.jim.2015.03.018openalex-snapshot
Simultaneous assessment of NF-κB/p65 phosphorylation and nuclear localization using imaging flow cytometry
inferredcites →https://doi.org/10.1016/j.jim.2016.01.007openalex-snapshot
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1
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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
inferredcites →https://doi.org/10.1016/j.molcel.2012.11.003openalex-snapshot
Dynamic Response Diversity of NFAT Isoforms in Individual Living Cells
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Chimeric Antigen Receptor Library Screening Using a Novel NF-κB/NFAT Reporter Cell Platform
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Structure of ionomycin - a novel diacidic polyether antibiotic having high affinity for calcium ions
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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
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Single-cell NF-κB dynamics reveal digital activation and analogue information processing
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Architecture of the human regulatory network derived from ENCODE data
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Combinatorial gene regulation by modulation of relative pulse timing
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Fast gapped-read alignment with Bowtie 2
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HISAT: a fast spliced aligner with low memory requirements
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Oscillation dynamics underlie functional switching of NF-κB for B-cell activation
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Chimeric antigen receptor T-cell therapies for lymphoma
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Chimeric antigen receptor T-cell therapy — assessment and management of toxicities
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The non-canonical NF-κB pathway in immunity and inflammation
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NFAT, immunity and cancer: a transcription factor comes of age
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Molecular mechanisms of T cell co-stimulation and co-inhibition
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Signal-dependent dynamics of transcription factor translocation controls gene expression
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Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs
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Recent advances and discoveries in the mechanisms and functions of CAR T cells
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Calcium signalling in T cells
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On schemes of combinatorial transcription logic
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The Ca2+-dependent Phosphatase Calcineurin Controls the Formation of the Carma1-Bcl10-Malt1 Complex during T Cell Receptor-induced NF-κB Activation
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Phorbol myristate acetate: a mitogen selective for a T-lymphocyte subpopulation.
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Analysing high-throughput sequencing data in Python with HTSeq 2.0
inferredcites →https://doi.org/10.1093/bioinformatics/btq033openalex-snapshot
BEDTools: a flexible suite of utilities for comparing genomic features
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BEDOPS: high-performance genomic feature operations
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Twelve years of SAMtools and BCFtools
inferredcites →https://doi.org/10.1093/nar/gkx1013openalex-snapshot
TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions
inferredcites →https://doi.org/10.1126/science.1099962openalex-snapshot
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
inferredcites →https://doi.org/10.1126/science.1218351openalex-snapshot
p53 Dynamics Control Cell Fate
inferredcites →https://doi.org/10.1126/science.1239999openalex-snapshot
Functional Roles of Pulsing in Genetic Circuits
inferredcites →https://doi.org/10.1126/science.1254933openalex-snapshot
Accurate information transmission through dynamic biochemical signaling networks
inferredcites →https://doi.org/10.1126/science.275.5308.1930openalex-snapshot
Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3
inferredcites →https://doi.org/10.1126/scisignal.2000599openalex-snapshot
A Noisy Paracrine Signal Determines the Cellular NF-κB Response to Lipopolysaccharide
inferredcites →https://doi.org/10.1126/scisignal.abe2606openalex-snapshot
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function
inferredcites →https://doi.org/10.1146/annurev-cellbio-092910-154008openalex-snapshot
Mechanisms of T Cell Development and Transformation
inferredcites →https://doi.org/10.1146/annurev.immunol.021908.132706openalex-snapshot
T Cell Activation
inferredcites →https://doi.org/10.1186/gb-2008-9-9-r137openalex-snapshot
Model-based Analysis of ChIP-Seq (MACS)
inferredcites →https://doi.org/10.1186/s12964-020-00617-7openalex-snapshot
The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy
inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
inferredcites →https://doi.org/10.15252/embr.201846255openalex-snapshot
ChIP‐Atlas: a data‐mining suite powered by full integration of public ChIP‐seq data
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IκBε Is a Key Regulator of B Cell Expansion by Providing Negative Feedback on cRel and RelA in a Stimulus-Specific Manner
inferredcites →https://doi.org/10.7554/elife.06559openalex-snapshot
Limits on information transduction through amplitude and frequency regulation of transcription factor activity
inferredcites →https://doi.org/10.7554/elife.18458openalex-snapshot
Dynamic control of gene regulatory logic by seemingly redundant transcription factors
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