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Therapeutical approaches under investigation for treatment of Chagas disease
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jps.23010openalex-snapshot
First Century of Chagas' Disease: An Overview on Novel Approaches to Nifurtimox and Benznidazole Delivery Systems
inferredcites →https://doi.org/10.1007/s00436-002-0769-2openalex-snapshot
Formulation and biopharmaceutical issues in the development of drug delivery systems for antiparasitic drugs
inferredcites →https://doi.org/10.1007/s00436-008-0992-6openalex-snapshot
Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions
inferredcites →https://doi.org/10.1007/s00775-013-1024-2openalex-snapshot
Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells
inferredcites →https://doi.org/10.1007/s40262-014-0136-3openalex-snapshot
Determination of an Optimal Dosing Regimen for Fexinidazole, a Novel Oral Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Studies
inferredcites →https://doi.org/10.1016/0002-8703(94)90521-5openalex-snapshot
Treatment of chronic Chagas' disease with benznidazole: Clinical and serologic evolution of patients with long-term follow-up
inferredcites →https://doi.org/10.1016/1054-8807(93)90021-sopenalex-snapshot
Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic chagasic myocarditis: Light microscopy and immunohistochemical findings
inferredcites →https://doi.org/10.1016/j.actatropica.2009.10.023openalex-snapshot
Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches
inferredcites →https://doi.org/10.1016/j.addr.2009.11.024openalex-snapshot
Nanotechnology applied to the treatment of malaria
inferredcites →https://doi.org/10.1016/j.addr.2009.11.025openalex-snapshot
Nanotechnological approaches against Chagas disease
inferredcites →https://doi.org/10.1016/j.ejpb.2011.03.003openalex-snapshot
Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease
inferredcites →https://doi.org/10.1016/j.ijantimicag.2012.08.002openalex-snapshot
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains
inferredcites →https://doi.org/10.1016/j.ijbiomac.2013.10.007openalex-snapshot
Effects of benznidazole:cyclodextrin complexes on the drug bioavailability upon oral administration to rats
inferredcites →https://doi.org/10.1016/j.ijpharm.2004.03.025openalex-snapshot
Intravenous liposomal benznidazole as trypanocidal agent: increasing drug delivery to liver is not enough
inferredcites →https://doi.org/10.1016/j.jconrel.2004.12.012openalex-snapshot
Etanidazole in pH-sensitive liposomes: Design, characterization and in vitro/in vivo anti-Trypanosoma cruzi activity
inferredcites →https://doi.org/10.1016/j.niox.2008.06.181openalex-snapshot
P83. Activity of the a new ruthenium NO donor against Trypanosoma cruzi: trans-[RuCl([15]aneN4)NO]2+
inferredcites →https://doi.org/10.1016/j.parint.2012.09.001openalex-snapshot
Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi
inferredcites →https://doi.org/10.1016/j.vetimm.2009.01.004openalex-snapshot
Development of chronic cardiomyopathy in canine Chagas disease correlates with high IFN-γ, TNF-α, and low IL-10 production during the acute infection phase
inferredcites →https://doi.org/10.1016/j.vetimm.2010.06.010openalex-snapshot
Increased type 1 chemokine expression in experimental Chagas disease correlates with cardiac pathology in Beagle dogs
inferredcites →https://doi.org/10.1016/s0001-706x(02)00139-0openalex-snapshot
The dog as model for chemotherapy of the Chagas’ disease
inferredcites →https://doi.org/10.1016/s0277-5387(00)00495-2openalex-snapshot
Toward a novel metal-based chemotherapy against tropical diseases.
inferredcites →https://doi.org/10.1016/s0924-8579(02)00273-xopenalex-snapshot
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease
inferredcites →https://doi.org/10.1016/s1054-3589(08)60229-xopenalex-snapshot
Chemotherapy of Trypanosoma cruzi Infections
inferredcites →https://doi.org/10.1017/s0031182013000176openalex-snapshot
Combined treatment with benznidazole and allopurinol in mice infected with a virulent Trypanosoma cruzi isolate from Nicaragua
inferredcites →https://doi.org/10.1021/jm050441zopenalex-snapshot
The Protein Farnesyltransferase Inhibitor Tipifarnib as a New Lead for the Development of Drugs against Chagas Disease
inferredcites →https://doi.org/10.1021/jm050691fopenalex-snapshot
Amiodarone Has Intrinsic Anti- Trypanosoma c ruzi Activity and Acts Synergistically with Posaconazole
inferredcites →https://doi.org/10.1021/jm401610copenalex-snapshot
Two Analogues of Fenarimol Show Curative Activity in an Experimental Model of Chagas Disease
inferredcites →https://doi.org/10.1021/jm9013136openalex-snapshot
Second Generation Analogues of the Cancer Drug Clinical Candidate Tipifarnib for Anti-Chagas Disease Drug Discovery
inferredcites →https://doi.org/10.1021/jm901633vopenalex-snapshot
Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy
inferredcites →https://doi.org/10.1038/nm1744openalex-snapshot
Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease
inferredcites →https://doi.org/10.1080/00034983.1983.11811668openalex-snapshot
The activity of fexinidazole (HOE 239) against experimental infections with Trypanosoma cruzi, trichomonads and Entamoeba histolytica
inferredcites →https://doi.org/10.1084/jem.188.4.725openalex-snapshot
Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection
inferredcites →https://doi.org/10.1093/infdis/jis034openalex-snapshot
New Drugs for the Treatment of Tuberculosis: Needs, Challenges, Promise, and Prospects for the Future
inferredcites →https://doi.org/10.1093/infdis/jit042openalex-snapshot
VNI Cures Acute and Chronic Experimental Chagas Disease
inferredcites →https://doi.org/10.1093/infdis/jit420openalex-snapshot
New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice
inferredcites →https://doi.org/10.1093/jac/45.6.819openalex-snapshot
A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease
inferredcites →https://doi.org/10.1093/jac/47.1.101openalex-snapshot
Cure of experimental Chagas' disease by the bis-triazole DO870 incorporated into 'stealth' polyethyleneglycol-polylactide nanospheres
inferredcites →https://doi.org/10.1093/jac/dks135openalex-snapshot
Cardiomyopathy prognosis after benznidazole treatment in chronic canine Chagas' disease
inferredcites →https://doi.org/10.1111/j.1476-5381.2009.00524.xopenalex-snapshot
Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity
inferredcites →https://doi.org/10.1111/j.1476-5381.2009.00576.xopenalex-snapshot
Nitric oxide donor trans‐[RuCl([15]aneN4)NO]2+ as a possible therapeutic approach for Chagas' disease
inferredcites →https://doi.org/10.1111/tmi.12002openalex-snapshot
Myocardial scars correlate with eletrocardiographic changes in chronic Trypanosoma cruzi infection for dogs treated with Benznidazole
inferredcites →https://doi.org/10.1128/aac.00070-13openalex-snapshot
In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi
inferredcites →https://doi.org/10.1128/aac.00281-10openalex-snapshot
A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection
inferredcites →https://doi.org/10.1128/aac.00332-10openalex-snapshot
Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis
inferredcites →https://doi.org/10.1128/aac.00436-07openalex-snapshot
A Cysteine Protease Inhibitor Cures Chagas' Disease in an Immunodeficient-Mouse Model of Infection
inferredcites →https://doi.org/10.1128/aac.00617-13openalex-snapshot
Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease
inferredcites →https://doi.org/10.1128/aac.00796-12openalex-snapshot
2-Alkylaminoethyl-1,1-Bisphosphonic Acids Are Potent Inhibitors of the Enzymatic Activity of Trypanosoma cruzi Squalene Synthase
inferredcites →https://doi.org/10.1128/aac.01617-09openalex-snapshot
Arylimidamide DB766, a Potential Chemotherapeutic Candidate for Chagas' Disease Treatment
inferredcites →https://doi.org/10.1128/aac.01742-09openalex-snapshot
Effects of Ravuconazole Treatment on Parasite Load and Immune Response in Dogs Experimentally Infected with Trypanosoma cruzi
inferredcites →https://doi.org/10.1128/aac.01855-13openalex-snapshot
Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure
inferredcites →https://doi.org/10.1128/aac.05575-11openalex-snapshot
In Vitro and In Vivo Trypanocidal Synergistic Activity of N -Butyl-1-(4-Dimethylamino)Phenyl-1,2,3,4-Tetrahydro-β-Carboline-3-Carboxamide Associated with Benznidazole
inferredcites →https://doi.org/10.1128/aac.06244-11openalex-snapshot
Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib
inferredcites →https://doi.org/10.1128/aac.37.6.1353openalex-snapshot
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease
inferredcites →https://doi.org/10.1128/aac.44.1.150-155.2000openalex-snapshot
Activities of the Triazole Derivative SCH 56592 (Posaconazole) against Drug-Resistant Strains of the Protozoan Parasite Trypanosoma ( Schizotrypanum ) cruzi in Immunocompetent and Immunosuppressed Murine Hosts
inferredcites →https://doi.org/10.1128/aac.47.1.223-230.2003openalex-snapshot
Chemotherapy with Benznidazole and Itraconazole for Mice Infected with Different Trypanosoma cruzi Clonal Genotypes
inferredcites →https://doi.org/10.1128/aac.48.11.4286-4292.2004openalex-snapshot
Activity of the New Triazole Derivative Albaconazole against Trypanosoma ( Schizotrypanum ) cruzi in Dog Hosts
inferredcites →https://doi.org/10.1128/aac.49.1.126-130.2005openalex-snapshot
Buthionine Sulfoximine Increases the Toxicity of Nifurtimox and Benznidazole toTrypanosoma cruzi
inferredcites →https://doi.org/10.1128/aac.49.12.5160-5161.2005openalex-snapshot
A Cysteine Protease Inhibitor Protects Dogs from Cardiac Damage during Infection byTrypanosoma cruzi
inferredcites →https://doi.org/10.1128/aac.49.4.1521-1528.2005openalex-snapshot
Treatment with Benznidazole during the Chronic Phase of Experimental Chagas' Disease Decreases Cardiac Alterations
inferredcites →https://doi.org/10.1191/0960327106het653oaopenalex-snapshot
Toxic Side Effects of Drugs Used to Treat Chagas’ Disease (American Trypanosomiasis)
inferredcites →https://doi.org/10.1371/journal.pntd.0000488openalex-snapshot
Feasibility, Drug Safety, and Effectiveness of Etiological Treatment Programs for Chagas Disease in Honduras, Guatemala, and Bolivia: 10-Year Experience of Médecins Sans Frontières
inferredcites →https://doi.org/10.1371/journal.pntd.0000923openalex-snapshot
Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness
inferredcites →https://doi.org/10.1371/journal.pntd.0001870openalex-snapshot
Fexinidazole: A Potential New Drug Candidate for Chagas Disease
inferredcites →https://doi.org/10.1371/journal.pntd.0002367openalex-snapshot
Benznidazole and Posaconazole in Experimental Chagas Disease: Positive Interaction in Concomitant and Sequential Treatments
inferredcites →https://doi.org/10.1371/journal.pone.0022155openalex-snapshot
Combined Treatment of Heterocyclic Analogues and Benznidazole upon Trypanosoma cruzi In Vivo
inferredcites →https://doi.org/10.1590/s0036-46651992000200015openalex-snapshot
Avaliação da atividade terapêutica do itraconazol nas infecções crônicas, experimental e humana, pelo Trypanosoma cruzi
inferredcites →https://doi.org/10.1590/s0036-46652002000100006openalex-snapshot
Long term evaluation of etiological treatment of Chagas disease with benznidazole
inferredcites →https://doi.org/10.1590/s0037-86822002000400010openalex-snapshot
Comparison of Trypanosoma cruzi infection in dogs inoculated with blood or metacyclic trypomastigotes of Berenice-62 and Berenice-78 strains via intraperitoneal and conjunctival routes
inferredcites →https://doi.org/10.1590/s0074-02761991000200008openalex-snapshot
Reversibility of cardiac fibrosis in mice chronically infected with Trypanosoma cruzi, under specific chemotherapy
inferredcites →https://doi.org/10.1590/s0074-02761993000100023openalex-snapshot
An experimental and clinical assay with ketoconazole in the treatment of Chagas disease
inferredcites →https://doi.org/10.1590/s1516-31801995000200020openalex-snapshot
Ethiological treatment of acute and chronic Chagas' heart disease
inferredcites →https://doi.org/10.2174/092986712802884222openalex-snapshot
Innovative Lead Compounds and Formulation Strategies As Newer Kinetoplastid Therapies
inferredcites →https://doi.org/10.2174/1389557043487493openalex-snapshot
Metal Complexes as Chemotherapeutic Agents Against Tropical Diseases: Trypanosomiasis, Malaria and Leishmaniasis
inferredcites →https://doi.org/10.2174/1568026023393048openalex-snapshot
Enzymes of the Trypanothione Metabolism as Targets for Antitrypanosomal Drug Development
inferredcites →https://doi.org/10.4269/ajtmh.1990.43.159openalex-snapshot
Therapeutic Efficacy of Allopurinol in Patients with Chronic Chagas' Disease
inferredcites →https://doi.org/10.4269/ajtmh.1993.48.348openalex-snapshot
Amplification of a Trypanosoma Cruzi DNA Sequence from Inflammatory Lesions in Human Chagasic Cardiomyopathy
inferredcites →https://doi.org/10.4269/ajtmh.1998.59.133openalex-snapshot
Treatment of chronic Chagas' disease with itraconazole and allopurinol.
inferredcites →https://doi.org/10.4269/ajtmh.2010.09-0620openalex-snapshot
Successful Treatment with Posaconazole of a Patient with Chronic Chagas Disease and Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.7326/0003-4819-137-5_part_2-200209031-00001openalex-snapshot
Guidelines for Using Antiretroviral Agents among HIV-Infected Adults and Adolescents: The Panel on Clinical Practices for Treatment of HIV*
inferredcites →https://doi.org/10.7326/0003-4819-144-10-200605160-00006openalex-snapshot
Long-Term Cardiac Outcomes of Treating Chronic Chagas Disease with Benznidazole versus No Treatment
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4658483openalex-extracted
Synthesis of New Trypanocidal Agents from the Hybridisation of Metronidazole and Eugenol Analogues
inferred← citeshttps://doi.org/10.1007/s00436-018-6084-3openalex-snapshot
Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1007/s00436-020-06645-zopenalex-snapshot
The role of fat on cardiomyopathy outcome in mouse models of chronic Trypanosoma cruzi infection
inferred← citeshttps://doi.org/10.1007/s00436-022-07618-0openalex-snapshot
In vitro interaction of polyethylene glycol-block-poly(D,L-lactide) nanocapsule devices with host cardiomyoblasts and Trypanosoma cruzi-infective forms
inferred← citeshttps://doi.org/10.1016/b978-0-12-803267-1.00023-5openalex-snapshot
Chagas Cardiomyopathy
inferred← citeshttps://doi.org/10.1016/b978-0-12-821100-7.00008-xopenalex-snapshot
Nanomedicines against Chagas disease
inferred← citeshttps://doi.org/10.1016/b978-0-443-15178-1.00009-2openalex-snapshot
Where do we stand? Insight on patented products and those under clinical trials
inferred← citeshttps://doi.org/10.1016/b978-0-443-15650-2.00009-xopenalex-snapshot
Role of coumarins in different infectious diseases
inferred← citeshttps://doi.org/10.1016/j.actatropica.2022.106607openalex-snapshot
5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents
inferred← citeshttps://doi.org/10.1016/j.bcp.2018.01.005openalex-snapshot
Time and dose-dependence evaluation of nitroheterocyclic drugs for improving efficacy following Trypanosoma cruzi infection: A pre-clinical study
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107288openalex-snapshot
Synthesis of new trypanocidal agents from the hybridisation of metronidazole and eugenol analogues
inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110218openalex-snapshot
Drug-natural molecule coupling as a rational strategy in the development of an innovative antiparasitic, anti-inflammatory and cardioprotective drug for Chagas disease treatment
inferred← citeshttps://doi.org/10.1016/j.drudis.2016.06.021openalex-snapshot
Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.02.028openalex-snapshot
In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51
inferred← citeshttps://doi.org/10.1016/j.exppara.2020.107834openalex-snapshot
Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon
inferred← citeshttps://doi.org/10.1016/j.exppara.2021.108142openalex-snapshot
Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease
inferred← citeshttps://doi.org/10.1016/j.exppara.2022.108266openalex-snapshot
Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs
inferred← citeshttps://doi.org/10.1016/j.heliyon.2021.e07024openalex-snapshot
Synthesis and evaluation of the in vitro and in vivo antitrypanosomal activity of 2-styrylquinolines
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2025.100623openalex-snapshot
Comparative transcriptomics of naturally susceptible and resistant Trypanosoma cruzi strains in response to Benznidazole
inferred← citeshttps://doi.org/10.1016/j.intimp.2020.106611openalex-snapshot
Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2015.02.002openalex-snapshot
Identification of novel cyclic nucleotide binding proteins in Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.molstruc.2018.06.089openalex-snapshot
Computational study of substituent effects on the physicochemical properties and chemical reactivity of selected antiparasitic 5-nitrofurans
inferred← citeshttps://doi.org/10.1016/j.phymed.2016.06.017openalex-snapshot
Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin E2 pathway induced during Trypanosoma cruzi infection
inferred← citeshttps://doi.org/10.1016/j.saa.2016.01.040openalex-snapshot
Simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: A tool for quality control in the development of formulations
inferred← citeshttps://doi.org/10.1017/s0031182016001098openalex-snapshot
Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes onTrypanosoma cruzibloodstream trypomastigotes
inferred← citeshttps://doi.org/10.1017/s0031182019001276openalex-snapshot
Activity of the sesquiterpene lactone goyazensolide against Trypanosoma cruzi in vitro and in vivo
inferred← citeshttps://doi.org/10.1021/acsinfecdis.8b00253openalex-snapshot
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1038/s41598-017-08469-xopenalex-snapshot
Increased Body Exposure to New Anti-Trypanosomal Through Nanoencapsulation
inferred← citeshttps://doi.org/10.1039/c6dt04615kopenalex-snapshot
Glycosylated metal chelators as anti-parasitic agents with tunable selectivity
inferred← citeshttps://doi.org/10.1039/c9nj02207dopenalex-snapshot
Substituent effects on the stability, physicochemical properties and chemical reactivity of nitroimidazole derivatives with potential antiparasitic effect: a computational study
inferred← citeshttps://doi.org/10.1080/03639045.2016.1220574openalex-snapshot
Preparation of benznidazole pellets for immediate drug delivery using the extrusion spheronization technique
inferred← citeshttps://doi.org/10.1080/13543784.2024.2349289openalex-snapshot
Drugs in preclinical and early clinical development for the treatment of Chagas´s disease: the current status
inferred← citeshttps://doi.org/10.1080/21678707.2019.1701432openalex-snapshot
The senseless orphanage of Chagas disease
inferred← citeshttps://doi.org/10.1093/ofid/ofy236openalex-snapshot
Validation of Apolipoprotein A-1 and Fibronectin Fragments as Markers of Parasitological Cure for Congenital Chagas Disease in Children Treated With Benznidazole
inferred← citeshttps://doi.org/10.1101/2020.09.11.294199openalex-snapshot
Galectin-1-deficient mice are protected against Trypanosoma cruzi infection through altered neutrophil migration and production of reactive oxygen species and nitric oxide
inferred← citeshttps://doi.org/10.1128/aac.00178-16openalex-snapshot
Efficacy of Lychnopholide Polymeric Nanocapsules after Oral and Intravenous Administration in Murine Experimental Chagas Disease
inferred← citeshttps://doi.org/10.1128/aac.00401-18openalex-snapshot
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice
inferred← citeshttps://doi.org/10.1128/aac.01191-18openalex-snapshot
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease
inferred← citeshttps://doi.org/10.1128/aac.01937-19openalex-snapshot
Lychnopholide in Poly( d , l -Lactide)- Block -Polyethylene Glycol Nanocapsules Cures Infection with a Drug-Resistant Trypanosoma cruzi Strain at Acute and Chronic Phases
inferred← citeshttps://doi.org/10.1128/aac.02497-19openalex-snapshot
Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection
inferred← citeshttps://doi.org/10.1128/aac.02717-16openalex-snapshot
Nitrotriazole-Based Compounds as Antichagasic Agents in a Long-Treatment In Vivo Assay
inferred← citeshttps://doi.org/10.1155/2018/8676578openalex-snapshot
Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta‐Analysis, and In Silico Integrated Approach
inferred← citeshttps://doi.org/10.1155/2020/9794575openalex-snapshot
DNA Vaccine Treatment in Dogs Experimentally Infected with Trypanosoma cruzi
inferred← citeshttps://doi.org/10.11606/t.60.2014.tde-31102014-143222openalex-snapshot
Envolvimento de galectina-1 na infecção experimental aguda por Trypanosoma cruzi
inferred← citeshttps://doi.org/10.11606/t.60.2016.tde-02052016-103221openalex-snapshot
Influência da doença de Chagas na farmacocinética-farmacodinâmica dos isômeros do nebivolol e seus metabólitos em pacientes idosos metabolizadores rápidos para o CYP2D6
inferred← citeshttps://doi.org/10.1186/s12906-021-03248-8openalex-snapshot
Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II
inferred← citeshttps://doi.org/10.1371/journal.pntd.0004540openalex-snapshot
Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1371/journal.pntd.0005657openalex-snapshot
LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion
inferred← citeshttps://doi.org/10.1371/journal.pntd.0006132openalex-snapshot
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection
inferred← citeshttps://doi.org/10.1371/journal.pone.0128707openalex-snapshot
Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease
inferred← citeshttps://doi.org/10.1590/0037-8682-0585-2023openalex-snapshot
Screening of synthetic 1,2,3-triazolic compounds inspired by SRPIN340 as anti-Trypanosoma cruzi agents
inferred← citeshttps://doi.org/10.1590/0074-02760170267openalex-snapshot
Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment
inferred← citeshttps://doi.org/10.19080/ctbeb.2017.06.555693openalex-snapshot
Advances in the Neglected Chagas Disease: Drug Targets and Trypanocide Compounds
inferred← citeshttps://doi.org/10.2139/ssrn.5240565openalex-snapshot
Dual-Action Metronidazole-5-Nitrodihydroeugenol Hybrid: Reduces Parasitism, Cardiac Risk, and Inflammatory Response, While Boosting Benznidazole Efficacy
inferred← citeshttps://doi.org/10.2147/jep.s267378openalex-snapshot
Review on Experimental Treatment Strategies Against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.2174/0929867322666150521091652openalex-snapshot
Cruzipain: An Update on its Potential as Chemotherapy Target against the Human Pathogen Trypanosoma cruzi
inferred← citeshttps://doi.org/10.2174/0929867325666180410101728openalex-snapshot
Polypharmacology in the Treatment of Chagas Disease
inferred← citeshttps://doi.org/10.2174/0929867328666210913090928openalex-snapshot
Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents
inferred← citeshttps://doi.org/10.2174/1574891x11666161024165304openalex-snapshot
Targets and Patented Drugs for Chemotherapy of Chagas Disease in the Last 15 Years-Period
inferred← citeshttps://doi.org/10.29057/esh.v8i16.5699openalex-snapshot
Enfermedad de Chagas y Células Gliales Entéricas
inferred← citeshttps://doi.org/10.3109/14756366.2015.1077330openalex-snapshot
Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease
inferred← citeshttps://doi.org/10.3389/fchem.2021.622286openalex-snapshot
An Overview on the Therapeutics of Neglected Infectious Diseases—Leishmaniasis and Chagas Diseases
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1340755openalex-snapshot
Trypanosoma cruzi antigen detection in blood to assess treatment efficacy and cure in mice models of Chagas disease
inferred← citeshttps://doi.org/10.3389/fmicb.2021.617504openalex-snapshot
The Potent Trypanocidal Effect of LQB303, a Novel Redox-Active Phenyl-Tert-Butyl-Nitrone Derivate That Causes Mitochondrial Collapse in Trypanosoma cruzi
inferred← citeshttps://doi.org/10.3390/biomedicines12071410openalex-snapshot
Exploring the Dimensions of Pre-Clinical Research: 3D Cultures as an Investigative Model of Cardiac Fibrosis in Chagas Disease
inferred← citeshttps://doi.org/10.3390/iecp2020-08686openalex-snapshot
Solid Dispersions as a Technological Strategy to Improve the Bio-Performance of Antiparasitic Drugs with Limited Solubility
inferred← citeshttps://doi.org/10.3390/jcm13092565openalex-snapshot
Chagas Disease: Comparison of Therapy with Nifurtimox and Benznidazole in Indigenous Communities in Colombia
inferred← citeshttps://doi.org/10.3390/molecules26185676openalex-snapshot
In Vitro Phenotypic Activity and In Silico Analysis of Natural Products from Brazilian Biodiversity on Trypanosoma cruzi
inferred← citeshttps://doi.org/10.3390/molecules27228087openalex-snapshot
Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches
inferred← citeshttps://doi.org/10.3390/pathogens12050701openalex-snapshot
Arylimidamides Have Potential for Chemoprophylaxis against Blood-Transmitted Chagas Disease
inferred← citeshttps://doi.org/10.3390/pharmaceutics15041126openalex-snapshot
Poly-ε-Caprolactone Implants for Benznidazole Prolonged Release: An Alternative to Chagas Disease Oral Treatment
inferred← citeshttps://doi.org/10.3390/pharmaceutics15051535openalex-snapshot
Antiparasitic Activity of Plumbago auriculata Extracts and Its Naphthoquinone Plumbagin against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.4155/fmc-2016-0236openalex-snapshot
Molecular Modeling and Structure–Activity Relationships for a Series of Benzimidazole Derivatives as Cruzain Inhibitors
inferred← citeshttps://doi.org/10.5772/intechopen.77234openalex-snapshot
Slowed Development of Natural Products for Chagas Disease, how to Move Forward?
inferred← citeshttps://doi.org/10.5772/intechopen.80373openalex-snapshot
Biology of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.5772/intechopen.84472openalex-snapshot
Parasite, Compartments, and Molecules: Trick versus Treatment on Chagas Disease
inferred← citeshttps://doi.org/10.70675/23df73c0z64a9z4919zb792z5b3e98c9dd91openalex-snapshot
Synthèse et étude de l'activité anti-kinétoplastidés de nouvelles 8-nitroquinoléin-2(1H))-ones bioactivées par les nitroréductases de type 1
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