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Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ijc.2910510316openalex-snapshot
Pharmacologic interactions between the resistance‐modifying cyclosporine sdz psc 833 and etoposide (VP 16–213) enhance In Vivo cytostatic activity and toxicity
inferredcites →https://doi.org/10.1002/jps.20563openalex-snapshot
Effects of citronellal, a monoterpenoid in Zanthoxyli Fructus, on the intestinal absorption of digoxin in vitro and in vivo
inferredcites →https://doi.org/10.1002/jps.2600811018openalex-snapshot
Pharmacokinetic profile of glycyrrhizin in healthy volunteers by a new high‐performance liquid chromatographic method
inferredcites →https://doi.org/10.1002/jps.2600820317openalex-snapshot
Kinetic Analysis of Glycyrrhetic Acid, an Active Metabolite of Glycyrrhizin, in Rats: Role of Enterohepatic Circulation
inferredcites →https://doi.org/10.1002/pds.1197openalex-snapshot
Trends in new drug interactions for pharmaceutical products in Japan
inferredcites →https://doi.org/10.1006/bbrc.2001.6000openalex-snapshot
Active Transport of Fluorescent P-Glycoprotein Substrates: Evaluation as Markers and Interaction with Inhibitors
inferredcites →https://doi.org/10.1007/s002800050258openalex-snapshot
Inhibition of intestinal P-glycoprotein and effects on etoposide absorption
inferredcites →https://doi.org/10.1016/0006-2952(94)90580-0openalex-snapshot
Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers
inferredcites →https://doi.org/10.1016/0022-1759(83)90438-6openalex-snapshot
An enzyme-release assay for natural cytotoxicity
inferredcites →https://doi.org/10.1016/0022-1759(88)90310-9openalex-snapshot
A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity
inferredcites →https://doi.org/10.1016/j.taap.2005.04.001openalex-snapshot
Inhibition of P-glycoprotein-mediated transport by extracts of and monoterpenoids contained in Zanthoxyli Fructus
inferredcites →https://doi.org/10.1016/s0006-2952(02)01446-6openalex-snapshot
Reversal of P-glycoprotein-mediated multidrug resistance by ginsenoside Rg3
inferredcites →https://doi.org/10.1016/s0009-9236(97)90027-8openalex-snapshot
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*
inferredcites →https://doi.org/10.1016/s0021-9258(18)35757-0openalex-snapshot
Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.
inferredcites →https://doi.org/10.1016/s0022-3565(25)10423-0openalex-snapshot
Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).
inferredcites →https://doi.org/10.1016/s0024-3205(02)01799-xopenalex-snapshot
The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: The role of gut CYP3A and P-glycoprotein
inferredcites →https://doi.org/10.1016/s0168-3659(99)00034-6openalex-snapshot
Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery
inferredcites →https://doi.org/10.1016/s0169-409x(97)00043-4openalex-snapshot
Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery
inferredcites →https://doi.org/10.1016/s1054-3589(08)60934-5openalex-snapshot
Structure and Function of P-Glycoprotein in Normal Liver and Small Intestine
inferredcites →https://doi.org/10.1021/jf010924lopenalex-snapshot
Volatile Components of Peel and Leaf Oils of Lemon and Lime Species
inferredcites →https://doi.org/10.1021/jf981064kopenalex-snapshot
Grapefruit Gland Oil Composition Is Affected by Wax Application, Storage Temperature, and Storage Time
inferredcites →https://doi.org/10.1073/pnas.050585397openalex-snapshot
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
inferredcites →https://doi.org/10.1073/pnas.97.7.3473openalex-snapshot
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
inferredcites →https://doi.org/10.1111/j.2042-7158.1958.tb10349.xopenalex-snapshot
THE ANTI-INFLAMMATORY ACTIVITY OF GLYCYRRHETINIC ACID AND DERIVATIVES
inferredcites →https://doi.org/10.1136/gut.52.12.1788openalex-snapshot
ABC of oral bioavailability: transporters as gatekeepers in the gut
inferredcites →https://doi.org/10.1146/annurev.cb.08.110192.000435openalex-snapshot
ABC Transporters: From Microorganisms to Man
inferredcites →https://doi.org/10.1146/annurev.mi.47.100193.001451openalex-snapshot
ATP-DEPENDENT TRANSPORT SYSTEMS IN BACTERIA AND HUMANS: Relevance to Cystic Fibrosis and Multidrug Resistance
inferredcites →https://doi.org/10.1246/bcsj.41.1945openalex-snapshot
Constituents of Fruit Oil from Japanese Pepper
inferredcites →https://doi.org/10.1248/bpb.21.1062openalex-snapshot
Inhibition of Vinblastine Efflux Mediated by P-Glycoprotein by Grapefruit Juice Components in Caco-2 Cells.
inferredcites →https://doi.org/10.1507/endocrj1954.4.17openalex-snapshot
STUDY ON THE CORTICOID-LIKE ACTION OF GLYCYRRHIZINE AND THE MECHANISM OF ITS ACTION
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Protection of Glycyrrhetinic Acid Against Diosbulbin B-Induced Hepatotoxicity by Modulating the Metabolism of Diosbulbin B
inferred← citeshttps://doi.org/10.1002/jat.4450openalex-snapshot
Glycyrrhetinic acid ameliorates diosbulbin B‐induced hepatotoxicity in mice by modulating metabolic activation of diosbulbin B
inferred← citeshttps://doi.org/10.1002/ptr.2563openalex-snapshot
Echinacea purpureaand P‐glycoprotein drug transport in Caco‐2 cells
inferred← citeshttps://doi.org/10.1002/ptr.5893openalex-snapshot
Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review
inferred← citeshttps://doi.org/10.1007/978-94-007-0526-5_19openalex-snapshot
An Evidence-based Perspective of Herbal Remedies for Cancer Patients
inferred← citeshttps://doi.org/10.1007/978-981-15-6255-6_11openalex-snapshot
Nanoemulsion Delivery of Herbal Products: Prospects and Challenges
inferred← citeshttps://doi.org/10.1007/s00228-012-1391-6openalex-snapshot
Lack of effect of continuous glycyrrhizin administration on the pharmacokinetics of the P-glycoprotein substrate talinolol in healthy volunteers
inferred← citeshttps://doi.org/10.1007/s00425-018-3064-xopenalex-snapshot
A lavender ABC transporter confers resistance to monoterpene toxicity in yeast
inferred← citeshttps://doi.org/10.1007/s11418-016-1049-2openalex-snapshot
The effects of 18β-glycyrrhetinic acid and glycyrrhizin on intestinal absorption of paeoniflorin using the everted rat gut sac model
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5-FU and the dietary flavonoid carvacrol: a synergistic combination that induces apoptosis in MCF-7 breast cancer cells
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Kinetics and dosing
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Valorisation of softwood bark through extraction of utilizable chemicals. A review
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Synthesis and anticancer activity of quinopimaric and maleopimaric acids’ derivatives
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Pulmonary vasodilators: Latest evidence and outcomes in the perioperative setting
inferred← citeshttps://doi.org/10.1016/j.drudis.2013.07.018openalex-snapshot
Triterpenoids as reversal agents for anticancer drug resistance treatment
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2016.10.022openalex-snapshot
Effects of pharmaceuticals and personal care products (PPCPs) on multixenobiotic resistance (MXR) related efflux transporter activity in zebrafish (Danio rerio) embryos
inferred← citeshttps://doi.org/10.1016/j.ejps.2014.11.011openalex-snapshot
Membrane transport of nobilin conjugation products and use of the extract of Chamomillae romanae flos influence absorption of nobilin in the Caco-2 model
inferred← citeshttps://doi.org/10.1016/j.fitote.2025.107039openalex-snapshot
Herb-immunosuppressive drug interactions: Implications for kidney transplant recipients
inferred← citeshttps://doi.org/10.1016/j.foodchem.2012.07.061openalex-snapshot
Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A
inferred← citeshttps://doi.org/10.1016/j.jafr.2024.101384openalex-snapshot
Recent overview of kaffir lime (Citrus hystrix DC) dual functionality in food and nutraceuticals
inferred← citeshttps://doi.org/10.1016/j.jchromb.2007.04.030openalex-snapshot
Development of a quantitative LC–MS/MS analytical method coupled with turbulent flow chromatography for digoxin for the in vitro P-gp inhibition assay
inferred← citeshttps://doi.org/10.1016/j.jchromb.2015.11.024openalex-snapshot
Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb–drug interactions
inferred← citeshttps://doi.org/10.1016/j.jep.2022.115406openalex-snapshot
Cytochrome P450 inhibition activities of non-standardized botanical products
inferred← citeshttps://doi.org/10.1016/j.jep.2023.117598openalex-snapshot
Overcoming multi drug resistance mediated by ABC transporters by a novel acetogenin- annonacin from Annona muricata L.
inferred← citeshttps://doi.org/10.1016/j.pharep.2017.04.012openalex-snapshot
Effects of friedelin on the intestinal permeability and bioavailability of apigenin
inferred← citeshttps://doi.org/10.1016/j.phymed.2021.153768openalex-snapshot
Biological properties of terpinolene evidenced by in silico, in vitro and in vivo studies: A systematic review
inferred← citeshttps://doi.org/10.1016/j.taap.2013.12.015openalex-snapshot
Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: Herb–drug interactions mediated via P-gp
inferred← citeshttps://doi.org/10.1016/j.vetpar.2022.109713openalex-snapshot
Phytochemical modulation of P-Glycoprotein and its gene expression in an ivermectin-resistant Haemonchus contortus isolate in vitro
inferred← citeshttps://doi.org/10.1016/s0065-2806(08)00001-5openalex-snapshot
Insect Excretory Mechanisms
inferred← citeshttps://doi.org/10.1038/s41598-023-49939-9openalex-snapshot
Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein
inferred← citeshttps://doi.org/10.1055/a-1766-5491openalex-snapshot
Carvacrol Enhance Apoptotic Effect of 5-FU on MCF-7 Cell Line via inhibiting P-glycoprotein: An In-silco and In-vitro Study
inferred← citeshttps://doi.org/10.1080/03602532.2022.2048007openalex-snapshot
Implication of metabolomics and transporter modulation based strategies to minimize multidrug resistance and enhance site-specific bioavailability: a needful consideration toward modern anticancer drug discovery
inferred← citeshttps://doi.org/10.1080/03639045.2020.1862178openalex-snapshot
Glycyrrhizic acid-based self-assembled micelles for improving oral bioavailability of paeoniflorin
inferred← citeshttps://doi.org/10.1080/1061186x.2024.2356751openalex-snapshot
Comprehensive insights into herbal P-glycoprotein inhibitors and nanoformulations for improving anti-retroviral therapy efficacy
inferred← citeshttps://doi.org/10.1080/10717544.2021.1989087openalex-snapshot
CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas
inferred← citeshttps://doi.org/10.1089/jmf.2010.0125openalex-snapshot
Antinociceptive Action and Redox Properties of Citronellal, an Essential Oil Present in Lemongrass
inferred← citeshttps://doi.org/10.1111/jvp.13386openalex-snapshot
Characterization of P‐glycoprotein orthologs from human, sheep, pig, dog, and cat
inferred← citeshttps://doi.org/10.1124/dmd.107.019513openalex-snapshot
Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport
inferred← citeshttps://doi.org/10.1124/pharmrev.120.000046openalex-snapshot
Analgesic Potential of Terpenes Derived from Cannabis sativa
inferred← citeshttps://doi.org/10.1134/s1068162013020088openalex-snapshot
Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid
inferred← citeshttps://doi.org/10.1155/2014/145325openalex-snapshot
Cyclosporine and Herbal Supplement Interactions
inferred← citeshttps://doi.org/10.11606/t.64.2023.tde-31102023-094720openalex-snapshot
Incremento da atividade anti-helmíntica da Ivermectina pela ação sinérgica de compostos fitoquímicos sob isolados de Haemonchus contortus susceptível e resistente a anti-helmínticos
inferred← citeshttps://doi.org/10.1186/s42269-019-0043-8openalex-snapshot
Targeting multidrug resistance in cancer by natural chemosensitizers
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Cardiovascular effects induced by Cymbopogon winterianus essential oil in rats: involvement of calcium channels and vagal pathway
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Mechanisms of drug resistance in nutrient-depleted colorectal cancer cells: insights into lysosomal and mitochondrial drug sequestration
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Multi-Drug Resistance Transporters and a Mechanism-Based Strategy for Assessing Risks of Pesticide Combinations to Honey Bees
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Effect of Orange Oil on the Oral Absorption of Enrofloxacin in Rats
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The effects of herbal teas on drug permeability
inferred← citeshttps://doi.org/10.1590/s1984-82502012000300002openalex-snapshot
Overview of P-glycoprotein inhibitors: a rational outlook
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Chemopreventive activity of celastrol in drug-resistant human colon carcinoma cell cultures
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Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer
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Comparative Evaluation of Nano-Assemblies From Shaoyao Gancao Decoction on Paeoniflorin Bioavailability
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Absorption, Disposition, and Pharmacokinetics of Saponins from Chinese Medicinal Herbs: What Do We Know and What Do We Need to Know More?
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Discovering Natural Product Modulators to Overcome Multidrug Resistance in Cancer Chemotherapy
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Herbal Medicine of the 21st Century: A Focus on the Chemistry, Pharmacokinetics and Toxicity of Five Widely Advocated Phytotherapies
inferred← citeshttps://doi.org/10.2174/1874467214666210309120626openalex-snapshot
Suppression of Molecular Targets and Antiproliferative Effect of Citronellal on Triple-Negative Breast Cancer Cells
inferred← citeshttps://doi.org/10.2174/9798898815851126010010openalex-snapshot
Exploring the Science of Aromatherapy: Revealing the Chemistry Behind the Captivating Agents
inferred← citeshttps://doi.org/10.3109/03602532.2015.1029634openalex-snapshot
Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid
inferred← citeshttps://doi.org/10.3109/14756360903389856openalex-snapshot
Acetylcholinesterase and butyrylcholinesterase inhibitory activity of Pinus species essential oils and their constituents
inferred← citeshttps://doi.org/10.3109/14756366.2016.1149476openalex-snapshot
Advances in plant-based inhibitors of P-glycoprotein
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Discovery of drug transporter inhibitors tied to long noncoding RNA in resistant cancer cells; a computational model -in silico- study
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Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery
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In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity
inferred← citeshttps://doi.org/10.3390/antiox11112241openalex-snapshot
Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus
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Synthesis, In Vitro and In Silico Analysis of New Oleanolic Acid and Lupeol Derivatives against Leukemia Cell Lines: Involvement of the NF-κB Pathway
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The Biological Activities of Sesterterpenoid-Type Ophiobolins
inferred← citeshttps://doi.org/10.3390/molecules20034337openalex-snapshot
Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles
inferred← citeshttps://doi.org/10.3390/molecules21070826openalex-snapshot
Kazakh Ziziphora Species as Sources of Bioactive Substances
inferred← citeshttps://doi.org/10.3390/molecules22060871openalex-snapshot
Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition
inferred← citeshttps://doi.org/10.3390/ph13120476openalex-snapshot
Anticancer Effect of Citrus hystrix DC. Leaf Extract and Its Bioactive Constituents Citronellol and, Citronellal on the Triple Negative Breast Cancer MDA-MB-231 Cell Line
inferred← citeshttps://doi.org/10.3390/pharmaceutics15071942openalex-snapshot
Coleon U, Isolated from Plectranthus mutabilis Codd., Decreases P-Glycoprotein Activity Due to Mitochondrial Inhibition
inferred← citeshttps://doi.org/10.3390/plants11111432openalex-snapshot
Antimicrobial, Multidrug Resistance Reversal and Biofilm Formation Inhibitory Effect of Origanum majorana Extracts, Essential Oil and Monoterpenes
inferred← citeshttps://doi.org/10.3892/ijo.2013.1979openalex-snapshot
Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity
inferred← citeshttps://doi.org/10.3897/pharmacia.68.e65878openalex-snapshot
Carvacrol effect on topotecan cytotoxicity in various human cancer cells in vitro
inferred← citeshttps://doi.org/10.4103/0973-7847.176546openalex-snapshot
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Natural Compounds: Molecular Weapons against Leukemia’s
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