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An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cne.10481openalex-snapshot
Molecular mapping of the origin of postnatal spinal cord ependymal cells: Evidence that adult ependymal cells are derived from Nkx6.1+ ventral neural progenitor cells
inferredcites →https://doi.org/10.1002/cne.23104openalex-snapshot
Biciliated ependymal cell proliferation contributes to spinal cord growth
inferredcites →https://doi.org/10.1002/cne.23501openalex-snapshot
The Adult Macaque Spinal Cord Central Canal Zone Contains Proliferative Cells And Closely Resembles The Human
inferredcites →https://doi.org/10.1002/glia.21077openalex-snapshot
Prospectively isolated CD133/CD24‐positive ependymal cells from the adult spinal cord and lateral ventricle wall differ in their long‐term in vitro self‐renewal and in vivo gene expression
inferredcites →https://doi.org/10.1002/glia.22579openalex-snapshot
The adult spinal cord harbors a population of GFAP-positive progenitors with limited self-renewal potential
inferredcites →https://doi.org/10.1002/jnr.21646openalex-snapshot
Adult human spinal cord harbors neural precursor cells that generate neurons and glial cells in vitro
inferredcites →https://doi.org/10.1002/path.5151openalex-snapshot
Cells in the adult human spinal cord ependymal region do not proliferate after injury
inferredcites →https://doi.org/10.1002/stem.226openalex-snapshot
A Mesenchymal-Like ZEB1+ Niche Harbors Dorsal Radial Glial Fibrillary Acidic Protein-Positive Stem Cells in the Spinal Cord
inferredcites →https://doi.org/10.1006/dbio.1996.8449openalex-snapshot
The Expression of the MouseZic1, Zic2,andZic3Gene Suggests an Essential Role forZicGenes in Body Pattern Formation
inferredcites →https://doi.org/10.1007/s004010050982openalex-snapshot
Age-related morphologic changes of the central canal of the human spinal cord
inferredcites →https://doi.org/10.1016/0092-8674(94)90421-9openalex-snapshot
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
inferredcites →https://doi.org/10.1016/0165-0173(85)90016-5openalex-snapshot
Ependyma: Normal and pathological. A review of the literature☆
inferredcites →https://doi.org/10.1016/j.ccell.2020.06.004openalex-snapshot
Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma
inferredcites →https://doi.org/10.1016/j.cell.2008.12.002openalex-snapshot
PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt
inferredcites →https://doi.org/10.1016/j.cell.2018.03.063openalex-snapshot
Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function
inferredcites →https://doi.org/10.1016/j.cell.2018.06.021openalex-snapshot
Molecular Architecture of the Mouse Nervous System
inferredcites →https://doi.org/10.1016/j.cell.2019.05.031openalex-snapshot
Comprehensive Integration of Single-Cell Data
inferredcites →https://doi.org/10.1016/j.celrep.2019.01.088openalex-snapshot
Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor
inferredcites →https://doi.org/10.1016/j.celrep.2020.108023openalex-snapshot
Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology
inferredcites →https://doi.org/10.1016/j.celrep.2022.110440openalex-snapshot
Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties
inferredcites →https://doi.org/10.1016/j.devcel.2009.08.002openalex-snapshot
Redefining the Progression of Lineage Segregations during Mammalian Embryogenesis by Clonal Analysis
inferredcites →https://doi.org/10.1016/j.devcel.2015.01.001openalex-snapshot
Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!
inferredcites →https://doi.org/10.1016/j.devcel.2022.07.012openalex-snapshot
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential
inferredcites →https://doi.org/10.1016/j.ebiom.2016.10.035openalex-snapshot
Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time
inferredcites →https://doi.org/10.1016/j.expneurol.2013.01.026openalex-snapshot
Neural stem cells in the adult spinal cord
inferredcites →https://doi.org/10.1016/j.pneurobio.2018.04.002openalex-snapshot
The spinal ependymal zone as a source of endogenous repair cells across vertebrates
inferredcites →https://doi.org/10.1016/j.stem.2008.06.011openalex-snapshot
Stem Cells for Spinal Cord Repair
inferredcites →https://doi.org/10.1016/j.stem.2010.07.014openalex-snapshot
Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
inferredcites →https://doi.org/10.1016/j.stem.2015.07.002openalex-snapshot
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury
inferredcites →https://doi.org/10.1016/j.stem.2015.07.013openalex-snapshot
Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis
inferredcites →https://doi.org/10.1016/j.stem.2019.08.007openalex-snapshot
Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells
inferredcites →https://doi.org/10.1016/j.stemcr.2015.11.010openalex-snapshot
Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells
inferredcites →https://doi.org/10.1016/j.stemcr.2019.04.001openalex-snapshot
RNA Profiling of the Human and Mouse Spinal Cord Stem Cell Niches Reveals an Embryonic-like Regionalization with MSX1+ Roof-Plate-Derived Cells
inferredcites →https://doi.org/10.1016/j.ydbio.2006.02.029openalex-snapshot
Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells
inferredcites →https://doi.org/10.1016/j.ydbio.2017.06.027openalex-snapshot
1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the mouse but not essential for motile ciliogenesis
inferredcites →https://doi.org/10.1016/j.ydbio.2017.09.034openalex-snapshot
Salamander spinal cord regeneration: The ultimate positive control in vertebrate spinal cord regeneration
inferredcites →https://doi.org/10.1016/j.yexcr.2017.06.002openalex-snapshot
An ex vivo spinal cord injury model to study ependymal cells in adult mouse tissue
inferredcites →https://doi.org/10.1016/j.yexcr.2018.04.017openalex-snapshot
FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential
inferredcites →https://doi.org/10.1016/s0092-8674(00)80783-7openalex-snapshot
Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
inferredcites →https://doi.org/10.1016/s0092-8674(00)80956-3openalex-snapshot
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
inferredcites →https://doi.org/10.1016/s0896-6273(02)00835-8openalex-snapshot
LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal
inferredcites →https://doi.org/10.1016/s0925-4773(97)00062-2openalex-snapshot
Expression of a novel aristaless related homeobox gene ‘Arx’ in the vertebrate telencephalon, diencephalon and floor plate
inferredcites →https://doi.org/10.1016/s1525-0016(03)00221-1openalex-snapshot
Targeting expression of a transgene to the airway surface epithelium using a ciliated cell-specific promoter
inferredcites →https://doi.org/10.1038/nmeth.2019openalex-snapshot
Fiji: an open-source platform for biological-image analysis
inferredcites →https://doi.org/10.1038/nmeth.2639openalex-snapshot
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
inferredcites →https://doi.org/10.1038/nn.2268openalex-snapshot
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
inferredcites →https://doi.org/10.1038/nn.2467openalex-snapshot
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
inferredcites →https://doi.org/10.1038/nprot.2014.006openalex-snapshot
Full-length RNA-seq from single cells using Smart-seq2
inferredcites →https://doi.org/10.1038/nrm.2017.21openalex-snapshot
The development and functions of multiciliated epithelia
inferredcites →https://doi.org/10.1038/nrn2591openalex-snapshot
The bright side of the glial scar in CNS repair
inferredcites →https://doi.org/10.1038/s41467-017-02440-0openalex-snapshot
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
inferredcites →https://doi.org/10.1038/s41467-021-26321-9openalex-snapshot
Introducing dorsoventral patterning in adult regenerating lizard tails with gene-edited embryonic neural stem cells
inferredcites →https://doi.org/10.1038/s41467-022-28626-9openalex-snapshot
Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors
inferredcites →https://doi.org/10.1038/s41586-018-0590-4openalex-snapshot
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
inferredcites →https://doi.org/10.1038/s41593-020-00795-0openalex-snapshot
Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons
inferredcites →https://doi.org/10.1038/s41598-018-23353-yopenalex-snapshot
Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling
inferredcites →https://doi.org/10.1073/pnas.0407893101openalex-snapshot
Radial glia give rise to adult neural stem cells in the subventricular zone
inferredcites →https://doi.org/10.1073/pnas.1319962111openalex-snapshot
PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors
inferredcites →https://doi.org/10.1073/pnas.1507125112openalex-snapshot
A survey of human brain transcriptome diversity at the single cell level
inferredcites →https://doi.org/10.1073/pnas.1803297115openalex-snapshot
Wnt/β-catenin signaling regulates ependymal cell development and adult homeostasis
inferredcites →https://doi.org/10.1073/pnas.1803780115openalex-snapshot
Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders
inferredcites →https://doi.org/10.1074/jbc.m702792200openalex-snapshot
Ucma, a Novel Secreted Cartilage-specific Protein with Implications in Osteogenesis
inferredcites →https://doi.org/10.1084/jem.20210040openalex-snapshot
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord
inferredcites →https://doi.org/10.1091/mbc.e08-07-0691openalex-snapshot
Sentan: A Novel Specific Component of the Apical Structure of Vertebrate Motile Cilia
inferredcites →https://doi.org/10.1093/bfgp/elx035openalex-snapshot
Experimental design for single-cell RNA sequencing
inferredcites →https://doi.org/10.1093/bioinformatics/bts635openalex-snapshot
STAR: ultrafast universal RNA-seq aligner
inferredcites →https://doi.org/10.1093/gigascience/giy083openalex-snapshot
Clustering trees: a visualization for evaluating clusterings at multiple resolutions
inferredcites →https://doi.org/10.1093/nar/gkz369openalex-snapshot
g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
inferredcites →https://doi.org/10.1098/rstb.2006.2016openalex-snapshot
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain
inferredcites →https://doi.org/10.1101/2021.05.05.442755openalex-snapshot
STARsolo: accurate, fast and versatile mapping/quantification of single-cell and single-nucleus RNA-seq data
inferredcites →https://doi.org/10.1111/j.1467-985x.2010.00676_9.xopenalex-snapshot
ggplot2: Elegant Graphics for Data Analysis
inferredcites →https://doi.org/10.1111/joa.13094openalex-snapshot
Multiple steps characterise ventricular layer attrition to form the ependymal cell lining of the adult mouse spinal cord central canal
inferredcites →https://doi.org/10.1126/science.1242576openalex-snapshot
Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice
inferredcites →https://doi.org/10.1126/science.abb8795openalex-snapshot
A latent lineage potential in resident neural stem cells enables spinal cord repair
inferredcites →https://doi.org/10.1172/jci73015openalex-snapshot
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging
inferredcites →https://doi.org/10.1242/dev.02852openalex-snapshot
A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors
inferredcites →https://doi.org/10.1242/dev.090845openalex-snapshot
Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord
inferredcites →https://doi.org/10.1242/dev.119768openalex-snapshot
Neuromesodermal progenitors and the making of the spinal cord
inferredcites →https://doi.org/10.1242/dev.159343openalex-snapshot
Wnt produced by stretched roof-plate cells is required for the promotion of cell proliferation around the central canal of the spinal cord
inferredcites →https://doi.org/10.1242/dev.199711openalex-snapshot
Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features
inferredcites →https://doi.org/10.1242/jcs.026534openalex-snapshot
Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration
inferredcites →https://doi.org/10.1371/journal.pbio.0060182openalex-snapshot
Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
inferredcites →https://doi.org/10.1371/journal.pone.0024538openalex-snapshot
Adult Spinal Cord Radial Glia Display a Unique Progenitor Phenotype
inferredcites →https://doi.org/10.1371/journal.pone.0027079openalex-snapshot
Neural Stem/Progenitor Cells from the Adult Human Spinal Cord Are Multipotent and Self-Renewing and Differentiate after Transplantation
inferredcites →https://doi.org/10.1371/journal.pone.0085916openalex-snapshot
Central Canal Ependymal Cells Proliferate Extensively in Response to Traumatic Spinal Cord Injury but Not Demyelinating Lesions
inferredcites →https://doi.org/10.1387/ijdb.160232nbopenalex-snapshot
Floor plate descendants in the ependyma of the adult mouse Central Nervous System
inferredcites →https://doi.org/10.14806/ej.17.1.200openalex-snapshot
Cutadapt removes adapter sequences from high-throughput sequencing reads
inferredcites →https://doi.org/10.1523/jneurosci.1108-04.2005openalex-snapshot
Adult Ependymal Cells Are Postmitotic and Are Derived from Radial Glial Cells during Embryogenesis
inferredcites →https://doi.org/10.1523/jneurosci.1189-08.2008openalex-snapshot
Motor Neuron Regeneration in Adult Zebrafish
inferredcites →https://doi.org/10.1523/jneurosci.17-13-05046.1997openalex-snapshot
Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
inferredcites →https://doi.org/10.1523/jneurosci.19-11-04462.1999openalex-snapshot
Adult Mammalian Forebrain Ependymal and Subependymal Cells Demonstrate Proliferative Potential, but only Subependymal Cells Have Neural Stem Cell Characteristics
inferredcites →https://doi.org/10.1523/jneurosci.2056-19.2020openalex-snapshot
Connexin Signaling Is Involved in the Reactivation of a Latent Stem Cell Niche after Spinal Cord Injury
inferredcites →https://doi.org/10.2144/0000113878openalex-snapshot
Trehalose-Enhanced Isolation of Neuronal Sub-Types from Adult Mouse Brain
inferredcites →https://doi.org/10.2741/3734openalex-snapshot
The spinal cord ependymal region: A stem cell niche in the caudal central nervous system
inferredcites →https://doi.org/10.3171/jns.1979.51.1.0085openalex-snapshot
Relation of age and cerebral ventricle size to central canal in man
inferredcites →https://doi.org/10.3171/jns.1994.80.4.0716openalex-snapshot
Stenosis of central canal of spinal cord in man: incidence and pathological findings in 232 autopsy cases
inferredcites →https://doi.org/10.3390/cells10092235openalex-snapshot
The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals
inferredcites →https://doi.org/10.3390/cells10123332openalex-snapshot
RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate
inferredcites →https://doi.org/10.3390/jdb9030030openalex-snapshot
Morphological and Functional Changes of Roof Plate Cells in Spinal Cord Development
inferredcites →https://doi.org/10.48550/arxiv.1802.03426openalex-snapshot
UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction
inferredcites →https://doi.org/10.7554/elife.10230openalex-snapshot
Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration
inferredcites →https://doi.org/10.7554/elife.34389openalex-snapshot
ZMYND10 functions in a chaperone relay during axonemal dynein assembly
inferredcites →https://doi.org/10.7554/elife.53085openalex-snapshot
Chloride channels regulate differentiation and barrier functions of the mammalian airway
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Ezrin, a novel marker of ependymal cells, can be used to demonstrate their proliferation regulation after spinal cord injury in mice
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Comparative analysis of meningeal transcriptomes in birds: Potential pathways of resilience to repeated impacts
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inferred← citeshttps://doi.org/10.1007/s10571-026-01711-zopenalex-snapshot
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Ezrin, a novel marker of ependymal cells, can be used to demonstrate their proliferation regulation after spinal cord injury in mice
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Polyamine metabolic reprogramming in ependymal cells promotes endogenous repair after spinal cord injury
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Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells
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Ependymal and neural stem cells are close relatives
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From neural tube to spinal cord: The dynamic journey of the dorsal neuroepithelium
inferred← citeshttps://doi.org/10.1016/j.ydbio.2025.01.015openalex-snapshot
Shh signaling directs dorsal ventral patterning in the regenerating X. tropicalis spinal cord
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Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair
inferred← citeshttps://doi.org/10.1038/s41593-024-01684-6openalex-snapshot
Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice
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Augmenting AMPA receptor signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery
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Characterizing progenitor cells in developing and injured spinal cord: Insights from single-nucleus transcriptomics and lineage tracing
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The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity
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GFAP + FOXF2 + ependymal cells promote blood–brain barrier repair via DLL4–NOTCH signaling after neural injury
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Astrocyte regeneration via FGF8-DBX1 signalling facilitates recovery in neuromyelitis optica rats
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Lineage tracing of Shh+ floor plate cells and dynamics of dorsal–ventral gene expression in the regenerating axolotl spinal cord
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Microglia-Mediated Ependymal Injury in Bacille Calmette-Guérin-Induced Meningitis Is Attenuated by Sodium Butyrate with Restoration of Hmgcs2 Expression
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Transient activation of potent progenitor cells is required for spinal cord regeneration
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The glial action potential and its role during the emergence of motor behaviour
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