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Separase Sensor Reveals Dual Roles for Separase Coordinating Cohesin Cleavage and Cdk1 Inhibition
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/j.1460-2075.1991.tb05009.xopenalex-snapshot
Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M‐phase, but only cyclin B delta 97 turns on cyclin destruction.
inferredcites →https://doi.org/10.1002/j.1460-2075.1996.tb01052.xopenalex-snapshot
Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.
inferredcites →https://doi.org/10.1016/0092-8674(91)90417-wopenalex-snapshot
A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis
inferredcites →https://doi.org/10.1016/j.cell.2004.08.016openalex-snapshot
Vertebrate Shugoshin Links Sister Centromere Cohesion and Kinetochore Microtubule Stability in Mitosis
inferredcites →https://doi.org/10.1016/j.cell.2009.01.040openalex-snapshot
Separase Is Recruited to Mitotic Chromosomes to Dissolve Sister Chromatid Cohesion in a DNA-Dependent Manner
inferredcites →https://doi.org/10.1016/j.cub.2004.06.052openalex-snapshot
Regulation of Sister Chromatid Cohesion between Chromosome Arms
inferredcites →https://doi.org/10.1016/j.cub.2009.02.046openalex-snapshot
Cdk1 Negatively Regulates Midzone Localization of the Mitotic Kinesin Mklp2 and the Chromosomal Passenger Complex
inferredcites →https://doi.org/10.1016/j.molcel.2005.05.022openalex-snapshot
Mutual Inhibition of Separase and Cdk1 by Two-Step Complex Formation
inferredcites →https://doi.org/10.1016/s0014-5793(02)03238-6openalex-snapshot
Anaphase specific auto‐cleavage of separase
inferredcites →https://doi.org/10.1016/s0092-8674(00)00130-6openalex-snapshot
Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
inferredcites →https://doi.org/10.1016/s0092-8674(00)81211-8openalex-snapshot
An ESP1/PDS1 Complex Regulates Loss of Sister Chromatid Cohesion at the Metaphase to Anaphase Transition in Yeast
inferredcites →https://doi.org/10.1016/s0092-8674(01)00340-3openalex-snapshot
Securin Is Required for Chromosomal Stability in Human Cells
inferredcites →https://doi.org/10.1016/s0092-8674(01)00603-1openalex-snapshot
Dual Inhibition of Sister Chromatid Separation at Metaphase
inferredcites →https://doi.org/10.1016/s0092-8674(02)00618-9openalex-snapshot
Separase, Polo Kinase, the Kinetochore Protein Slk19, and Spo12 Function in a Network that Controls Cdc14 Localization during Early Anaphase
inferredcites →https://doi.org/10.1016/s0960-9822(01)00204-4openalex-snapshot
The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis
inferredcites →https://doi.org/10.1016/s0960-9822(01)00325-6openalex-snapshot
Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts
inferredcites →https://doi.org/10.1016/s0960-9822(02)01073-4openalex-snapshot
Regulation of Human Separase by Securin Binding and Autocleavage
inferredcites →https://doi.org/10.1016/s0960-9822(03)00242-2openalex-snapshot
Cyclin B Destruction Triggers Changes in Kinetochore Behavior Essential for Successful Anaphase
inferredcites →https://doi.org/10.1038/10049openalex-snapshot
Temporal and spatial control of cyclin B1 destruction in metaphase
inferredcites →https://doi.org/10.1038/21831openalex-snapshot
Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
inferredcites →https://doi.org/10.1038/381438a0openalex-snapshot
Cut2 proteolysis required for sister-chromatid separation in fission yeast
inferredcites →https://doi.org/10.1038/nature02256openalex-snapshot
Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase
inferredcites →https://doi.org/10.1038/nature03240openalex-snapshot
Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation
inferredcites →https://doi.org/10.1038/nature04652openalex-snapshot
The reversibility of mitotic exit in vertebrate cells
inferredcites →https://doi.org/10.1038/nature07050openalex-snapshot
Positive feedback sharpens the anaphase switch
inferredcites →https://doi.org/10.1038/ncb1350openalex-snapshot
Complex formation of Plk1 and INCENP required for metaphase–anaphase transition
inferredcites →https://doi.org/10.1038/ncb1467openalex-snapshot
Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes
inferredcites →https://doi.org/10.1038/ncb2018openalex-snapshot
Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei
inferredcites →https://doi.org/10.1038/nmeth.1199openalex-snapshot
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals
inferredcites →https://doi.org/10.1038/nrm2712openalex-snapshot
Clearing the way for mitosis: is cohesin a target?
inferredcites →https://doi.org/10.1038/sj.emboj.7600303openalex-snapshot
Preferential cleavage of chromatin‐bound cohesin after targeted phosphorylation by Polo‐like kinase
inferredcites →https://doi.org/10.1038/sj.emboj.7601163openalex-snapshot
Dose‐dependent effects of stable cyclin B1 on progression through mitosis in human cells
inferredcites →https://doi.org/10.1042/bst0381639openalex-snapshot
Getting through anaphase: splitting the sisters and beyond
inferredcites →https://doi.org/10.1073/pnas.91.25.12253openalex-snapshot
Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids.
inferredcites →https://doi.org/10.1083/jcb.200111001openalex-snapshot
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1
inferredcites →https://doi.org/10.1083/jcb.200208091openalex-snapshot
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
inferredcites →https://doi.org/10.1083/jcb.200208092openalex-snapshot
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
inferredcites →https://doi.org/10.1091/mbc.e05-03-0190openalex-snapshot
Securin and Separase Phosphorylation Act Redundantly to Maintain Sister Chromatid Cohesion in Mammalian Cells
inferredcites →https://doi.org/10.1093/emboj/cdf604openalex-snapshot
Syndapins integrate N‐WASP in receptor‐mediated endocytosis
inferredcites →https://doi.org/10.1093/emboj/cdg627openalex-snapshot
Mitotic regulation of the human anaphase‐promoting complex by phosphorylation
inferredcites →https://doi.org/10.1126/science.1061376openalex-snapshot
Cohesin Cleavage by Separase Required for Anaphase and Cytokinesis in Human Cells
inferredcites →https://doi.org/10.1126/science.1091936openalex-snapshot
Separase Regulates INCENP-Aurora B Anaphase Spindle Function Through Cdc14
inferredcites →https://doi.org/10.1126/science.285.5426.418openalex-snapshot
Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis
inferredcites →https://doi.org/10.1210/me.15.11.1870openalex-snapshot
Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere Division
inferredcites →https://doi.org/10.1242/jcs.011528openalex-snapshot
The complete removal of cohesin from chromosome arms depends on separase
inferredcites →https://doi.org/10.1242/jcs.03083openalex-snapshot
Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction
inferredcites →https://doi.org/10.1371/journal.pbio.0030086openalex-snapshot
Shugoshin Prevents Dissociation of Cohesin from Centromeres During Mitosis in Vertebrate Cells
inferredcites →https://doi.org/10.1371/journal.pbio.0030416openalex-snapshot
Securin Is Not Required for Chromosomal Stability in Human Cells
inferredcites →https://doi.org/10.1371/journal.pgen.1000919openalex-snapshot
Fragilities Caused by Dosage Imbalance in Regulation of the Budding Yeast Cell Cycle
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/9780470015902.a0022413.pub2openalex-snapshot
Sister Chromatid Cohesion, Chromosome Instability ( CIN ) and Diseases
inferred← citeshttps://doi.org/10.1002/bies.70093openalex-snapshot
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division
inferred← citeshttps://doi.org/10.1002/cbin.70220openalex-snapshot
Sister Chromatid Cohesion: A Multilayered Regulatory Network Beyond the Cohesin Ring
inferred← citeshttps://doi.org/10.1002/embj.201488098openalex-snapshot
PP2A delays APC/C‐dependent degradation of separase‐associated but not free securin
inferred← citeshttps://doi.org/10.1002/jcb.25835openalex-snapshot
Separase: Function Beyond Cohesion Cleavage and an Emerging Oncogene
inferred← citeshttps://doi.org/10.1007/978-1-4939-8603-3_11openalex-snapshot
Detection of Separase Activity Using a Cleavage Sensor in Live Mouse Oocytes
inferred← citeshttps://doi.org/10.1007/978-3-319-58592-5_20openalex-snapshot
Centromeric Cohesin: Molecular Glue and Much More
inferred← citeshttps://doi.org/10.1016/j.ceb.2018.01.010openalex-snapshot
Establishing and dissolving cohesion during the vertebrate cell cycle
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108652openalex-snapshot
Prolonged mitosis causes separase deregulation and chromosome nondisjunction
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111723openalex-snapshot
Autocleavage of Separase Suppresses its Premature Activation by Promoting Binding to Cyclin B1
inferred← citeshttps://doi.org/10.1016/j.cub.2018.04.019openalex-snapshot
The Post-anaphase SUMO Pathway Ensures the Maintenance of Centromeric Cohesion through Meiosis I-II Transition in Mammalian Oocytes
inferred← citeshttps://doi.org/10.1016/j.cub.2021.01.062openalex-snapshot
Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation
inferred← citeshttps://doi.org/10.1016/j.cub.2022.03.041openalex-snapshot
Aurora B/C-dependent phosphorylation promotes Rec8 cleavage in mammalian oocytes
inferred← citeshttps://doi.org/10.1016/j.cub.2024.02.038openalex-snapshot
Securin acetylation prevents precocious separase activation and premature sister chromatid separation
inferred← citeshttps://doi.org/10.1016/j.devcel.2021.06.019openalex-snapshot
Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition
inferred← citeshttps://doi.org/10.1016/j.molcel.2013.09.005openalex-snapshot
The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation
inferred← citeshttps://doi.org/10.1016/j.molcel.2015.03.025openalex-snapshot
Human Chromosome Segregation Involves Multi-Layered Regulation of Separase by the Peptidyl-Prolyl-Isomerase Pin1
inferred← citeshttps://doi.org/10.1016/j.molcel.2015.09.022openalex-snapshot
Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2022.111776openalex-snapshot
Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy
inferred← citeshttps://doi.org/10.1016/j.omtn.2026.103100openalex-snapshot
Roles of meiotic and mitotic cohesin in stem cell gene regulation and genome stability
inferred← citeshttps://doi.org/10.1016/j.tcb.2016.07.008openalex-snapshot
Time To Split Up: Dynamics of Chromosome Separation
inferred← citeshttps://doi.org/10.1016/j.urolonc.2025.09.007openalex-snapshot
Exploring the tumor-promoting function and prognostic value of ESPL1 in prostate adenocarcinoma
inferred← citeshttps://doi.org/10.1021/acschembio.2c00527openalex-snapshot
Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor
inferred← citeshttps://doi.org/10.1021/acschembio.9b00661openalex-snapshot
Identification of Bioactive Small Molecule Inhibitors of Separase
inferred← citeshttps://doi.org/10.1038/bjc.2017.301openalex-snapshot
Separase is a marker for prognosis and mitotic activity in breast cancer
inferred← citeshttps://doi.org/10.1038/d41586-021-01944-6openalex-snapshot
Two giants of cell division in an oppressive embrace
inferred← citeshttps://doi.org/10.1038/ncb2842openalex-snapshot
Kinetic framework of spindle assembly checkpoint signalling
inferred← citeshttps://doi.org/10.1038/nrm3934openalex-snapshot
Spatiotemporal regulation of the anaphase-promoting complex in mitosis
inferred← citeshttps://doi.org/10.1038/s41467-019-13209-yopenalex-snapshot
Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
inferred← citeshttps://doi.org/10.1038/s41467-021-24554-2openalex-snapshot
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
inferred← citeshttps://doi.org/10.1038/s41586-021-03764-0openalex-snapshot
Structural basis of human separase regulation by securin and CDK1–cyclin B1
inferred← citeshttps://doi.org/10.1038/s44318-025-00522-0openalex-snapshot
Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II
inferred← citeshttps://doi.org/10.1042/bst20221400openalex-snapshot
The molecular mechanisms of human separase regulation
inferred← citeshttps://doi.org/10.1080/15384101.2015.1064567openalex-snapshot
Cyclin B3 controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes
inferred← citeshttps://doi.org/10.1083/jcb.201402041openalex-snapshot
Multiple mechanisms determine the order of APC/C substrate degradation in mitosis
inferred← citeshttps://doi.org/10.1083/jcb.201808088openalex-snapshot
Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I
inferred← citeshttps://doi.org/10.1083/jcb.201808091openalex-snapshot
Cyclin B3 promotes anaphase I onset in oocyte meiosis
inferred← citeshttps://doi.org/10.1083/jcb.202312099openalex-snapshot
Securin regulates the spatiotemporal dynamics of separase
inferred← citeshttps://doi.org/10.1083/jcb.202602088openalex-snapshot
Chromosome segregation synchrony in S. pombe is noise limited and arises without positive feedback
inferred← citeshttps://doi.org/10.1091/mbc.e13-07-0421openalex-snapshot
The spindle and kinetochore–associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit
inferred← citeshttps://doi.org/10.1093/jxb/erz076openalex-snapshot
Caught green-handed: methods for in vivo detection and visualization of protease activity
inferred← citeshttps://doi.org/10.1093/nar/gkag841openalex-snapshot
Lamin B1-dependent regulation of human separase in mitosis
inferred← citeshttps://doi.org/10.1101/2025.01.06.631516openalex-snapshot
Securin and cyclin B1-CDK1, but not SGO2, regulate separase activity during meiosis I in mouse oocytes
inferred← citeshttps://doi.org/10.1101/2025.02.11.637638openalex-snapshot
Elimination of separase inhibition reveals absence of cohesin protection in oocyte metaphase II
inferred← citeshttps://doi.org/10.1101/2025.02.16.638358openalex-snapshot
Hybrid female sterility due to cohesin protection errors in oocytes
inferred← citeshttps://doi.org/10.1101/cshperspect.a015792openalex-snapshot
Chromosome Dynamics during Mitosis
inferred← citeshttps://doi.org/10.1101/cshperspect.a026476openalex-snapshot
Cohesin Mutations in Cancer
inferred← citeshttps://doi.org/10.1111/cas.14989openalex-snapshot
Unraveling pathologies underlying chromosomal instability in cancers
inferred← citeshttps://doi.org/10.1111/cas.70438openalex-snapshot
Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development
inferred← citeshttps://doi.org/10.1126/sciadv.adx9729openalex-snapshot
Hybrid female sterility due to cohesin protection errors in mouse oocytes
inferred← citeshttps://doi.org/10.1128/mbio.03561-21openalex-snapshot
Novel CRK-Cyclin Complex Controls Spindle Assembly Checkpoint in Toxoplasma Endodyogeny
inferred← citeshttps://doi.org/10.1146/annurev-genet-120215-035303openalex-snapshot
Aneuploidy in Cancer and Aging
inferred← citeshttps://doi.org/10.1155/2020/4625123openalex-snapshot
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer
inferred← citeshttps://doi.org/10.1172/jci82277openalex-snapshot
Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy
inferred← citeshttps://doi.org/10.1186/s12859-019-2895-1openalex-snapshot
Time varying causal network reconstruction of a mouse cell cycle
inferred← citeshttps://doi.org/10.1186/s13008-019-0057-5openalex-snapshot
Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome
inferred← citeshttps://doi.org/10.1186/s40364-016-0059-2openalex-snapshot
c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia
inferred← citeshttps://doi.org/10.1242/bio.201410793openalex-snapshot
MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C
inferred← citeshttps://doi.org/10.1242/dev.090589openalex-snapshot
Molecular causes of aneuploidy in mammalian eggs
inferred← citeshttps://doi.org/10.1242/jcs.259102openalex-snapshot
Direct evaluation of cohesin-mediated sister kinetochore associations at meiosis I in fission yeast
inferred← citeshttps://doi.org/10.1371/journal.pbio.3003131openalex-snapshot
SGO2 does not play an essential role in separase inhibition during meiosis I in mouse oocytes
inferred← citeshttps://doi.org/10.1371/journal.pgen.1004672openalex-snapshot
Sensors at Centrosomes Reveal Determinants of Local Separase Activity
inferred← citeshttps://doi.org/10.1371/journal.pgen.1008928openalex-snapshot
Chromosome separation during Drosophila male meiosis I requires separase-mediated cleavage of the homolog conjunction protein UNO
inferred← citeshttps://doi.org/10.18297/etd/3949openalex-snapshot
Molecular mechanisms of hexavalent chromium-induced centrosome amplification.
inferred← citeshttps://doi.org/10.2147/ott.s136491openalex-snapshot
Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer
inferred← citeshttps://doi.org/10.2220/biomedres.39.75openalex-snapshot
Quantitative analyses of the metaphase-to-anaphase transition reveal differential kinetic regulation for securin and cyclin B1
inferred← citeshttps://doi.org/10.3390/cells11213399openalex-snapshot
Separase Control and Cohesin Cleavage in Oocytes: Should I Stay or Should I Go?
inferred← citeshttps://doi.org/10.3390/cells8080814openalex-snapshot
Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis
inferred← citeshttps://doi.org/10.3390/ijms22136788openalex-snapshot
Cohesin Mutations in Cancer: Emerging Therapeutic Targets
inferred← citeshttps://doi.org/10.3390/ijms24054604openalex-snapshot
Separase and Roads to Disengage Sister Chromatids during Anaphase
inferred← citeshttps://doi.org/10.4161/cc.29336openalex-snapshot
Inefficient degradation of cyclin B1 re-activates the spindle checkpoint right after sister chromatid disjunction
inferred← citeshttps://doi.org/10.70675/8a35d253z2bc1z4f60za910za75252660eadopenalex-snapshot
Implications de la lamine B1 dans la stabilité des télomères et la mitose
inferred← citeshttps://doi.org/10.70675/eb921333z2b62z4270z9720zd65f15cb9a8fopenalex-snapshot
Control of meiotic divisions in oocytes : a novel role for cyclin B3
inferred← citeshttps://doi.org/10.7150/jca.17478openalex-snapshot
Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability
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