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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1096-8628(19980605)77:5<431::aid-ajmg15>3.0.co;2-jopenalex-snapshot
Anomalies in Down syndrome individuals in a large population-based registry
inferredcites →https://doi.org/10.1002/(sici)1097-0177(200002)217:2<137::aid-dvdy1>3.0.co;2-nopenalex-snapshot
Parallels of craniofacial maldevelopment in down syndrome and Ts65Dn mice
inferredcites →https://doi.org/10.1002/ajmg.10175openalex-snapshot
Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome
inferredcites →https://doi.org/10.1002/ajmg.1320370706openalex-snapshot
The consequences of chromosome imbalance
inferredcites →https://doi.org/10.1002/ajmg.1320370719openalex-snapshot
Down syndrome: Toward a molecular definition of the phenotype
inferredcites →https://doi.org/10.1006/dbio.2001.0179openalex-snapshot
Altered Primary Myogenesis in NFATC3−/− Mice Leads to Decreased Muscle Size in the Adult
inferredcites →https://doi.org/10.1016/b978-0-12-462002-5.50009-1openalex-snapshot
The Molecular Genetics of Down Syndrome
inferredcites →https://doi.org/10.1016/j.cell.2004.08.010openalex-snapshot
A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis
inferredcites →https://doi.org/10.1016/s0092-8674(01)00396-8openalex-snapshot
Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature
inferredcites →https://doi.org/10.1016/s0092-8674(01)00585-2openalex-snapshot
Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like Memory
inferredcites →https://doi.org/10.1016/s0092-8674(03)00390-8openalex-snapshot
Neurotrophins and Netrins Require Calcineurin/NFAT Signaling to Stimulate Outgrowth of Embryonic Axons
inferredcites →https://doi.org/10.1016/s0959-437x(00)00225-2openalex-snapshot
NFAT signaling in vertebrate development
inferredcites →https://doi.org/10.1017/cbo9780511529702openalex-snapshot
The Consequences of Chromosome Imbalance
inferredcites →https://doi.org/10.1038/32419openalex-snapshot
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
inferredcites →https://doi.org/10.1038/32426openalex-snapshot
The transcription factor NF-ATc is essential for cardiac valve formation
inferredcites →https://doi.org/10.1038/352803a0openalex-snapshot
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
inferredcites →https://doi.org/10.1038/369497a0openalex-snapshot
NF-AT components define a family of transcription factors targeted in T-cell activation
inferredcites →https://doi.org/10.1038/383837a0openalex-snapshot
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
inferredcites →https://doi.org/10.1038/44378openalex-snapshot
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
inferredcites →https://doi.org/10.1038/74823openalex-snapshot
Large-scale oscillatory calcium waves in the immature cortex
inferredcites →https://doi.org/10.1038/nature02518openalex-snapshot
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons
inferredcites →https://doi.org/10.1038/ng1095-177openalex-snapshot
A mouse model for Down syndrome exhibits learning and behaviour deficits
inferredcites →https://doi.org/10.1038/nrg1448openalex-snapshot
Chromosome 21 and Down syndrome: from genomics to pathophysiology
inferredcites →https://doi.org/10.1042/bj3550609openalex-snapshot
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase
inferredcites →https://doi.org/10.1073/pnas.1432926100openalex-snapshot
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
inferredcites →https://doi.org/10.1073/pnas.91.11.4997openalex-snapshot
Down syndrome phenotypes: the consequences of chromosomal imbalance.
inferredcites →https://doi.org/10.1073/pnas.95.11.6256openalex-snapshot
Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities
inferredcites →https://doi.org/10.1074/jbc.271.7.3488openalex-snapshot
Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity Is Dependent on Tyrosine Residues between Subdomains VII and VIII
inferredcites →https://doi.org/10.1074/jbc.275.12.8719openalex-snapshot
A Protein Encoded within the Down Syndrome Critical Region Is Enriched in Striated Muscles and Inhibits Calcineurin Signaling
inferredcites →https://doi.org/10.1074/jbc.m408741200openalex-snapshot
The Transcription Factor NFAT3 Mediates Neuronal Survival
inferredcites →https://doi.org/10.1093/hmg/10.18.1915openalex-snapshot
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome
inferredcites →https://doi.org/10.1093/hmg/9.11.1681openalex-snapshot
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways
inferredcites →https://doi.org/10.1093/hmg/9.2.195openalex-snapshot
Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse
inferredcites →https://doi.org/10.1101/gad.1102703openalex-snapshot
Transcriptional regulation by calcium, calcineurin, and NFAT
inferredcites →https://doi.org/10.1101/gad.4.10.1823openalex-snapshot
Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.
inferredcites →https://doi.org/10.1126/science.1069883openalex-snapshot
A Genomic Regulatory Network for Development
inferredcites →https://doi.org/10.1126/science.1087694openalex-snapshot
A Bacterial Cell-Cycle Regulatory Network Operating in Time and Space
inferredcites →https://doi.org/10.1126/science.1098992openalex-snapshot
A Chromosome 21 Critical Region Does Not Cause Specific Down Syndrome Phenotypes
inferredcites →https://doi.org/10.1126/science.1114535openalex-snapshot
An Aneuploid Mouse Strain Carrying Human Chromosome 21 with Down Syndrome Phenotypes
inferredcites →https://doi.org/10.1126/science.275.5308.1930openalex-snapshot
Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3
inferredcites →https://doi.org/10.1128/mcb.22.18.6636-6647.2002openalex-snapshot
Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice
inferredcites →https://doi.org/10.1172/jci200420049openalex-snapshot
Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4669820openalex-extracted
Dyrk1a is Required for Craniofacial Development in Xenopus Laevis
inferred← citeshttps://doi.org/10.1002/1873-3468.14723openalex-snapshot
Functions of SRPK , CLK and DYRK kinases in stem cells, development, and human developmental disorders
inferred← citeshttps://doi.org/10.1002/9781119017127.ch4openalex-snapshot
Mitochondrial Ca2+Transport in the Control of Neuronal Functions
inferred← citeshttps://doi.org/10.1002/9783527665433.ch9openalex-snapshot
Noncoding RNAs, Neurodevelopment, and Neurodegeneration
inferred← citeshttps://doi.org/10.1002/acn3.51624openalex-snapshot
Upregulation of RCAN1 .4 by HIF1α alleviates OGD ‐induced inflammatory response in astrocytes
inferred← citeshttps://doi.org/10.1002/ajmg.a.31974openalex-snapshot
A girl with Down syndrome and partial trisomy for 21pter‐q22.13: A clue to narrow the Down syndrome critical region
inferred← citeshttps://doi.org/10.1002/ajmg.a.33217openalex-snapshot
Identification of a 21q22 duplication in a Silver–Russell syndrome patient further narrows down the Down syndrome critical region
inferred← citeshttps://doi.org/10.1002/ajmg.a.33735openalex-snapshot
Clinical manifestations of the deletion of Down syndrome critical region including DYRK1A and KCNJ6
inferred← citeshttps://doi.org/10.1002/ajmg.a.36006openalex-snapshot
Non‐trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome
inferred← citeshttps://doi.org/10.1002/alz.70034openalex-snapshot
Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome
inferred← citeshttps://doi.org/10.1002/ame2.70251openalex-snapshot
Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy
inferred← citeshttps://doi.org/10.1002/bdra.23129openalex-snapshot
Commonality in Down and fetal alcohol syndromes
inferred← citeshttps://doi.org/10.1002/bdrc.20195openalex-snapshot
Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases
inferred← citeshttps://doi.org/10.1002/bies.20644openalex-snapshot
Calcineurin/NFAT signaling in the β‐cell: From diabetes to new therapeutics
inferred← citeshttps://doi.org/10.1002/cbin.12094openalex-snapshot
The role of NFATc1 in the progression and metastasis of prostate cancer: A review on the molecular mechanisms and signaling pathways
inferred← citeshttps://doi.org/10.1002/ccr3.22openalex-snapshot
Prenatal diagnosis of complex rearrangement of chromosome 21: The significance of interphase and metaphase fluorescence in situ hybridization and comparative genomic hybridization
inferred← citeshttps://doi.org/10.1002/cjoc.201400432openalex-snapshot
Light Induced Inhibition of Protein Phosphatase Calcineurin
inferred← citeshttps://doi.org/10.1002/cm.20388openalex-snapshot
Cytoskeletal pathologies of Alzheimer disease
inferred← citeshttps://doi.org/10.1002/cmdc.202100512openalex-snapshot
Rational Design and Identification of Harmine‐Inspired, N ‐Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System**
inferred← citeshttps://doi.org/10.1002/cne.21433openalex-snapshot
Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype‐phenotype relationships
inferred← citeshttps://doi.org/10.1002/cyto.b.20387openalex-snapshot
Nuclear protein contents in peripheral blood mononuclear cells of trisomy 21 infants
inferred← citeshttps://doi.org/10.1002/dneu.22895openalex-snapshot
Modulation of calcineurin signaling during development
inferred← citeshttps://doi.org/10.1002/dvdy.21416openalex-snapshot
Characterization of the cardiac phenotype in neonatal Ts65Dn mice
inferred← citeshttps://doi.org/10.1002/dvdy.22295openalex-snapshot
Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome
inferred← citeshttps://doi.org/10.1002/eji.201242580openalex-snapshot
Regulation and dysregulation of innate immunity by NFAT signaling downstream of pattern recognition receptors (PRRs)
inferred← citeshttps://doi.org/10.1002/emmm.200900003openalex-snapshot
Induced chromosome deletions cause hypersociability and other features of Williams–Beuren syndrome in mice
inferred← citeshttps://doi.org/10.1002/glia.22797openalex-snapshot
NFAT transcription factors regulate survival, proliferation, migration, and differentiation of neural precursor cells
inferred← citeshttps://doi.org/10.1002/humu.20517openalex-snapshot
Epistatic interactions with a common hypomorphicRET allele in syndromic Hirschsprung disease
inferred← citeshttps://doi.org/10.1002/humu.20944openalex-snapshot
Interaction between a chromosome 10 RET enhancer and chromosome 21 in the Down syndrome-Hirschsprung disease association
inferred← citeshttps://doi.org/10.1002/ijc.25692openalex-snapshot
Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both Mirk/dyrk1b and p130/Rb2
inferred← citeshttps://doi.org/10.1002/ijc.28329openalex-snapshot
Nuclear factor of activated T cells-A transcription factor family as critical regulator in lung and colon cancer
inferred← citeshttps://doi.org/10.1002/ijc.34766openalex-snapshot
Natural resistance to cancer: A window of hope
inferred← citeshttps://doi.org/10.1002/iub.1060openalex-snapshot
TRAF3 negatively regulates calcineurin‐NFAT pathway by targeting calcineurin B subunit for degradation
inferred← citeshttps://doi.org/10.1002/jbmr.1727openalex-snapshot
The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis
inferred← citeshttps://doi.org/10.1002/jcb.22216openalex-snapshot
KiSS1 suppresses TNFα‐induced breast cancer cell invasion via an inhibition of RhoA‐Mediated NF‐κB activation
inferred← citeshttps://doi.org/10.1002/jcp.27255openalex-snapshot
Nerve growth factor prevents arsenic‐induced toxicity in PC12 cells through the AKT/GSK‐3β/NFAT pathway
inferred← citeshttps://doi.org/10.1002/jnr.23279openalex-snapshot
Intracellular distribution of differentially phosphorylated dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A)
inferred← citeshttps://doi.org/10.1002/mgg3.334openalex-snapshot
Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits
inferred← citeshttps://doi.org/10.1002/mnfr.201500781openalex-snapshot
Differential effects of Epigallocatechin‐3‐gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model
inferred← citeshttps://doi.org/10.1002/mnfr.201600530openalex-snapshot
Lycopene inhibits regulator of calcineurin 1‐mediated apoptosis by reducing oxidative stress and down‐regulating Nucling in neuronal cells
inferred← citeshttps://doi.org/10.1002/mrdd.20162openalex-snapshot
Genetic mechanisms involved in the phenotype of Down syndrome
inferred← citeshttps://doi.org/10.1002/pd.4586openalex-snapshot
Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms
inferred← citeshttps://doi.org/10.1002/pro.70631openalex-snapshot
Orchestrating mitochondrial protein import: The emerging role of DYRK1A in health and disease
inferred← citeshttps://doi.org/10.1007/978-1-4419-0461-4_389openalex-snapshot
Regulator of Calcineurin 1 (RCAN1)
inferred← citeshttps://doi.org/10.1007/978-1-4419-1050-9_8openalex-snapshot
NFATc1 in Inflammatory and Musculoskeletal Conditions
inferred← citeshttps://doi.org/10.1007/978-1-4419-7197-5_2openalex-snapshot
Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms Towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome
inferred← citeshttps://doi.org/10.1007/978-1-4614-6438-9_389-1openalex-snapshot
Regulator of Calcineurin 1 (RCAN1)
inferred← citeshttps://doi.org/10.1007/978-1-4614-8621-3_5openalex-snapshot
Dysregulation of Long Non-coding RNAs in Human Disease
inferred← citeshttps://doi.org/10.1007/978-1-60761-287-2_10openalex-snapshot
Congenital, Non-inheritable Chromosomal Abnormalities Responsible for Neurological Disorders
inferred← citeshttps://doi.org/10.1007/978-2-8178-0385-2_9openalex-snapshot
Quels traitements pour la trisomie 21 ?
inferred← citeshttps://doi.org/10.1007/978-3-030-42937-9_9-1openalex-snapshot
The Role of Genetics in Development of Congenital Heart Disease
inferred← citeshttps://doi.org/10.1007/978-3-031-07563-6_9openalex-snapshot
The Role of Genetics in Development of Congenital Heart Disease
inferred← citeshttps://doi.org/10.1007/978-3-031-78611-2_5openalex-snapshot
Using Drosophila to Study the Mechanisms That Underlie Down Syndrome
inferred← citeshttps://doi.org/10.1007/978-3-031-96947-8_13openalex-snapshot
Skull Development: Normal Findings and Craniosynostosis
inferred← citeshttps://doi.org/10.1007/978-3-319-05798-9_5openalex-snapshot
Origin of Leukemia in Children with Down Syndrome
inferred← citeshttps://doi.org/10.1007/978-3-319-14544-0_19openalex-snapshot
CK2 Inhibitors and the DYRK Family Protein Kinases
inferred← citeshttps://doi.org/10.1007/978-3-319-57732-6_21openalex-snapshot
Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes
inferred← citeshttps://doi.org/10.1007/978-3-319-67199-4_389openalex-snapshot
Regulator of Calcineurin 1 (RCAN1)
inferred← citeshttps://doi.org/10.1007/978-3-540-69389-5_14openalex-snapshot
Simulating Complex Calcium-Calcineurin Signaling Network
inferred← citeshttps://doi.org/10.1007/978-3-7091-0932-8_20openalex-snapshot
Synaptic Pathology of Down Syndrome
inferred← citeshttps://doi.org/10.1007/978-981-10-5203-3_6openalex-snapshot
Long Noncoding RNAs in Mammalian Development and Diseases
inferred← citeshttps://doi.org/10.1007/bf02700622openalex-snapshot
Cofilin-mediated neurodegeneration in alzheimer’s disease and other amyloidopathies
inferred← citeshttps://doi.org/10.1007/s00018-006-6169-5openalex-snapshot
Aneuploidy in the normal and diseased brain
inferred← citeshttps://doi.org/10.1007/s00018-009-0123-2openalex-snapshot
Function and regulation of Dyrk1A: towards understanding Down syndrome
inferred← citeshttps://doi.org/10.1007/s00018-013-1321-5openalex-snapshot
Key role of ERK1/2 molecular scaffolds in heart pathology
inferred← citeshttps://doi.org/10.1007/s00018-016-2276-0openalex-snapshot
Synthetic combinations of missense polymorphic genetic changes underlying Down syndrome susceptibility
inferred← citeshttps://doi.org/10.1007/s00018-020-03626-4openalex-snapshot
DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesis
inferred← citeshttps://doi.org/10.1007/s00134-012-2589-xopenalex-snapshot
Clinical course and outcome for critically ill children with Down syndrome: a retrospective cohort study
inferred← citeshttps://doi.org/10.1007/s00335-006-0082-yopenalex-snapshot
Faithful tissue-specific expression of the human chromosome 21-linked COL6A1 gene in BAC-transgenic mice
inferred← citeshttps://doi.org/10.1007/s00335-007-9030-8openalex-snapshot
The power of comparative and developmental studies for mouse models of Down syndrome
inferred← citeshttps://doi.org/10.1007/s00335-008-9121-1openalex-snapshot
Gene expression variation increase in trisomy 21 tissues
inferred← citeshttps://doi.org/10.1007/s00343-010-9073-7openalex-snapshot
Characterization of DYRK2 (dual-specificity tyrosine-phosphorylation-regulated kinase 2) from Zebrafish (Dario rerio)
inferred← citeshttps://doi.org/10.1007/s00383-008-2188-7openalex-snapshot
Down syndrome and the enteric nervous system
inferred← citeshttps://doi.org/10.1007/s00383-015-3685-0openalex-snapshot
Anorectal malformation: the etiological factors
inferred← citeshttps://doi.org/10.1007/s00383-017-4204-2openalex-snapshot
A review of genetic factors contributing to the etiopathogenesis of anorectal malformations
inferred← citeshttps://doi.org/10.1007/s00383-018-4344-zopenalex-snapshot
Advances in understanding the association between Down syndrome and Hirschsprung disease (DS–HSCR)
inferred← citeshttps://doi.org/10.1007/s00424-007-0238-yopenalex-snapshot
Calcium-dependent transcription of cytokine genes in T lymphocytes
inferred← citeshttps://doi.org/10.1007/s00439-011-0980-2openalex-snapshot
Genetic analysis of Down syndrome-associated heart defects in mice
inferred← citeshttps://doi.org/10.1007/s10059-013-0073-2openalex-snapshot
Orai1-NFAT Signalling Pathway Triggered by T Cell Receptor Stimulation
inferred← citeshttps://doi.org/10.1007/s10456-026-10029-9openalex-snapshot
Calcineurin-NFAT-DSCR1.4 signaling as druggable axis in Gαq-R183Q–driven capillary malformations
inferred← citeshttps://doi.org/10.1007/s10571-021-01060-zopenalex-snapshot
TTC3-Mediated Protein Quality Control, A Potential Mechanism for Cognitive Impairment
inferred← citeshttps://doi.org/10.1007/s10974-006-9080-7openalex-snapshot
Parallel mechanisms for resting nucleo-cytoplasmic shuttling and activity dependent translocation provide dual control of transcriptional regulators HDAC and NFAT in skeletal muscle fiber type plasticity
inferred← citeshttps://doi.org/10.1007/s11033-018-4214-8openalex-snapshot
Regulation of nuclear factor of activated T cells (NFAT) and downstream myogenic proteins during dehydration in the African clawed frog
inferred← citeshttps://doi.org/10.1007/s11427-012-4340-9openalex-snapshot
p38α MAP kinase phosphorylates RCAN1 and regulates its interaction with calcineurin
inferred← citeshttps://doi.org/10.1007/s11914-021-00674-yopenalex-snapshot
Current Analysis of Skeletal Phenotypes in Down Syndrome
inferred← citeshttps://doi.org/10.1007/s12012-022-09746-6openalex-snapshot
Impact of DYRK1A Expression on TNNT2 Splicing and Daunorubicin Toxicity in Human iPSC-Derived Cardiomyocytes
inferred← citeshttps://doi.org/10.1007/s12035-007-0009-yopenalex-snapshot
Cofilin-mediated neurodegeneration in alzheimer’s disease and other amyloidopathies
inferred← citeshttps://doi.org/10.1007/s12035-012-8284-7openalex-snapshot
BDNF and DYRK1A Are Variable and Inversely Correlated in Lymphoblastoid Cell Lines from Down Syndrome Patients
inferred← citeshttps://doi.org/10.1007/s12035-013-8434-6openalex-snapshot
Using C. elegans to Decipher the Cellular and Molecular Mechanisms Underlying Neurodevelopmental Disorders
inferred← citeshttps://doi.org/10.1007/s12035-018-1416-yopenalex-snapshot
A Prognostic Signature for Lower Grade Gliomas Based on Expression of Long Non-Coding RNAs
inferred← citeshttps://doi.org/10.1007/s12035-024-04129-0openalex-snapshot
NFATc4 Knockout Promotes Neuroprotection and Retinal Ganglion Cell Regeneration After Optic Nerve Injury
inferred← citeshttps://doi.org/10.1007/s12035-025-04806-8openalex-snapshot
Unlocking the Therapeutic Potential of the Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitors in Alzheimer’s Diseases
inferred← citeshttps://doi.org/10.1007/s12250-016-3898-yopenalex-snapshot
Roles of IκB kinase ε in the innate immune defense and beyond
inferred← citeshttps://doi.org/10.1007/s12281-010-0027-5openalex-snapshot
On the Roles of Calcineurin in Fungal Growth and Pathogenesis
inferred← citeshttps://doi.org/10.1007/s12640-016-9613-9openalex-snapshot
Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension
inferred← citeshttps://doi.org/10.1007/s13237-016-0187-yopenalex-snapshot
Down syndrome: from the age of characterization to the era of curative approach
inferred← citeshttps://doi.org/10.1007/s13238-019-0650-zopenalex-snapshot
Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b
inferred← citeshttps://doi.org/10.1007/s40263-013-0089-3openalex-snapshot
Prospects for Improving Brain Function in Individuals with Down Syndrome
inferred← citeshttps://doi.org/10.1016/b978-0-12-387038-4.00006-9openalex-snapshot
MicroRNAs and Hematopoietic Cell Development
inferred← citeshttps://doi.org/10.1016/b978-0-12-804078-2.00005-2openalex-snapshot
Computational Models
inferred← citeshttps://doi.org/10.1016/b978-0-12-809324-5.21125-5openalex-snapshot
Genetic Mechanisms of Memory Disorders (Excluding Alzheimer's Disease)
inferred← citeshttps://doi.org/10.1016/b978-0-12-812215-0.00009-1openalex-snapshot
Emerging Role of Epigenetics in Human Neurodevelopmental Disorders
inferred← citeshttps://doi.org/10.1016/b978-0-12-813008-7.00035-7openalex-snapshot
Can Green Tea Polyphenols Improve Phenotypes Associated With Down Syndrome?
inferred← citeshttps://doi.org/10.1016/b978-0-323-90456-8.00001-6openalex-snapshot
Disarrayed mitochondrial function on pathobiology in Down syndrome and targeted therapeutics
inferred← citeshttps://doi.org/10.1016/b978-0-323-90456-8.00002-8openalex-snapshot
Development of specific phenotypes and genetic consequences in Down syndrome
inferred← citeshttps://doi.org/10.1016/b978-0-323-90456-8.00004-1openalex-snapshot
Chromosomal etiology of Down syndrome
inferred← citeshttps://doi.org/10.1016/b978-0-323-90456-8.00005-3openalex-snapshot
Gene-dosage imbalance due to trisomic HSA21 and genotype–phenotype association in Down syndrome
inferred← citeshttps://doi.org/10.1016/b978-0-323-90456-8.00011-9openalex-snapshot
MicroRNAs and epigenetic signatures in Down syndrome
inferred← citeshttps://doi.org/10.1016/b978-0-323-90456-8.00012-0openalex-snapshot
Triplicated HSA21 genes and mtDNA on mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1016/b978-0-443-18661-5.00022-1openalex-snapshot
Emerging role of epigenetics in human neurodevelopmental disorders
inferred← citeshttps://doi.org/10.1016/b978-0-444-54299-1.00005-4openalex-snapshot
Pathways to cognitive deficits in Down syndrome
inferred← citeshttps://doi.org/10.1016/b978-0-444-54299-1.00009-1openalex-snapshot
The in vivo Down syndrome genomic library in mouse
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2016.07.001openalex-snapshot
Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A
inferred← citeshttps://doi.org/10.1016/bs.pbr.2019.08.001openalex-snapshot
Modeling Down syndrome in animals from the early stage to the 4.0 models and next
inferred← citeshttps://doi.org/10.1016/bs.pbr.2019.10.003openalex-snapshot
Modeling Down syndrome in cells: From stem cells to organoids
inferred← citeshttps://doi.org/10.1016/j.ajhg.2008.08.012openalex-snapshot
DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome
inferred← citeshttps://doi.org/10.1016/j.ajhg.2008.09.010openalex-snapshot
Targeting Dyrk1A with AAVshRNA Attenuates Motor Alterations in TgDyrk1A, a Mouse Model of Down Syndrome
inferred← citeshttps://doi.org/10.1016/j.ajhg.2022.10.014openalex-snapshot
Consequences of chromosome gain: A new view on trisomy syndromes
inferred← citeshttps://doi.org/10.1016/j.ajodo.2009.10.032openalex-snapshot
Patterns of tooth agenesis in patients with Down syndrome in relation to hypothyroidism and congenital heart disease: An aid for treatment planning
inferred← citeshttps://doi.org/10.1016/j.ajog.2010.06.019openalex-snapshot
Complete trisomy 21 vs translocation Down syndrome: a comparison of modes of ascertainment
inferred← citeshttps://doi.org/10.1016/j.ajoms.2016.07.007openalex-snapshot
A novel therapeutic strategy for midfacial hypoplasia using the CNP/GC-B system
inferred← citeshttps://doi.org/10.1016/j.ajoms.2024.04.005openalex-snapshot
The role of the cartilage guanylyl cyclase-B receptor in craniofacial skeletal development
inferred← citeshttps://doi.org/10.1016/j.archoralbio.2009.07.009openalex-snapshot
Influences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts
inferred← citeshttps://doi.org/10.1016/j.archoralbio.2022.105433openalex-snapshot
Effect of C-type natriuretic peptide on craniofacial skeletogenesis in mice during the pubertal growth spurt
inferred← citeshttps://doi.org/10.1016/j.arr.2015.07.008openalex-snapshot
The new insight on the regulatory role of the vitamin D3 in metabolic pathways characteristic for cancerogenesis and neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2014.07.019openalex-snapshot
THAP1, the gene mutated in DYT6 dystonia, autoregulates its own expression
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2011.06.023openalex-snapshot
DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2021.119081openalex-snapshot
Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2022.119305openalex-snapshot
Nuclear Dishevelled: An enigmatic role in governing cell fate and Wnt signaling
inferred← citeshttps://doi.org/10.1016/j.bbr.2015.01.006openalex-snapshot
Effects of embryonic cyclosporine exposures on brain development and behavior
inferred← citeshttps://doi.org/10.1016/j.bbr.2021.113544openalex-snapshot
A zebrafish model for calcineurin-dependent brain function
inferred← citeshttps://doi.org/10.1016/j.bbrc.2006.10.169openalex-snapshot
MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins
inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.09.033openalex-snapshot
Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.07.072openalex-snapshot
NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator
inferred← citeshttps://doi.org/10.1016/j.bcp.2008.05.021openalex-snapshot
Role for DYRK family kinases on regulation of apoptosis
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115167openalex-snapshot
NFAT signaling dysregulation in cancer: Emerging roles in cancer stem cells
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.02.114openalex-snapshot
Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.11.043openalex-snapshot
Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.03.037openalex-snapshot
Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus
inferred← citeshttps://doi.org/10.1016/j.bone.2010.09.028openalex-snapshot
Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice
inferred← citeshttps://doi.org/10.1016/j.bone.2011.04.003openalex-snapshot
The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells
inferred← citeshttps://doi.org/10.1016/j.bone.2011.09.049openalex-snapshot
Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis
inferred← citeshttps://doi.org/10.1016/j.bone.2013.07.007openalex-snapshot
MicroRNA-124 regulates osteoclast differentiation
inferred← citeshttps://doi.org/10.1016/j.bone.2019.115153openalex-snapshot
Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation
inferred← citeshttps://doi.org/10.1016/j.bone.2019.115215openalex-snapshot
Skeletal dynamics of Down syndrome: A developing perspective
inferred← citeshttps://doi.org/10.1016/j.bpj.2008.11.064openalex-snapshot
Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes
inferred← citeshttps://doi.org/10.1016/j.bpj.2017.05.010openalex-snapshot
Impact of Zygosity on Bimodal Phenotype Distributions
inferred← citeshttps://doi.org/10.1016/j.brainres.2010.03.110openalex-snapshot
Long non-coding RNAs in nervous system function and disease
inferred← citeshttps://doi.org/10.1016/j.brainres.2010.09.107openalex-snapshot
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice
inferred← citeshttps://doi.org/10.1016/j.canlet.2006.10.010openalex-snapshot
Oncogenic pathways of AML1-ETO in acute myeloid leukemia: Multifaceted manipulation of marrow maturation
inferred← citeshttps://doi.org/10.1016/j.canlet.2018.05.045openalex-snapshot
Precision medicine approaches may be the future for CRLF2 rearranged Down Syndrome Acute Lymphoblastic Leukaemia patients
inferred← citeshttps://doi.org/10.1016/j.canlet.2021.07.038openalex-snapshot
TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.cclet.2021.10.003openalex-snapshot
Recent research and development of DYRK1A inhibitors
inferred← citeshttps://doi.org/10.1016/j.cell.2008.06.030openalex-snapshot
Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution
inferred← citeshttps://doi.org/10.1016/j.cell.2009.06.026openalex-snapshot
SnapShot: Ca2+-Calcineurin-NFATSignaling
inferred← citeshttps://doi.org/10.1016/j.cellsig.2008.01.023openalex-snapshot
System-level investigation into the regulatory mechanism of the calcineurin/NFAT signaling pathway
inferred← citeshttps://doi.org/10.1016/j.cellsig.2011.06.013openalex-snapshot
Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.04.008openalex-snapshot
DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.12.065openalex-snapshot
Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111441openalex-snapshot
Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112663openalex-snapshot
NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cells
inferred← citeshttps://doi.org/10.1016/j.cmpb.2020.105494openalex-snapshot
Structural based study to identify new potential inhibitors for dual specificity tyrosine-phosphorylation- regulated kinase
inferred← citeshttps://doi.org/10.1016/j.conb.2012.05.002openalex-snapshot
Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome
inferred← citeshttps://doi.org/10.1016/j.cub.2006.06.036openalex-snapshot
Calcium Influx: Beyond ‘Current’ Biology
inferred← citeshttps://doi.org/10.1016/j.devcel.2008.10.014openalex-snapshot
The Protein Kinase DYRK1A Regulates Caspase-9-Mediated Apoptosis during Retina Development
inferred← citeshttps://doi.org/10.1016/j.devcel.2012.05.014openalex-snapshot
Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT
inferred← citeshttps://doi.org/10.1016/j.devcel.2014.02.012openalex-snapshot
Murine Creld1 Controls Cardiac Development through Activation of Calcineurin/NFATc1 Signaling
inferred← citeshttps://doi.org/10.1016/j.drudis.2024.104145openalex-snapshot
Mechanical network motifs as targets for mechanomedicine
inferred← citeshttps://doi.org/10.1016/j.earlhumdev.2025.106270openalex-snapshot
High altitude exposure and the birth prevalence of congenital anomalies in newborns with Down syndrome
inferred← citeshttps://doi.org/10.1016/j.ebiom.2015.01.010openalex-snapshot
DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113948openalex-snapshot
Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A
inferred← citeshttps://doi.org/10.1016/j.ejphar.2010.10.048openalex-snapshot
Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.ejpn.2007.08.010openalex-snapshot
Mental retardation and associated neurological dysfunctions in Down syndrome: A consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways
inferred← citeshttps://doi.org/10.1016/j.exger.2014.05.008openalex-snapshot
EGCG mediated downregulation of NF-AT and macrophage infiltration in experimental hepatic steatosis
inferred← citeshttps://doi.org/10.1016/j.exphem.2020.05.001openalex-snapshot
Cyclosporine enhances the sensitivity to lenalidomide in MDS/AML in vitro
inferred← citeshttps://doi.org/10.1016/j.febslet.2006.09.064openalex-snapshot
Switching feedback mechanisms realize the dual role of MCIP in the regulation of calcineurin activity
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2015.06.023openalex-snapshot
The calcineurin antagonist RCAN1-4 is induced by exhaustive exercise in rat skeletal muscle
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2017.07.026openalex-snapshot
Neurogenesis impairment: An early developmental defect in Down syndrome
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2017.08.009openalex-snapshot
mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia
inferred← citeshttps://doi.org/10.1016/j.gendis.2021.12.004openalex-snapshot
New insights into the roles for DYRK family in mammalian development and congenital diseases
inferred← citeshttps://doi.org/10.1016/j.gene.2012.07.018openalex-snapshot
A patient with Down syndrome with a de novo derivative chromosome 21
inferred← citeshttps://doi.org/10.1016/j.gene.2013.11.078openalex-snapshot
A patient with partial trisomy 21 and 7q deletion expresses mild Down syndrome phenotype
inferred← citeshttps://doi.org/10.1016/j.genrep.2024.102106openalex-snapshot
Genetic interactions and co-operating effects of non-HSA21 genes on the phenotypic variability in Down syndrome
inferred← citeshttps://doi.org/10.1016/j.ijcard.2009.10.043openalex-snapshot
Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats
inferred← citeshttps://doi.org/10.1016/j.ijdevneu.2007.10.004openalex-snapshot
NFAT signaling in neural development and axon growth
inferred← citeshttps://doi.org/10.1016/j.ijdevneu.2008.09.054openalex-snapshot
[P1.04]: The protein kinase Dyrk1A regulates cell number during the development of the central nervous system
inferred← citeshttps://doi.org/10.1016/j.isci.2023.107036openalex-snapshot
What the BTBR/J mouse has taught us about diabetes and diabetic complications
inferred← citeshttps://doi.org/10.1016/j.it.2006.08.005openalex-snapshot
NFATc1 autoregulation: a crucial step for cell-fate determination
inferred← citeshttps://doi.org/10.1016/j.jmb.2015.07.017openalex-snapshot
Regulator of Calcineurin (RCAN-1) Regulates Thermotaxis Behavior in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1016/j.jmb.2015.09.004openalex-snapshot
Navigating toward an Understanding of the Role of Regulator of Calcineurin in Thermotaxis
inferred← citeshttps://doi.org/10.1016/j.jmb.2018.04.001openalex-snapshot
Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylation
inferred← citeshttps://doi.org/10.1016/j.mam.2019.07.004openalex-snapshot
The importance of long non-coding RNAs in neuropsychiatric disorders
inferred← citeshttps://doi.org/10.1016/j.mito.2022.05.007openalex-snapshot
Triplication of HSA21 on alterations in structure and function of mitochondria
inferred← citeshttps://doi.org/10.1016/j.mod.2014.12.004openalex-snapshot
Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner
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