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Puerarin suppresses MPP+/MPTP-induced oxidative stress through an Nrf2-dependent mechanism
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jamaneurol.2014.131openalex-snapshot
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Identification of (Antioxidative) Plants in Herbal Pharmaceutical Preparations and Dietary Supplements
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Parkinson’s disease: experimental models and reality
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Molecular basis of dopamine replacement therapy and its side effects in Parkinson’s disease
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Nrf2: a modulator of Parkinson’s disease?
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Chronic MPTP administration regimen in monkeys: a model of dopaminergic and non-dopaminergic cell loss in Parkinson’s disease
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Botanical Drug Puerarin Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Neurotoxicity via Upregulating Mitochondrial Enzyme Arginase-2
inferredcites →https://doi.org/10.1016/bs.irn.2017.02.004openalex-snapshot
Effect and Mechanism of Chinese Herbal Medicine on Parkinson's Disease
inferredcites →https://doi.org/10.1016/j.ejmech.2017.09.068openalex-snapshot
Recent advances in discovery and development of natural products as source for anti-Parkinson's disease lead compounds
inferredcites →https://doi.org/10.1016/j.ejphar.2010.09.045openalex-snapshot
Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo
inferredcites →https://doi.org/10.1016/j.expneurol.2017.05.009openalex-snapshot
Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease
inferredcites →https://doi.org/10.1016/j.fct.2018.03.029openalex-snapshot
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2015.07.147openalex-snapshot
Nrf2—a therapeutic target for the treatment of neurodegenerative diseases
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2018.03.028openalex-snapshot
Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells
inferredcites →https://doi.org/10.1016/j.gde.2017.01.016openalex-snapshot
PINK1/Parkin mitophagy and neurodegeneration—what do we really know in vivo?
inferredcites →https://doi.org/10.1016/j.gene.2007.06.013openalex-snapshot
Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits
inferredcites →https://doi.org/10.1016/j.jchemneu.2016.05.005openalex-snapshot
Estrogen modulation of calretinin and BDNF expression in midbrain dopaminergic neurons of ovariectomised mice
inferredcites →https://doi.org/10.1016/j.lfs.2014.08.004openalex-snapshot
Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: Involvement of ERK1/2–Nrf2 signaling pathway
inferredcites →https://doi.org/10.1016/j.mam.2008.08.009openalex-snapshot
Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
inferredcites →https://doi.org/10.1016/j.maturitas.2018.06.012openalex-snapshot
Phytoestrogen supplementation and body composition in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials
inferredcites →https://doi.org/10.1016/j.neuro.2018.02.001openalex-snapshot
Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity
inferredcites →https://doi.org/10.1016/j.pharep.2017.06.008openalex-snapshot
Mechanistic evaluation of neuroprotective effect of estradiol on rotenone and 6-OHDA induced Parkinson’s disease
inferredcites →https://doi.org/10.1016/j.pneurobio.2016.07.005openalex-snapshot
Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.redox.2018.03.012openalex-snapshot
Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning
inferredcites →https://doi.org/10.1016/j.steroids.2017.12.010openalex-snapshot
Sex-related differences in oxidative stress and neurodegeneration
inferredcites →https://doi.org/10.1016/s0306-3623(01)00082-9openalex-snapshot
17β-Estradiol protects lymphocytes against dopamine and iron-induced apoptosis by a genomic-independent mechanism
inferredcites →https://doi.org/10.1017/s146114571300148xopenalex-snapshot
Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice
inferredcites →https://doi.org/10.1021/acs.jafc.8b01079openalex-snapshot
Methods To Measure the Antioxidant Activity of Phytochemicals and Plant Extracts
inferredcites →https://doi.org/10.1021/acschemneuro.7b00247openalex-snapshot
Gastrodin and Isorhynchophylline Synergistically Inhibit MPP+-Induced Oxidative Stress in SH-SY5Y Cells by Targeting ERK1/2 and GSK-3β Pathways: Involvement of Nrf2 Nuclear Translocation
inferredcites →https://doi.org/10.1038/s41374-017-0009-0openalex-snapshot
β-Ecdysterone protects SH-SY5Y cells against β-amyloid-induced apoptosis via c-Jun N-terminal kinase- and Akt-associated complementary pathways
inferredcites →https://doi.org/10.1073/pnas.0813361106openalex-snapshot
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
inferredcites →https://doi.org/10.1074/jbc.m611336200openalex-snapshot
GSK-3β Acts Upstream of Fyn Kinase in Regulation of Nuclear Export and Degradation of NF-E2 Related Factor 2
inferredcites →https://doi.org/10.1080/00207454.2017.1403916openalex-snapshot
Prooxidant–antioxidant balance, advanced oxidation protein products and lipid peroxidation in Serbian patients with Parkinson's disease
inferredcites →https://doi.org/10.1089/ars.2017.7123openalex-snapshot
The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures?
inferredcites →https://doi.org/10.1093/hmg/ddx040openalex-snapshot
Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration
inferredcites →https://doi.org/10.1111/cns.12334openalex-snapshot
Botanical Drug Puerarin Coordinates with Nerve Growth Factor in the Regulation of Neuronal Survival and Neuritogenesis via Activating ERK 1/2 and PI 3K/Akt Signaling Pathways in the Neurite Extension Process
inferredcites →https://doi.org/10.1111/j.1476-5381.2009.00361.xopenalex-snapshot
Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF‐I receptor signalling pathway
inferredcites →https://doi.org/10.1111/tpj.13510openalex-snapshot
Molecular characterization of the C‐glucosylation for puerarin biosynthesis in Pueraria lobata
inferredcites →https://doi.org/10.1159/000485089openalex-snapshot
Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species
inferredcites →https://doi.org/10.1212/wnl.0000000000001776openalex-snapshot
Estrogen actions in the nervous system
inferredcites →https://doi.org/10.1517/13543780802716501openalex-snapshot
The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease
inferredcites →https://doi.org/10.1586/17474124.2016.1145546openalex-snapshot
A mechanistic review on plant-derived natural compounds as dietary supplements for prevention of inflammatory bowel disease
inferredcites →https://doi.org/10.18433/j30h04openalex-snapshot
Levodopa in Parkinson’s Disease: A Review of Population Pharmacokinetics/Pharmacodynamics Analysis
inferredcites →https://doi.org/10.2147/ndt.s69918openalex-snapshot
Hormone replacement therapy and Parkinson’s disease risk in women: a meta-analysis of 14 observational studies
inferredcites →https://doi.org/10.2174/1381612822666151112151653openalex-snapshot
Oxidative stress and Parkinson's disease: New hopes in treatment with herbal antioxidants
inferredcites →https://doi.org/10.3389/fphar.2017.00599openalex-snapshot
Brain Pharmacokinetics and the Pharmacological Effects on Striatal Neurotransmitter Levels of Pueraria lobata Isoflavonoids in Rat
inferredcites →https://doi.org/10.7417/t.2018.2050openalex-snapshot
The potential role of herbal products in the treatment of Parkinson's disease.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4668924openalex-extracted
Study on the Neuroinflammation-Related Mechanism of Puerarin in Improving Cognitive Impairment Induced by Alcohol Exposure/Withdrawal in Female Mice
inferred← citeshttps://doi.org/10.1002/fsn3.3609openalex-snapshot
Puerarin protects against acetaminophen‐induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway
inferred← citeshttps://doi.org/10.1002/mnfr.202300123openalex-snapshot
Puerarin Attenuates Iron Overload‐Induced Ferroptosis in Retina through a Nrf2‐Mediated Mechanism
inferred← citeshttps://doi.org/10.1002/ptr.70214openalex-snapshot
Research Progress of Natural Components Improving Parkinson's Disease by Regulating the Oxidative Stress
inferred← citeshttps://doi.org/10.1002/ptr.8342openalex-snapshot
Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols
inferred← citeshttps://doi.org/10.1002/tox.23437openalex-snapshot
Puerarin alleviates cadmium‐induced oxidative damage to bone by reducing autophagy in rats
inferred← citeshttps://doi.org/10.1007/978-3-030-74779-4_21openalex-snapshot
Biology and Biotechnological Strategies for Conservation Management of Pueraria tuberosa, a Traditionally Established Medicinal Liana
inferred← citeshttps://doi.org/10.1007/s00109-021-02071-5openalex-snapshot
Nrf2 as a potential target for Parkinson’s disease therapy
inferred← citeshttps://doi.org/10.1007/s00192-022-05325-zopenalex-snapshot
Puerarin protects fibroblasts against mechanical stretching injury through Nrf2/TGF-β1 signaling pathway
inferred← citeshttps://doi.org/10.1007/s10787-021-00895-8openalex-snapshot
Therapeutic benefits of flavonoids against neuroinflammation: a systematic review
inferred← citeshttps://doi.org/10.1007/s11011-024-01452-2openalex-snapshot
Emerging role of Nrf2 in Parkinson’s disease therapy: a critical reassessment
inferred← citeshttps://doi.org/10.1007/s11011-025-01552-7openalex-snapshot
Unraveling the role of Nrf2 in dopaminergic neurons: a review of oxidative stress and mitochondrial dysfunction in Parkinson’s disease
inferred← citeshttps://doi.org/10.1007/s11064-024-04258-xopenalex-snapshot
Atractylenolide-I Attenuates MPTP/MPP+‑Mediated Oxidative Stress in Parkinson’s Disease Through SIRT1/PGC‑1α/Nrf2 Axis
inferred← citeshttps://doi.org/10.1007/s12035-024-04222-4openalex-snapshot
Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases
inferred← citeshttps://doi.org/10.1007/s12035-025-05499-9openalex-snapshot
Metformin Inhibits Microglial Activation-Mediated Cuproptosis by Modulating the TLR4/Myd88/NF-κB Signaling Pathway in Parkinson’s Disease
inferred← citeshttps://doi.org/10.1016/j.arr.2022.101756openalex-snapshot
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.arr.2023.102063openalex-snapshot
Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products
inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.149324openalex-snapshot
Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108277openalex-snapshot
Volatile oils of Schisandra chinensis (Turcz.) Baill alleviates Parkinson's disease by activating the Nrf2 pathway to positively regulate autophagy and oxidative stress
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117101openalex-snapshot
Pharmacological mechanisms of puerarin in the treatment of Parkinson's disease: An overview
inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.175695openalex-snapshot
Therapeutic potential of puerarin against cerebral diseases: From bench to bedside
inferred← citeshttps://doi.org/10.1016/j.fbio.2022.101886openalex-snapshot
Preparation, characterization and antioxidant activity of inclusion complex loaded with puerarin and corn peptide
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.11.018openalex-snapshot
Ferritin confers protection against iron-mediated neurotoxicity and ferroptosis through iron chelating mechanisms in MPP+-induced MES23.5 dopaminergic cells
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2025.07.038openalex-snapshot
Blue honeysuckle (Lonicera caerulea L.)-anthocyanins and cyanidin-3-O-glucoside protect dopaminergic neurons against ferroptosis by activating the Nrf2-GPX7 axis
inferred← citeshttps://doi.org/10.1016/j.jep.2024.119095openalex-snapshot
Exploring the therapeutic potential of Chinese herbs on comorbid type 2 diabetes mellitus and Parkinson's disease: A mechanistic study
inferred← citeshttps://doi.org/10.1016/j.molimm.2026.04.011openalex-snapshot
Puerarin and DHEA combination therapy alleviates primary dysmenorrhea via inhibition of the Hsp90ab1/p38/JNK pathway
inferred← citeshttps://doi.org/10.1016/j.nut.2024.112610openalex-snapshot
Plant-derived compounds as potential neuroprotective agents in Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154582openalex-snapshot
Targeting the Nrf2 signaling pathway using phytochemical ingredients: A novel therapeutic road map to combat neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.redox.2021.102095openalex-snapshot
Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c00867openalex-snapshot
Virtual Screening of Nrf2 Dietary-Derived Agonists and Safety by a New Deep-Learning Model and Verified In Vitro and In Vivo
inferred← citeshttps://doi.org/10.1021/acssensors.5c03087openalex-snapshot
A Near-Infrared Chemiluminescent Probe for Visualizing Norepinephrine in Parkinson's Disease
inferred← citeshttps://doi.org/10.1038/s41392-023-01353-3openalex-snapshot
Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions
inferred← citeshttps://doi.org/10.1080/1028415x.2021.2017662openalex-snapshot
Nutrigenomics in Parkinson’s disease: diversity of modulatory actions of polyphenols on epigenetic effects induced by toxins
inferred← citeshttps://doi.org/10.1096/fj.202101567ropenalex-snapshot
Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3β/Fyn‐dependent Nrf2 activation
inferred← citeshttps://doi.org/10.1109/seb4sdg60871.2024.10630141openalex-snapshot
Puerarin: A Stimulator of NRF-2 Against Oxidative Damage in Diseases
inferred← citeshttps://doi.org/10.1111/jcmm.16679openalex-snapshot
Puerarin attenuates intracerebral hemorrhage‐induced early brain injury possibly by PI3K/Akt signal activation‐mediated suppression of NF‐κB pathway
inferred← citeshttps://doi.org/10.1155/2022/8624318openalex-snapshot
Therapeutic Targets for Regulating Oxidative Damage Induced by Ischemia‐Reperfusion Injury: A Study from a Pharmacological Perspective
inferred← citeshttps://doi.org/10.1155/2022/9191284openalex-snapshot
Therapeutic and Neuroprotective Effects of Bushen Jianpi Decoction on a Rotenone-Induced Rat Model of Parkinson’s Disease
inferred← citeshttps://doi.org/10.1177/11786388241253436openalex-snapshot
The Protection of EGCG Against 6-OHDA-Induced Oxidative Damage by Regulating PPARγ and Nrf2/HO-1 Signaling
inferred← citeshttps://doi.org/10.1186/s43556-024-00207-wopenalex-snapshot
Ulcerative colitis: molecular insights and intervention therapy
inferred← citeshttps://doi.org/10.14336/ad.2021.1205openalex-snapshot
Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2642361/v1openalex-snapshot
Metformin Inhibits Ferroptosis by Inducing Autophagy in MPTP/MPP+ Models of Parkinson’s Disease
inferred← citeshttps://doi.org/10.2147/ndt.s476969openalex-snapshot
Shisandra Decoction Alleviates Parkinson’s Disease Symptoms in a Mouse Model Through PI3K/AKT/mTOR Signalling Pathway
inferred← citeshttps://doi.org/10.2174/0118715273367688250528122144openalex-snapshot
Zebrafish-Based Parkinson's Disease Models: Unveiling Genetic Mechanisms and Therapeutic Pathways
inferred← citeshttps://doi.org/10.31083/j.fbe1404027openalex-snapshot
Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline
inferred← citeshttps://doi.org/10.3389/fncel.2021.743353openalex-snapshot
Role of Exosomes in Brain Diseases
inferred← citeshttps://doi.org/10.3389/fphar.2021.757161openalex-snapshot
Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease
inferred← citeshttps://doi.org/10.3390/antiox11010041openalex-snapshot
Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons
inferred← citeshttps://doi.org/10.3390/antiox11112121openalex-snapshot
Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin
inferred← citeshttps://doi.org/10.3390/antiox14060756openalex-snapshot
Puerarin as a Phytochemical Modulator of Gastrointestinal Homeostasis in Livestock: Molecular Mechanisms and Translational Applications
inferred← citeshttps://doi.org/10.3390/biom15010149openalex-snapshot
Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications
inferred← citeshttps://doi.org/10.3390/cells10051090openalex-snapshot
Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities
inferred← citeshttps://doi.org/10.3390/fishes10050197openalex-snapshot
Dietary Puerarin Enhances Growth, Immune Function, Antioxidant Capacity, and Disease Resistance in Farmed Largemouth Bass, Micropterus salmoides
inferred← citeshttps://doi.org/10.3390/ijms26136416openalex-snapshot
Parkinson Disease Signaling Pathways, Molecular Mechanisms, and Potential Therapeutic Strategies: A Comprehensive Review
inferred← citeshttps://doi.org/10.3390/nu14224724openalex-snapshot
Puerarin Reduces Oxidative Damage and Photoaging Caused by UVA Radiation in Human Fibroblasts by Regulating Nrf2 and MAPK Signaling Pathways
inferred← citeshttps://doi.org/10.3390/pharmaceutics15010013openalex-snapshot
Antiparkinsonian Agents in Investigational Polymeric Micro- and Nano-Systems
inferred← citeshttps://doi.org/10.5114/fn.2023.133039openalex-snapshot
Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson’s disease mice model
inferred← citeshttps://doi.org/10.5483/bmbrep.2022.55.1.162openalex-snapshot
Stem cell-derived extracellular vesicle therapy for acute brain insults and neurodegenerative diseases
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