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Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways

https://doi.org/10.1016/j.chom.2020.11.011
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/β-catenin signal pathways
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The Enteric Nervous System and Gastrointestinal Innervation: Integrated Local and Central Control
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Immunohistochemical analysis of neuron types in the mouse small intestine
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TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
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Reciprocal Gut Microbiota Transplants from Zebrafish and Mice to Germ-free Recipients Reveal Host Habitat Selection
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Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
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Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
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A Neural Circuit for Gut-Induced Reward
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Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping
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Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells
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The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells
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Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion
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Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes
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Activation of aryl hydrocarbon receptor by dioxin directly shifts gut microbiota in zebrafish
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Indole and other aromatic compounds activate the yeast TRPY1 channel
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Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
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Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4
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Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection
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The role of SOX10 during enteric nervous system development
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Activation of the Ah Receptor by Tryptophan and Tryptophan Metabolites
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Confocal Imaging–Guided Laser Ablation of Basal Cell Carcinomas: An Ex Vivo Study
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A single-cell survey of the small intestinal epithelium
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Photochemical activation of TRPA1 channels in neurons and animals
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TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
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Fiji: an open-source platform for biological-image analysis
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Methods for generating and colonizing gnotobiotic zebrafish
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The gut as a sensory organ
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Extrinsic primary afferent signalling in the gut
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Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link
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Microbial tryptophan catabolites in health and disease
inferredcites →https://doi.org/10.1038/s41586-020-1975-8openalex-snapshot
Neuronal programming by microbiota regulates intestinal physiology
inferredcites →https://doi.org/10.1038/srep12689openalex-snapshot
Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
inferredcites →https://doi.org/10.1073/pnas.0805323106openalex-snapshot
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
inferredcites →https://doi.org/10.1073/pnas.1102999108openalex-snapshot
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
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Spatial organization of the extracellular matrix regulates cell–cell junction positioning
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Epithelial delamination is protective during pharmaceutical-induced enteropathy
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inferredcites →https://doi.org/10.1073/pnas.2006949117openalex-snapshot
Vitamin B12 and folic acid alleviate symptoms of nutritional deficiency by antagonizing aryl hydrocarbon receptor
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A MODIFICATION OF THE METHOD FOR DETERMINING THE PRODUCTION OF INDOL BY BACTERIA
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5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
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Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti‐inflammatory effects of eucalyptol
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The zebrafish as a model for gastrointestinal tract–microbe interactions
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Review article: serotonin receptors and transporters — roles in normal and abnormal gastrointestinal motility
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The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication
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Edwardsiella piscicida sp. nov. , a novel species pathogenic to fish
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Image velocimetry and spectral analysis enable quantitative characterization of larval zebrafish gut motility
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Irritating channels: the case of TRPA1
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Development of Novel CH223191-Based Antagonists of the Aryl Hydrocarbon Receptor
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Microbiome-Derived Tryptophan Metabolites and Their Aryl Hydrocarbon Receptor-Dependent Agonist and Antagonist Activities
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Labeling of active neural circuits in vivo with designed calcium integrators
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A gut-brain neural circuit for nutrient sensory transduction
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Functional Genomics Approach to the Identification of Virulence Genes Involved in Edwardsiella tarda Pathogenesis
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Mechanisms of activation of mouse and human enteroendocrine cells by nutrients
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The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases
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TRPA1: A Gatekeeper for Inflammation
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BRAINSTEM CIRCUITS REGULATING GASTRIC FUNCTION
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Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin
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Intrinsic Sensory Neurons of Mouse Gut—Toward a Detailed Knowledge of Enteric Neural Circuitry Across Species. Focus on “Characterization of Myenteric Sensory Neurons in the Mouse Small Intestine”
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Electrophysiological Features of Morphological Dogiel Type II Neurons in the Myenteric Plexus of Pig Small Intestine
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TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility
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Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells
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Pathogenesis of and strategies for preventing Edwardsiella tarda infection in fish
inferredcites →https://doi.org/10.1186/1471-2164-14-642openalex-snapshot
Comparative genomics reveals that a fish pathogenic bacterium Edwardsiella tarda has acquired the locus of enterocyte effacement (LEE) through horizontal gene transfer
inferredcites →https://doi.org/10.1186/1749-8104-7-23openalex-snapshot
Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling
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Tol2: a versatile gene transfer vector in vertebrates
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Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
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Free Fatty Acid Receptors in Enteroendocrine Cells
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Metformin triggers PYY secretion in human gut mucosa
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Ret signalling integrates a craniofacial muscle module during development
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Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons
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Single continuous lumen formation in the zebrafish gut is mediated by smoothened -dependent tissue remodeling
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Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium
inferredcites →https://doi.org/10.1242/dev.155655openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pbio.2000689openalex-snapshot
The enteric nervous system promotes intestinal health by constraining microbiota composition
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inferredcites →https://doi.org/10.1371/journal.pone.0089881openalex-snapshot
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Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization
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Activation of Intrinsic Afferent Pathways in Submucosal Ganglia of the Guinea Pig Small Intestine
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TRP Channels in the Digestive System
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Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling
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Brain Aromatase Modulates Serotonergic Neuron by Regulating Serotonin Levels in Zebrafish Embryos and Larvae
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Bacterial Signaling at the Intestinal Epithelial Interface in Inflammation and Cancer
inferredcites →https://doi.org/10.3389/fnins.2018.00049openalex-snapshot
The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis
inferredcites →https://doi.org/10.3389/fnins.2018.00216openalex-snapshot
Indole, a Signaling Molecule Produced by the Gut Microbiota, Negatively Impacts Emotional Behaviors in Rats
inferredcites →https://doi.org/10.3389/fped.2019.00363openalex-snapshot
Small Intestinal Bacterial Overgrowth in Children: A State-Of-The-Art Review
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inferredcites →https://doi.org/10.3791/4434openalex-snapshot
Microgavage of Zebrafish Larvae
inferredcites →https://doi.org/10.3791/4434-vopenalex-snapshot
Microgavage of Zebrafish Larvae
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The role of TRPA1 in visceral inflammation and pain
inferredcites →https://doi.org/10.5009/gnl16126openalex-snapshot
Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy
inferredcites →https://doi.org/10.7554/elife.48479openalex-snapshot
High fat diet induces microbiota-dependent silencing of enteroendocrine cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.bbih.2023.100655openalex-snapshot
Chronic early life stress alters the neuroimmune profile and functioning of the developing zebrafish gut
inferred← citeshttps://doi.org/10.1016/j.bbr.2021.113635openalex-snapshot
Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.109259openalex-snapshot
Reversibly and repeatedly controlling pain sensation through photo-dependent activation and deactivation of TRPA1 channels induced by Photoswitches
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115395openalex-snapshot
Abnormal tryptophan catabolism in diabetes mellitus and its complications: Opportunities and challenges
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117207openalex-snapshot
The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118861openalex-snapshot
Microbiota-brain interaction: The role of gut-derived proteins in addressing various neurological disorders including Parkinson’s (PD) and Alzheimer’s diseases (AD)
inferred← citeshttps://doi.org/10.1016/j.biopsych.2026.06.014openalex-snapshot
Enterochromaffin Cells Drive Anxiety-Like Behaviors in Sleep-Deprived Mice
inferred← citeshttps://doi.org/10.1016/j.cell.2022.09.024openalex-snapshot
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110572openalex-snapshot
Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112095openalex-snapshot
Cell-type-specific responses to the microbiota across all tissues of the larval zebrafish
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114079openalex-snapshot
The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116212openalex-snapshot
Bacterial anti-toxin HigA dysregulates host intestinal serotonin homeostasis in a T6SS-dependent manner
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.141971openalex-snapshot
Enrofloxacin exposure undermines gut health and disrupts neurotransmitters along the microbiota-gut-brain axis in zebrafish
inferred← citeshttps://doi.org/10.1016/j.chom.2021.01.009openalex-snapshot
Tryptophan metabolites get the gut moving
inferred← citeshttps://doi.org/10.1016/j.cmet.2021.12.011openalex-snapshot
Emerging targetome and signalome landscape of gut microbial metabolites
inferred← citeshttps://doi.org/10.1016/j.coemr.2022.100318openalex-snapshot
Nutrient sensing in the gut and the regulation of appetite
inferred← citeshttps://doi.org/10.1016/j.coi.2020.12.004openalex-snapshot
Regulation of host physiology and immunity by microbial indole-3-aldehyde
inferred← citeshttps://doi.org/10.1016/j.coi.2025.102639openalex-snapshot
Microbial regulation of serotonin and neuroimmune interactions
inferred← citeshttps://doi.org/10.1016/j.coi.2025.102692openalex-snapshot
Toward indole postbiotics precision therapy via AI-powered drug delivery technologies
inferred← citeshttps://doi.org/10.1016/j.conb.2025.103045openalex-snapshot
Molecular mechanisms of stimulus detection and secretion in enteroendocrine cells
inferred← citeshttps://doi.org/10.1016/j.cophys.2021.100468openalex-snapshot
Wrapping Things Up: Recent Developments in Understanding the Role of the Microbiome in Regulating Myelination
inferred← citeshttps://doi.org/10.1016/j.crmicr.2026.100603openalex-snapshot
Bifidobacterium stercoris KC84 attenuates IBS-D-like symptoms via modulation of serotonin-related pathways and dendritic cell-mediated IFN-β induction
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115888openalex-snapshot
From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish
inferred← citeshttps://doi.org/10.1016/j.enceco.2024.12.001openalex-snapshot
Carbendazim led to neurological abnormalities by interfering metabolic profiles in zebrafish brain after short-term exposure
inferred← citeshttps://doi.org/10.1016/j.fbio.2025.106996openalex-snapshot
Physicochemical characteristics and therapeutic mechanisms of Sargassum horneri-derived soluble dietary fiber in cyclophosphamide-induced intestinal damage via gut microbiota and metabolic modulation
inferred← citeshttps://doi.org/10.1016/j.fitote.2024.106150openalex-snapshot
Explore the mechanisms of triterpenoids from Ganoderma lucidum in the protection against Alzheimer's disease via microbiota-gut-brain axis with the aid of network pharmacology
inferred← citeshttps://doi.org/10.1016/j.foodchem.2024.138739openalex-snapshot
Dietary polyphenols regulate appetite mechanism via gut-brain axis and gut homeostasis
inferred← citeshttps://doi.org/10.1016/j.foodres.2023.112730openalex-snapshot
Effects of ultra-processed foods on the microbiota-gut-brain axis: The bread-and-butter issue
inferred← citeshttps://doi.org/10.1016/j.foodres.2025.116757openalex-snapshot
Fermented Gastrodia elata Bl. Intervenes gut microbiota and amino acid metabolism in zebrafish to promote 5-HT homeostasis against sleep disturbances
inferred← citeshttps://doi.org/10.1016/j.foodres.2026.119188openalex-snapshot
Regulation of appetite via gut microbiota-modulated calcium ion channels: focus on tea polyphenols
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e20797openalex-snapshot
An underlying mechanism behind interventional pulmonology techniques for refractory asthma treatment: Neuro-immunity crosstalk
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e37510openalex-snapshot
A zebrafish gene with sequence similarities to human uromodulin and GP2 displays extensive evolutionary diversification among teleost and confers resistance to bacterial infection
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.139863openalex-snapshot
Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics
inferred← citeshttps://doi.org/10.1016/j.ijchp.2022.100349openalex-snapshot
Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2021.120610openalex-snapshot
Enteric formulated indole-3-carboxaldehyde targets the aryl hydrocarbon receptor for protection in a murine model of metabolic syndrome
inferred← citeshttps://doi.org/10.1016/j.immuni.2023.07.011openalex-snapshot
Boundaries and integration between microbiota, the nervous system, and immunity
inferred← citeshttps://doi.org/10.1016/j.isci.2024.111699openalex-snapshot
Select microbial metabolites in the small intestinal lumen regulate vagal activity via receptor-mediated signaling
inferred← citeshttps://doi.org/10.1016/j.isci.2026.116206openalex-snapshot
Gut distension evokes rapid neural dynamics in vagal and hindbrain populations of larval zebrafish
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2024.01.024openalex-snapshot
Advances in Brain–Gut–Microbiome Interactions: A Comprehensive Update on Signaling Mechanisms, Disorders, and Therapeutic Implications
inferred← citeshttps://doi.org/10.1016/j.jep.2025.119446openalex-snapshot
A glucan from Ganoderma lucidum: Structural characterization and the anti-inflammatory effect on Parkinson's disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.jff.2026.107287openalex-snapshot
Gut microbiota-derived tryptophan metabolites mediate the interplay between dietary bioactive ingredients and host health
inferred← citeshttps://doi.org/10.1016/j.lfs.2023.122036openalex-snapshot
Influence of Escherichia coli infection on intestinal mucosal barrier integrity of germ-free piglets
inferred← citeshttps://doi.org/10.1016/j.mam.2022.101115openalex-snapshot
Systems to model the personalized aspects of microbiome health and gut dysbiosis
inferred← citeshttps://doi.org/10.1016/j.mce.2024.112339openalex-snapshot
Enteroendocrine cells regulate intestinal homeostasis and epithelial function
inferred← citeshttps://doi.org/10.1016/j.medmic.2021.100042openalex-snapshot
Zebrafish model for human gut microbiome-related studies: advantages and limitations
inferred← citeshttps://doi.org/10.1016/j.mehy.2024.111550openalex-snapshot
Dysfunction of the Gut-Brain-Axis in delayed encephalopathy after carbon monoxide poisoning
inferred← citeshttps://doi.org/10.1016/j.micres.2023.127440openalex-snapshot
Gut microbes influence the development of central nervous system disorders through epigenetic inheritance
inferred← citeshttps://doi.org/10.1016/j.micres.2024.127733openalex-snapshot
Bacterial extracellular vesicles: Vital contributors to physiology from bacteria to host
inferred← citeshttps://doi.org/10.1016/j.micres.2026.128510openalex-snapshot
Microbial metabolites: Bridging the gut-brain divide in ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.microb.2026.100668openalex-snapshot
Serotonin and the gut microbiome: Pathways, functions, and health implications
inferred← citeshttps://doi.org/10.1016/j.molmed.2024.05.002openalex-snapshot
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes
inferred← citeshttps://doi.org/10.1016/j.molmed.2025.10.009openalex-snapshot
Tryptophan metabolites at the service of neuroimmune sensing of microbes
inferred← citeshttps://doi.org/10.1016/j.neuron.2021.09.036openalex-snapshot
Microbiota-brain interactions: Moving toward mechanisms in model organisms
inferred← citeshttps://doi.org/10.1016/j.neuron.2025.11.026openalex-snapshot
Intestinal interoception: A nexus of environment-body-brain interactions
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107255openalex-snapshot
The dual roles of serotonin in antitumor immunity
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107749openalex-snapshot
IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107909openalex-snapshot
The aryl hydrocarbon receptor: A promising target for intestinal fibrosis therapy
inferred← citeshttps://doi.org/10.1016/j.phymed.2024.156012openalex-snapshot
Microbiota–gut–brain axis: Natural antidepressants molecular mechanism
inferred← citeshttps://doi.org/10.1016/j.phymed.2026.158061openalex-snapshot
Natural products targeting the gut-brain axis for the treatment of post-cardiac procedures anxiety or depression
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2026.111860openalex-snapshot
Cannabinoid receptor-mediated modulation of the gut-brain axis under chronic stress: Neuroinflammatory mechanisms, microbial metabolites, and sexual dimorphism
inferred← citeshttps://doi.org/10.1016/j.psj.2022.102008openalex-snapshot
Intestinal microbiota of layer hens and its association with egg quality and safety
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2025.179102openalex-snapshot
Link between gut damage and neurotoxicity with gender differences in zebrafish: Dibutyl phthalate-driven microbiota dysbiosis as a possible major cause
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2025.179697openalex-snapshot
Novel insight into the mechanisms of neurotoxicity induced by type I and type II pyrethroids via disrupting the gut-brain axis in lizards
inferred← citeshttps://doi.org/10.1016/j.semcdb.2023.07.009openalex-snapshot
Vagal sensory pathway for the gut-brain communication
inferred← citeshttps://doi.org/10.1016/j.tem.2024.07.014openalex-snapshot
Host–microbe serotonin metabolism
inferred← citeshttps://doi.org/10.1016/j.tifs.2025.105264openalex-snapshot
Nanoencapsulated flavonoids for enhanced modulation of the microbiota-gut-brain axis and neurodegenerative add-on therapy
inferred← citeshttps://doi.org/10.1016/j.tim.2023.08.013openalex-snapshot
Sex shapes gut–microbiota–brain communication and disease
inferred← citeshttps://doi.org/10.1016/j.tjnut.2023.06.031openalex-snapshot
Limosilactobacillus mucosae and Lactobacillus amylovorus Protect Against Experimental Colitis via Upregulation of Colonic 5-Hydroxytryptamine Receptor 4 and Transforming Growth Factor-β2
inferred← citeshttps://doi.org/10.1017/s0029665122000805openalex-snapshot
Personal diet–microbiota interactions and weight loss
inferred← citeshttps://doi.org/10.1017/s0031182022001160openalex-snapshot
Parasites and the neuroendocrine control of fish intestinal function: an ancient struggle between pathogens and host
inferred← citeshttps://doi.org/10.1021/acs.est.3c05282openalex-snapshot
Bisphenol A Analogues Induce Neuroendocrine Disruption via Gut–Brain Regulation in Zebrafish
inferred← citeshttps://doi.org/10.1021/acs.jpcb.4c00267openalex-snapshot
Riboswitch Distribution in the Human Gut Microbiome Reveals Common Metabolite Pathways
inferred← citeshttps://doi.org/10.1021/acschembio.4c00095openalex-snapshot
Discovery of a Gut Bacterial Metabolic Pathway that Drives α-Synuclein Aggregation
inferred← citeshttps://doi.org/10.1021/acschemneuro.3c00127openalex-snapshot
Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders
inferred← citeshttps://doi.org/10.1038/s41366-021-01049-0openalex-snapshot
Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study
inferred← citeshttps://doi.org/10.1038/s41380-022-01479-wopenalex-snapshot
The gut microbiome and mental health: advances in research and emerging priorities
inferred← citeshttps://doi.org/10.1038/s41390-025-04222-7openalex-snapshot
Isovaleric acid alleviates food allergy-related constipation in mice via repairing serotonin synthesis in serotonergic neurons
inferred← citeshttps://doi.org/10.1038/s41522-025-00810-xopenalex-snapshot
Enteroendocrine cells: the gatekeepers of microbiome-gut-brain communication
inferred← citeshttps://doi.org/10.1038/s41574-022-00794-0openalex-snapshot
The gut microbiota in obesity and weight management: microbes as friends or foe?
inferred← citeshttps://doi.org/10.1038/s41575-024-00962-9openalex-snapshot
Cellular and molecular basis of proximal small intestine disorders
inferred← citeshttps://doi.org/10.1038/s41575-024-01005-zopenalex-snapshot
Bitter taste receptors as sensors of gut luminal contents
inferred← citeshttps://doi.org/10.1038/s41579-024-01136-9openalex-snapshot
Microbiota–neuroepithelial signalling across the gut–brain axis
inferred← citeshttps://doi.org/10.1038/s41584-026-01378-2openalex-snapshot
The gut–joint axis in osteoarthritis
inferred← citeshttps://doi.org/10.1038/s41586-025-09301-7openalex-snapshot
A gut sense for a microbial pattern regulates feeding
inferred← citeshttps://doi.org/10.1038/s44318-025-00588-wopenalex-snapshot
IL-26 from innate lymphoid cells regulates early-life gut epithelial homeostasis by shaping microbiota composition
inferred← citeshttps://doi.org/10.1039/d2mo00205aopenalex-snapshot
Multi-omic analysis of host-microbial interactions central to the gut-brain axis
inferred← citeshttps://doi.org/10.1039/d3fo04152bopenalex-snapshot
A hydrolyzed casein diet promotes Ngn3 controlling enteroendocrine cell differentiation to increase gastrointestinal motility in mice
inferred← citeshttps://doi.org/10.1042/cs20240787openalex-snapshot
Cross-talk between microbiota–gut–brain axis and blood pressure regulation
inferred← citeshttps://doi.org/10.1053/j.gastro.2025.04.002openalex-snapshot
Gut Feelings: The Critical Role of Interoception in Obesity and Disorders of Gut–Brain Interaction
inferred← citeshttps://doi.org/10.1053/j.gastro.2026.02.015openalex-snapshot
The Intestinal Microenvironment and Disorders of Gut–Brain Interaction
inferred← citeshttps://doi.org/10.1055/a-2839-9811openalex-snapshot
Vagal Modulation in Chronic Musculoskeletal Pain: Mechanisms, Clinical Implications, and Therapeutic Potential
inferred← citeshttps://doi.org/10.1056/nejmra2402679openalex-snapshot
The Physiology of Hunger
inferred← citeshttps://doi.org/10.1073/pnas.2409754122openalex-snapshot
A 5-HT-mediated urethral defense against urinary tract infections
inferred← citeshttps://doi.org/10.1073/pnas.2514992123openalex-snapshot
Sex differences in Drosophila intestinal metabolism contribute to sexually dimorphic infection outcome and alter gut pathogen virulence
inferred← citeshttps://doi.org/10.1073/pnas.2600339123openalex-snapshot
Enteroendocrine cells wire the gut–brain vagal axis
inferred← citeshttps://doi.org/10.1080/01635581.2026.2645922openalex-snapshot
Amino Acid-Based Enteral Nutrition Enhances Postoperative Recovery in Colorectal Cancer Patients: A Randomized Controlled Trial
inferred← citeshttps://doi.org/10.1080/10408398.2023.2183935openalex-snapshot
Linking serotonin homeostasis to gut function: Nutrition, gut microbiota and beyond
inferred← citeshttps://doi.org/10.1080/10408398.2024.2369947openalex-snapshot
Microbial tryptophan catabolism as an actionable target via diet-microbiome interactions
inferred← citeshttps://doi.org/10.1080/10408398.2025.2599514openalex-snapshot
Research advances on whole grains benefit on metabolic syndrome via gut homeostasis regulation
inferred← citeshttps://doi.org/10.1080/17582024.2026.2705869openalex-snapshot
Targeting the microbiota-gut-brain axis in neurodegeneration: Zebrafish-based investigations
inferred← citeshttps://doi.org/10.1080/19490976.2021.1997296openalex-snapshot
Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies
inferred← citeshttps://doi.org/10.1080/19490976.2022.2078619openalex-snapshot
Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium
inferred← citeshttps://doi.org/10.1080/19490976.2022.2102878openalex-snapshot
Microbiota-derived metabolites as drivers of gut–brain communication
inferred← citeshttps://doi.org/10.1080/19490976.2023.2201156openalex-snapshot
Gut microbiome at the crossroad of genetic variants and behavior disorders
inferred← citeshttps://doi.org/10.1080/19490976.2024.2413367openalex-snapshot
A pathophysiologic framework for the overlap of disorders of gut-brain interaction and the role of the gut microbiome
inferred← citeshttps://doi.org/10.1080/19490976.2026.2722485openalex-snapshot
Glycosylation in gut-brain communication: from the intestinal barrier and microbiota to immune and neural signaling
inferred← citeshttps://doi.org/10.1080/21645515.2026.2719313openalex-snapshot
The gut microbiota-tryptophan metabolism-immune axis in inflammatory bowel disease: Mechanisms and therapeutic prospects
inferred← citeshttps://doi.org/10.1084/jem.20202507openalex-snapshot
TRPA1: An asthma target with a zing
inferred← citeshttps://doi.org/10.1091/mbc.e24-03-0143openalex-snapshot
Integration of signal transduction pathways in sensory epithelial enteroendocrine cells
inferred← citeshttps://doi.org/10.1093/alcalc/agae050openalex-snapshot
2023 ESBRA Nordmann Award Lecture: Involvement of the gut microbiome-brain axis in alcohol use disorder
inferred← citeshttps://doi.org/10.1093/femsre/fuaf038openalex-snapshot
Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection
inferred← citeshttps://doi.org/10.1093/function/zqaf037openalex-snapshot
Beyond the Microbiome: The Gut’s Role in Hypertension
inferred← citeshttps://doi.org/10.1093/genetics/iyac133openalex-snapshot
Conserved roles for Hnf4 family transcription factors in zebrafish development and intestinal function
inferred← citeshttps://doi.org/10.1093/gerona/glaf053openalex-snapshot
Severe Cognitive Decline in Long-term Care Is Related to Gut Microbiome Production of Metabolites Involved in Neurotransmission, Immunomodulation, and Autophagy
inferred← citeshttps://doi.org/10.1093/ibd/izad211openalex-snapshot
Brain-Gut Axis: Invasive and Noninvasive Vagus Nerve Stimulation, Limitations, and Potential Therapeutic Approaches
inferred← citeshttps://doi.org/10.1093/lifemeta/loae039openalex-snapshot
Serotonin signaling to regulate energy metabolism: a gut microbiota perspective
inferred← citeshttps://doi.org/10.1093/procel/pwad028openalex-snapshot
Microbial sensing in the intestine
inferred← citeshttps://doi.org/10.1093/toxsci/kfaf076openalex-snapshot
The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract
inferred← citeshttps://doi.org/10.1096/fj.202401669ropenalex-snapshot
Limosilactobacillus reuteri promotes the expression and secretion of enteroendocrine‐ and enterocyte‐derived hormones
inferred← citeshttps://doi.org/10.1096/fj.202602925ropenalex-snapshot
TRPA1 Channels as Multimodal Environmental Sensors: Structure–Function Insights From Aquatic Organisms
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000002542openalex-snapshot
Common bacterial metabolite indole directly activates nociceptive neuron through transient receptor potential ankyrin 1 channel
inferred← citeshttps://doi.org/10.1097/spc.0000000000000717openalex-snapshot
The gut microbiome and the brain
inferred← citeshttps://doi.org/10.1098/rstb.2025.0265openalex-snapshot
The microbiota–proteostasis axis: implications in neurodegenerative diseases
inferred← citeshttps://doi.org/10.1101/2022.04.04.486775openalex-snapshot
Gut Enterochromaffin Cells are Critical Drivers of Visceral Pain and Anxiety
inferred← citeshttps://doi.org/10.1101/2022.06.08.495350openalex-snapshot
Discovery of a Gut Bacterial Metabolic Pathway that Drives α-Synuclein Aggregation and Neurodegeneration
inferred← citeshttps://doi.org/10.1101/2023.09.27.558332openalex-snapshot
Gut microbiota promotes enteroendocrine cell maturation and mitochondrial function
inferred← citeshttps://doi.org/10.1101/2023.12.18.572257openalex-snapshot
Vagal interoception of microbial metabolites from the small intestinal lumen
inferred← citeshttps://doi.org/10.1101/2025.01.17.633579openalex-snapshot
Intestinal enteroendocrine cell subtype differentiation and hormone production in zebrafish
inferred← citeshttps://doi.org/10.1101/2025.03.26.645305openalex-snapshot
Whole-brain, all-optical interrogation of neuronal dynamics underlying gut interoception in zebrafish
inferred← citeshttps://doi.org/10.1101/2025.04.25.650580openalex-snapshot
Interleukin-22 in enteroendocrine cells controls early-life gut motility through interactions with the microbiota
inferred← citeshttps://doi.org/10.1101/2025.06.24.661421openalex-snapshot
The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis by enhancing GLP-1 secretion and L-cell differentiation
inferred← citeshttps://doi.org/10.1111/1348-0421.13187openalex-snapshot
Gut Microbiota and Metabolite Profiles Associated With Functional Constipation Severity
inferred← citeshttps://doi.org/10.1111/bph.15930openalex-snapshot
Role of 5‐HT in the enteric nervous system and enteroendocrine cells
inferred← citeshttps://doi.org/10.1111/bph.16429openalex-snapshot
Subcutaneous administration of a novel TRPM8 antagonist reverses cold hypersensitivity while attenuating the drop in core body temperature
inferred← citeshttps://doi.org/10.1111/bph.70526openalex-snapshot
Decoding visceral pain: Molecular pathways and translational targets in gaseous signalling and pharmacology
inferred← citeshttps://doi.org/10.1111/brv.12765openalex-snapshot
Diverse roles of microbial indole compounds in eukaryotic systems
inferred← citeshttps://doi.org/10.1111/cns.70427openalex-snapshot
Unraveling the Interplay Between Metabolism and Neurodevelopment in Health and Disease
inferred← citeshttps://doi.org/10.1111/febs.16067openalex-snapshot
The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review
inferred← citeshttps://doi.org/10.1111/febs.17249openalex-snapshot
Obesity and the gut microbiota: implications of neuroendocrine and immune signaling
inferred← citeshttps://doi.org/10.1111/jcmm.70099openalex-snapshot
Microbiota–gut–brain axis in health and neurological disease: Interactions between gut microbiota and the nervous system
inferred← citeshttps://doi.org/10.1111/jcmm.70553openalex-snapshot
Progresses in Questing for the Truth of Opioid‐Related Constipation in Cancer Patients
inferred← citeshttps://doi.org/10.1111/jfb.16005openalex-snapshot
Transient receptor potential a1b regulates primordial germ cell numbers and sex differentiation in developing zebrafish
inferred← citeshttps://doi.org/10.1111/jnc.16022openalex-snapshot
Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain
inferred← citeshttps://doi.org/10.1111/nmo.14589openalex-snapshot
Paracrine relationship between incretin hormones and endogenous 5‐hydroxytryptamine in the small and large intestine
inferred← citeshttps://doi.org/10.1111/nmo.14675openalex-snapshot
Systematic analysis of proximal midgut‐ and anorectal‐originating contractions in larval zebrafish using event feature detection and supervised machine learning algorithms
inferred← citeshttps://doi.org/10.1111/nmo.70155openalex-snapshot
Retinoic Acid Inhibition Alters Intestinal Composition in Zebrafish: A Non‐genetic Model to Study Hirschsprung Disease?
inferred← citeshttps://doi.org/10.1111/nmo.70260openalex-snapshot
Lactobacillus reuteri DSM 17938 Improves Intestinal Motility in Mice With Postoperative Ileus by Modulating Gut Microbiota and Macrophage
inferred← citeshttps://doi.org/10.1126/sciadv.abg1371openalex-snapshot
Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine
inferred← citeshttps://doi.org/10.1126/science.adr1707openalex-snapshot
IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota
inferred← citeshttps://doi.org/10.1126/science.adr3545openalex-snapshot
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
inferred← citeshttps://doi.org/10.1128/msystems.00358-22openalex-snapshot
The Effect of Limosilactobacillus reuteri on Social Behavior Is Independent of the Adaptive Immune System
inferred← citeshttps://doi.org/10.1128/spectrum.00747-25openalex-snapshot
Variation in microbiome and metabolites is associated with advantageous effects of cholestyramine on primary biliary cholangitis with pruritus
inferred← citeshttps://doi.org/10.1134/s0022093026020134openalex-snapshot
Intrinsic Primary Afferent Neurons of the Gastrointestinal Tract: Polyfunctional and Polymodal
inferred← citeshttps://doi.org/10.1136/gutjnl-2023-331092openalex-snapshot
Akkermansia muciniphila derived tripeptide jams the gear of sepsis, inflammation and mortality
inferred← citeshttps://doi.org/10.1146/annurev-food-053124-111149openalex-snapshot
Functional Diversity of Probiotic Effector Molecules: Insights into Their Role in Improving Gut Health
inferred← citeshttps://doi.org/10.1146/annurev-micro-032421-111819openalex-snapshot
Essential Amino Acid Metabolites as Chemical Mediators of Host-Microbe Interaction in the Gut
inferred← citeshttps://doi.org/10.1152/ajpcell.00608.2025openalex-snapshot
Host-microbiota interactions regulate gut serotonergic signaling: implications for hypertension
inferred← citeshttps://doi.org/10.1152/ajpgi.00075.2024openalex-snapshot
Neuroimmunophysiology of the gastrointestinal tract
inferred← citeshttps://doi.org/10.1152/ajpgi.00240.2025openalex-snapshot
Microbial dysbiosis alters serotonin signaling in a postinflammatory murine model of visceral pain
inferred← citeshttps://doi.org/10.1152/physiolgenomics.00013.2024openalex-snapshot
Chronotropic and vasoactive properties of the gut bacterial short-chain fatty acids in larval zebrafish
inferred← citeshttps://doi.org/10.1152/physrev.00018.2022openalex-snapshot
The enteric nervous system
inferred← citeshttps://doi.org/10.11569/wcjd.v33.i8.666openalex-snapshot
Clinical effects of Changyanning granules combined with Bifidobacterium triple viable capsules in treatment of acute bacterial enteritis in children
inferred← citeshttps://doi.org/10.11606/t.9.2024.tde-25042024-144356openalex-snapshot
Composição da microbiota intestinal durante a gestação e puerpério em mulheres com diferentes intensidades de sintomas depressivos
inferred← citeshttps://doi.org/10.1161/atvbaha.123.318287openalex-snapshot
Zebrafish ApoB-Containing Lipoprotein Metabolism: A Closer Look
inferred← citeshttps://doi.org/10.1172/jci.insight.172192openalex-snapshot
Gut mucosal cells transfer α-synuclein to the vagus nerve
inferred← citeshttps://doi.org/10.1172/jci143768openalex-snapshot
The gut, its microbiome, and the brain: connections and communications
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