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Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease

https://doi.org/10.1016/j.ejpb.2011.03.003

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00436-008-0992-6openalex-snapshot

Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions

inferredcites →https://doi.org/10.1016/0035-9203(87)90020-4openalex-snapshot

Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease

inferredcites →https://doi.org/10.1016/j.apt.2009.12.019openalex-snapshot

Time-dependence of particle size during comminution and a scale-up procedure for stirred media mills

inferredcites →https://doi.org/10.1016/j.ejpb.2007.12.006openalex-snapshot

Effect of powder processing on performance of fenofibrate formulations

inferredcites →https://doi.org/10.1016/j.ejpb.2008.02.014openalex-snapshot

Dissolution rate enhancement of the novel antitumoral β-lapachone by solvent change precipitation of microparticles

inferredcites →https://doi.org/10.1016/j.ijpharm.2004.03.025openalex-snapshot

Intravenous liposomal benznidazole as trypanocidal agent: increasing drug delivery to liver is not enough

inferredcites →https://doi.org/10.1016/j.ijpharm.2005.10.004openalex-snapshot

Development of parenteral formulations and evaluation of the biological activity of the trypanocide drug benznidazole

inferredcites →https://doi.org/10.1016/j.ijpharm.2008.09.036openalex-snapshot

Development of novel formulations for Chagas’ disease: Optimization of benznidazole chitosan microparticles based on artificial neural networks

inferredcites →https://doi.org/10.1016/s0022-0248(99)00819-2openalex-snapshot

Crystallization processes in pharmaceutical technology and drug delivery design

inferredcites →https://doi.org/10.1016/s0378-5173(02)00072-8openalex-snapshot

Enhanced drug dissolution using evaporative precipitation into aqueous solution

inferredcites →https://doi.org/10.1016/s0939-6411(00)00091-6openalex-snapshot

Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards

inferredcites →https://doi.org/10.1016/s0939-6411(02)00168-6openalex-snapshot

In-situ-micronization of disodium cromoglycate for pulmonary delivery

inferredcites →https://doi.org/10.1016/s1385-8947(98)00145-4openalex-snapshot

Optimization of a Kenics static mixer for non-creeping flow conditions

inferredcites →https://doi.org/10.1021/jm701306ropenalex-snapshot

Complexation of the anti-Trypanosoma cruzi Drug Benznidazole Improves Solubility and Efficacy

inferredcites →https://doi.org/10.1023/a:1021410028371openalex-snapshot

Dissolution Rate Enhancement by in Situ Micronization of Poorly Water-Soluble Drugs

inferredcites →https://doi.org/10.1093/ajhp/44.8.1946openalex-snapshot

Handbook of Pharmaceutical Excipients

inferredcites →https://doi.org/10.1208/s12249-010-9441-9openalex-snapshot

Gliclazide Microcrystals Prepared by Two Methods of In Situ Micronization: Pharmacokinetic Studies in Diabetic and Normal Rats

inferredcites →https://doi.org/10.1590/s0074-02762002000100001openalex-snapshot

A Critical Review on Chagas Disease Chemotherapy

inferredcites →https://doi.org/10.1590/s0074-02762009000900041openalex-snapshot

Ergosterol biosynthesis and drug development for Chagas disease

inferredcites →https://doi.org/10.18433/j31p4popenalex-snapshot

Dissolution Enhancement of Gliclazide Using pH Change Approach in Presence of Twelve Stabilizers with Various Physico-Chemical Properties

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Chagas Disease: History, Pathophysiology and Therapeutic Treatment

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Nanosuspensions with Enhanced Drug Dissolution Rates of Poorly Water‐Soluble Drugs

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Rapid and sensitive ultra‐high‐pressure liquid chromatography method for quantification of antichagasic benznidazole in plasma: application in a preclinical pharmacokinetic study

inferred← citeshttps://doi.org/10.1002/jps.23010openalex-snapshot

First Century of Chagas' Disease: An Overview on Novel Approaches to Nifurtimox and Benznidazole Delivery Systems

inferred← citeshttps://doi.org/10.1007/s40005-013-0051-xopenalex-snapshot

Nanosuspensions: a new approach for organ and cellular targeting in infectious diseases

inferred← citeshttps://doi.org/10.1016/j.actatropica.2018.02.008openalex-snapshot

Technological innovation strategies for the specific treatment of Chagas disease based on Benznidazole

inferred← citeshttps://doi.org/10.1016/j.actatropica.2019.105218openalex-snapshot

The effect of benznidazole dose among the efficacy outcome in the murine animal model. A quantitative integration of the literature

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Improving the oral delivery of benznidazole nanoparticles by optimizing the formulation parameters through a design of experiment and optimization strategy

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Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes

inferred← citeshttps://doi.org/10.1016/j.exppara.2015.01.002openalex-snapshot

Novel solid dispersions of benznidazole: Preparation, dissolution profile and biological evaluation as alternative antichagasic drug delivery system

inferred← citeshttps://doi.org/10.1016/j.ijpharm.2014.10.070openalex-snapshot

Nanonization of curcumin by antisolvent precipitation: Process development, characterization, freeze drying and stability performance

inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.05.017openalex-snapshot

Polysaccharides-based multiparticulated interpolyelectrolyte complexes for controlled benznidazole release

inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124417openalex-snapshot

Supramolecular eutectogel as new oral paediatric delivery system to enhance benznidazole bioavailability

inferred← citeshttps://doi.org/10.1016/j.jconrel.2020.05.002openalex-snapshot

Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides

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Drug-excipient compatibility studies in formulation development: A case study with benznidazole and monoglycerides

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Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole

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Simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: A tool for quality control in the development of formulations

inferred← citeshttps://doi.org/10.1016/j.talanta.2014.08.040openalex-snapshot

Development of a LC–MS/MS methodology for the monitoring of the antichagasic drug benznidazole in human urine

inferred← citeshttps://doi.org/10.1016/j.tca.2013.10.007openalex-snapshot

Preformulation studies of itraconazole associated with benznidazole and pharmaceutical excipients

inferred← citeshttps://doi.org/10.1017/s0031182020002310openalex-snapshot

In vitro studies and preclinical evaluation of benznidazole microparticles in the acute Trypanosoma cruzi murine model

inferred← citeshttps://doi.org/10.1021/acs.cgd.0c00490openalex-snapshot

Cocrystal Polymorphs and Solvates of the Anti-Trypanosoma cruzi Drug Benznidazole with Improved Dissolution Performance

inferred← citeshttps://doi.org/10.1080/03639045.2016.1220574openalex-snapshot

Preparation of benznidazole pellets for immediate drug delivery using the extrusion spheronization technique

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Supercritical CO 2 versus water as an antisolvent in the crystallization process to enhance dissolution rate of curcumin

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Therapeutic Potential of 3D ‐Printed Nifurtimox for Chagas Disease: Effects on Survival, Parasitemia Control and Immune Modulation

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An impact of nanocrystals on dissolution rate of Lercanidipine: Supersaturation and crystallization by addition of solvent to antisolvent

inferred← citeshttps://doi.org/10.1208/s12249-020-01659-3openalex-snapshot

A Novel Prototype Device for Microencapsulation of Benznidazole: In Vitro/In Vivo Studies

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Solubility and dissolution optimization of paracetamol using in situ micronization by solvent change method

inferred← citeshttps://doi.org/10.1517/13543784.2014.922952openalex-snapshot

Therapeutical approaches under investigation for treatment of Chagas disease

inferred← citeshttps://doi.org/10.1590/s2175-97902023e22111openalex-snapshot

Encapsulation of benznidazole in nanostructured lipid carriers and increased trypanocidal activity in a resistant Trypanosoma cruzi strain

inferred← citeshttps://doi.org/10.21275/sr23713202410openalex-snapshot

Design and Characterization of Lercanidipine Microcrystals for Enhancement of Dissolution Rate

inferred← citeshttps://doi.org/10.2217/nnm.14.185openalex-snapshot

Nanomedicines Against Chagas Disease: an Update on Therapeutics, Prophylaxis and Diagnosis

inferred← citeshttps://doi.org/10.3109/10837450.2011.644299openalex-snapshot

Modulated dissolution rate from the inclusion complex of antichagasic benznidazole and cyclodextrin using hydrophilic polymer

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Formulation and Evaluation of Silymarin Microcrystals by In- Situ Micronization Technique

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Solid Dispersions as a Technological Strategy to Improve the Bio-Performance of Antiparasitic Drugs with Limited Solubility

inferred← citeshttps://doi.org/10.3390/pharmaceutics14091822openalex-snapshot

Solid Nanomedicines of Nifurtimox and Benznidazole for the Oral Treatment of Chagas Disease

inferred← citeshttps://doi.org/10.3390/pharmaceutics15041126openalex-snapshot

Poly-ε-Caprolactone Implants for Benznidazole Prolonged Release: An Alternative to Chagas Disease Oral Treatment

inferred← citeshttps://doi.org/10.3390/pharmaceutics16060800openalex-snapshot

Benznidazole-Loaded Polymeric Nanoparticles for Oral Chemotherapeutic Treatment of Chagas Disease

inferred← citeshttps://doi.org/10.3978/j.issn.2223-3652.2012.08.03openalex-snapshot

Bone marrow-derived cell therapy in chagasic cardiac disease: a review of pre-clinical and clinical results.

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Vibrational characterization of active drug to the treatment of chagas disease, benznidazole by using force fields and internal coordinates

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Etude de la cristallisation d’une nouvelle molécule à efficacité cardiotonique dans un mélange liquide ionique - eau

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